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排序方式: 共有1370条查询结果,搜索用时 31 毫秒
1.
Takashi Ohnishi Yuki Ogawa Kota Suda Miki Komatsu Satoko Matsumoto Harmon Mitsuru Asukai Masahiko Takahata Norimasa Iwasaki Akio Minami 《International journal of molecular sciences》2021,22(9)
Pyogenic spondylodiscitis can cause severe osteolytic and destructive lesions in the spine. Elderly or immunocompromised individuals are particularly susceptible to infectious diseases; specifically, infections in the spine can impair the ability of the spine to support the trunk, causing patients to be bedridden, which can also severely affect the physical condition of patients. Although treatments for osteoporosis have been well studied, treatments for bone loss secondary to infection remain to be elucidated because they have pathological manifestations that are similar to but distinct from those of osteoporosis. Recently, we encountered a patient with severely osteolytic pyogenic spondylodiscitis who was treated with romosozumab and exhibited enhanced bone formation. Romosozumab stimulated canonical Wnt/β-catenin signaling, causing robust bone formation and the inhibition of bone resorption, which exceeded the bone loss secondary to infection. Bone loss due to infections involves the suppression of osteoblastogenesis by osteoblast apoptosis, which is induced by the nuclear factor-κB and mitogen-activated protein kinase pathways, and osteoclastogenesis with the receptor activator of the nuclear factor-κB ligand-receptor combination and subsequent activation of the nuclear factor of activated T cells cytoplasmic 1 and c-Fos. In this study, we review and discuss the molecular mechanisms of bone loss secondary to infection and analyze the efficacy of the medications for osteoporosis, focusing on romosozumab, teriparatide, denosumab, and bisphosphonates, in treating this pathological condition. 相似文献
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T. Takeuchi T. Sasaki M. Hayashi K. Hamamoto K. Makita K. Taguchi K. Komatsu 《Photonics Technology Letters, IEEE》1996,8(3):361-363
A transceiver PIC consisting of a DFB-LD, a receiver PD and a Y-shaped branch waveguides is realized by in-plane bandgap energy controlled selective MOVPE. Both active and passive core layers are formed in one step selective growth, and complicated fabrication procedure is no longer required. More than 1 mW fiber coupled power and 7 GHz receiver bandwidth are obtained. The modulation and detection operations at 500 Mb/s are successfully demonstrated. 相似文献
5.
Hiroshi Ito Takehiko Ishiguro Tokutaro Komatsu Nozomu Matsukawa Gunzi Saito Hiroyuki Anzai 《Journal of Superconductivity and Novel Magnetism》1994,7(3):667-669
The superconducting transition of the organic compoundsκ-(BEDT-TTF)2 X is studied by resistive measurement in a magnetic field up to 10 T applied normal to the conducting plane. For the salts withX=Cu[N(CN)2]Br andX=CuCN[N(CN)2] the transition shows fanshaped broadening caused by superconductivity fluctuation. For theX=Cu(NCS)2 salt the resistivity shows a peak in the transition region in a magnetic field below 4 T.This phenomenon is suppressed in defect-reduced samples for intralayer conduction. We discuss this peak in relation to the thermal fluctuation on the Josephson junction structures in this salt. 相似文献
6.
M. Komatsu Y. Matsukawa K. Yasunaga M. Kiritani 《Materials Science and Engineering: A》2003,350(1-2):25-29
Heavy plastic deformation of fcc metal thin foils to fracture has been found recently to proceed without involving dislocations, and it results in the formation of high density of vacancy clusters. Thin foil specimens of bcc metals such as V and Mo were plastically deformed to fracture in in situ elongation experiments under an electron microscope. Morphology of thinning and fracture was found to be similar to fcc metals, and no dislocation was observed during heavy deformation. Electron diffraction analysis at the tip of a crack during deformation confirmed a large elastic deformation of up to 5%. Unlike in fcc metal thin foil specimens, point defect clusters were not observed near fractured tips. This difference is attributed to the difference in vacancy reaction, though the deformation in bcc metals without dislocation most likely does produce vacancies. 相似文献
7.
