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排序方式: 共有49条查询结果,搜索用时 31 毫秒
1.
Roberta Squecco Alessia Tani Flaminia Chellini Rachele Garella Eglantina Idrizaj Irene Rosa Sandra Zecchi-Orlandini Mirko Manetti Chiara Sassoli 《International journal of molecular sciences》2021,22(7)
Bone marrow-mesenchymal stem/stromal cells (MSCs) may offer promise for skeletal muscle repair/regeneration. Growing evidence suggests that the mechanisms underpinning the beneficial effects of such cells in muscle tissue reside in their ability to secrete bioactive molecules (secretome) with multiple actions. Hence, we examined the effects of MSC secretome as conditioned medium (MSC-CM) on ex vivo murine extensor digitorum longus muscle injured by forced eccentric contraction (EC). By combining morphological (light and confocal laser scanning microscopies) and electrophysiological analyses we demonstrated the capability of MSC-CM to attenuate EC-induced tissue structural damages and sarcolemnic functional properties’ modifications. MSC-CM was effective in protecting myofibers from apoptosis, as suggested by a reduced expression of pro-apoptotic markers, cytochrome c and activated caspase-3, along with an increase in the expression of pro-survival AKT factor. Notably, MSC-CM also reduced the EC-induced tissue redistribution and extension of telocytes/CD34+ stromal cells, distinctive cells proposed to play a “nursing” role for the muscle resident myogenic satellite cells (SCs), regarded as the main players of regeneration. Moreover, it affected SC functionality likely contributing to replenishment of the SC reservoir. This study provides the necessary groundwork for further investigation of the effects of MSC secretome in the setting of skeletal muscle injury and regenerative medicine. 相似文献
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3.
Lisa Biasetto Rachele Bertolini Hamada Elsayed Andrea Ghiotti Stefania Bruschi 《Ceramics International》2019,45(5):5941-5951
Rods of commercially pure titanium were machined using standard oil-based emulsion and cryogenic cooling, and were then coated with sphene (CaTiSiO5) bioceramic by spray coating using an automatic airbrush. The sphene bioceramic was synthesized in-situ starting from a suspension of polysiloxane that used as SiO2 precursor, CaCO3 and TiO2 nanoparticles. The suspension was deposited on the machined substrates, which were heat treated up to 950?°C in order to promote the formation of sphene ceramic. The produced coated prototypes were characterized to evaluate the effect of the machining conditions on surface roughness and microstructure of the substrate, and thereby their effect on coating adhesion. Nanoindentation tests were employed to determine the hardness and elastic modulus of the coating through its thickness. Results showed that the reduced amount of defects on the surface of the cryo-machined substrates, contributed to increase the hardness, elastic modulus and adhesion strength of the coating-substrate interfaces compared to standard machined samples, therefore improving adhesion of the coating to the underlying substrate. 相似文献
4.
Lapolla A Reitano R Seraglia R Sartore G Ragazzi E Traldi P 《Molecular nutrition & food research》2005,49(7):685-690
Advanced glycation end products (AGE) and dicarbonyl compounds accumulate in serum and tissues of patients with diabetes and chronic renal failure. Pentosidine, free pentosidine, glyoxal and methylglyoxal have been evaluated in plasma of diabetic patients with poor metabolic control at baseline and after the improvement of glycemic levels, and in plasma and peritoneal dialysate of patients with renal failure before and after 12 h of peritoneal dialysis. In diabetic patients, acceptable metabolic control was unable to normalize levels of pentosidine (after 2 and 10 months), glyoxal and methylglyoxal (after 2 months). In patients with end-stage renal disease, mean values of pentosidine, free pentosidine, glyoxal and methylglyoxal decreased in plasma after dialysis. No pentosidine or free pentosidine were present in the peritoneal dialysate at time 0, but were found after 12 h of peritoneal dialysis; glyoxal and methylglyoxal decreased after 12 h of dialysis. So, glyoxal and methylglyoxal, already present in the dialysis fluid, can react with the peritoneal matrix protein, giving a reason for the gradual loss of peritoneal membrane function often observed in patients undergoing long-term peritoneal dialysis. 相似文献
5.
Benedetta Angeloni Rachele Bigi Gianmarco Bellucci Rosella Mechelli Chiara Ballerini Carmela Romano Emanuele Morena Giulia Pellicciari Roberta Reni Virginia Rinaldi Maria Chiara Buscarinu Silvia Romano Giovanni Ristori Marco Salvetti 《International journal of molecular sciences》2021,22(7)
Multiple sclerosis is a complex, multifactorial, dysimmune disease prevalent in women. Its etiopathogenesis is extremely intricate, since each risk factor behaves as a variable that is interconnected with others. In order to understand these interactions, sex must be considered as a determining element, either in a protective or pathological sense, and not as one of many variables. In particular, sex seems to highly influence immune response at chromosomal, epigenetic, and hormonal levels. Environmental and genetic risk factors cannot be considered without sex, since sex-based immunological differences deeply affect disease onset, course, and prognosis. Understanding the mechanisms underlying sex-based differences is necessary in order to develop a more effective and personalized therapeutic approach. 相似文献
6.
