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排序方式: 共有333条查询结果,搜索用时 31 毫秒
1.
Su-Il Ri Song-Il Hong Jong-Chol Kim Ju-Hyok Wi 《International Journal of Hydrogen Energy》2021,46(5):3319-3328
We investigated some properties of the hydride Mg2FeH6 substituted with yttrium by a first principles calculation. Some experimental results showed that 4d transition metal, yttrium serves as a good catalyst for magnesium based hydrogen storage alloys, but there are a few theoretical studies about magnesium based hydrides substituted with it. Mg2FeH6 is regarded as a cheaper material than pure MgH2, while it is crystalized into Fm3m structure (space group 225). Although it has high hydrogen storage capacity, many investigations have not been devoted to it due to its extremely high thermodynamic stability. The yttrium substituted Mg2FeH6 exhibits very low energy of formation, and its desorption temperature, 75 °C is very suitable for practical hydrogen storage applications. Our results showed that Mg2FeH6 is destabilized effectively by yttrium substitution and introducing vacancy defects has additive effect to the improvement of dehydrogenation performance. 相似文献
2.
Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models
Beata Filip-Psurska Mateusz Psurski Artur Anisiewicz Patrycja Libako Ewa Zbrojewicz Magdalena Maciejewska Micha Chodyski Andrzej Kutner Joanna Wietrzyk 《International journal of molecular sciences》2021,22(5)
1,25-Dihydroxycholecalciferol, the hormonally active vitamin D3 metabolite, is known to exhibit therapeutic effects against breast cancer, mainly by lowering the expression of estrogen receptors and aromatase activity. Previously, the safety of the vitamin D active metabolite (24R)-1,24-dihydroxycholecalciferol (PRI-2191) and 1,25(OH)2D3 analog PRI-2205 was tested, and the in vitro activity of these analogs against different cancer cell lines was studied. We determined the effect of the two vitamin D compounds on anastrozole (An) activity against breast cancer based on antiproliferative activity, ELISA, flow cytometry, enzyme inhibition potency, PCR, and xenograft study. Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression. Combined with An, PRI-2191 and PRI-2205 significantly inhibited the tumor growth of MCF-7 cells. Potentiation of the antitumor activity in combined treatment of MCF-7 tumor-bearing mice is related to the reduced activity of aromatase by both An (enzyme inhibition) and vitamin D compounds (switched off/decreased aromatase gene expression, decreased expression of other genes related to estrogen signaling) and by regulation of the expression of the estrogen receptor ERα and VDR. 相似文献
3.
M Zawadzka B Barański J Wi?niewska-Knypl T Wrońska-Nofer 《Canadian Metallurgical Quarterly》1993,6(4):391-397
Genotoxic effect and hepatic microsomal monooxygenase activities were assessed in mice treated with Acid Green 16 (single i.p. injection at dose 75 mg/kg) superimposed on prolonged ethanol consumption (10% solution in drinking water for 2-4 months). Treatment of mice with Acid Green 16 led to an increased frequency of micronucleated erythrocytes in bone marrow. In animals pretreated with ethanol the frequency of micronucleated erythrocytes, produced by Acid Green 16, was significantly higher. The changes in frequency of micronucleated erythrocytes were accompanied by the enhanced activity of microsomal monooxygenases manifested by higher activity of 7-ethoxycoumarin o-deethylase (the level of cytochrome P-450 was not altered). The obtained results showed that ethanol tended to increase the genotoxic effect of Acid Green 16. However, the slight inductive effect of ethanol on microsomal monooxygenases did not provide clear evidence that the genotoxic effect of Acid Green 16 was associated with ethanol stimulation of the metabolic activation of the dye in the liver. 相似文献
4.
The interactions of NO with carbon and carbon-supported catalysts have been investigated by means Fourier transform infrared spectroscopy. Nitric oxide direct decomposition over carbon-supported catalysts (Cu, Pt) was studied in a temperature ranging from 473 to 623 K. NO conversion increased with increasing reaction temperature in the whole temperature range. The carbon-supported Pt catalyst has a very high activity for the decomposition of NO in the absence of oxygen. As a result of NO chemisorption isocyanate (-NCO) species on the surface of carbon containing Cu were observed. When the reaction temperature was increased, the -NCO band at 2229 cm−1 became more intense. 相似文献
5.
Jan Korbecki Klaudyna Kojder Patrycja Kapczuk Patrycja Kupnicka Barbara Gawroska-Szklarz Izabela Gutowska Dariusz Chlubek Irena Baranowska-Bosiacka 《International journal of molecular sciences》2021,22(2)
Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing a stronger proinflammatory influence. One of the systems affected by hypoxia is the CXC chemokine system. This paper reviews all available information on hypoxia-induced changes in the expression of all CXC chemokines (CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8 (IL-8), CXCL9, CXCL10, CXCL11, CXCL12 (SDF-1), CXCL13, CXCL14, CXCL15, CXCL16, CXCL17) as well as CXC chemokine receptors—CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, CXCR7 and CXCR8. First, we present basic information on the effect of these chemoattractant cytokines on cancer processes. We then discuss the effect of hypoxia-induced changes on CXC chemokine expression on the angiogenesis, lymphangiogenesis and recruitment of various cells to the tumor niche, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), regulatory T cells (Tregs) and tumor-infiltrating lymphocytes (TILs). Finally, the review summarizes data on the use of drugs targeting the CXC chemokine system in cancer therapies. 相似文献
6.