Masaaki Miyamoto Hiroyuki Koike Toshio Sada Yasuteru Ijima Junichiro Fukushige Norio Nakamura 《Lipids》1991,26(12):1316-1319
Platelet-activating factor (PAF) is a potent inflammatory mediator which is released by various inflammatory cells and produced
by certain tissues, including the kidney. PAF has been shown to increase glomerular permeability to protein and to decrease
glomerular filtration rate (GFR) by contracting mesangium. On the basis of these observations, it has been suspected that
PAF may play a role as mediator of glomerular damage in glomerular nephritis. To examine this possibility, we studied the
effects of a specific PAF antagonist, R-75,317, on the development of an experimental model of anti-glomerular basement membrane
(anti-GBM) glomerulonephritis. Glomerulonephritis was initiated by injecting rabbit anti-rat GBM serum into rats. Proteinuria
gradually developed after serum injection, plateaued at week 2, and remained at the high level of week 2 throughout the experimental
period (6 wk). Chronic treatment with R-75,317 (10 mg/kg/day i.p.) tended to delay the onset of proteinuria and significantly
accelerated the recovery phase. Creatinine clearance (Ccr) fell to 40% at week 3. R-75,317 treatment completely prevented
this decline of Ccr. Histological changes in this model (glomerular hypertrophy, proliferation of mesangial matrix and interstitial
fibrosis) were also ameliorated by the R-75,317 treatment. The results suggest that PAF may play a role in the development
of glomerulonephritis and that PAF antagonists could be used in the treatment of human renal disease.
Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl
Ether Lipids, May 1989. 相似文献
8.
Microstructural change of ultrafine-grained aluminum during high-speed plastic deformation 总被引:5,自引:0,他引:5
N. Tsuji T. Toyoda Y. Minamino Y. Koizumi T. Yamane M. Komatsu M. Kiritani 《Materials Science and Engineering: A》2003,350(1-2):108-116
Effect of strain rate on microstructural change in deformation of the ultrafine grained (UFG) aluminum produced by severe plastic deformation (SPD) was studied. Commercial purity 1100 aluminum sheets were highly strained up to an equivalent strain of 4.8 by the Accumulative Roll-Bonding (ARB) process at ambient temperature. The ARB-processed sheets were found to be filled with pancake-shaped ultrafine grains surrounded by high-angle grain boundaries. The ultrafine grains had a mean grain thickness of 200 nm and a mean grain length of 1100 nm. The ultrafine-grained aluminum sheets were deformed at various strain rates ranging from 2 to 6.0×104 s−1 by conventional rolling, ultra-high-speed rolling, and impact compression. High-speed plastic deformation generates a large amount of heat, inducing coarsening of the ultrafine grains during and after deformation. On the other hand, it was also suggested that high-speed plastic deformation is effective for grain-subdivision, in other words, ultra-grain refinement, if the effect of heat generation is extracted. 相似文献
9.
Nakazawa Y. Komatsu T. Saito T. 《Vision, Image and Signal Processing, IEE Proceedings -》1996,143(4):234-240
The authors propose an image processing-based approach towards the development of a super-high-resolution image acquisition system. Imaging methods based on this approach can be classified into two main categories: a spatial integration imaging method and a temporal integration imaging method. With regard to the spatial integration imaging method, the authors have previously presented a method for acquiring an improved-resolution image by integrating multiple images taken simultaneously with multiple different cameras. They develop their work, aiming at a particular class of application where a user indicates a region of interest (ROI) on an observed image in advance, and apply a prototypal temporal integration imaging method. The prototypal temporal integration imaging method does not involve global image segmentation, but uses a subpixel registration algorithm which describes an image warp within the ROI, with subpixel accuracy, as a deformation of quadrilateral patches. The method then performs a subpixel registration by warping an observed image with the warping function recovered from the deformed quadrilateral patches. Experimental simulations demonstrate that the temporal integration imaging is promising as a basic means of high resolution imaging 相似文献
10.