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排序方式: 共有214条查询结果,搜索用时 15 毫秒
1.
Carmen de Jesús-Gil Lídia Sans-de San Nicols Ester Ruiz-Romeu Marta Ferran Laura Soria-Martínez Irene García-Jimnez Anca Chiriac Josep Manel Casanova-Seuma Josep Manel Fernndez-Armenteros Sherry Owens Antonio Celada Michael D. Howell Ramn María Pujol Luis Francisco Santamaria-Babí 《International journal of molecular sciences》2021,22(4)
Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA− cutaneous lymphocyte antigen (CLA)+/− T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls. CA cellular response is confined to CLA+ T cells and is primarily Th17. The levels of anti-CA IgA are directly associated with CLA+ Th17 response in plaque psoriasis. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA. C-C motif chemokine ligand 18, chitinase-3-like protein 1 and azurocidin were significantly elevated in the plasma from plaque psoriasis patients with high anti-CA levels and severe disease. Our results indicate a mechanism by which Candida albicans exposure can trigger a clinically relevant IL-17 response in psoriasis. Assessing anti-CA IgA levels may be useful in order to evaluate chronic psoriasis patients. 相似文献
2.
Information diffusion in large-scale networks has been studied to identify the users influence. The influence has been targeted as a key feature either to reach large populations or influencing public opinion. Through the use of micro-blogs, such as Twitter, global influencers have been identified and ranked based on message propagation (retweets). In this paper, a new application is presented, which allows to find first and classify then the local influence on Twitter: who have influenced you and who have been influenced by you. Until now, social structures of tweets’ original authors that have been either retweeted or marked as favourites are unobservable. Throughout this application, these structures can be discovered and they reveal the existence of communities formed by users of similar profile (that are connected among them) interrelated with other similar profile users’ communities. 相似文献
3.
We present ECOC-DRF, a framework where potential functions for Discriminative Random Fields are formulated as an ensemble of classifiers. We introduce the label trick, a technique to express transitions in the pairwise potential as meta-classes. This allows to independently learn any possible transition between labels without assuming any pre-defined model. The Error Correcting Output Codes matrix is used as ensemble framework for the combination of margin classifiers. We apply ECOC-DRF to a large set of classification problems, covering synthetic, natural and medical images for binary and multi-class cases, outperforming state-of-the art in almost all the experiments. 相似文献
4.
Output feedback of Markov jump linear systems with no mode observation: An automotive throttle application 下载免费PDF全文
Alessandro N. Vargas Leonardo Acho Gisela Pujol Eduardo F. Costa João Y. Ishihara João B. R. do Val 《国际强度与非线性控制杂志
》2016,26(9):1980-1993
》2016,26(9):1980-1993
The note presents an output feedback control strategy for Markov jump linear systems with no mode observation. Based on minimizing a finite‐time quadratic cost, we derive an algorithm that generates output feedback gains that satisfy a necessary optimality condition. These gains can be computed off‐line relying only on the initial condition of the system. This result expands a previous one from the literature that considered state‐feedback only. To illustrate the usefulness of the approach, real‐time laboratory experiments were performed to control an automotive electronic throttle valve subject to Markov‐driven voltage fluctuations. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
5.
Sequential learning is the discipline of machine learning that deals with dependent data such that neighboring labels exhibit some kind of relationship. The paper main contribution is two-fold: first, we generalize the stacked sequential learning, highlighting the key role of neighboring interactions modeling. Second, we propose an effective and efficient way of capturing and exploiting sequential correlations that takes into account long-range interactions. We tested the method on two tasks: text lines classification and image pixel classification. Results on these tasks clearly show that our approach outperforms the standard stacked sequential learning as well as state-of-the-art conditional random fields. 相似文献
6.
Habibar Chowdhury Sk Hafijur Rahaman Rajarshi Ghosh Sajal K. Sarkar Montse Corbella Barindra K. Ghosh 《Inorganic chemistry communications》2006,9(12):1276-1280
A new dinuclear complex [Cu2(OAc)2(OH)(dpa)2] PF6 · H2O (1) is prepared and structurally and magneto-structurally characterized. The monocationic core contains one acetate in familiar bidentate η1:η1:μ2-bridge and another in the rare monoatomic bridge along with one hydroxo intermediary. 1 packs through N–H…O and O–H…O hydrogen bonds and π…π interaction resulting a 3D supramolecular continuum and displays high-energy intraligand 1(π − π*) fluorescence and intraligand 3(π − π*) phosphorescence in glassy solution. 相似文献
7.
