The domain of function: who''s got it? Who''s competing for it?

We report on two patients with sulbactam/ampicillin (SBT/ABPC)-induced pneumonitis. Both patients were being treated with SBT/ABPC for respiratory-tract infections. Following the initiation of SBT/ABPC chemotherapy, however, chest X-ray films showed a shift of shadow in patient 1 and new pulmonary infiltration shadows in patient 2. Bronchoalveolar lavage fluid (BALF) findings showed a marked increase in the total cell count and percentage of eosinophils in patient 1 and of lymphocytes in patient 2. The results of lymphocyte stimulation tests were SBT/ABPC positive for both patients. SBT/ABPC therapy was therefore discontinued and corticosteroid therapy started. Both patients were subsequently relieved of their symptoms demonstrated significantly lower and pulmonary infiltrate levels. Based on these findings, both patients were given a diagnosis of SBT/ABPC-induced pneumonitis. It has been widely reported that CD 4/CD 8 ratio in BALF decreases in cases of drug-induced pneumonitis. However, some reports have cited increase in the CD 4/CD 8 ratio. In our two patients as well, the CD 4/CD 8 ratio increased. These results, together with the findings from several other case reports, indicate that the CD 4/CD 8 ratio may not be good basis for diagnosing drug-induced pneumonitis. Recently, the incidence of drug-induced pneumonitis has been rising. To our knowledge this is the first report documenting cases of SBT/ABPC-induced pneumonitis.     

Corrosion fatigue of extruded magnesium alloys

Corrosion fatigue tests were carried out on extruded AZ31 (3% Al, 1% Zn, 0.3% Mn, Mg—the rest), AM50 (5% Al, 0.4% Mn, Mg—the rest) and ZK60 (5% Zn, 0.5% Zr, Mg—the rest) Mg alloys in air, NaCl-based and borate solutions. N_sol/N_air ratios (the relative fatigue life) were used for the analysis of the corrosion fatigue behavior of Mg alloys in various environments, where N_sol and N_air are the numbers of cycles to failure in the solution and in air, respectively. Extruded ZK60 alloy reveals very high fatigue and corrosion fatigue properties in comparison with other alloys. However, it has the lowest relative fatigue life (N_sol/N_air 10⁻³–10⁻²) or the highest sensitivity to the action of NaCl-based solutions in comparison with that of AM50 and AZ31 alloys (N_sol/N_air 10⁻²–10⁻¹). Under the same stress, the corrosion fatigue life of extruded alloys is significantly longer than that of die-cast alloys (N_sol for extruded AM50 in NaCl is two to three times longer than that of die-cast AM50).     

Application of the CALPHAD approach to Mg-alloys design

The CALPHAD method can be applied as a tool for both alloy development and process guideline determination. In this study, two Mg alloys were designed, their process parameters derived and, using the CALPHAD method, the final results simulated. These results were later confirmed using tangible experimental methods. It was found that γ$\gamma$- Mg₁₇Al₁₂ precipitates along the grain boundaries (GB), Mg₂Sn forms both along the GB and as fine precipitates in the α$\alpha$-Mg matrix and the addition of Ce mishmetal (MM) leads to the formation of elongated Al- rare earth (RE) precipitates along the GB. The microstructural stability at 200 ^°C is high, showing no decrease in microhardness for 32 days. It is shown that the CALPHAD method considerably reduces the effort of alloy design and that the reliability of the results is high.     

A new view of anti‐windup design for uncertain linear systems in the frequency domain

This paper presents a new perspective on the stability problem for uncertain LTI feedback systems with actuator input amplitude saturation. The solution is obtained using the quantitative feedback theory and a 3 DoF non‐interfering control structure. Describing function (DF) analysis is used as a criterion for closed loop stability and limit cycle avoidance, but the circle or Popov criteria could also be employed. The novelty is the combination of a controller parameterization from the literature and describing function‐based limit cycle avoidance with margins for uncertain plants. Two examples are given. The first is a benchmark problem and a comparison is made with other proposed solutions. The second is an example that was implemented and tested on an X‐Y linear stage used for nano‐positioning applications. Design and implementation considerations are given. An example is given on how the method can be extended to amplitude and rate saturation with the help of the generalized describing function, and a novel anti‐windup compensation structure inspired by previous contributions. Copyright © 2015 John Wiley & Sons, Ltd.     

Straining phenomena of POY revealed by thermal retraction and other techniques

Partially oriented polyesters yarns (POY) were strained at different strain rates (0.03–12.00 min^?1) and temperatures above and below T_g (3–92°C). Thermal retraction, density, DSC, and WAXS techniques show that strain-induced crystallization takes place by straining at temperatures above as well as below T_g. Above T_g, depending upon the strain rate, two regimes are observed: Below the strain rate of 1.5 min^?1, the flow regime; the degree of crystallinity is reduced as the strain rate increases. Above the strain rate of 1.5 min^?1, the strain-induced crystallization regime; the degree of crystallinity increases as the strain rate increases. Thermal retraction, stress–relaxation, and sonic modulus techniques indicate that, upon cold straining, instead of the original T_g at 65–69°C, two glass transitions occur: an upper T_g (u) and a lower T_g (l). For POY strained at 3°C and at a strain rate of 10 min^?1, the values are 78°C and 37°C, respectively. The higher the strain rate and the lower the straining temperature, the large the difference between T_g (u) and T_g (l).     

