Comparative influence of a single allergen exposure on the different components of airway response to methacholine

We compared the effects of an allergen challenge on airway responsiveness to methacholine, the slope of the dose-response curve (DRC) and post-methacholine fall in forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV1)/FVC, and determined whether any changes in these parameters were related to the presence and magnitude of the late asthmatic response (LAR) in mild stable asthma. Twenty-three allergic asthmatic subjects had an allergen challenge, preceded and followed 24 (n = 12) and/or 48 (n = 22) h later by a methacholine challenge. Sixteen subjects had a dual asthmatic response to the allergen. On the post-allergen methacholine challenge, as compared with the pre-allergen test, differences in mean fall in FVC or FEV1/FVC at 20% fall in FEV1 and the slope of the DRC did not achieve statistical significance, even in the group with LAR, which showed a significant increase in airway responsiveness at 24 h. There was, however, a correlation between allergen-induced changes in PC20 and (1) the change in post-methacholine FVC fall in the LAR group at 48 h, and (2) the change in the slope of the DRC in the early-asthmatic-response group at 24 h. In conclusion, allergen-challenge-induced changes in airway response to methacholine are heterogeneous among asthmatic subjects and although it may increase airway responsiveness (PC20), particularly in late responders, it minimally affects the other aspects of airway response to methacholine, suggesting that a more powerful or sustained allergic stimulus is required to modify the latter.     

Covalent surface functionalization of nonwoven fabrics with controlled hydrophobicity,water absorption,and pH regulation properties

A modular method for functionalization of nonwoven fabrics was developed using a two-step process. In the first step, the fabrics were grafted with a linker molecule, 10-undecenoyl chloride, via esterification, followed by attachment of a functional material under UV irradiation. Perfluorodecanethiol and 3-mercaptopropionic acid (MPA) were connected to the linker-modified fabrics using thiol-ene click chemistry. Perfluorodecanethiol modified fabrics exhibited hydrophobicity with water contact angle of about 140° while MPA-modified fabrics were able to lower the pH of a solution by about 1.6. We additionally demonstrated the possibility to connect functional polymers to the linker-modified fabrics by radical graft polymerization of acrylic acid; this produced a thin layer of the polymer on the surface of the fabric. Fabrics modified with poly(acrylic acid) exhibited increased hydrophilicity with water contact angle of 0° for both cotton and viscose-polyester fabrics, while the water absorption capability for polypropylene fabrics increased from about 50 to 1200%.     

Establishing quality performance of distribution companies based on yardstick regulation

This paper proposes a procedure and methodology for performance target setting related to continuity metrics in electricity distribution networks. This proposal deals with one of the key issues in the monopoly regulation, which is either the reduction of the information asymmetry among economic agents or the emulation of a competitive environment in industry segments usually considered as natural monopolies. This paper develops an approach toward standard definitions for Customer Average Interruption Duration Index (DEC) and Customer Average Interruption Frequency Index (FEC) based on inter-companies comparative analysis. This approach introduces productive efficiency concepts to the definition of network performance. In order to do so, the data envelopment analysis (DEA) technique, used for defining the efficiency frontier, was combined with the dynamic cluster technique, oriented toward models of identification of similar networks. A technique for comparative analysis was used for the definition of the network expected performance. Examples with the Brazilian electric systems are provided to clarify the methodology suggested by this paper.     

Preparation,characterization, viscosity,and thermal conductivity of nitrogen-doped graphene aqueous nanofluids

Nanofluids perform a crucial role in the development of newer technologies ideal for industrial purposes. In this study, Nitrogen-doped graphene (NDG) nanofluids, with varying concentrations of nanoparticles (0.01, 0.02, 0.04, and 0.06 wt%) were prepared using the two-step method in a 0.025 wt% Triton X-100 (as a surfactant) aqueous solution as a base. Stability, zeta potential, thermal conductivity, viscosity, specific heat, and electrical conductivity of nanofluids containing NDG particles were studied. The stability of the nanofluids was investigated by UV–vis over a time span of 6 months and concentrations remain relatively constant while the maximum relative concentration reduction was 20 %. The thermal conductivity of nanofluids was increased with the particle concentration and temperature, while the maximum enhancement was about 36.78 % for a nanoparticle loading of 0.06 wt%. These experimental results compared with some theoretical models including Maxwell and Nan’s models and observed a good agreement between Nan’s model and the experimental results. Study of the rheological properties of NDG nanofluids reveals that it followed the Newtonian behaviors, where viscosity decreased linearly with the rise of temperature. It has been observed that the specific heat of NDG nanofluid reduced gradually with the increase of concentration of nanoparticles and temperature. The electrical conductivity of the NDG nanofluids enhanced significantly due to the dispersion of NDG in the base fluid. This novel type of fluids demonstrates an outstanding potential for use as innovative heat transfer fluids in medium-temperature systems such as solar collectors.     

Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat

BACKGROUND & AIMS: Inflammatory stimuli and lipid peroxidation up-regulate cyclooxygenase (COX)-2. This study evaluated the relationship between inflammatory mediators, COX expression, and pathological changes in experimental alcoholic liver disease. METHODS: Rats (5 per group) were fed ethanol and a diet containing saturated fat, corn oil, or fish oil by intragastric infusion. Dextrose isocalorically replaced ethanol in controls. In the first set of experiments, whole livers were analyzed. In the second set of experiments, Kupffer cells, endothelial cells, and hepatocytes were isolated from rats in each group. Pathological analyses and measurements of lipid peroxidation, tumor necrosis factor (TNF)-alpha, COX-1 and COX-2 messenger RNA (mRNA), endotoxin, and liver and plasma thromboxane were performed. RESULTS: Increased expression of COX-2 mRNA was detected in the livers of rats showing necroinflammatory changes. The Kupffer cell was the cell primarily responsible for the increase in COX-2 mRNA level. Increased expression of COX-2 was associated with increased levels of endotoxin, TNF-alpha mRNA, lipid peroxidation, and synthesis of thromboxane. COX-1 mRNA was decreased in Kupffer cells in rats with the most severe liver injury. CONCLUSIONS: Up-regulation of COX-2 in alcoholic liver injury occurred in the presence of proinflammatory stimuli and resulted in increased synthesis of inflammatory and vasoactive eicosanoids. Down-regulation of COX-1 may result in decreased synthesis of cytoprotective eicosanoids and additionally exacerbate liver injury.     

Effect of Initial Particle and Agglomerate Size on the Elastic Moduli of Porous Yttria (Y2O3)

The present study shows the effect of porosity on the dynamic elastic moduli of partially dense yttria (Y₂O₃). This article reveals that the sound velocities and the elastic moduli of the porous samples depend not only on density, but also upon the reciprocal of the initial particle and agglomerate size. These findings explain some of the variation in the elastic moduli found especially, but not only, for highly porous yttria.     

Shear Lag and Effective Breadth in Rectangular Plates with Material Orthotropy. Part 2: Typical Results of Parametric Studies

In this, the second of a two-part series of articles on boundary-shear solutions applied to the phenomenon of shear lag in orthotropic rectangular plates, the salient results of parametric studies conducted on this problem are presented and discussed.     

Preparation and Characterization of BaxSr1-x, TiO3 Thin Films by a Sol-Gel Technique

Barium strontium titanate, (Ba_x,Sr_1-x TiO₃, thin films of various compositions were prepared by a sol-gel method. Solutions consisting of acetate powders and titanium IV isopropoxide in a mixture of acetic acid and ethylene glycol were spin-coated onto silicon and platinum-coated silicon substrates. Processing parameters were optimized to develop stable solutions which yielded films with relatively low crystallization temperatures. It was determined that ethylene glycol was a necessary component of the solution to increase stability to precipitation and to decrease the crystallization temperature of the films. The grain size of the films varied with annealing temperature and atmosphere and directly affected the dielectric properties. A dielectric constant of 400 and a dissipation factor of 0.04 were measured at 1 kHz for (Ba_0.8,Sr_0.2) TiO₃ films heated to 700°C for 1 h with a thickness of approximately 400 nm. Films of this composition maintained low leakage current densities for extended time periods when measured at an applied field of 75 kV/cm.     

Review of phenotypic diversity formulations for diagnostic tool

Practitioners often rely on search results to learn about the performance of a particular optimizer as applied to a real-world problem. However, even the best fitness measure is often not precise enough to reveal the behavior of the optimizer's added features or the nature of the interactions among its parameters. This makes customization of an efficient search method a rather difficult task.The aim of this paper is to propose a diagnostic tool to help determine the impact of parameter setting by monitoring the exploration/exploitation balance (EEB) of the search process, as this constitutes a key characteristic of any population-based optimizer. It is common practice to evaluate the EEB through a diversity measure. For any diagnostic tool developed to perform this function, it will be critical to be able to certify its reliability. To achieve this, the performance of the selected measure needs to be assessed, and the EEB framework must be able to accommodate any landscape structure. We show that to devise a diagnostic tool, the EEB must be viewed from an orthogonal perspective, which means that two diversity measures need to be involved: one for the exploration axis, and one for the exploitation axis. Exploration is best described by a genotypic diversity measure (GDM), while exploitation is better represented by a phenotypic convergence measure (PCM). Our paper includes a complete review of PCM formulations, and compares nearly all the published PCMs over a validation framework involving six test cases that offer controlled fitness distribution. This simple framework makes it possible to portray the underlying behavior of phenotypic formulations based on three established requirements: monotonicity in fitness varieties, twinning, and monotonicity in distance. We prove that these requirements are sufficient to identify phenotypic formulation weaknesses, and, from this conclusion, we propose a new PCM, which, once validated, is shown to comply with all the above-mentioned requirements. We then compare these phenotypic formulations over three specially designed fitness landscapes, and, finally, the new phenotypic formulation is combined with a genotypic formulation to form the foundation of the EEB diagnostic tool. The value of such a tool is substantiated through a comparison of the behaviors of various genetic operators and parameters.