Deterministic planning in the fifth international planning competition: PDDL3 and experimental evaluation of the planners

The international planning competition (IPC) is an important driver for planning research. The general goals of the IPC include pushing the state of the art in planning technology by posing new scientific challenges, encouraging direct comparison of planning systems and techniques, developing and improving a common planning domain definition language, and designing new planning domains and problems for the research community. This paper focuses on the deterministic part of the fifth international planning competition (IPC5), presenting the language and benchmark domains that we developed for the competition, as well as a detailed experimental evaluation of the deterministic planners that entered IPC5, which helps to understand the state of the art in the field.We present an extension of pddl, called pddl3, allowing the user to express strong and soft constraints about the structure of the desired plans, as well as strong and soft problem goals. We discuss the expressive power of the new language focusing on the restricted version that was used in IPC5, for which we give some basic results about its compilability into pddl2. Moreover, we study the relative performance of the IPC5 planners in terms of solved problems, CPU time, and plan quality; we analyse their behaviour with respect to the winners of the previous competition; and we evaluate them in terms of their capability of dealing with soft goals and constraints, and of finding good quality plans in general. Overall, the results indicate significant progress in the field, but they also reveal that some important issues remain open and require further research, such as dealing with strong constraints and computing high quality plans in metric-time domains and domains involving soft goals or constraints.     

Hiding message delivery latency using Direct-to-Cache-Transfer techniques in message passing environments

Communication overhead is the key obstacle to reaching hardware performance limits. The majority is associated with software overhead, a significant portion of which is attributed to message copying. To reduce this copying overhead, we have devised techniques that do not require to copy a received message in order for it to be bound to its final destination. Rather, a late-binding mechanism, which involves address translation and a dedicated cache, facilitates fast access to received messages by the consuming process/thread.We have introduced two policies namely Direct to Cache Transfer (DTCT) and lazy DTCT that determine whether a message after it is bound needs to be transferred into the data cache. We have studied the proposed methods in simulation and have shown their effectiveness in reducing access times to message payloads by the consuming process.     

Evolving knowledge for the solution of clustering problems in cellular manufacturing

Hierarchical clustering has been widely used for the solution of problems in the area of cellular manufacturing. Hierarchical clustering procedures utilize coefficients that quantify the level of similarity between pairs of machines or parts in the plant. An evolutionary methodology is proposed for the construction of new similarity coefficients that can be used by standard hierarchical clustering methodologies for the solution of cell-formation problems. A typical application is presented for the simplest case of the cell-formation problem. However, alternative similarity coefficients can be evolved for advanced formulations of the problem by suitably modifying the set of fitness cases that constitute the environment of the evolutionary process.     

Favorable outcome of ovarian germ cell malignancies treated with cisplatin or carboplatin-based chemotherapy: a Hellenic Cooperative Oncology Group study

The effect of pretreatment of human polymorphonuclear leukocites (PMNs), for 30 min with fluconazole (0.1, 1, 5 and 50 microgram/ml) and itraconazole (0.05, 0.5 and 5 microgram/ml) on phagocytosis and generation of free radicals (superoxide anion and hydrogen peroxide) was studied in vitro. Phorbol miristate acetate (200 nM) was used as a stimulant. The mean amount of superoxide anion generated by 2.5 x 10(5) PMNs per hour was 4.39 +/- 1.13 nmol for fluconazole-treated PMNs and 4.56 +/- 1.2 nmol for itraconazole, and that of hydrogen peroxide was 11.19 +/- 2.18 and 11.28 +/- 3.61 nmol, respectively. The phagocytosis percentages were 83.8% for the control group and 88. 7% in antifungal agent- treated PMNs; the phagocytosis index was 3.0 yeasts per PMN for both groups. The differences between the control and treated PMNs were not statistically significant at any of the tested concentrations.     

Design of circular steel arches with hollow circular cross-sections according to EC3

Design of either pin-ended or fixed circular steel arches with hollow circular cross-sections subjected to a uniformly distributed vertical load along the horizontal projection of the entire arch with the aid of the EC3 provisions is discussed. Appropriate modification factors are proposed that should be included in EC3 interaction equations, to improve their accuracy for the design of such arches.     

Management of blood pressure instability in severe tetanus: the use of clonidine

OBJECTIVE: To evaluate the effectiveness of clonidine in the management of unstable blood pressure in severe tetanus. DESIGN: Patients with severe tetanus and blood pressure instability were treated with clonidine and the results were compared with those of other patients with severe tetanus who were not treated with clonidine. SETTING: Intensive care unit of the Chest Hospital of Athens. PATIENTS: We studied 27 patients with severe tetanus and autonomic dysfunction. INTERVENTIONS: Patients were managed according to a protocol. MEASUREMENTS AND RESULTS: Clonidine was administered until blood pressure stability was the fully restored and the dose was then gradually reduced. Five patients from the nonclonidine group and 2 from the clonidine group died. CONCLUSIONS: These results suggest that clonidine is effective in the treatment of blood pressure instability in severe tetanus.     

Eosinophilic cystitis: a rare case which presented as an invasive bladder tumor

Eosinophilic cystitis is a rare inflammatory lesion of the bladder of unknown etiology. It can be confused clinically and cytoscopically with invasive bladder cancer. We report a case in which the lesion presented as an invasive bladder tumor and we discuss the literature in brief.     

Magnetic resonance imaging in the staging of solitary plasmacytoma of bone

PURPOSE: To assess prospectively the role of magnetic resonance (MR) imaging in the staging of patients with a solitary bone plasmacytoma (SBP). PATIENTS AND METHODS: Twelve consecutive patients with an apparent SBP underwent MR imaging of both the primary tumor and the thoracic and lumbosacral spine to seek additional foci of marrow involvement that might have been undetected by standard skeletal survey. All patients received megavoltage irradiation (total dose, 40 Gy) to the primary lesion. RESULTS: MR imaging of the thoracic and lumbosacral spine showed additional foci of marrow replacement in four of 12 patients, with signal characteristics identical to those of the primary tumor. In all four patients, the abnormal protein persisted at greater than 50% of the pretreatment value following radiation treatment. In contrast, the myeloma protein disappeared or was reduced by greater than 50% in five of the six patients with secretory disease and without additional marrow abnormalities. One of four patients progressed to multiple myeloma 10 months after diagnosis with new lesions on conventional radiographs in the same areas as detected previously by MR imaging. CONCLUSION: Four of 12 patients considered to have a SBP by standard criteria may have been understaged, because MR imaging showed additional marrow abnormalities consistent with myeloma. MR imaging of the spine may contribute to the initial staging of SBP, especially since some patients may be cured with radiotherapy.     

采用“欧洲规范3”对圆形空心截面钢拱的设计

讨论采用"欧洲规范3"对沿拱水平方向均布竖向荷载作用下的末端销接或固接的空心圆形横截面钢拱的设计方法,并提出了修正系数,以提高对此类拱结构设计的准确性。