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排序方式: 共有195条查询结果,搜索用时 15 毫秒
1.
Ottavia Colombo Simona Villani Giovanna Pinelli Claudia Trentani Maurizia Baldi Orazio Tomarchio Anna Tagliabue 《Nutrition journal》2008,7(1):5
Background
Excess body fat is a major risk factor for disease primarily due to its endocrine activity. In recent years several criteria have been introduced to evaluate this factor. Nevertheless, treatment need is currently assessed only on the basis of an individual's Body Mass Index (BMI), calculated as body weight (in kg) divided by height in m2. The aim of our study was to determine whether application of the BMI, compared to adiposity-based criteria, results in underestimation of the number of subjects needing lifestyle intervention. 相似文献2.
IMP2, a nuclear gene controlling the mitochondrial dependence of galactose, maltose and raffinose utilization in Saccharomyces cerevisiae. 总被引:3,自引:0,他引:3
The IMP2 gene of Saccharomyces cerevisiae is involved in the nucleo-mitochondrial control of maltose, galactose and raffinose utilization as shown by the inability of imp2 mutants to grow on these carbon sources in respiratory-deficient conditions or in the presence of ethidium bromide and erythromycin. The negative phenotype cannot be scored in the presence of inhibitors of respiration and oxidative phosphorylation, indicating that the role of the mitochondria in the utilization of the above-mentioned carbon sources in imp2 mutants is not at the energetical level. Mutations in the IMP2 gene also confer many phenotypic alterations in respiratory-sufficient conditions, e.g. leaky phenotype on oxidizable carbon sources, sensitivity to heat shock and sporulation deficiency. The IMP2 gene has been cloned, sequenced and disrupted. The phenotype of null imp2 mutants is indistinguishable from that of the originally isolated mutant. 相似文献
3.
Raman spectra of virgin and damaged graphite edge planes 总被引:1,自引:0,他引:1
First-order Raman spectra of virgin and ion irradiated highly oriented pyrolytic graphite were performed along the basal and edge planes. Ion irradiation was performed in the low fluence regime (≈ 1012–1013 ions cm−2) using a 400 keV Ar+ beam in order to a introduce controlled amount of defects in the structure. Virgin edge Raman spectra reveal the presence of a 1351 cm−1 structure (D*) shifted 10 cm−1 away from the disorder induced D-line found upon irradiating or grinding the graphite surface.The 1351 cm−1 D* structure is then considered as the feature coming from the rupture of the D6h4 space group symmetry. A comparison between D* and the classical 1360 cm−1 D-line is discussed in terms of induced disorder. 相似文献
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Pignatello R Spadaro D Vandelli MA Forni F Puglisi G 《Drug development and industrial pharmacy》2004,30(3):277-288
The present study is a preliminary exploration of the affinity between a carboxylic model drug, the nonsteroidal antiinflammatory agent ibuprofen (IBU) and Eudragit RL100 (RL) polymer. Due to the presence of a variable amount of quaternary ammonium groups in this matrix, physical and chemical interaction with the carboxylic drug can occur, which reinforces its scant mechanical dispersion in the polymer network and can ultimately affect its release profile in vitro and in vivo. To study these aspects, IBU was mixed at increasing weight ratios and in different chemical forms (free acid, sodium salt, and n-butyl ester), to investigate further the role of the carboxylic group in the interaction with the RL polymer. Therefore, IBU-RL solid dispersions (coevaporates) were obtained and fully characterized in the solid state through spectroscopic, calorimetric, and x-ray diffractometric analyses. The in vitro release pattern of the drug, in the different chemical states, was studied for the coevaporates, compared with drug-RL physical mixtures, along with drug adsorption profiles from aqueous solutions on the surface of the polymer granules. 相似文献
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We propose to study the scattering properties of dense distributions of spherical scatterers by resorting to an iterative solution of the Foldy-Twersky equation for the propagation of the coherent field. As a result of the first step of the iterative procedure, the host medium is substituted by an effective medium of complex refractive index to account for the multiple-scattering processes that occur among the particles. Although we truncate the above-mentioned iterative procedure to the second step, the results of our calculations are in excellent agreement with previous experimental results of Zaccanti et al. ("Measurement of optical properties of high-density media," to be published in Applied Optics) for the scattering coefficient of Intralipid solutions up to a volume density of 15% and show a limited disagreement at a volume density of 22%. 相似文献