Relating organic fouling of reverse osmosis membranes to intermolecular adhesion forces

Organic fouling of reverse osmosis (RO) membranes and its relation to foulant--foulant intermolecular adhesion forces has been investigated. Alginate and Suwannee River natural organic matter were used as model organic foulants. Atomic force microscopy was utilized to determine the adhesion force between bulk organic foulants and foulants deposited on the membrane surface under various solution chemistries. The measured adhesion force was related to the RO fouling rate determined from fouling experiments under solution chemistries similar to those used in the AFM measurements. A remarkable correlation was obtained between the measured adhesion force and the fouling rate under the solution chemistries investigated. Fouling was more severe at solution chemistries that resulted in larger adhesion forces, namely, lower pH, higher ionic strength, presence of calcium ions (but not magnesium ions), and higher mass ratio of alginate to Suwannee River natural organic matter. The significant adhesion force measured with alginate in the presence of calcium ions indicated the formation of a crossed-linked alginate gel layer during fouling through intermolecular bridging among alginate molecules.     

Aggregation kinetics of alginate-coated hematite nanoparticles in monovalent and divalent electrolytes

The early stage aggregation kinetics of bare and alginate-coated hematite nanoparticles are acquired through time-resolved dynamic light scattering (DLS). Varying concentrations of monovalent (NaCl) and divalent (MgCl2 and CaCl2) electrolytes are employed to induce aggregation. In the presence of NaCl and MgCl2, the alginate-coated hematite nanoparticles undergo aggregation through electrostatic destabilization as described by the classic Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. This is ascertained through examination of the favorable and unfavorable regimes of the stability curves depicting the attachment efficiency as a function of salt concentration. Additional evidence may be found in the aggregation kinetics of alginate-coated particles, which, under favorable aggregation conditions, are reasonably close to that of bare hematite nanoparticles. However, in the presence of CaCl2, the aggregate growth rate of alginate-coated hematite nanoparticles is much higher than that which conventional diffusive aggregation predicts. Dispersed hematite primary particles and lower-order aggregates enmeshed within extended alginate gel networks were observed under transmission electron microscope (TEM). The proposed mechanism for enhanced aggregation suggests an apparent increase in the collision radii of alginate-coated hematite nanoparticles through alginate gel network formation from the particle surface. Additionally, cross-linking between unadsorbed (suspended) alginate macromolecules may form bridges between hematite-alginate gel clusters. It is further established that the presence of background electrolyte NaCl in solution is detrimental to the calcium-induced enhanced aggregation.     

Influence of growth phase on bacterial deposition: interaction mechanisms in packed-bed column and radial stagnation point flow systems

The influence of bacterial growth stage on cell deposition kinetics has been examined using a mutant of Escherichia coli K12. Two experimental techniques--a packed-bed column and a radial stagnation point flow (RSPF) system--were employed to determine bacterial deposition rates onto quartz surfaces over a wide range of solution ionic strengths. Stationary-phase cells were found to be more adhesive than mid-exponential phase cells in both experimental systems. The divergence in deposition behavior was notably more pronounced in the RSPF than in the packed-bed system. For instance, in the RSPF system, the deposition rate of the stationary-phase cells at 0.03 M ionic strength was 14 times greater than that of the mid-exponential cells. The divergence in the packed-bed system was most significant at 0.01 M, where the deposition rate for the stationary-phase cells was nearly 4 times greater than for the mid-exponential cells. To explain the observed adhesion behavior, the stationary and mid-exponential bacterial cells were characterized for their size, surface charge density, electrophoretic mobility, viability, and hydrophobicity. On the basis of this analysis, it is suggested that the stationary cells have a more heterogeneous distribution of charged functional groups on the bacterial surface than the mid-exponential cells, which results in higher deposition kinetics. Furthermore, because the RSPF system enumerates only bacterial cells retained in primary minima, whereas the packed column captures mostly cells deposited in secondary minima, the difference in the stationary and mid-exponential cell deposition kinetics is much more pronounced in the RSPF system.     

Model reference adaptive control of state delayed system with actuator failures

This paper develops adaptive state feedback control schemes for a class of linear systems with state delay in the presence of unknown actuator failures. The main contributions of this paper are the development of two controller parametrizations which attempt to anticipate the future states, the introduction of an appropriate Lyapunov–Krasovskii type functional to design the new class of adaptation algorithms, and a stability proof.