Surgical treatment of aneurysms of the left ventricle. Immediate and long-term results. Apropos of a consecutive series of 121 cases

From 1978 to 1992, 121 cases of postinfarction left ventricular aneurysm (99 males, 22 females, mean age 60 years) were operated on. The authors insist on a high rate of clinical arhythmogenicity (31.4%) and associated mechanical complications (21%). 76% of patients were in functional NYHA class III or IV. Resection was performed in 90% of patients, plication in 10%. 58% underwent coronary artery bypass grafting (1.7 graft/patient), 16% encircling ventriculotomy, 8% mitral valve replacement and 13% closure of ventricular septal defect. Operative mortality was 14.9% (10% when other mechanical complications where excluded). 5-year survival is 67.9%. Late cardiac deaths are as follow: left ventricular failure (1.8% A/P), Sudden death (1.4% A/P), Myocardial infarction (0.6% A/P). 82% of survivals are in functional NYHA class I or II. Only functional class NYHA III or IV is predictive of late death. We conclude that postinfarction left ventricular aneurysm remains a high risk complication especially when associated with other mechanical complications. When arhythmogenicity is present we suggest rhythmologic surgery and in all cases, complete revascularization.     

Can bilharziasis be considered a health priority in western Africa, justifying control programs of large scope?

INTRODUCTION: The aim of the study was the evaluation of the usefulness of transesophageal atrial pacing in predicting chronic oral treatment efficacy of symptomatic reciprocating supraventricular tachycardia in infants and in avoiding the risk of very dangerous recurrences at home. METHODS: We studied 13 infants (11 males, 2 females, mean age 43 +/- 31 days) with symptomatic reciprocating supraventricular tachycardia and no structural heart disease. All patients had chronic oral therapy, using the drug effective in acute i.v. somministration. Each patient was discharged when supraventricular tachycardia was not inducible with transesophageal atrial pacing after 5 half-lives of the drug used in chronic oral treatment. All patients, every 6 months, were retested with transesophageal atrial pacing alternatively during chronic oral therapy and after complete wash out. Oral therapy was stopped in each patient when supraventricular tachycardia was not inducible after the wash out. RESULTS: The number of oral treatments tested for each patient were 2 +/- 1 (range 1-5). The number of transesophageal studies performed for each patient were 4 +/- 2 (range 3-7). No patient had symptomatic episodes of supraventricular tachycardia or needed to change therapy during the follow-up. The oral treatment was stopped after the twelfth month of life in 8 patients and after the twenty-fourth in 2 others without recurrences. CONCLUSION: Transesophageal atrial pacing seems to be useful in predicting accurately and rapidly the oral treatment efficacy of supraventricular tachycardia in infants. Our protocol seems to be effective to avoid dangerous recurrences of tachycardia and to decide when we can stop therapy without risk.     

Self-organized porous TiO2 and ZrO2 produced by anodization

The present work investigates the electrochemical formation of self-organized high aspect ratio TiO₂ and ZrO₂ nanotube layers. The formation and growth of a self-organized porous layer can be achieved directly by anodization without any templates in fluoride containing electrolytes. The morphology of the porous layers is affected by the electrochemical conditions such as the electrolyte composition, the pH and the exact polarization treatment (such as the potential sweep rate from the open-circuit potential to the anodizing potential). For Ti, nanotube layers are formed with diameters varying from approx. 20 nm to 100 nm and lengths from approx. 0.25 μm to 2.5 μm depending on the electrolytes and pH. On the other hand, for Zr, tubes of 50 nm in diameter and up to approx. 17 μm in length can be grown—a key parameter in this case is the potential sweep rate. The large difference between Ti and Zr in the achievable thickness of nanotube layers indicates a difference in the growth mechanism which may be based on the different chemical dissolution rates of electrochemically formed oxides.     