Martyna Zagrska-Dziok Patrycja Kleczkowska Ewa Oldzka Ramona Figat Marcin Sobczak 《International journal of molecular sciences》2021,22(7)
Polymeric hydrogels play an increasingly important role in medicine, pharmacy and cosmetology. They appear to be one of the most promising groups of biomaterials due to their favorable physicochemical properties and biocompatibility. The objective of the presented study was to synthesize new poly(chitosan-ester-ether-urethane) hydrogels and to study the kinetic release of genistein (GEN) from these biomaterials. In view of the above, six non-toxic hydrogels were synthesized via the Ring-Opening Polymerization (ROP) and polyaddition processes. The poly(ester-ether) components of the hydrogels have been produced in the presence of the enzyme as a biocatalyst. In some cases, the in vitro release rate of GEN from the obtained hydrogels was characterized by near-zero-order kinetics, without “burst release” and with non-Fickian transport. It is important to note that developed hydrogels have been shown to possess the desired safety profile due to lack of cytotoxicity to skin cells (keratinocytes and fibroblasts). Taking into account the non-toxicity of hydrogels and the relatively highly controlled release profile of GEN, these results may provide fresh insight into polymeric hydrogels as an effective dermatological and/or cosmetological tool. 相似文献
7.
The changes of ZnFe2O4 caused by mechanical activation as well as the structural evolution of nonactivated and mechanically activated zinc ferrite occurring during heating, have been investigated by in situ Mössbauer spectroscopy. Attention is directed to mechanically induced changes in magnetic properties of zinc ferrite, the variation of nuclear quadrupolar interactions, the thermally induced changes of the Mössbauer shift, and also to the structural response of mechanically activated zinc ferrite to changes in temperature. 相似文献
8.
Bartosz Więckowski 《Journal of Logic, Language and Information》2016,25(2):215-268
A first-order language with a defined identity predicate is proposed whose apparatus for atomic predication is sensitive to grammatical categories of natural language (e.g., common nouns, verbs, adjectives, adverbs, modifiers). Subatomic natural deduction systems are defined for this naturalistic first-order language. These systems contain subatomic systems which govern the inferential relations which obtain between naturalistic atomic sentences and between their possibly composite components. As a main result it is shown that normal derivations in the defined systems enjoy the subexpression property which subsumes the subformula property with respect to atomic and identity formulae as a special case. The systems admit a proof-theoretic semantics which does not only apply to logically compound but also to atomic and identity formulae—as well as to their components. The potential of the defined systems for a meticulous first-order analysis of natural inferences whose validity crucially depends on expressions of some of the aforementioned categories is demonstrated. 相似文献
9.
Rheological characteristics of oligomeric semiproducts gained via chemical degradation of polyurethane foam using crude glycerin in the presence of different catalysts 下载免费PDF全文
Polyurethane (PU) recycling is a topic of growing interest due to the increasing amount of polyurethane waste. The main purpose of polyurethane chemical recycling is to recover the starting polyol. In this study, a method of polyurethane thermochemical recycling, glycerolysis by means of crude glycerin, is proposed. This work presents a comparative study of commercial catalysts used in order to accelerate the decomposition process, namely triethylamine (TEA), potassium acetate (KAc), 1,4‐diazabicyclo[2.2.2]octane (DABCO), sodium hydroxide (NaOH), dibutyltin dilaurate (DbDl), and stannous octoate (StOc).The effect of used catalyst on the chemical structure and rheological properties was studied. The type of catalyst does not have significant influence on the chemical structure, but causes different course of reaction: split‐ and single‐phase in applied conditions. Glycerolysates were measured by Brookfield Rheometer. It was found that repolyols can be described by the Herschel–Bulkely mathematical model in the best accuracy. The investigation showed that the rheological behavior of glycerolysates depended on the catalyst used in glycerolysis process. POLYM. ENG. SCI., 57:891–900, 2017. © 2016 Society of Plastics Engineers 相似文献
10.
Chang-Won Kim Wi Sung Yoo Hyunsu Lim Ilhan Yu Hunhee Cho Kyung-In Kang 《International Journal of Project Management》2018,36(5):730-743
An early-warning performance monitoring system (EPMS) is proposed to objectively measure and monitor the performance of a project for early detection of inherent poor performance problems. The EPMS is built based on project progress data and consists of a database of business information, an optimized theoretical model used as a performance measurement baseline, and an index for monitoring and forecasting the performance. By monitoring the performance through an application of the EPMS to the Korean construction project, the quarterly variation of index was found to differ by project type. These results could explain the environmental changes in the project execution. Therefore, the EPMS is expected to be an alternative for objective performance monitoring and forecasting while applying the existing methods is difficult because of the limited available data on performance indicators. The development procedures may also be useful to researchers interested in approaches to quantitatively analyze trends in various industries. 相似文献