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Reynolds Brady; Patak Michele; Shroff Palak; Penfold Robert B.; Melanko Shane; Duhig Amy M. 《Canadian Metallurgical Quarterly》2007,15(3):264
This research compared adolescent daily smokers (n = 25) and nonsmokers (n = 26) on different measures of impulsivity. Assessments included question-based measures of delay (DDQ) and probability (PDQ) discounting, a measure of behavioral disinhibition (go-stop task), and a self-report measure of impulsivity (Barratt Impulsiveness Scale-Adolescent). Adolescent smokers were more impulsive on the DDQ and Barratt Impulsiveness Scale--Adolescent but not on the PDQ or the go-stop task. However, there was a significant interaction between smoking status and gender on the go-stop task, with male smokers performing less impulsively on this measure than male nonsmokers--an effect not observed with the female adolescents. These findings indicate that adolescents who smoke cigarettes are more impulsive with respect to some, but not all, types of impulsivity than are adolescents who do not smoke. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Sarvi Yadav Rajesh Sachin Kumar Singh Parth Sharma Palak Bawa Bimlesh Kumar 《Drug development and industrial pharmacy》2018,44(7):1056-1069
Development of self-nanoemulsifying drug delivery systems (SNEDDS) of glimepiride is reported with the aim to achieve its oral delivery. Lauroglycol FCC, Tween-80, and ethanol were used as oil, surfactant, and co-surfactant, respectively as independent variables. The optimized composition of SNEDDS formulation (F1) was 10% v/v Lauroglycol FCC, 45% v/v Tween 80, 45% v/v ethanol, and 0.005% w/v glimepiride. Further, the optimized liquid SNEDDS were solidified through spray drying using various hydrophilic and hydrophobic carriers. Among the various carriers, Aerosil 200 was found to provide desirable flow, compression, dissolution, and diffusion. Both, liquid and solid-SNEDDS have shown release of more than 90% within 10?min. Results of permeation studies performed on Caco-2 cell showed that optimized SNEDDS exhibited 1.54 times higher drug permeation amount and 0.57 times lower drug excretion amount than that of market tablets at 4?hours (p?.01). Further, the cytotoxicity study performed on Caco-2 cell revealed that the cell viability was lower in SNEDDS (92.22%?±?4.18%) compared with the market tablets (95.54%?±?3.22%; p?>?.05, i.e. 0.74). The formulation was found stable with temperature variation and freeze thaw cycles in terms of droplet size, zeta potential, drug precipitation and phase separation. Crystalline glimepiride was observed in amorphous state in solid SNEDDS when characterized through DSC, PXRD, and FT-IR studies. The study revealed successful formulation of SNEDDS for glimepiride. 相似文献
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Palak Bansal Anoop Verma Charu Mehta Jayishnu Singla Amrit Pal Toor 《Journal of Materials Science》2018,53(10):7326-7343
A novel concept of integrated process by coupling photocatalysis and photo-Fenton especially in fixed mode has been presented in the current study for the removal of recalcitrant pharmaceuticals like cephalexin (CEX) from aqueous solution in reduced treatment time. Waste materials like foundry sand (FS) was used as a substitute for iron along with TiO2. The parametric optimization was carried out in slurry mode using Box–Behnken design model (BBD) and response surface methodology. For fixed-bed studies, support materials of varying shapes (hollow circular disk, rectangular slabs, spherical beads) were prepared using clay in conjunction with FS for TiO2 immobilization. Different supports were compared on the basis of degradation efficiency, exposed surface area of catalyst as well as their recyclability capacity for the degradation of CEX. Iron was leaching by default from the supports during the degradation process which contributed simultaneously to photo-Fenton process along with photocatalysis. Spherical beads with 0.0265 m2 exposed surface area of catalyst and better recyclability efficiency (10 cycles) yielded best degradation efficiency (80%) of CEX after 240 min of treatment time. The presence of iron along with TiO2 on the surface of beads was confirmed through TGA, SEM/EDS, XRD, DRS and FTIR. The mineralization of CEX was validated through quantification of nitrite, nitrate and sulfate ions along with reduction in COD. A tentative pathway for the degradation of CEX was also proposed based on the identification of intermediates through GC–MS analysis. 相似文献
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Luis Cabellos Isabel Campos Enol Fernández-del-Castillo Micha? Owsiak Bartek Palak Marcin P?óciennik 《Computer Physics Communications》2011,(4):890-897
In this work we describe our developments towards the provision of a unified access method to different types of computing infrastructures at the interoperation level. For that, we have developed a middleware suite which bridges not interoperable middleware stacks used for building distributed computing infrastructures, UNICORE and gLite. Our solution allows to transparently access and operate on HPC and HTC resources from a single interface. Using Kepler as workflow manager, we provide users with the needed integration of codes to create scientific workflows accessing both types of infrastructures. 相似文献
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Lester J Lambert Stefan Grotegut Maria Celeridad Palak Gosalia Laurent JS De Backer Andrey A Bobkov Sumeet Salaniwal Thomas DY Chung Fu-Yue Zeng Ian Pass Paul J Lombroso Nicholas DP Cosford Lutz Tautz 《International journal of molecular sciences》2021,22(9)
Many human diseases are the result of abnormal expression or activation of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Not surprisingly, more than 30 tyrosine kinase inhibitors (TKIs) are currently in clinical use and provide unique treatment options for many patients. PTPs on the other hand have long been regarded as “undruggable” and only recently have gained increased attention in drug discovery. Striatal-enriched tyrosine phosphatase (STEP) is a neuron-specific PTP that is overactive in Alzheimer’s disease (AD) and other neurodegenerative and neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, and fragile X syndrome. An emergent model suggests that the increase in STEP activity interferes with synaptic function and contributes to the characteristic cognitive and behavioral deficits present in these diseases. Prior efforts to generate STEP inhibitors with properties that warrant clinical development have largely failed. To identify novel STEP inhibitor scaffolds, we developed a biophysical, label-free high-throughput screening (HTS) platform based on the protein thermal shift (PTS) technology. In contrast to conventional HTS using STEP enzymatic assays, we found the PTS platform highly robust and capable of identifying true hits with confirmed STEP inhibitory activity and selectivity. This new platform promises to greatly advance STEP drug discovery and should be applicable to other PTP targets. 相似文献
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Palak Babbar Mizuki Sato Yogavel Manickam Siddhartha Mishra Karl Harlos Swati Gupta Suhel Parvez Haruhisa Kikuchi Amit Sharma 《Chembiochem : a European journal of chemical biology》2021,22(14):2468-2477
Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) represents a promising therapeutic anti-malarial target. Cladosporin was identified as a selective and potent PfKRS inhibitor but lacks metabolic stability. Here, we report chemical synthesis, biological evaluation and structural characterization of analogues where the tetrahydropyran (THP) frame of cladosporin is replaced with the piperidine ring bearing functional group variations. Thermal binding, enzymatic, kinetic and parasitic assays complemented with X-ray crystallography reveal compounds that are moderate in potency. Co-crystals of Cla−B and Cla−C with PfKRS reveal key atomic configurations that allow drug binding to and inhibition of the enzyme. Collectively these piperidine ring scaffold inhibitors lay a framework for further structural editing and functional modifications of the cladosporin scaffold to obtain a potent lead. 相似文献
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Bagga Palak Das Ashok Kumar Chamola Vinay Guizani Mohsen 《Telecommunication Systems》2022,81(1):125-173
Telecommunication Systems - With rapid advancements in the technology, almost all the devices around are becoming smart and contribute to the Internet of Things (IoT) network. When a new IoT device... 相似文献