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排序方式: 共有186条查询结果,搜索用时 15 毫秒
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Mio Yamaguchi Kiyoshi Takagi Koki Narita Yasuhiro Miki Yoshiaki Onodera Minoru Miyashita Hironobu Sasano Takashi Suzuki 《International journal of molecular sciences》2021,22(4)
Chemokines secreted from stromal cells have important roles for interactions with carcinoma cells and regulating tumor progression. C-C motif chemokine ligand (CCL) 5 is expressed in various types of stromal cells and associated with tumor progression, interacting with C-C chemokine receptor (CCR) 1, 3 and 5 expressed in tumor cells. However, the expression on CCL5 and its receptors have so far not been well-examined in human breast carcinoma tissues. We therefore immunolocalized CCL5, as well as CCR1, 3 and 5, in 111 human breast carcinoma tissues and correlated them with clinicopathological characteristics. Stromal CCL5 immunoreactivity was significantly correlated with the aggressive phenotype of breast carcinomas. Importantly, this tendency was observed especially in the CCR3-positive group. Furthermore, the risk of recurrence was significantly higher in the patients with breast carcinomas positive for CCL5 and CCR3 but negative for CCR1 and CCR5, as compared with other patients. In summary, the CCL5-CCR3 axis might contribute to a worse prognosis in breast cancer patients, and these findings will contribute to a better understanding of the significance of the CCL5/CCRs axis in breast carcinoma microenvironment. 相似文献
3.
Daiji Noda Makoto Tanaka Kazuma Shimada Wataru Yashiro Atsushi Momose Tadashi Hattori 《Microsystem Technologies》2008,14(9-11):1311-1315
X-ray imaging is a very important technology in the fields of medical, biological, inspection, material science, etc. However, it is not enough to get the clear X-ray imaging with low absorbance. We have produced a diffraction gratings for obtaining high resolution X-ray phase imaging, such as X-ray Talbot interferometer. In this X-ray Talbot interferometer, diffraction gratings were required to have a fine, high accuracy, high aspect ratio structure. Then, we succeeded to fabricate a high aspect ratio diffraction grating with a pitch of 8 μm and small area using a deep X-ray lithography technique. We discuss that the diffraction gratings having a narrow pitch and an large effective area to obtain imaging size of practical use in medical application. If the pitch of diffraction gratings were narrow, it is expected high resolution imaging for X-ray Talbot interferometer. We succeeded and fabricated the diffraction grating with pitch of 5.3 μm, Au height of 28 μm and an effective area of 60 × 60 mm2. 相似文献
4.
Engineering Transition Metal Layers for Long Lasting Anionic Redox in Layered Sodium Manganese Oxide
Natalia Voronina Jun Ho Yu Hee Jae Kim Najma Yaqoob Olivier Guillon Hyungsub Kim Min-Gi Jung Hun-Gi Jung Koji Yazawa Hitoshi Yashiro Payam Kaghazchi Seung-Taek Myung 《Advanced functional materials》2023,33(5):2210423
Oxygen-redox-based-layered cathode materials are of great importance in realizing high-energy-density sodium-ion batteries (SIBs) that can satisfy the demands of next-generation energy storage technologies. However, Mn-based-layered materials (P2-type Na-poor Nay[AxMn1−x]O2, where A = alkali ions) still suffer from poor reversibility during oxygen-redox reactions and low conductivity. In this work, the dual Li and Co replacement is investigated in P2-type-layered NaxMnO2. Experimentally and theoretically, it is demonstrated that the efficacy of the dual Li and Co replacement in Na0.6[Li0.15Co0.15Mn0.7]O2 is that it improves the structural and cycling stability despite the reversible Li migration from the transition metal layer during de-/sodiation. Operando X-ray diffraction and ex situ neutron diffraction analysis prove that the material maintains a P2-type structure during the entire range of Na+ extraction and insertion with a small volume change of ≈4.3%. In Na0.6[Li0.15Co0.15Mn0.7]O2, the reversible electrochemical activity of Co3+/Co4+, Mn3+/Mn4+, and O2-/(O2)n- redox is identified as a reliable mechanism for the remarkable stable electrochemical performance. From a broader perspective, this study highlights a possible design roadmap for developing cathode materials with optimized cationic and anionic activities and excellent structural stabilities for SIBs. 相似文献
5.
