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1.
Ji Hye Yang Sae Kwang Ku IL Je Cho Je Hyeon Lee Chang-Su Na Sung Hwan Ki 《International journal of molecular sciences》2021,22(4)
Hepatic fibrosis occurs when liver tissue becomes scarred from repetitive liver injury and inflammatory responses; it can progress to cirrhosis and eventually to hepatocellular carcinoma. Previously, we reported that neoagarooligosaccharides (NAOs), produced by the hydrolysis of agar by β-agarases, have hepatoprotective effects against acetaminophen overdose-induced acute liver injury. However, the effect of NAOs on chronic liver injury, including hepatic fibrosis, has not yet been elucidated. Therefore, we examined whether NAOs protect against fibrogenesis in vitro and in vivo. NAOs ameliorated PAI-1, α-SMA, CTGF and fibronectin protein expression and decreased mRNA levels of fibrogenic genes in TGF-β-treated LX-2 cells. Furthermore, downstream of TGF-β, the Smad signaling pathway was inhibited by NAOs in LX-2 cells. Treatment with NAOs diminished the severity of hepatic injury, as evidenced by reduction in serum alanine aminotransferase and aspartate aminotransferase levels, in carbon tetrachloride (CCl4)-induced liver fibrosis mouse models. Moreover, NAOs markedly blocked histopathological changes and collagen accumulation, as shown by H&E and Sirius red staining, respectively. Finally, NAOs antagonized the CCl4-induced upregulation of the protein and mRNA levels of fibrogenic genes in the liver. In conclusion, our findings suggest that NAOs may be a promising candidate for the prevention and treatment of chronic liver injury via inhibition of the TGF-β/Smad signaling pathway. 相似文献
2.
Xiao Zhu Chen Yanxun Jiang Hongbo Hu Zhenzhen Lui John C. S. Min Geyong Dustdar Schahram 《Wireless Networks》2022,28(7):3305-3322
Wireless Networks - Unmanned aerial vehicles (UAV) have been widely used in various fields because of their high mobility and portability. At the same time, due to the rapid development of... 相似文献
4.
了解我国儿童家长的家庭食品安全知识知晓情况及其影响因素,对开展精准食品安全宣教,减少家庭食源性疾病具有积极意义。本研究在7个城市的13 923名3~12岁儿童家长中开展问卷调查,收集基本信息、家庭食品安全知识知晓情况及需求。家长家庭食品安全知识平均得分为18.6分(总分29分),及格率为68.7%。易错知识点包括熟食室温存储时间、食品保质期、易引起中毒的食物以及食品贮存环境等。多因素logistics回归分析显示:家长家庭食品安全知识及格率受地区、文化程度、职业、家长类型、是否关注食品安全、孩子是否讲过食品安全知识以及是否阅读孩子带回来资料的影响。家长最关心的前三位内容为滥用食品添加剂(84.9%)、卫生状况不合格(82.9%)、农药/药物残留(82.7%)。受家长信任的信息来源主要为电视/广播/广告(76.1%)、书籍/报纸/期刊(70.4%)、微博/微信等新媒体(57.7%)。家长的家庭食品安全知识仍存在短板,需利用传统媒体和新媒体结合的方式以及小手牵大手形式开展精准专题宣传,并特别关注文化程度低,从事食品行业的家长以及孩子父亲和保姆。 相似文献
5.
Kai Liu Chenyang Zhou Jiaming Hu Song Zhang Qingqing Zhang Ce Sun Yusheng Shi Huajun Sun Changxia Yin Yuzhen Zhang Yu Fu 《Journal of the European Ceramic Society》2021,41(12):5909-5917
A digital light processing (DLP) technology has been developed for 3D printing lead-free barium titanate (BTO) piezoelectric ceramics. By comparing the curing and rheological properties of slurries with different photosensitive monomer, a high refractive index monomer acryloyl morpholine (ACMO) was chosen, and a design and preparation method of BTO slurry with high solid content, low viscosity and high curing ability was proposed. By further selecting the printing parameters, the single-layer exposure time was reduced and the forming efficiency has been greatly improved. Sintered specimens were obtained after a nitrogen-air double-step debinding and furnace sintering process, and the BTO ceramics fabricated with 80 wt% slurry shows the highest relative density (95.32 %) and piezoelectric constant (168.1 pC/N). Furthermore, complex-structured BTO ceramics were prepared, impregnated by epoxy resin and finally assembly made into hydrophones, which has significance for the future design and manufacture of piezoelectric ceramic-based composites that used in functional devices. 相似文献
6.
Yixuan ZHOU Huajie WANG Yi YU Yihang CHEN Rui KE Min XU Chijie XIAO Zhanhui WANG Jiquan LI Xuru DUAN Minyou YE 《等离子体科学和技术》2021,23(7):75105-52
In this article, we present the optical design of a novel diagnostic on the HL-2 A tokamak, i.e. the20-channel edge Lyman-alpha beam emission spectroscopy, which is a promising solution for edge density turbulence research on tokamaks, as it offers the possibility of density fluctuation measurement with a 3.3 mm spatial resolution while maintains a high temporal resolution of1 μs. The optical path, including the reflective collection optics, the high-dispersion spectrometer, and the linear detector array, is carefully optimized to obtain a good image quality and a high throughput. The maximum root mean square radius of the collection optics is 64 μm.The detected photon flux is estimated to be about 10~(11) photons/s/channel. 相似文献
7.
Journal of Porous Materials - Co3O4 has been widely investigated as a promising candidate anode material for lithium-ion batteries. We report on the porous Co3O4 column synthesized via a simple... 相似文献
8.
9.
Zhenkun Ke Xin Cao Chuanli Shan Lifen Shi Pingping Wang Yong Yang Fengyang Zhao Jiedong Cui Jinwei Li Gang Zhou Min Guan Tao Yu 《Ceramics International》2021,47(14):19605-19613
The purpose of the current work was to research the effect of alkali metal oxide on the structure, thermal properties, viscosity and chemical stability in the glass system (R2O–CaO–B2O3–SiO2) systematically. Because the glass would emulsify when Li2O was added to the glass batch, this article did not discuss Li2O. The results showed that when the amount of Na2O was less than 4 mol.%, there was a higher interconnectivity of borate and silicate sub-networks in glass, as more mixed Si–O–B bonds were present in glass. The glass samples exhibited excellent thermal properties and chemical stabilities. As the amount of Na2O exceeded 4 mol.%, the interconnectivity of borate and silicate sub-networks was weakened. The thermal properties and chemical stabilities of the glass samples were reduced. The connectivity of the silicate sub-network was weakened slightly as the Na/K ratio varied, and the coefficient of thermal expansion (CTE) of the glass samples gradually increased, and the resistance to thermal shock (RTS) value gradually decreased. Moreover, the viscosity of the glass samples decreased with the ratio of Na/Si and Na/K increased. 相似文献
10.