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排序方式: 共有632条查询结果,搜索用时 15 毫秒
1.
Pasquale Stano Tereza Pereira de Souza Paolo Carrara Emiliano Altamura Erica D’Aguanno Margherita Caputo 《先进材料力学与结构力学》2015,22(9):748-759
Here we report some recent biophysical issues on the preparation of solute-filled lipid vesicles and their relevance to the construction of “synthetic cells.” First, we introduce the “semi-synthetic minimal cells” as the liposome-based cell-like systems, which contain a minimal number of biomolecules required to display simple and complex biological functions. Next, we focus on recent aspects related to the construction of synthetic cells. Emphasis is given to the interplay between the methods of synthetic cell preparation and the physics of solute encapsulation. We briefly introduce the notion of structural and compositional “diversity” in synthetic cell populations. 相似文献
2.
Silvia Ravera Esteban Colombo Claudio Pasquale Stefano Benedicenti Luca Solimei Antonio Signore Andrea Amaroli 《International journal of molecular sciences》2021,22(9)
Background: Injury of the trigeminal nerve in oral and maxillofacial surgery can occur. Schwann cell mitochondria are regulators in the development, maintenance and regeneration of peripheral nerve axons. Evidence shows that after the nerve injury, mitochondrial bioenergetic dysfunction occurs and is associated with pain, neuropathy and nerve regeneration deficit. A challenge for research is to individuate new therapies able to normalise mitochondrial and energetic metabolism to aid nerve recovery after damage. Photobiomodulation therapy can be an interesting candidate, because it is a technique involving cell manipulation through the photonic energy of a non-ionising light source (visible and NIR light), which produces a nonthermal therapeutic effect on the stressed tissue. Methods: The review was based on the following questions: (1) Can photo-biomodulation by red and NIR light affect mitochondrial bioenergetics? (2) Can photobiomodulation support damage to the trigeminal nerve branches? (preclinical and clinical studies), and, if yes, (3) What is the best photobiomodulatory therapy for the recovery of the trigeminal nerve branches? The papers were searched using the PubMed, Scopus and Cochrane databases. This review followed the ARRIVE-2.0, PRISMA and Cochrane RoB-2 guidelines. Results and conclusions: The reliability of photobiomodulatory event strongly bases on biological and physical-chemical evidence. Its principal player is the mitochondrion, whether its cytochromes are directly involved as a photoacceptor or indirectly through a vibrational and energetic variation of bound water: water as the photoacceptor. The 808-nm and 100 J/cm2 (0.07 W; 2.5 W/cm2; pulsed 50 Hz; 27 J per point; 80 s) on rats and 800-nm and 0.2 W/cm2 (0.2 W; 12 J/cm2; 12 J per point; 60 s, CW) on humans resulted as trustworthy therapies, which could be supported by extensive studies. 相似文献
3.
Responds to Gauthier (see record 2004-17185-003) who commented on the two articles by Koerner et al (see record 2004-17185-001) and by Roberge et al (see record 2004-17185-002. The purpose of this response is to discuss the issue of limited availability of mental health services for anxiety disorders in Canada. From a public health perspective, the authors emphasize the importance of gathering Canadian empirical data on the organization of mental health services for anxiety disorders. Specifically more research is needed on care requirements, and the financial and structural barriers that restrict access to mental health services at the regional, provincial and national levels. The authors also discuss the role of psychologists in improving mental health care in Canada. Cost-effectiveness studies conducted in interdisciplinary practice environments could demonstrate the value added by psychology in the organization of mental health care for anxiety disorders. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Leonardo Candela Fuat Akal Henri Avancini Donatella Castelli Luigi Fusco Veronica Guidetti Christoph Langguth Andrea Manzi Pasquale Pagano Heiko Schuldt Manuele Simi Michael Springmann Laura Voicu 《International Journal on Digital Libraries》2007,7(1-2):59-80
This paper introduces DILIGENT, a digital library infrastructure built by integrating digital library and Grid technologies and resources. This infrastructure
allows different communities to dynamically build specialised digital libraries capable to support the entire e-Science knowledge
production and consumption life-cycle by using shared computing, storage, content, and application resources. The paper presents
some of the main software services that implement the DILIGENT system. Moreover, it exemplifies the provided features by presenting how the DILIGENT infrastructure is being exploited in supporting the activity of user communities working in the Earth Science Environmental
sector.