The effect of small dose of topiroxostat on serum uric acid in patients receiving hemodialysis
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Yume Nagaoka Yoshiko Tanaka Hiroshi Yoshimoto Rie Suzuki Kakei Ryu Mio Ueda Minako Akiyama Miho Nagai Yoshitaka Miyaoka Eiichiro Kanda Shinnichi Iwai Michio Nagaoka Yoshihiko Kanno 《Hemodialysis international. International Symposium on Home Hemodialysis》2018,22(3):388-393
Introduction : Topiroxostat, a recently developed xanthine oxidase inhibitor, is expected to have fewer adverse effects than allopurinol because it has different mechanism of action from alloprinol. However, its dosage, usage and safety have not been established in patients with impaired renal function or those undergoing dialysis at the development since no studies was conducted in these patients. Methods : Cross over clinical trial using 3 months of allopurinol and topiroxostat on 27 maintain Japanese HD patients were carried out. The effects on oxidative stress status of both drugs were also evaluated by measuring oxidation reduction potential. Findings : Twenty‐five of twenty‐seven patients completed study. The mean serum uric acid levels in the topiroxostat‐treated arm was significantly lower than it in the allopurinol‐treated arm time‐dependently (P < 0.0001). Corrected oxidative stress ratio defined as biological antioxidant potential/diacron reactive oxygen metabolites was significantly increased in topiroxostat‐arm (*P = 0.0035), but not in allopurinol‐arm (P = 0.1429). No significant difference was seen in diacron reactive oxygen metabolites, biological antioxidant potential, static oxidation‐reduction potential, and capacity oxidation‐reduction potential between pre and post treatment of both drugs. Discussion : It is suggested that a low dose of topiroxostat decreased serum uric acid sufficiently to maintain it below 7.0 mg/dL in patients receiving hemodialysis. 相似文献
6.
H. Takahashi L. H. Liu Y. Yashiro K. Ioku G. Bignall N. Yamasaki T. Kori 《Journal of Materials Science》2006,41(5):1585-1589
The reduction of CO2 under hydrothermal conditions has been investigated. In typical experiment, Fe-powder, Ni-powder, solvent, and CO2 have been reacted in a batch-type micro autoclave under hydrothermal conditions for several hours. Methane, formic acid,
and hydrogen were generated after treatment in water. With the rise of Ni amount, the methane yield increased while hydrogen
and formic acid decreased. It is supposed that Ni has acted as a hydrogenation catalyst. In basic solution, CO2 was converted to formic acid selectively at 300°C involved with trace of methane. Considering the reduction characteristics
of formic acid, the reaction pathway has been discussed. In experiments with the mixture of Fe and Fe3O4, trace of methanol was detected at the experiments with less amount of metallic Fe. It is inferred that the control on the
effect of reductant is indispensable for oxygenated organic compound formation. Experiment on the effect of water has been
conducted using hydrogen. Ethane yield increased with the amount of water, while there was no drastic change in the yield
of methane. From these results, it is supposed that the steam reforming reaction of methane was involved in the reduction
of CO2, and effected on the C–C bond formation. 相似文献
7.
T. Kawada T. Ichikawa L. Q. Han K. Yashiro H. Matsumoto J. Mizusaki 《Journal of Electroceramics》2004,13(1-3):715-719
Metal or oxide electrodes (Pt, Au, Ag, (La, Sr)CoO3) were deposited on single crystals of 0.02 mol% Nb doped SrTiO3 by pulsed laser deposition. Current-voltage and capacitance-voltage responses were measured using three-terminal electrode configuration. Under high oxygen partial pressures, clear rectification behaviors were observed. Diffusion model well explained the current vs. voltage relationship with ideality factors close to unity. The barrier height varied reversibly with oxygen partial pressure, and was almost independent of the electrode materials, which suggested that the Fermi level at the interface was pinned by the surface states. The origin of the surface states was discussed in terms of oxygen adsorption or oxidative formation of metal vacancies around the surface. Chemical interaction between the surface and oxygen and resulting cation rearrangement was concluded to play an important role from the long stabilization time on oxygen partial pressure change. The water vapor pressure dependence of the barrier height was also explained by competitive adsorption of oxygen and water. 相似文献
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9.
This paper proposes a new method for properly estimating the rotor initial phase (i.e., the position) of the newly emerging self‐excited hybrid‐field synchronous motors (SelE‐HFSMs), which have the rotor held by both a permanent magnet and a diode‐shorted held winding. The proposed method injects a spatially rotating high‐frequency voltage and detects the rotor phase directly by evaluating the norm of the associated current. The method is very simple, but has a high degree of usability. 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(3): 49–58, 2010; Published online in Wiley InterScience ( www.interscience. wiley.com ). DOI 10.1002/eej.21027 相似文献
10.
Wataru Sakamoto Mio Yamada Naoya Iizawa Yu-Ki Mizutani Daichi Togawa Koichi Kikuta Toshinobu Yogo Takashi Hayashi Shin-Ichi Hirano 《Journal of Electroceramics》2004,13(1-3):339-343
Neodymium-modified Bi4Ti3O12, (Bi, Nd)4Ti3O12 (BNT) ferroelectric thin films have been prepared on Pt/TiOx/SiO2/Si substrates using metal-organic precursor solutions by the chemical solution deposition method. The BNT precursor films crystallized into the Bi layered perovskite Bi4Ti3O12 (BIT) as a single-phase above 600C. The synthesized BNT films revealed a random orientation having a strong 117 reflection, whereas non-substituted BIT thin films exhibited a random orientation with strong 00l diffractions. Among Bi4 – xNdxTi3O12 [x = 0.0, 0.5, 0.75, 1.0] thin films, Bi3.25Nd0.75Ti3O12 thin films showed a well-saturated P-E hysteresis loop with the highest Pr (22 C/cm2) and a low Ec (69 kV/cm) at an applied voltage of 5 V. The Nd-substitution with the optimum amount for the Bi site in the BIT structure was effective not only for promoting the 117 preferred orientation but also for improving the microstructure and ferroelectric properties of the resultant films. 相似文献