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Parinbhai Shah Benjamin Goodyear Nirali Dholaria Vinam Puri Bozena Michniak-Kohn 《International journal of molecular sciences》2021,22(4)
Psoriasis is a chronic autoimmune skin disease impacting the population globally. Pharmaceutical products developed to combat this condition commonly used in clinical settings are IV bolus or oral drug delivery routes. There are some major challenges for effectively developing new dosage forms for topical use: API physicochemical nature, the severity of the disease state, and low bioavailability present challenges for pharmaceutical product developers. For non-severe cases of psoriasis, topical drug delivery systems may be preferred or used in conjunction with oral or parenteral therapy to address local symptoms. Elastic vesicular systems, termed “niosomes”, are promising drug delivery vehicles developed to achieve improved drug delivery into biological membranes. This study aimed to effectively incorporate a corticosteroid into the niosomes for improving the drug bioavailability of desoximetasone, used to treat skin conditions via topical delivery. Niosomes characterization measurements were drug content, pH, spreadability, specific gravity, content uniformity, rheology, and physicochemical properties. Formulations used a topical gelling agent, Carbomer 980 to test for in vitro skin permeation testing (IVPT) and accelerated stability studies. The developed niosomal test gel provided approximately 93.03 ± 0.23% to 101.84 ± 0.11% drug content with yield stresses ranging from 16.12 to 225.54 Pa. The permeated amount of desoximetasone from the niosomal gel after 24 h was 9.75 ± 0.44 µg/cm2 compared to 24.22 ± 4.29 µg/cm2 released from the reference gel tested. Furthermore, a drug retention study compared the test gel to a reference gel, demonstrating that the skin retained 30.88 ng/mg of desoximetasone while the reference product retained 26.01 ng/mg. A controlled drug release profile was obtained with a niosomal formulation containing desoximetasone for use in a topical gel formulation showing promise for potential use to treat skin diseases like psoriasis. 相似文献
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The conducting and relaxation dynamics of Ag+ ions in poly(ethylene oxide) (PEO)–silver triflate (AgCF3SO3) solid polymer electrolytes (SPEs) containing nanosize SiO2 filler and poly(ethylene glycol) (PEG) as a plasticizer were studied in the frequency range 10 Hz to 10 MHz and in the temperature range 303–328 K. The comparatively lower conductivity of the plasticized (PEG) PEO–AgCF3SO3–SiO2 nanocomposite electrolyte system was examined by analysis of the Fourier transform infrared (FTIR) spectroscopy and conductivity data. The electric modulus (M″) properties of the SPE systems were investigated. A shift of the M″ peak spectra with frequency was found to depend on the translation ion dynamics and the conductivity relaxation of the mobile ions. The value of the conductivity relaxation time was observed to be lower for the PEO–AgCF3SO3 system only with nanofiller SiO2. The scaling behavior of the M″ spectra showed that the dynamical relaxation processes was temperature-independent in the PEO–AgCF3SO3 and PEO–AgCF3SO3–SiO2–PEG polymer systems, whereas they were temperature-dependent for the PEO–AgCF3SO3–SiO2 system. However, the relaxation processes of all of theses systems were found to be dependent on their respective compositions. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 相似文献
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Nirali Gondaliya D.K. Kanchan Poonam Sharma Manish S. Jayswal 《Polymer Composites》2012,33(12):2195-2200
The effect of plasticizer poly(ethylene glycol) (PEG) on dielectric and electrical properties of an ionically conducting polymer nanocomposite electrolyte PEO: AgCF3SO3: SiO2: PEG has been investigated. The variation of relative dielectric constant and tangent loss peak with frequency have been discussed. The ionic and polymer segmental motions have been analyzed by electrical modulus and dielectric permittivity. The electrical modulus formalism is used to study the ionic relaxation process in these composites in terms of conductivity relaxation time. On addition of plasticizer, the modulus peak shifts toward higher frequency side suggesting the speeding up of the relaxation time. The frequency dependence of AC conductivity follows the universal power law. POLYM. COMPOS., 2012. © 2012 Society of Plastics Engineers 相似文献
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Manish S. Jayswal D.K. Kanchan Poonam Sharma Nirali Gondaliya 《Materials Science and Engineering: B》2013,178(11):775-784
Silver ion conducting super-ionic glass system xPbI2–(100 − x) [Ag2O–2(V2O5–B2O3)], where, 5 ≤ x ≤ 25, were prepared via melt quenching route and -characterized by XRD and DSC. Their electrical properties were measured by impedance spectroscopy in the frequency range of 2 MHz to 20 Hz from 30 to 120 °C. The electrical relaxation mechanism has been studied using AC conductivity, dielectric modulus function and frequency dependent dielectric permittivity over a wide range of frequency and temperature. Two different scaling approaches for AC conductivity as well as dielectric permittivity spectra were used to understand the nature of relaxation processes. 相似文献
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