This work is partially funded by the European Commission in the context of the DILIGENT project, under the 2nd call of FP6 IST priority. 相似文献
5.
Claudia Penna Saveria Femmin Fabrizio Caldera Alberto Rubin Pedrazzo Claudio Cecone Edoardo Alfì Stefano Comit Takanobu Higashiyama Francesco Trotta Pasquale Pagliaro Roberta Cavalli 《International journal of molecular sciences》2021,22(8)
Heart failure (HF) prevalence is increasing among the aging population, and the mortality rate remains unacceptably high despite improvements in therapy. Myocardial ischemia (MI) and, consequently, ischemia/reperfusion injury (IRI), are frequently the basis of HF development. Therefore, cardioprotective strategies to limit IRI are mandatory. Nanocarriers have been proposed as alternative therapy for cardiovascular disease. Controlled reoxygenation may be a promising strategy. Novel nanocarriers, such as cyclic nigerosyl-nigerose (CNN), can be innovative tools for oxygen delivery in a controlled manner. In this study we analyzed new CNN-based formulations as oxygen nanocarriers (O2-CNN), and compared them with nitrogen CNN (N2-CNN). These different CNN-based formulations were tested using two cellular models, namely, cardiomyoblasts (H9c2), and endothelial (HMEC) cell lines, at different concentrations. The effects on the growth curve during normoxia (21% O2, 5% CO2 and 74% N2) and their protective effects during hypoxia (1% O2, 5% CO2 and 94% N2) and reoxygenation (21% O2, 5% CO2 and 74% N2) were studied. Neither O2-CNN nor N2-CNN has any effect on the growth curve during normoxia. However, O2-CNN applied before hypoxia induces a 15–30% reduction in cell mortality after hypoxia/re-oxygenation when compared to N2-CNN. O2-CNN showed a marked efficacy in controlled oxygenation, which suggests an interesting potential for the future medical application of soluble nanocarrier systems for MI treatment. 相似文献
6.
Laura Francesca Pisani Gian Eugenio Tontini Carmine Gentile Beatrice Marinoni Isabella Teani Nicoletta Nandi Pasquale Creo Emanuele Asti Luigi Bonavina Maurizio Vecchi Luca Pastorelli 《International journal of molecular sciences》2021,22(11)
Interleukin (IL)-33 is a member of the interleukin (IL)-1 family of cytokines linked to the development of inflammatory conditions and cancer in the gastrointestinal tract. This study is designed to investigate whether IL-33 has a direct effect on human gastric epithelial cells (GES-1), the human gastric adenocarcinoma cell line (AGS), and the gastric carcinoma cell line (NCI-N87) by assessing its role in the regulation of cell proliferation, migration, cell cycle, and apoptosis. Cell cycle regulation was also determined in ex vivo gastric cancer samples obtained during endoscopy and surgical procedures. Cell lines and tissue samples underwent stimulation with rhIL-33. Proliferation was assessed by XTT and CFSE assays, migration by wound healing assay, and apoptosis by caspase 3/7 activity assay and annexin V assay. Cell cycle was analyzed by means of propidium iodine assay, and gene expression regulation was assessed by RT-PCR profiling. We found that IL-33 has an antiproliferative and proapoptotic effect on cancer cell lines, and it can stimulate proliferation and reduce apoptosis in normal epithelial cell lines. These effects were also confirmed by the analysis of cell cycle gene expression, which showed a reduced expression of pro-proliferative genes in cancer cells, particularly in genes involved in G0/G1 and G2/M checkpoints. These results were confirmed by gene expression analysis on bioptic and surgical specimens. The aforementioned results indicate that IL-33 may be involved in cell proliferation in an environment- and cell-type-dependent manner. 相似文献
7.
Elisabetta Tornatore Pasquale Vetro Stefania Maria Buccellato 《Neural computing & applications》2014,24(2):309-315
We propose a stochastic disease model where vaccination is included and such that the immunity is permanent. The existence, uniqueness, and positivity of the solution and the stability of the disease-free equilibrium are studied. 相似文献
8.
Garrett BC Dixon DA Camaioni DM Chipman DM Johnson MA Jonah CD Kimmel GA Miller JH Rescigno TN Rossky PJ Xantheas SS Colson SD Laufer AH Ray D Barbara PF Bartels DM Becker KH Bowen KH Bradforth SE Carmichael I Coe JV Corrales LR Cowin JP Dupuis M Eisenthal KB Franz JA Gutowski MS Jordan KD Kay BD Laverne JA Lymar SV Madey TE McCurdy CW Meisel D Mukamel S Nilsson AR Orlando TM Petrik NG Pimblott SM Rustad JR Schenter GK Singer SJ Tokmakoff A Wang LS Wettig C Zwier TS 《Chemical reviews》2005,105(1):355-390
9.
