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1.
This paper presents a new real-time method for locating fault section at substations. When a fault occurs, considerable information resulting from protective relay operation and circuit-breaker operation is recorded. Using this information an attempt is made to locate the fault section, especially by considering the sequential relationship of the information and by dividing fault areas. Primarily, in this method, the fault area is divided into several sections based on protection area and operation time of protective relays. Next, expecting subsequent operation of backup relays, the “waiting time” for reasoning is given to each divided section. After a lapse of “waiting time,” all the suspected fault sections are extracted and given priority based on the empirical knowledge of experts. A prototype of the expert system was developed for fault section location, which was applied to various complicated fault cases. The effectiveness of the method was proved even in case of multiple faults and no-operation of protective relays the circuit breakers. 相似文献
2.
M Ishikawa T Masumoto T Oguni N Hyoudou K Michitaka N Horiike M Onji 《Canadian Metallurgical Quarterly》1997,20(5):447-452
We investigated if complement-mediated enhancement of HIV infection occurs in peripheral blood mononuclear cells (PBMC). In 7 experiments, we evaluated the effect of human complement on HIVIIIB infection in vitro. We measured HIV antigen production on day 4 and found that pre-incubation of HIV with complement led to enhanced production of antigen with a median enhancement of 2.5-fold (range 1.1-6.8). This complement-mediated increase in antigen production was statistically significant (p < 0.02). Complement-mediated enhancement of HIV infection was also tested in CD4 cells enriched from PBMC, and CD4 cells persistently gave higher levels of infection enhancement than PBMC. Thus, CD4 cells appear to be sufficient for complement-mediated enhancement of HIV infection to occur. In addition, we tested if it was possible to detect complement-mediated enhancement of primary HIV isolates in PBMC. We tested 3 isolates and found only a minor effect on antigen production (median enhancement 1.2-fold, range 0.6-1.5). Furthermore, addition of HIV-specific antibodies in combination with complement resulted in enhanced antigen production in 2/3 sera tested. However, the combination of complement and antibodies resulted in only a minor increase in enhancement of HIV infection compared to that obtained with complement alone. Finally, we found evidence of complement-mediated enhancement of HIV infection in resting PBMC. In conclusion, we demonstrated that complement-mediated enhancement of HIV infection does occur in vitro in PBMC. 相似文献
3.
Keiji Uchiyama Hideyuki Hara Junji Chida Agriani Dini Pasiana Morikazu Imamura Tsuyoshi Mori Hanae Takatsuki Ryuichiro Atarashi Suehiro Sakaguchi 《International journal of molecular sciences》2021,22(21)
Prion diseases are a group of fatal neurodegenerative disorders caused by accumulation of proteinaceous infectious particles, or prions, which mainly consist of the abnormally folded, amyloidogenic prion protein, designated PrPSc. PrPSc is produced through conformational conversion of the cellular isoform of prion protein, PrPC, in the brain. To date, no effective therapies for prion diseases have been developed. In this study, we incidentally noticed that mouse neuroblastoma N2a cells persistently infected with 22L scrapie prions, termed N2aC24L1-3 cells, reduced PrPSc levels when cultured in advanced Dulbecco’s modified eagle medium (DMEM) but not in classic DMEM. PrPC levels remained unchanged in prion-uninfected parent N2aC24 cells cultured in advanced DMEM. These results suggest that advanced DMEM may contain an anti-prion compound(s). We then successfully identified ethanolamine in advanced DMEM has an anti-prion activity. Ethanolamine reduced PrPSc levels in N2aC24L1-3 cells, but not PrPC levels in N2aC24 cells. Also, oral administration of ethanolamine through drinking water delayed prion disease in mice intracerebrally inoculated with RML scrapie prions. These results suggest that ethanolamine could be a new anti-prion compound. 相似文献
4.
NH4Zr2(PO4)3 with different particle sizes and different specific surface areas were obtained by controlling the preparation conditions. HZr2(PO4)3, cation exchangers in the hydrogen form, were prepared by the thermal treatment of NH4Zr2(PO4)3 in the temperature range of 400 to 700°C and their ion exchange properties were investigated with the main focus on the selectivity for group I and II metal ions and lithium isotopes. Irrespective of the temperature of the thermal treatment, HZr2(PO4)3 showed especially high affinity toward the lithium ion, high affinity toward the sodium ion and had little selectivity for the rubidium and cerium ions from the group I metal ions, and showed no specific affinity toward any of group II metal ions. HZr2(PO4)3 were isotopically 6Li-specific in any conditions examined. The 6Li-to-7Li isotopic separation factor was nearly independent of temperature of the thermal treatment. It depended, however, on the pH of lithium ion-containing solution used as the solution phase in an ion exchange experiment. This pH dependence of the lithium isotope separation effect was due to the appearance of the LiZr2(PO4)3 phase and/or the hydration number of the lithium ion in the ion exchanger phase. 相似文献
5.
Kenichi Hashizume Ryosuke Onji Shinpei Niiki Hideaki Tsukuda Ryota Yoshida 《亚洲传热研究》2009,38(3):156-167
Heat transfer coefficients were measured on tube bundles of fundamental layouts including in‐line layouts embedded horizontally in a liquid‐fluidized bed. Tested tube layouts were single tubes, transverse single tube rows, longitudinal single tube rows, and in‐line arranged tube bundles. A total of 7 kinds of particles were used. Comparisons of the experimental data showed a good agreement with the heat transfer correlation developed for staggered layouts, when the average liquid velocity through each tube bundle was used as the reference velocity for the particle Reynolds number. Distribution of the local heat transfer coefficient was also investigated around tubes. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/htj.20245 相似文献
6.