Luca Pezzato Leonardo Bertolucci Coelho Rachele Bertolini Alessio Giorgio Settimi Katya Brunelli Marjorie Olivier Manuele Dabal 《工业材料与腐蚀》2019,70(11):2103-2112
Plasma electrolytic oxidation (PEO) coatings were produced on AZ80 magnesium alloy in a solution containing silicates and phosphates and working at high current densities with short treatment times. The effect of a sealing treatment in boiling water on corrosion and mechanical properties of the coatings were investigated. Moreover, the corrosion mechanism of the samples with and without the sealing treatment was evaluated. The microstructure of the coatings was characterized with scanning electron microscope observation and X‐ray diffraction analysis. The mechanical properties were evaluated with nanoindentation tests and the corrosion resistance was studied by potentiodynamic polarization, electrochemical impedance spectroscopy, and scanning vibrating electrode technique. The results showed that the sealing did not influence the microstructure and the mechanical properties of the samples and instead produced a remarkable increase in the corrosion resistance. The crevice corrosion, present in the sample without the sealing, was avoided with the treatment in boiling water. 相似文献
7.
Stefany Castaldi Claudia Petrillo Giuliana Donadio Fabrizio Dal Piaz Alessio Cimmino Marco Masi Antonio Evidente Rachele Isticato 《International journal of molecular sciences》2021,22(7)
In recent decades, intensive crop management has involved excessive use of pesticides or fertilizers, compromising environmental integrity and public health. Accordingly, there has been worldwide pressure to find an eco-friendly and safe strategy to ensure agricultural productivity. Among alternative approaches, Plant Growth-Promoting (PGP) rhizobacteria are receiving increasing attention as suitable biocontrol agents against agricultural pests. In the present study, 22 spore-forming bacteria were selected among a salt-pan rhizobacteria collection for their PGP traits and their antagonistic activity against the plant pathogen fungus Macrophomina phaseolina. Based on the higher antifungal activity, strain RHFS10, identified as Bacillus vallismortis, was further examined and cell-free supernatant assays, column purification, and tandem mass spectrometry were employed to purify and preliminarily identify the antifungal metabolites. Interestingly, the minimum inhibitory concentration assessed for the fractions active against M. phaseolina was 10 times lower and more stable than the one estimated for the commercial fungicide pentachloronitrobenzene. These results suggest the use of B. vallismortis strain RHFS10 as a potential plant growth-promoting rhizobacteria as an alternative to chemical pesticides to efficiently control the phytopathogenic fungus M. phaseolina. 相似文献
8.
Physical properties of straw lignin-based polymer blends 总被引:1,自引:0,他引:1
Rachele Pucciariello Vincenzo Villani Carlo Bonini Maurizio D'Auria Teresa Vetere 《Polymer》2004,45(12):4159-4169
Lignin powder, obtained from an abundant and low cost source, straw, through a low environmental impact process, the steam explosion, is used for the preparation of blends with low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), high-density polyethylene (HDPE) and atactic polystyrene (PS).The obtained blends are processable through the conventional techniques used for thermoplastics; the modulus slightly increases for most lignin-polymer blends, while the tensile stress and elongation reduce. Moreover, lignin acts as a stabilzer against the UV radiation for PS, LDPE and LLDPE. 相似文献
9.
Carlo Bonini Maurizio D'Auria Giacomo Mauriello Rachele Pucciariello Roberto Teghil Daniela Tofani Licia Viggiani Donato Viggiano Francesco Zimbardi 《应用聚合物科学杂志》2001,79(1):72-79
The synthesis of copolymers between lignin from steam‐exploded straw and 1‐ethenylbenzene is described. Beforehand, lignin from steam‐exploded straw was fully characterized by using elemental analysis, ultraviolet spectroscopy, gel permeation chromatography (GPC), Fourier transform infrared (FTIR), and both 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. Using a previously described procedure utilizing calcium chloride and hydrogen peroxide as reagents the synthesis of the copolymers was performed. FTIR of the copolymers showed the presence of both lignin and polystyrene. GPC analysis showed the presence of a fraction with high molecular weights. These results were confirmed from both viscosity data and differential calorimetry. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 79: 72–79, 2001 相似文献
10.
Rachele Pucciariello 《应用聚合物科学杂志》1996,59(8):1227-1235
The melting behavior of the alternating copolymer of ethylene and tetrafluoroethylene (ETFE) was investigated by differential scanning calorimetry (DSC). A complex melting pattern is observed, strongly influenced by the thermal history. Three melting processes can be identified, whose heats of fusion and peak temperatures (Tm1′, Tm1, and Tm2 at increasing values) strongly depend upon thermal treatments. The higher-temperature melting peak Tm2 is not affected by the crystallization conditions (i.e., cooling rate and annealing); therefore, it can be attributed to more perfect crys+als present in the original sample. The peak at Tm1 increases when the cooling rate is decreased and upon prolonged and/or higher-temperature annealing, and it fastly merges to the higher-temperature peak at Tm2. The peak at Tm1 can be due to crystals that are able to recrystallize and perfect during thermal treatments. Lastly, the peak at the lowest-temperature Tm1′, produced only by annealing and strongly developing on increasing annealing time and temperature, is the so-called annealing peak that can be attributed to much poorer crystallites grown among the larger ones. The melting behavior of ETFE is compared with that of the ethylenechlorotrifluoroethylene (ECTFE) alternating copolymer. © 1996 John Wiley & Sons, Inc. 相似文献