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Accelerated photooxidation under ultraviolet (UV) test of polyamide 11 (PA11) films filled with unmodified vermiculite clay at 5 wt% was investigated up to 600 h. Film samples of ~60‐μm thick were prepared by melt compounding using a cast extruder and exposed to UV light irradiation at λ > 295 nm. Fourier transform infrared (FTIR) spectra indicated similar structural changes occurring in both PA11 and PA11/unmodified vermiculite nanoclay (UVMC) nanocomposite along the photooxidation process, resulting in imides and carboxylic acids as the main carbonyl products. It was however observed that the formation rate of carbonyls in the PA11/UVMC nanocomposite was slower than neat PA11. This behavior is consistent with the yellowing index evolution determined by ultraviolet–visible (UV–vis) spectroscopy. Further, the photooxidation stability of the samples was also evaluated by the onset oxidation temperature determined by differential scanning calorimetry. The results indicated a better stability of the nanocomposite film than neat PA11, corroborating well the data obtained by FTIR and UV–vis techniques. POLYM. ENG. SCI., 59:2449–2457, 2019. © 2019 Society of Plastics Engineers  相似文献   
3.
The present work reports an efficient synthesis of fluorinated pyridinium salts-based hydrazones under both conventional and eco-friendly ultrasound procedures. The synthetic approach first involves the preparation of halogenated pyridinium salts through the condensation of isonicotinic acid hydrazide (1) with p-fluorobenzaldehyde (2) followed by the nucleophilic alkylation of the resulting N-(4-fluorobenzylidene)isonicotinohydrazide (3) with a different alkyl iodide. The iodide counteranion of 5–10 was subjected to an anion exchange metathesis reaction in the presence of an excess of the appropriate metal salts to afford a new series of fluorinated pyridinium salts tethering a hydrazone linkage 11–40. Ultrasound irradiation led to higher yields in considerably less time than the conventional methods. The newly synthesized ILs were well-characterized with FT-IR, 1H NMR, 13C NMR, 11B, 19F, 31P and mass spectral analyses. The ILs were also screened for their antimicrobial and antitumor activities. Within the series, the salts tethering fluorinated counter anions 11–13, 21–23, 31–33 and 36–38 were found to be more potent against all bacterial and fungal strains at MIC 4–8 µg/mL. The in vitro antiproliferative activity was also investigated against four tumor cell lines (human ductal breast epithelial tumor T47D, human breast adenocarcinoma MCF-7, human epithelial carcinoma HeLa and human epithelial colorectal adenocarcinoma Caco-2) using the MTT assay, which revealed that promising antitumor activity was exhibited by compounds 5, 12 and 14.  相似文献   
4.
Air pollution has a major influence on health. It is thus not surprising that air quality (AQ) increasingly becomes a central issue in the environmental information policy worldwide. The most common way to deliver AQ information is in terms of graphics, tables, pictograms, or color scales that display either the concentrations of the pollutant substances or the corresponding AQ indices. However, all of these presentation modi lack the explanatory dimension; nor can they be easily tailored to the needs of the individual users. MARQUIS is an AQ information generation service that produces user-tailored multilingual bulletins on the major measured and forecasted air pollution substances and their relevance to human health in five European regions. It incorporates modules for the assessment of pollutant time series episodes with respect to their relevance to a given addressee, for planning of the discourse structure of the bulletins and the selection of the adequate presentation mode, and for generation proper. The positive evaluation of the bulletins produced by MARQUIS by users shows that the use of automatic text generation techniques in such a complex and sensitive application is feasible.  相似文献   
5.
Novel dicationic pyridinium ionic liquids tethering amphiphilic long alkyl side chains and fluorinated counter anions have been successfully synthesized by means of the quaternization of the dipyridinium hydrazone through its alkylation with different alkyl halides. The resulting halogenated di-ionic liquids underwent a metathesis reaction in order to incorporate some fluorinated counter anions in their structures. The structures of all the resulting di-ionic liquids were characterized by several spectroscopic experiments. The antitumorigenic activities of the investigated compounds were further studied against three different human lung cancer cell lines. Compared to the standard chemotherapeutic agent, cisplatin, the synthesized di-ionic liquids exerted equal, even more active, moderate, or weak anticancer activities against the various lung cancer cell lines under investigation. The observed anticancer activity appears to be enhanced by increasing the length of the aliphatic side chains. Moreover, dicationic pyridinium bearing a nine carbon chain as counter cation and hexafluoro phosphate and/or tetrafluoro bororate as counter anion were selected for further evaluation and demonstrated effective and significant antimetastatic effects and suppressed the colonization ability of the lung cancer cells, suggesting a therapeutic potential for the synthesized compounds in lung cancer treatment.  相似文献   
6.
