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排序方式: 共有466条查询结果,搜索用时 15 毫秒
1.
Milena Jankovic Ivana Novakovic Dejan Nikolic Jasmina Mitrovic Maksic Slavko Brankovic Ivana Petronic Dragana Cirovic Sinisa Ducic Mirko Grajic Dragana Bogicevic 《International journal of molecular sciences》2021,22(9)
Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping they will become significant for diagnosis, therapy and prevention of DN. 相似文献
2.
3.
Niklas Schlimm Mirko Novakovic Robert Spielmann Tobias Knierim 《Informatik-Spektrum》2007,48(6):251-258
Nicht-funktionale Anforderungen an ein Softwaresystem beschreiben Aspekte, die nicht direkt die Funktionalit?t, wie sie der
Benutzer sieht, betreffen. 相似文献
4.
A. Bianconi Y. Busby M. Fratini V. Palmisano L. Simonelli M. Filippi S. Sanna F. Congiu A. Saccone M. Giovannini S. De Negri 《Journal of Superconductivity and Novel Magnetism》2007,20(7-8):495-501
Here we report synthesis and characterization of high quality samples of the superconducting system Mg1−x
Al
x
B2, with a novel optimized preparation method, in a wide range of Al concentration. All the physical properties of the samples
can be tuned continuously with increasing Al content. We have characterized the samples for their structural, morphological
and magnetic properties with high resolution XRD, SEM-EDS and susceptibility measurements. We have prepared a large number
of Al doped MgB2 in the range 0<x<0.57. All the samples are bulk superconductors and the critical temperature show a smooth and regular behavior as a function
of x.
This work was supported by European project 517039 “Controlling Mesoscopic Phase Separation” (COMEPHS) (2005).
An erratum to this article can be found at 相似文献
5.
Andrea Omicini Alessandro Ricci Mirko Viroli 《Electronic Notes in Theoretical Computer Science》2006,150(3):21-36
Human intelligence has evolved along with the use of more and more sophisticated tools, allowing Homo Faber (from Homo Habilis to Homo Sapiens Sapiens) to cope with environment changes, as well as to adapt the environment to his needs. Analogously, in this seminal paper we introduce the notion of Agens Faber, conveying the idea that agent intelligence should not be considered as separated by the agent ability to perceive and affect the environment—and so, that agent intelligence is strictly related to the artefacts that enable, mediate and govern any agent (intelligent) activity.
Along this line, we first discuss the notion of artefact for MAS in general, then we try to devise out the admissible / required / desirable features of an artefact for MAS. We elaborate on the many sorts of possible relations between agents and artefacts, focusing in particular on the issue of the rational exploitation of artefacts, and also rough out a possible taxonomy of artefacts for MAS. 相似文献
6.
7.
This paper studies the behavior of motions of large-scale (LS) semistate systems (SSS) governed byP
i
(t)x
i
=M
i
(t,x
i
)x
i
+f
i
(t)+h
i
(t, x), i=1,2,...,s, =(x
1
T
x
2
T
x
s
T
)T, where matricesP
i
(t) are singular. Using Lyapunov's approach and the tools for LS system analysis, a variant of attractivity and ultimate boundedness of appropriate time-variable sets are investigated. The results are based on a specific choice of the aggregate functions. It is assumed that the reduction of equations to a normal form of lower order is inconvenient. The aggregation-decomposition approach used in this paper reduces the dimensionality of an aggregate matrix of the system to the number of its systems. Motion properties of LS systems are deduced from the properties of its isolated subsystems, the character of interconnections, and the conditions imposed on the system aggregate matrix. Sufficient algebraic conditions for the above-mentioned motion properties are developed. 相似文献
8.
Roberta Squecco Alessia Tani Flaminia Chellini Rachele Garella Eglantina Idrizaj Irene Rosa Sandra Zecchi-Orlandini Mirko Manetti Chiara Sassoli 《International journal of molecular sciences》2021,22(7)
Bone marrow-mesenchymal stem/stromal cells (MSCs) may offer promise for skeletal muscle repair/regeneration. Growing evidence suggests that the mechanisms underpinning the beneficial effects of such cells in muscle tissue reside in their ability to secrete bioactive molecules (secretome) with multiple actions. Hence, we examined the effects of MSC secretome as conditioned medium (MSC-CM) on ex vivo murine extensor digitorum longus muscle injured by forced eccentric contraction (EC). By combining morphological (light and confocal laser scanning microscopies) and electrophysiological analyses we demonstrated the capability of MSC-CM to attenuate EC-induced tissue structural damages and sarcolemnic functional properties’ modifications. MSC-CM was effective in protecting myofibers from apoptosis, as suggested by a reduced expression of pro-apoptotic markers, cytochrome c and activated caspase-3, along with an increase in the expression of pro-survival AKT factor. Notably, MSC-CM also reduced the EC-induced tissue redistribution and extension of telocytes/CD34+ stromal cells, distinctive cells proposed to play a “nursing” role for the muscle resident myogenic satellite cells (SCs), regarded as the main players of regeneration. Moreover, it affected SC functionality likely contributing to replenishment of the SC reservoir. This study provides the necessary groundwork for further investigation of the effects of MSC secretome in the setting of skeletal muscle injury and regenerative medicine. 相似文献
9.
One approach for solving Constraint Satisfaction Problems (CSP) (and related Constraint Optimization Problems (COP)) involving integer and Boolean variables is reduction to propositional satisfiability problem (SAT). A number of encodings (e.g., direct, log, support, order) for this purpose exist as well as specific encodings for some constraints that are often encountered (e.g., cardinality constraints, global constraints). However, there is no single encoding that performs well on all classes of problems and there is a need for a system that supports multiple encodings. We present a system that translates specifications of finite linear CSP problems into SAT instances using several well-known encodings, and their combinations. We also present a methodology for selecting a suitable encoding based on simple syntactic features of the input CSP instance. Thorough evaluation has been performed on large publicly available corpora and our encoding selection method improves upon the efficiency of existing encodings and state-of-the-art tools used in comparison. 相似文献
10.
Mirko Suznjevic Ognjen Dobrijevic Maja Matijasevic 《Multimedia Tools and Applications》2009,45(1-3):191-214
Providing Massively Multiplayer Online Role-Playing Games (MMORPGs) is a big challenge for future mobile, IP-based networks. Understanding how the players’ actions affect the network parameters, the game platform, and the overall perceived quality is highly relevant for the purposes of game design, as well as for the networking infrastructure and network support for games. We break player actions down into discrete categories, and show that each category is distinct in terms of several key metrics. We discuss which categories of actions could be supported on current mobile devices, and present evidence in form of a user survey demonstrating the demand for such services. The starting points into the discussion include the networking, session and latency requirements for particular player actions on one side, and the players’ interest on the other. The Blizzard Entertainment’s World of Warcraft (WoW) is used as a case study. 相似文献