Context-Processing Deficits in Schizotypal Personality Disorder.

Research suggests that schizotypal personality disorder (SPD) is a part of the spectrum of schizophrenia-related illnesses. This article hypothesizes that a deficit in the representation and maintenance of context is a core cognitive disturbance in schizophrenia and that SPD individuals should demonstrate context-processing deficits. To test this hypothesis, the authors administered 3 versions of their AX-CPT task, designed to assess context processing, to 35 healthy controls and 26 individuals with DSM-IV SPD. They also administered working memory and selective attention tasks. SPD individuals displayed context representation deficits similar to those found in schizophrenia but did not show the same additional deficits in context maintenance. Context processing was strongly associated with working memory and selective attention performance in the SPD individuals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

第三代手机射频架构

大多数电信企业为获得3G许可证投入了巨额资金，现在他们还需要进行基础设施投资，以为这一企盼已久的技术提供支持。总的成本将会达数十亿英磅，因此电信商面临很大的压力，需要尽快偿还债务并快速获得赢利，达到这一目标的最快速的方法还是尽快启动3G的消费市场。对于价格竞争激烈的多媒体功能等服务，赢得消费者和商业客户青睐并迅速收回投资的关键是提供价格合理的手机。包括发射器和接收器在内的手机内部电路在手机成本中占了相当大的部分。为降低3G手机射频解决方案的总体成本，必须满足三个主要目标：即降低芯片成本、减少外部器件…     

Critical Speed Control of a Solar Car

The World Solar Challenge is a 3000 km race for solar powered cars across the Australian continent from Darwin to Adelaide. Each car is powered by a panel of photovoltaic cells which convert sunlight into electrical power. The power can be used directly to drive the car or stored in a battery for later use. Previous papers (P. Howlett, P. Pudney, T. Tarnopolskaya, and D. Gates, IMA Journal of Mathematics Applied in Business and Industry vol. 8, pp. 59–81, 1997; P.G. Howlett and P.J. Pudney, Dynamics of Continuous, Discrete and Impulsive Systems vol. 4, pp. 553–567, 1998) using a simplified model of the battery, have shown that the optimal strategy is essentially a speedholding strategy. In this paper, with a more realistic model of the battery, we show that the optimal driving strategy is a critical speed strategy. For an optimal journey with no beginning and no ending the solar car must always travel at the critical speed. For an optimal journey of finite length the speed must be close to the critical speed for most of the journey. The critical speed depends on the solar power and will normally vary slowly with time.     

The role of benchmarking for yardstick competition

With the increasing interest in yardstick regulation, there is a need to understand the most appropriate method for realigning tariffs at the outset. Benchmarking is the tool used for such realignment and is therefore a necessary first-step in the implementation of yardstick competition. A number of concerns have been raised about the application of benchmarking, making some practitioners reluctant to move towards yardstick based regimes. We assess five of the key concerns often discussed and find that, in general, these are not as great as perceived. The assessment is based on economic principles and experiences with applying benchmarking to regulated sectors, e.g. in the electricity and water industries in the UK, The Netherlands, Austria and Germany in recent years. The aim is to demonstrate that clarity on the role of benchmarking reduces the concern about its application in different regulatory regimes. We find that benchmarking can be used in regulatory settlements, although the range of possible benchmarking approaches that are appropriate will be small for any individual regulatory question. Benchmarking is feasible as total cost measures and environmental factors are better defined in practice than is commonly appreciated and collusion is unlikely to occur in environments with more than 2 or 3 firms (where shareholders have a role in monitoring and rewarding performance). Furthermore, any concern about companies under-recovering costs is a matter to be determined through the regulatory settlement and does not affect the case for using benchmarking as part of that settlement.     

Ultrastructural analysis of primary human urethral epithelial cell cultures infected with Neisseria gonorrhoeae

In men with gonococcal urethritis, the urethral epithelial cell is a site of infection. To study the pathogenesis of gonorrhea in this cell type, we have developed a method to culture primary human urethral epithelial cells obtained at the time of urologic surgery. Fluorescent analysis demonstrated that 100% of the cells stained for keratin. Microscopic analyses indicated that these epithelial cells arrayed in a pattern similar to that seen in urethral epithelium. Using immunoelectron and confocal microscopy, we compared the infection process seen in primary cells with events occurring during natural infection of the same cell type in men with gonococcal urethritis. Immunoelectron microscopy studies of cells infected with Neisseria gonorrhoeae 1291 Opa+ P+ showed adherence of organisms to the epithelial cell membrane, pedestal formation with evidence of intimate association between the gonococcal and the epithelial cell membranes, and intracellular gonococci present in vacuoles. Confocal studies of primary urethral epithelial cells showed actin polymerization upon infection. Polyclonal antibodies to the asialoglycoprotein receptor (ASGP-R) demonstrated the presence of this receptor on infected cells in the primary urethral cell culture. In situ hybridization using a fluorescent-labeled probe specific to the ASGP-R mRNA demonstrated this message in uninfected and infected cells. These features were identical to those seen in urethral epithelial cells in exudates from males with gonorrhea. Infection of primary urethral cells in culture mimics events seen in natural infection and will allow detailed molecular analysis of gonococcal pathogenesis in a human epithelial cell which is commonly infected.     

News: Presidential "green chemistry" awards promote industrial pollution prevention

Technology.     

Failure mechanisms in viscoelastic films

This paper presents the results of tensile tests on viscoelastic films of two materials: a 100 pen bitumen and a commercial corn syrup. Experiments were performed using double-cantilever beam specimens, and butt-joint specimens, for a wide range of testing conditions. Failure by brittle fracture, voiding, and various viscous flow mechanisms was observed. The results are presented in the form of maps and are discussed in conjunction with appropriate mathematical models.