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排序方式: 共有1209条查询结果,搜索用时 171 毫秒
1.
Raffael Ott Xenia Pawlow Andreas Weiß Anna Hofelich Melanie Herbst Nadine Hummel Cornelia Prehn Jerzy Adamski Werner Rmisch-Margl Gabi Kastenmüller Anette-G. Ziegler Sandra Hummel 《International journal of molecular sciences》2020,21(24)
Shared metabolomic patterns at delivery have been suggested to underlie the mother-to-child transmission of adverse metabolic health. This study aimed to investigate whether mothers with gestational diabetes mellitus (GDM) and their offspring show similar metabolomic patterns several years postpartum. Targeted metabolomics (including 137 metabolites) was performed in plasma samples obtained during an oral glucose tolerance test from 48 mothers with GDM and their offspring at a cross-sectional study visit 8 years after delivery. Partial Pearson’s correlations between the area under the curve (AUC) of maternal and offspring metabolites were calculated, yielding so-called Gaussian graphical models. Spearman’s correlations were applied to investigate correlations of body mass index (BMI), Matsuda insulin sensitivity index (ISI-M), dietary intake, and physical activity between generations, and correlations of metabolite AUCs with lifestyle variables. This study revealed that BMI, ISI-M, and the AUC of six metabolites (carnitine, taurine, proline, SM(-OH) C14:1, creatinine, and PC ae C34:3) were significantly correlated between mothers and offspring several years postpartum. Intergenerational metabolite correlations were independent of shared BMI, ISI-M, age, sex, and all other metabolites. Furthermore, creatinine was correlated with physical activity in mothers. This study suggests that there is long-term metabolic programming in the offspring of mothers with GDM and informs us about targets that could be addressed by future intervention studies. 相似文献
2.
The increasing prevalence of streptococci as causes of potentially fatal nosocomial bacteremia requires that antimicrobial agents used for empiric therapy in hospitalized patients include both pneumococci and viridans group streptococci as well as beta-hemolytic streptococci in their activity profile. In this study, the in vitro activity of cefepime, a new fourth-generation cephalosporin, was compared with other cephalosporins versus 197 nosocomial blood stream isolates of streptococci (20 Streptococcus pneumoniae, 104 viridans group, and 73 beta-hemolytic) isolated from patients at more than 30 medial centers from 1995 to 1997. Additional agents tested included penicillin, erythromycin, and vancomycin. Overall, cefepime inhibited 83% of the isolates at concentrations < or = 0.5 microgram/mL and 100% at < or = 8 micrograms/mL. By comparison, ceftazidime inhibited 35 and 88% of isolates at the same concentrations. Cefepime was approximately eightfold more potent than ceftazidime against S. pneumoniae, viridans group streptococci, and beta-hemolytic streptococci. Among the 42 isolates with penicillin MICs > 0.12 microgram/mL, 100% were inhibited by cefepime and only 48% by ceftazidime at < or = 8 micrograms/mL. The rank order of activity for all six agents against the 197 isolates was vancomycin > ceftriaxone > cefepime > penicillin > erythromycin > ceftazidime. Based on the results of the present study, cefepime and ceftriaxone were the superior cephalosporins in potency and spectrum for empiric coverage of patients at risk for streptococcal blood stream infections. 相似文献
3.
Transformations for nonideal uniform circular arrays operating in correlated signal environments 总被引:2,自引:0,他引:2
Buon Kiong Lau Yee Hong Leung Yanqun Liu Kok Lay Teo 《Signal Processing, IEEE Transactions on》2006,54(1):34-48
The Davies transformation is a method to transform the steering vector of a uniform circular array (UCA) to one with Vandermonde form. As such, it allows techniques such as spatial smoothing for direction-of-arrival (DOA) estimation in a correlated signal environment, developed originally for uniform linear arrays, to be applied to UCAs. However, the Davies transformation can be highly sensitive to perturbations of the underlying array model. This paper presents a method for deriving a more robust transformation using optimization techniques. The effectiveness of the method is illustrated through a number of DOA estimation examples. 相似文献
4.