Evolutionary computation is a class of global search techniques based on the learning process of a population of potential solutions to a given problem, that has been successfully applied to a variety of problems. In this paper a new approach to the construction of neural networks based on evolutionary computation is presented. A linear chromosome combined to a graph representation of the network are used by genetic operators, which allow the evolution of the architecture and the weights simultaneously without the need of local weight optimization. This paper describes the approach, the operators and reports results of the application of this technique to several binary classification problems. 相似文献
8.
Beladenta Amalia Marcela Fu Olena Tigova Montse Ballbè Yolanda Castellano Sean Semple Luke Clancy Constantine Vardavas Maria J. López Nuria Cortés Raúl Pérez-Ortuño José A. Pascual Esteve Fernández 《Indoor air》2021,31(5):1601-1613
Secondhand electronic cigarette (e-cigarette) aerosol (SHA) might impair indoor air quality and expose bystanders. This study aims to investigate exposure to SHA in controlled conditions of enclosed settings simulating real-world scenario. An experiment was performed in a car and in a room, in which SHA was generated during a 30-minute ad libitum use of an e-cigarette. The experiment was replicated on five consecutive days in each setting. We measured PM2.5, airborne nicotine concentrations, and biomarkers of exposure to SHA, such as nicotine metabolites, tobacco-specific nitrosamines, propylene glycol, and glycerol in bystanders’ saliva samples before, during, and after the exposure period. Self-reported health symptoms related to exposure to SHA were also recorded. The results showed that the highest median PM2.5 concentration was recorded during the exposure period, being 21 µg/m3 in the room setting and 16 µg/m3 in the car setting—about twofold increase compared to the baseline. Most concentrations of the airborne nicotine and all biomarkers were below the limit of quantification in both settings. Bystanders in both settings experienced some short-term irritation symptoms, expressed as dry throat, nose, eyes, and phlegm. In conclusion, short-term use of an e-cigarette in confined spaces increased indoor PM2.5 level and caused some irritation symptoms in bystanders. 相似文献
9.
Pujol M.C. Massons J. Aguilo M. Diaz F. Rico M. Zaldo C. 《Quantum Electronics, IEEE Journal of》2002,38(1):93-100
The spectroscopic properties of Ho3+ laser channels in KGd(WO4)2 crystals have been investigated using optical absorption, photoluminescence, and lifetime measurements. The radiative lifetimes of Ho3+ have been calculated through a Judd-Ofelt (JO) formalism using 300-K optical absorption results. The JO parameters obtained were Ω2=15.35×10-20 cm2, Ω 4=3.79×10-20 cm2, Ω6 =1.69×10-20 cm2. The 7-300-K lifetimes obtained in diluted (8·1018 cm-3) KGW:0.1% Ho samples are: τ(5F3)≈0.9 μs, τ( 5S2)=19-3.6 μs, and τ(5F5 )≈1.1 μs. For Ho concentrations below 1.5×1020 cm-3, multiphonon emission is the main source of non radiative losses, and the temperature independent multiphonon probability in KGW is found to follow the energy gap law τph -1(0)=βexp(-αΔE), where β=1.4×10-7 s-1, and α=1.4×103 cm. Above this holmium concentration, energy transfer between Ho impurities also contributes to the losses. The spectral distributions of the Ho3+ emission cross section σEM for several laser channels are calculated in σ- and π-polarized configurations. The peak a σEM values achieved for transitions to the 5I8 level are ≈2×10-20 cm2 in the σ-polarized configuration, and three main lasing peaks at 2.02, 2.05, and 2.07 μm are envisaged inside the 5I7→5I8 channel 相似文献
10.
E. William Barrera M. Cinta Pujol Concepción Cascales Joan J. Carvajal X. Mateos R. Solé J. Massons Magdalena Aguiló Francesc Díaz 《Optical Materials》2011,34(2):355-359
We synthesized crystalline Erbium Er3+ and Ytterbium Yb3+ codoped -Lu2O3 nanolayers on SiO2 microspheres using the modified Pechini method. Two different kinds of precursors, nitrates and chlorides, have been used leading to a layer-to-layer morphology and necklaces structures, respectively. In both cases, the size of nanocrystallites constituting the optical active layer is around 5 nm. We performed X-ray powder diffraction to confirm the cubic crystalline structure of the sesquioxides layer. High resolution transmission electron microscopy analyses corroborate the crystalline nature of the layer. The optical emission of Er3+ in the visible range has been recorded. 相似文献