Fractionation of human plasma on ion exchanger resin was performed on Amberlite IRC‐718 saturated with metal ions. Depletion of human immunoglobulin G was carried out by column chromatography using Tris‐HCl, pH 7 at different concentrations. Results showed that, when Cu+2 and Ni+2 were adsorbed on the resin, one or two fractions of purified IgG were obtained, respectively. Whereas Fe+2 and Zn+2, both retain IgG and serum albumin or serum albumin alone. Furthermore, the Ni+2‐resin retention of serum proteins is too strong that the use of 700 mMTris‐HCl cannot liberate any other proteins than nonadsorbed serum albumin. In conclusion, this investigation demonstrates that immobilized metal ion affinity chromatography with Cu2+, Ni2+, and Fe2+ immobilized on Amberlite IRC‐718 has the potential to be developed as part of a process to purify IgG out of untreated human plasma as acceptable adsorption and elution levels of IgG could be achieved. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010  相似文献   
7.
Toxoplasma gondii (T. gondii) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids 3a–c were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddition approach between prop-2-yn-1-alcohol 1 and sulfa drug azides 2a–c. The newly synthesized click products were fully characterized using different spectroscopic experiments and were loaded onto chitosan nanoparticles to form novel nanoformulations for further anti-Toxoplasma investigation. The current study proved the anti-Toxoplasma effectiveness of all examined compounds in experimentally infected mice. Relative to sulfadiazine, the synthesized sulfonamide-1,2,3-triazole (3c) nanoformulae demonstrated the most promising result for toxoplasmosis treatment as it resulted in 100% survival, 100% parasite reduction along with the remarkable histopathological improvement in all the studied organs.  相似文献   
8.
This paper presents the use of the B technique in its event based definition. We show that it is possible to encode, using Event B, the models (i.e., transition systems) associated to a process algebra with asynchronous semantics. The obtained Event B models consider that the Event B model associated to the left hand side of a BNF rule defining the algebra expressions is refined by a model corresponding to the right hand side of the same rule. The translation rules of each operator of a basic process algebra are given. Then, an example illustrating each translation rule is given. This approach is based on a proof technique and therefore it does not suffer from the state number explosion problem occurring in classical model checking. The interest of this work is the capability to validate user tasks or scenarios when using a given system and particularly a critical system. Finally, we discuss the application of this approach for validating user interfaces tasks in the human–computer interaction area.  相似文献   
9.
Conventional polyalkylene glycols (PAGs) that are derived from the polymerization of ethylene oxide and/or propylene oxide provide many performance benefits such as excellent friction control, good low temperature properties, high viscosity indices and excellent deposit control. One limitation is their poor miscibility in hydrocarbon oils. A new range of oil‐soluble PAG base oils has been developed using butylene oxide as one of the precursors, and these provide superior miscibility in hydrocarbon base stocks. The new base oils offer many of the traditional advantages of PAGs such as high viscosity indices, good low temperature properties and good traction behaviour. In addition, they can be used as a co‐base oil or additive in hydrocarbon base stocks to improve deposit control and provide good film‐forming behaviour. Examples of their structure property relationships will be discussed and also aspects of how this technology may enable application expansion of PAGs in the future. Copyright © 2012 John Wiley & Sons, Ltd.  相似文献   
10.
Tuberculosis (TB) caused by Mycobacterium tuberculosis is still a serious public health concern around the world. More treatment strategies or more specific molecular targets have been sought by researchers. One of the most important targets is M. tuberculosis’ enoyl-acyl carrier protein reductase InhA which is considered a promising, well-studied target for anti-tuberculosis medication development. Our team has made it a goal to find new lead structures that could be useful in the creation of new antitubercular drugs. In this study, a new class of 1,2,3- and 1,2,4-triazole hybrid compounds was prepared. Click synthesis was used to afford 1,2,3-triazoles scaffold linked to 1,2,4-triazole by fixable mercaptomethylene linker. The new prepared compounds have been characterized by different spectroscopic tools. The designed compounds were tested in vitro against the InhA enzyme. At 10 nM, the inhibitors 5b, 5c, 7c, 7d, 7e, and 7f successfully and totally (100%) inhibited the InhA enzyme. The IC50 values were calculated using different concentrations. With IC50 values of 0.074 and 0.13 nM, 7c and 7e were the most promising InhA inhibitors. Furthermore, a molecular docking investigation was carried out to support antitubercular activity as well as to analyze the binding manner of the screened compounds with the target InhA enzyme’s binding site.  相似文献   
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