Deterministic planning in the fifth international planning competition: PDDL3 and experimental evaluation of the planners

The international planning competition (IPC) is an important driver for planning research. The general goals of the IPC include pushing the state of the art in planning technology by posing new scientific challenges, encouraging direct comparison of planning systems and techniques, developing and improving a common planning domain definition language, and designing new planning domains and problems for the research community. This paper focuses on the deterministic part of the fifth international planning competition (IPC5), presenting the language and benchmark domains that we developed for the competition, as well as a detailed experimental evaluation of the deterministic planners that entered IPC5, which helps to understand the state of the art in the field.We present an extension of pddl, called pddl3, allowing the user to express strong and soft constraints about the structure of the desired plans, as well as strong and soft problem goals. We discuss the expressive power of the new language focusing on the restricted version that was used in IPC5, for which we give some basic results about its compilability into pddl2. Moreover, we study the relative performance of the IPC5 planners in terms of solved problems, CPU time, and plan quality; we analyse their behaviour with respect to the winners of the previous competition; and we evaluate them in terms of their capability of dealing with soft goals and constraints, and of finding good quality plans in general. Overall, the results indicate significant progress in the field, but they also reveal that some important issues remain open and require further research, such as dealing with strong constraints and computing high quality plans in metric-time domains and domains involving soft goals or constraints.     

Equivalence of some common linear feature extraction techniques for appearance-based object recognition tasks

Recently, a number of empirical studies have compared the performance of PCA and ICA as feature extraction methods in appearance-based object recognition systems, with mixed and seemingly contradictory results. In this paper, we briefly describe the connection between the two methods and argue that whitened PCA may yield identical results to ICA in some cases. Furthermore, we describe the specific situations in which ICA might significantly improve on PCA     

Subjective Probability Intervals: How to Reduce Overconfidence by Interval Evaluation.

Format dependence implies that assessment of the same subjective probability distribution produces different conclusions about over- or underconfidence depending on the assessment format. In 2 experiments, the authors demonstrate that the overconfidence bias that occurs when participants produce intervals for an uncertain quantity is almost abolished when they evaluate the probability that the same intervals include the quantity. The authors successfully apply a method for adaptive adjustment of probability intervals as a debiasing tool and discuss a tentative explanation in terms of a naive sampling model. According to this view, people report their experiences accurately, but they are naive in that they treat both sample proportion and sample dispersion as unbiased estimators, yielding small bias in probability evaluation but strong bias in interval production. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Leukotriene A4 Hydrolase and Hepatocyte Growth Factor Are Risk Factors of Sudden Cardiac Death Due to First-Ever Myocardial Infarction

Patients at a high risk for sudden cardiac death (SCD) without previous history of cardiovascular disease remain a challenge to identify. Atherosclerosis and prothrombotic states involve inflammation and non-cardiac tissue damage that may play active roles in SCD development. Therefore, we hypothesized that circulating proteins implicated in inflammation and tissue damage are linked to the future risk of SCD. We conducted a prospective nested case–control study of SCD cases with verified myocardial infarction (N = 224) and matched controls without myocardial infarction (N = 224), aged 60 ± 10 years time and median time to event was 8 years. Protein concentrations (N = 122) were measured using a proximity extension immunoassay. The analyses revealed 14 proteins significantly associated with an increased risk of SCD, from which two remained significant after adjusting for smoking status, systolic blood pressure, BMI, cholesterol, and glucose levels. We identified leukotriene A4 hydrolase (LTA4H, odds ratio 1.80, corrected confidence interval (CI_corr) 1.02–3.17) and hepatocyte growth factor (HGF; odds ratio 1.81, CI_corr 1.06–3.11) as independent risk markers of SCD. Elevated LTA4H may reflect increased systemic and pulmonary neutrophilic inflammatory processes that can contribute to atherosclerotic plaque instability. Increased HGF levels are linked to obesity-related metabolic disturbances that are more prevalent in SCD cases than the controls.     

Preface: Volume 66, Issue 5

This part of the volume contains the papers accepted for presentation at the workshop on Unification in Non-Classical Logics (UNCL), co-located with ICALP 2002, which took place on July 12, 2002 in M 'alaga, Spain.The workshop was concerned with one of the most promising areas of research on non-classical logics and its applications. Unification in non-classical logics, with various approaches to handling generalised terms, has drawn more and more attention in recent years. So far, most popular lines of research include fuzzy unification of (conventional) databases and the use of fuzzy concepts in information retrieval.This workshop was conceived as a forum for the exchange of ideas relevant for the concept of unification in non-classical logics, including, but not limited to, the topics of:

• Unification in multiple-valued and fuzzy logic programming.