Teruki Miyake Yoichi Hiasa Masashi Hirooka Yoshio Tokumoto Takao Watanabe Shinya Furukawa Teruhisa Ueda Shin Yamamoto Teru Kumagi Hiroaki Miyaoka Masanori Abe Bunzo Matsuura Morikazu Onji 《Lipids》2012,47(11):1053-1062
Hepatitis C virus (HCV) infection alters fatty acid synthesis and metabolism in association with HCV replication. The present study examined the effect of serum fatty acid composition on interferon (IFN)-based therapy. Fifty-five patients with HCV were enrolled and received IFN-based therapy. Patient characteristics, laboratory data (including fatty acids), and viral factors that could be associated with the anti-HCV effects of IFN-based therapy were evaluated. The effects of individual fatty acids on viral replication and IFN-based therapy were also examined in an in-vitro system. Multivariate logistic regression analysis showed that the level of serum palmitic acid before treatment and HCV genotype were significant predictors for rapid virological response (RVR), early virological response (EVR), and sustained virological response (SVR). High levels of palmitic acid inhibited the anti-HCV effects of IFN-based therapy. HCV replication assays confirmed the inhibitory effects of palmitic acid on anti-HCV therapy. The concentration of serum palmitic acid is an independent predictive factor for RVR, EVR, and SVR in IFN-based antiviral therapy. These results suggest that the effect of IFN-based antiviral therapy in patients with HCV infection might be enhanced by treatment that modulates palmitic acid levels. 相似文献
7.
N Horiike T Fujisawa K Michitaka K Tada T Masumoto H Iuchi N Kojima M Onji 《Canadian Metallurgical Quarterly》1998,5(5):1171-1174
To clarify the effect of interferon (IFN) therapy for chronic hepatitis C (CHC) on the occurrence of hepatocellular carcinoma (HCC), 149 patients who were observed over a period of five years (mean: 7.6 years) were studied. The C-1 group, 33 patients with complete response to IFN; the C-2 group, 55 patients with no response to IFN; and the C-3 group, 61 patients who did not receive IFN. The occurrence rate of HCC was 0.9%/year/person. In the C-1, C-2 and C-3 groups, the rates were 0%, 0.3%, and 1.6%, respectively. The rate in C-1 + C-2 groups was significantly lower than that of the C-3 group (P<0.05). These data suggest IFN may suppress the occurrence of HCC in CHC. 相似文献
8.
K Itahana T Tanaka Y Morikazu S Komatu N Ishida T Takeya 《Canadian Metallurgical Quarterly》1998,139(1):320-329
Sequences present at the genomic termini of herpesviruses become linked during lytic-phase replication and provide the substrate for cleavage and packaging of unit length viral genomes. We have previously shown that homologs of the consensus herpesvirus cleavage-packaging signals, pac1 and pac2, are located at the left and right genomic termini of human herpesvirus 6 (HHV-6), respectively. Immediately adjacent to these elements are two distinct arrays of human telomeric repeat sequences (TRS). We now show that the unique sequence element formed at the junction of HHV-6B genome concatemers (pac2-pac1) is necessary and sufficient for virally mediated cleavage of plasmid DNAs containing the HHV-6B lytic-phase origin of DNA replication (oriLyt). The concatemeric junction sequence also allowed for the packaging of these plasmid molecules into intracellular nucleocapsids as well as mature, infectious viral particles. In addition, this element significantly enhanced the replication efficiency of oriLyt-containing plasmids in virally infected cells. Experiments revealed that the concatemeric junction sequence possesses an unusual, S1 nuclease-sensitive conformation (anisomorphic DNA), which might play a role in this apparent enhancement of DNA replication--although additional studies will be required to test this hypothesis. Finally, we also analyzed whether the presence of flanking viral TRS had any effect on the functional activity of the minimal concatemeric junction (pac2-pac1). These experiments revealed that the TRS motifs, either alone or in combination, had no effect on the efficiency of virally mediated DNA replication or DNA cleavage. Taken together, these data show that the cleavage and packaging of HHV-6 DNA are mediated by cis-acting consensus sequences similar to those found in other herpesviruses, and that these sequences also influence the efficiency of HHV-6 DNA replication. Since the adjacent TRS do not influence either viral cleavage and packaging or viral DNA replication, their function remains uncertain. 相似文献
9.
Kito M Takimoto R Onji Y Yoshida T Nagasawa T 《Journal of Bioscience and Bioengineering》2003,96(1):92-94
The epsilon-poly-L-lysine-degrading enzyme of the epsilon-poly-L-lysine-tolerant Chryseobacterium sp. OJ7 was purified and characterized. The bacterium excreted the enzyme into the culture filtrate. The purified enzyme has a molecular mass of approximately 38.4 kDa and consists of two identical subunits with a molecular mass of 19.5 kDa. The enzyme catalyzed the endo-type degradation of epsilon-poly-L-lysine. A correlation between the epsilon-poly-L-lysine tolerance of the bacterium and the high epsilon-poly-L-lysine-degrading activity was suggested. 相似文献
10.
The authors present a case report of self-terminating ventricular fibrillation during an episode of variant angina. The causes of ventricular fibrillation in this disorder and the possible mechanisms for its rare spontaneous interruption are discussed. 相似文献