Fast algorithm for computing discrete cosine transform 总被引:8,自引:0,他引:8
An efficient method for computing the discrete cosine transform (DCT) is proposed. Based on direct decomposition of the DCT, the recursive properties of the DCT for an even length input sequence is derived, which is a generalization of the radix 2 DCT algorithm. Based on the recursive property, a new DCT algorithm for an even length sequence is obtained. The proposed algorithm is very structural and requires fewer computations when compared with others. The regular structure of the proposed algorithm is suitable for fast parallel algorithm and VLSI implementation 相似文献
5.
Kok Wai Wong Chun Che Fung Eren H. Gedeon T. 《IEEE transactions on instrumentation and measurement》2003,52(6):1865-1869
Fuzzy rule-based systems have been very popular in many engineering applications. In mineral engineering, fuzzy rules are normally constructed using some fuzzy rule extraction techniques to establish the determination model in predicting the d50c of hydrocyclones. However, when generating fuzzy rules from the available information, it may result in a sparse fuzzy rule base. The use of more than one input variable is also common in hydrocyclone data analysis. This paper examines the application of fuzzy interpolation to resolve the problems using sparse fuzzy rule bases, and to perform analysis of fuzzy interpolation in multidimensional input spaces. 相似文献
6.
7.
An optical nondestructive strain measurement technique was performed to analyze the mechanical deformation induced by an electrical field within the insulating materials. Poly(ethylene naphthalene 2,6‐dicarboxylate) (PEN) films were then subjected to constant electrical fields right up to their electrical breakdown. The experimental technique made it possible to follow the various stages of the mechanical behavior of PEN in real time. The final breakdown occurred in the observation zone and the related mechanical deformation was captured. A “margarita” structure was observed with a hole at the center. The experimental results indicated that the level of the induced‐mechanical deformations depended on the local environment. We defined two different zones representing the inside and the outside of the damaged area. The induced‐deformations were larger in the damaged zone. It was also observed that deformations increased when the sample had a lower degree of crystallinity. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 相似文献
8.
Kaslow Nadine J.; Rubin Nancy J.; Forrest Linda; Elman Nancy S.; Van Horne Barbara A.; Jacobs Sue C.; Huprich Steven K.; Benton Sherry A.; Pantesco Victor F.; Dollinger Stephen J.; Grus Catherine L.; Behnke Stephen H.; Miller David S. Shen; Shealy Craig N.; Mintz Laurie B.; Schwartz-Mette Rebecca; Van Sickle Kristi; Thorn Beverly E. 《Canadian Metallurgical Quarterly》2007,38(5):479
Working collaboratively, psychologist educators and trainers at the doctoral, internship, and postdoctoral levels; credentialers; practitioners; and students offer 8 proposals for psychologists to consider in recognizing, assessing, and intervening with problems of professional competence in students and practicing professionals. In the proposals, the authors address the following topics: definitions and categories; preparing the system; self-assessment; remediation; diversity; communication across various levels of the system; confidentiality; and ethical, regulatory, and legal underpinnings. They also propose future directions for the assessment of problems in professional competence in both students and practicing psychologists. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
Decentralized control design for large-scale systems with strong interconnections using neural networks 总被引:2,自引:0,他引:2
We propose a decentralized neural network (NN) controller for a class of large-scale nonlinear systems with the strong interconnections. The NNs are used to approximate the unknown subsystems and interconnections. Due to the functional approximation capabilities of NNs, the additional precautions are not required to be made for avoiding the possible control singularity problems. Semiglobal asymptotic stability results are obtained and the tracking error converges to zero. Furthermore, the issue of transient performance of the subsystems is also addressed under an analytical framework. 相似文献
10.
The combined generation of heat and power (cogeneration) is praised by many as a technique for reducing the emissions of CO2 in industrialized nations. This is generally true but not always. In this article we discuss the impact of some major variables on the CO2 emission reduction capacity of cogeneration. Two sets of variables are predominant: the characteristics of the CHP process and the composition of the electricity generation sector. We highlight the interaction between the two sets of variables with the help of diagrams. 相似文献