Stefania Perri Pasquale Corsonello Giuseppe Cocorullo 《Computer Vision and Image Understanding》2013,117(1):29-41
This paper presents a new hardware-oriented approach for the extraction of disparity maps from stereo images. The proposed method is based on the herein named Adaptive Census Transform that exploits adaptive support weights during the image transformation; the adaptively weighted sum of SADs is then used as the dissimilarity metric. Quality tests show that the proposed method reaches significantly better accuracy than alternative hardware-oriented approaches. To demonstrate the practical hardware feasibility, a specific architecture has been designed and its implementation has been carried out using a single FPGA chip. Such a VLSI implementation allows a frame rate up to 68 fps to be reached for 640 × 480 stereo images, using just 80,000 slices and 32 RAM blocks of a Virtex6 chip. 相似文献
10.
In this paper we present a novel methodology based on non-parametric deformable prototype templates for reconstructing the
outline of a shape from a degraded image. Our method is versatile and fast and has the potential to provide an automatic procedure
for classifying pathologies. We test our approach on synthetic and real data from a variety of medical and biological applications.
In these studies it is important to reconstruct accurately the shape of the object under investigation from very noisy data.
Here we assume that we have some prior knowledge about the object outline represented by a prototype shape. Our procedure
deforms this shape by means of non-affine transformations and the contour is reconstructed by minimizing a newly developed
objective function that depends on the transformation parameters. We introduce an iterative template deformation procedure
in which the scale of the deformation decreases as the algorithm proceeds. We compare our results with those from a Gaussian
Mixture Model segmentation and two state-of-the-art Level Set methods. This comparison shows that the proposed procedure performs
consistently well on both real and simulated data. As a by-product we develop a new filter that recovers the connectivity
of a shape.
Francesco de Pasquale received his Ph.D. in Applied Statistics from the University of Plymouth, United Kingdom in 2004 discussing a thesis on Bayesian and Template based methods for image analysis. Since his degree in Physics obtained at the University of Rome ‘La Sapienza’in 1999 his work has been focused on developing models and methods for Magnetic Resonance Imaging, in particular image registration, classification and segmentation in a Bayesian framework. After being appointed a 2-year contract as a Lecturer at the University of Plymouth from 2003 to 2004 he is now a post-Doc researcher at the ITAB, Institute for Advanced Biomedical Technologies, University of Chieti, Italy and he works on the analysis of fMRI and MEG data. Julian Stander was born in Plymouth, UK in 1964. He received a BA in Mathematics with first class honours from University of Oxford in 1987, a Diploma in Mathematical Statistics with distinction from University of Cambridge in 1988, and a PhD from University of Bath in 1992. He has been a lecturer at the School of Mathematics and Statistics, University of Plymouth, since 1993, and was promoted to Reader in 2006. His fields of interest are: applications of statistics including image analysis, spatial modelling and disclosure limitation. He has published over 20 refereed journal articles. 相似文献
Francesco de PasqualeEmail: |
Francesco de Pasquale received his Ph.D. in Applied Statistics from the University of Plymouth, United Kingdom in 2004 discussing a thesis on Bayesian and Template based methods for image analysis. Since his degree in Physics obtained at the University of Rome ‘La Sapienza’in 1999 his work has been focused on developing models and methods for Magnetic Resonance Imaging, in particular image registration, classification and segmentation in a Bayesian framework. After being appointed a 2-year contract as a Lecturer at the University of Plymouth from 2003 to 2004 he is now a post-Doc researcher at the ITAB, Institute for Advanced Biomedical Technologies, University of Chieti, Italy and he works on the analysis of fMRI and MEG data. Julian Stander was born in Plymouth, UK in 1964. He received a BA in Mathematics with first class honours from University of Oxford in 1987, a Diploma in Mathematical Statistics with distinction from University of Cambridge in 1988, and a PhD from University of Bath in 1992. He has been a lecturer at the School of Mathematics and Statistics, University of Plymouth, since 1993, and was promoted to Reader in 2006. His fields of interest are: applications of statistics including image analysis, spatial modelling and disclosure limitation. He has published over 20 refereed journal articles. 相似文献