• Unification based on similarities and fuzzy equivalence relations.

• Categorical unification.

• Practical use of non-classical unification, e.g. in expert systems and information retrieval.

The program committee selected six papers after a reviewing process in which each submitted paper received at least two reviews. Considerable effort was devoted for the evaluation of the submissions and to providing the authors with helpful feedback. The criteria for selection were originality, quality, and relevance to the topic of the workshop.Alsinet et al reviewed and compared two models which extend first order possibilistic logic in order to enable fuzzy unification. The extension considers mainly fuzzy constants, and in form of restrictions on existential quantifiers.Banerjee and Bujosa presented a non-classical interpretion of classical unification in terms of geometrical constructions over a suitable R-module M. The main result is that unification of two terms can be seen as the intersection of their corresponding affine varieties on M. This paves the way of using methods from computer algebra in the field of unification.In Eklund et al, substitutions and unifiers appear as constructs in Kleisli categories related to particular composed powerset term monads. It is shown that an often used similarity-based approach to fuzzy unification is compatible with the categorical approach, and can be adequately extended.Kutsia presented a unification procedure for a theory with individual and sequence variables, free fixed and flexible arity function symbols and patterns. These theories have been used in different contexts such as databases, rewriting, programming languages, or theorem proving.Medina et al introduced a formal model for similarity-based fuzzy unification in multi-adjoint logic programs. On this computational model, a similarity-based unification approach which provides a semantic framework for logic programming with different notions of similarity was constructed.Virtanen introduced unification in similarity-based logic programming. One of the crucial points is the definition of similarity degrees between sets, giving rise to [lambda]-interpretations. The selection of so called most significant terms again is one of the cornerstones of the paper.We would like to thank all those who submitted papers for consideration, the authors of accepted papers for their interesting discussions during the workshop, the additional referees for their careful work, and Inma Fortes from the local organising committee for her assistance.     

The Cognitive Benefit of Dynamic Representations on Procedural Skill Acquisition: A Computational Modeling Approach

Cognitive computational modeling is a viable methodology for further investigation of the hitherto inconclusive findings on the cognitive benefits of dynamic versus static visualization components of instructions. This is more so as contemporary cognitive architectures such as the Adaptive Control of Thought–Rational (ACT–R) 6.0 are increasingly applied to traditional cognitive psychology research problems. The application of this methodology is, however, restricted by the limited capability of existing architectures for implementing detailed atomic motor actions such as those involved in complex skill acquisition and performance. This article presents a 2-component computational modeling methodology for investigating the cognitive processes involved in the acquisition and performance of skilled motor tasks. The approach specifies a novel combination of a sequence-of-point technique with a movement control mechanism to implement variously acquired cognitive mental task representations and their intertwined role in postlearning performance as evident in the atomic control of motor actions. This paradigm is validated for 2 experiments using incrementally developed cognitive models developed in ACT–R 6.0. The model's quantitative outputs correlate significantly with equivalent empirical human data. This has implications for multimedia instructional design, especially where rapid, transferrable skill acquisition is desired on initial exposure.     

Search for Superconductivity in Ultra-dense Deuterium D(?1) at Room Temperature: Depletion of D(?1) at Field Strength >0.05 T

Ultra-dense deuterium D(?1) is expected to be both a superfluid and a superconductor as shown by recent theoretical research. Condensed D(?1) can be deposited on surfaces by a source which produces a stream of clusters. A magnetic field strongly influences the type of material formed. Very little of D(?1) and of the form D(1), which is strongly coupled to D(?1), exists on the magnet surface or within several mm from the magnet surface. Even the formation of D(?1) on the source emitter is strongly influenced by a magnetic field, with a critical field strength in the range 0.03?C0.07 T. Higher excitation levels D(2) and D(3) dominate in a magnetic field. The excitation level D(2) is now observed for the first time. The removal of D(?1) and D(1) in strong magnetic fields is proposed to be due to a Meissner effect in long D(?1) clusters by large-orbit electron motion. The lifting of long D(?1) clusters above the magnet surface is slightly larger than expected, possibly due to the coupling to D(1). The previously reported oscillation between D(?1) and D(1) in an electric field is proposed to be due to destruction of D(?1).