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排序方式: 共有615条查询结果,搜索用时 31 毫秒
1.
Ole Wiborg Martin O'Connell Richard Thiele Martin Wichert Gunther Kolb 《化学工程与技术》2015,38(8):1308-1314
Many critical issues need to be addressed when microstructured reactors are manufactured in large unit volumes. The most crucial of these are cost, ease of production, and reliability. The lack of breakthrough manufacturing technology to provide high‐efficiency, low‐cost, high‐precision plates is a hindrance to the early market implementation of systems requiring metallic microstructured plates. This contribution focuses on the development and optimization of a combined embossing and bending tool for the quick and continuous manufacture of easily machined plates. 相似文献
2.
Rats given medial frontal lesions on Postnatal Day 1 or Day 10 were trained on the Morris water task on Days 19–21 or Days 56–58. The operated groups were equally impaired at the water task on Days 19–21, but the Day 10 rats had recovered by 56 days. Dendritic arborization and spine density were analyzed in parietal layer II–III pyramidal cells. At Day 60, but not at Day 22, the Day 10 animals had more dendritic spines per unit dendritic length than did the controls or Day 1 rats. Thus, there was functional recovery rather than sparing after frontal lesions at 10 days, and the recovery was correlated with an increase in dendritic spines. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
F van Rhee RM Szydlo J Hermans A Devergie F Frassoni W Arcese T de Witte HJ Kolb D Niederwiser N Jacobsen G Gahrton G Bandini E Carreras A Bacigalupo M Michallet T Ruutu J Reiffers JM Goldman J Apperley A Gratwohl 《Canadian Metallurgical Quarterly》1997,20(7):553-560
The purpose of this study was to determine the long-term results of allogeneic bone marrow transplantation for chronic myeloid leukemia. A retrospective analysis was carried out of the outcome of 373 consecutive transplants performed at 38 European institutions between 1980 and 1988 and reported to the registry of the European Group for Blood and Marrow Transplantation. All transplants were carried out for first chronic phase of chronic myelogenous leukemia using unmanipulated marow cells from HLA-identical sibling donors. The probability of survival and leukemia-free survival at 8 years were 54% (95% CI: 49-59) and 47% (95% CI: 41-52) respectively. The probabilities of developing acute GVHD (II-IV) at 100 days and chronic GVHD at 4 years after transplant were 47% (95% CI: 41-53) and 52% (95% CI: 46-58) respectively. The probabilities of transplant-related mortality and leukemic relapse 8 years after BMT were 41% (95% CI: 36-48) and 19% (95% CI: 14-25), respectively. Transplant within 12 months of diagnosis was associated with reduced transplant-related mortality (34 vs 45%, P = 0.013) and resulted in improved leukemia-free survival (52 vs 44%, P = 0.03). The probability of relapse was significantly reduced in patients who developed chronic GVHD (RR = 0.33, P = 0.004). The probability of relapse occurring more than 2 years after transplant was increased more than five-fold in patients transplanted from a male donor (RR = 5.5, P = 0.006). Sixty-seven patients in hematologic remission were studied for residual disease by two-step RT/PCR for BCR-ABL mRNA and 61 (91%) tested negative. We conclude that bone marrow transplantation can induce long-term survival in approximately one-half of CML patients; the majority of survivors have no evidence of residual leukemia cells when studied by molecular techniques. The probability of late relapse is increased with use of a male donor. 相似文献
4.
R Albrecht TC Awes C Baktash P Beckmann F Berger R Bock G Claesson G Clewing L Dragon A Eklund RL Ferguson A Franz S Garpman R Glasow HA Gustafsson HH Gutbrod J Idh P Jacobs K Kampert BW Kolb P Kristiansson IY Lee H Loehner I Lund FE Obenshain A Oskarsson I Otterlund T Peitzmann S Persson F Plasil AM Poskanzer M Purschke H Ritter S Saini R Santo HR Schmidt T Siemiarczuk SP Sorensen E Stenlund ML Tincknell GR Young 《Canadian Metallurgical Quarterly》1991,44(6):2736-2752
5.
For timber the tensile stress perpendicular to the grain is a critical type of stress. The influence of long-term loading, temperature and climate changes upon the tensile strength perpendicular to the grain of timber is shown. The results prove that the greatest loss of strength happened after long-term outdoors loading. While storing under alternating climate conditions, great crepp strains appeared, and it is to be presumed that the damages of wooden components which fail across the grain are less a problem of “tensile stress perpendicular to the grain” than a problem of “strain under tension perpendicular to the grain”. 相似文献
6.
7.
Hebb's principal theoretical propositions, the cell assembly and the nature of synaptic change, were generated at a time when the focus of work in behavioural neuroscience was directed at understanding issues such as the principles governing the behaviour of animals in neuropsychological studies of learning and memory and the role of drives in the control of behaviours like sex and feeding and drinking. It was not until attention shifted to understanding the neural underpinnings of learning and memory that Hebb's propositions had an impact on behavioural neuroscience as they provided a simple, and testable, mechanism for synaptic plasticity observed both in learning and in other forms of experience-dependent neural change. But much of the field remains interested in other issues such as sensation and perception, motivation, attention, and so on, and to date, Hebb's propositions have had little impact. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
Markus Eisele Ralf Kolb Erwin Kraus Christian von Ehrenstein 《Informatik-Spektrum》2007,30(6):407-412
Zusammenfassung Das Schlagwort NetWeaver ist seit einiger Zeit in unserer Branche en vogue. Wie so oft, ist es nicht leicht, Marketingaspekte
vom informatischen Wesensgehalt zu unterscheiden. Dieser Beitrag m?chte hier helfen. 相似文献
9.
V Heinemann D Bosse U Jehn B K?hny K Wachholz A Debus P Scholz HJ Kolb W Wilmanns 《Canadian Metallurgical Quarterly》1997,41(6):1275-1280
The liposomal formulation of amphotericin B (AmBisome) greatly reduces the acute and chronic side effects of the parent drug. The present study describes the pharmacokinetic characteristics of AmBisome applied to 10 patients at a dose of 2.8 to 3.0 mg/kg of body weight and compares them to the pharmacokinetics observed in 6 patients treated with amphotericin B deoxycholate at the standard dose of 1.0 mg/kg. Interpatient variabilities of amphotericin B peak concentrations (Cmax) and areas under concentration-time curves (AUC) were 8- to 10-fold greater for patients treated with AmBisome than for patients treated with amphotericin B deoxycholate. At the threefold greater dose of AmBisome, median Cmaxs were 8.4-fold higher (14.4 versus 1.7 microg/ml) and median AUCs exceeded those observed with amphotericin B deoxycholate by 9-fold. This was in part explained by a 5.7-fold lower volume of distribution (0.42 liters/kg) in AmBisome-treated patients. The elimination of amphotericin B from serum was biphasic for both formulations. However, the apparent half-life of elimination was twofold shorter for AmBisome (P = 0.03). Neither hemodialysis nor hemofiltration had a significant impact on AmBisome pharmacokinetics as analyzed in one patient. In conclusion, the liposomal formulation of amphotericin B significantly (P = 0.001) reduces the volume of drug distribution, thereby allowing for greater drug concentrations in serum. The low toxicity of AmBisome therefore cannot readily be explained by its serum pharmacokinetics. 相似文献
10.