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排序方式: 共有1029条查询结果,搜索用时 15 毫秒
1.
Takashi Ohnishi Yuki Ogawa Kota Suda Miki Komatsu Satoko Matsumoto Harmon Mitsuru Asukai Masahiko Takahata Norimasa Iwasaki Akio Minami 《International journal of molecular sciences》2021,22(9)
Pyogenic spondylodiscitis can cause severe osteolytic and destructive lesions in the spine. Elderly or immunocompromised individuals are particularly susceptible to infectious diseases; specifically, infections in the spine can impair the ability of the spine to support the trunk, causing patients to be bedridden, which can also severely affect the physical condition of patients. Although treatments for osteoporosis have been well studied, treatments for bone loss secondary to infection remain to be elucidated because they have pathological manifestations that are similar to but distinct from those of osteoporosis. Recently, we encountered a patient with severely osteolytic pyogenic spondylodiscitis who was treated with romosozumab and exhibited enhanced bone formation. Romosozumab stimulated canonical Wnt/β-catenin signaling, causing robust bone formation and the inhibition of bone resorption, which exceeded the bone loss secondary to infection. Bone loss due to infections involves the suppression of osteoblastogenesis by osteoblast apoptosis, which is induced by the nuclear factor-κB and mitogen-activated protein kinase pathways, and osteoclastogenesis with the receptor activator of the nuclear factor-κB ligand-receptor combination and subsequent activation of the nuclear factor of activated T cells cytoplasmic 1 and c-Fos. In this study, we review and discuss the molecular mechanisms of bone loss secondary to infection and analyze the efficacy of the medications for osteoporosis, focusing on romosozumab, teriparatide, denosumab, and bisphosphonates, in treating this pathological condition. 相似文献
2.
K. Uchiyama T. Shiosaki T. Kosaka A. Kasamatsu M. Echizen 《Ceramics International》2008,34(4):979-983
Advanced sol–gel methods using a secondary solvent addition into (Pb, La)(Zr, Ti)O3 (PLZT) sol–gel solution and a methanol pre-treatment of sapphire substrates are demonstrated. For the secondary solvent addition, the additive affected the crystallinity and electro-optic (EO) property of PLZT films and only methanol addition can improve them. In addition, the methanol pre-treatment is also appeared to be effective to improve film characteristics.
Through these optimizations, epitaxially grown PLZT thin films on r-cut sapphire are obtained and a high Pockels coefficient which is comparable to those of bulk PLZTs is achieved. It is believed that these PLZT thin films are applicable for integrated EO devices and open the door for the future data communication systems. 相似文献
3.
K Endo K Morita Y Uchiyama K Takada A Tsujimoto T Dohi 《Canadian Metallurgical Quarterly》1993,62(3):325-328
Influences of drug-induced manipulations of central serotonergic function on lidocaine- and pentylenetetrazol (PTZ)-induced convulsions were examined in mice. Agents that suppressed serotonergic transmission increased, whereas drugs that facilitated serotonin (5-HT) function decreased the incidence of lidocaine-induced convulsions. These treatments had similar influences on the incidence of PTZ-induced convulsions. Lidocaine (10(-5)-10(-3) M) reduced the stimulation evoked [3H]5-HT release from cortical slices, followed with an increased spontaneous [3H] overflow at higher concentrations. These results may suggest that brain 5-HT neurons are causally involved as inhibitory neurons in lidocaine-induced convulsions as in the case of PTZ-induced convulsions. 相似文献
4.
5.
H Uchiyama T Obata T Tsubaki N Sakaguchi Y Iikura T Aoki 《Canadian Metallurgical Quarterly》1995,44(2):70-76
In our Department, continuous isoproterenol inhalation therapy has been conducted on status asthmatics over the last 10 years. In the present study, we investigated whether there are any differences in the therapeutic efficacy of continuous inhalation of isoproterenol in the presence or absence of respiratory infections which may induce or aggravate asthma attacks. The treatment period was significantly longer in patients with pneumonia. Further prolongation of the treatment period was noted in patients with atelectasis. However, there were no apparent differences in therapeutic efficacy according to age or the severity of attacks. These findings suggest that continuous inhalation of isoproterenol is very effective for status asthmatics if respiratory infections are thoroughly controlled. 相似文献
6.
Keishi Sakamoto Atsushi Kasugai Masaki Tsuneoka Koji Takahashi Yukiharu Ikeda Tsuyoshi Imai Takashi Nagashima Mitsuru Ohta Tsuyoshi Kariya Kenichi Hayashi Yoshika Mitsunaka Yosuke Hirata Yasuyuki Itoh Yukio Okazaki 《Journal of Infrared, Millimeter and Terahertz Waves》1997,18(9):1637-1654
A development of 170GHz/500kW level gyrotron was carried out as R&D work of ITER. The oscillation mode is TE31,8. In a short pulse experiment, the maximum power of 750kW was achieved at 85kV/40A. The efficiency was 22%. In the depressed collector operation, 500kW/36%/50ms was obtained. The maximum efficiency of 40% was obtained at PRF=470kW whereas the power decrease by the electron trapping was observed. Pulse extension was done up to 10s at PRF=170kW with the depressed collector operation. The power was limited by the temperature increase of the output window. 相似文献
7.
T Saito S Kurumada Y Kawakami H Go T Uchiyama K Ueki 《Canadian Metallurgical Quarterly》1996,56(2):105-106
A modified surgical splint for Le Fort I osteotomies with transverse expansion is presented. The splint is made of a transpalatal stainless steel bar with acrylic abutment against the palatal surface of the molar and bicuspid tooth. It is rigid and renders excellent retention. It causes minimal patient discomfort, and oral hygiene is hardly compromised. 相似文献
8.
The influence of multi-coatings of LaB6-Si/polycarbosilane/SiO2 on the oxidation behaviour of carbon/carbon composite materials was investigated in the temperature range from 500 to 1400 °C. The additives of LaB6-Si offered lower oxidation rates and accelerated increases in oxidation rates at temperatures below 900 °C. The coating of polycarbosilane (PCS) improved the compatibility of the coating on the carbon/carbon composite and lowered the oxidation rates of the LaB6-Si coated composite below the transition temperature. With the SiO2 coating, the cracks of the LaB6-Si/PCS coating was sealed and a good oxidation resistance of the LaB6-Si/PCS/SiO2 coated composite was found at temperatures up to 1300 °C. 相似文献
9.
K Kawano S Mori O Hirajima S Mitsuru T Natori 《Canadian Metallurgical Quarterly》1998,47(2):suppl 103-suppl 106
10.
Uchiyama K. Arakawa F. Narita S. Aoki H. Kawasaki I. Matsui S. Yamamoto M. Nakagawa N. Kudo I. 《Micro, IEEE》1993,13(5):12-22
The Gmicro/500, which features a RISC-like dual-pipeline structure for high-speed execution of basic instructions and represents a significant advance for the TRON architecture, is presented. Upwardly-object-compatible with earlier members of the Gmicro series, this microprocessor uses resident dedicated branch buffers to greatly enhance branch instruction execution speed. Its microprograms simultaneously use dual execution blocks to execute high-level language instructions effectively. Fabricated with a 0.6-μm CMOS technology on a 10.9-mm×16-mm die, the chip operates at 50/66 MHz and achieves a processing rate of 100/132 MIPS 相似文献