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1.
S Fletcher RG Jones HC Rayner P Harnden LD Hordon JE Aaron B Oldroyd AM Brownjohn JH Turney MA Smith 《Canadian Metallurgical Quarterly》1997,75(4):412-419
Bone biopsies were studied in 73 patients to determine if a two-site radioimmunometric assay for serum bone alkaline phosphatase (BAP), total serum alkaline phosphatase (ALP), serum intact parathyroid hormone (iPTH), hand X-rays, regional bone mineral density (BMD) measurements and parathyroid enlargement detected by ultrasonography could accurately predict renal osteodystrophy. In the patients studied 57 had hyperparathyroid bone disease, 4 mixed renal osteodystrophy, 3 adynamic bone disease, 1 osteomalacia and 8 normal histology. Serum BAP, ALP and iPTH correlated positively with mineral apposition rate, osteoblastic, osteoid and eroded surface. In the diagnosis of hyperparathyroid bone disease serum iPTH was the most sensitive investigation, detecting 81% of patients at a level > 100 pg/ml but with a specificity of only 66%. Serum BAP was more sensitive, 70% at a level of > 10 ng/ml, than serum total ALP, 30% at a level of 300 IU/l, with similar specificities, 92 and 100%, respectively. Ultrasound detection of an enlarged parathyroid gland had a sensitivity of 64% and a specificity of 100% for the diagnosis of hyperparathyroid bone disease. Hand X-rays had a poor sensitivity, 47%, but a high specificity, 92%, for the detection of hyperparathyroid bone disease. The majority of patients had regional BMD values within the normal reference range and this test was of poor discriminatory value. The non-invasive markers were unable to distinguish between patients with low turnover, mild hyperparathyroidism and patients with normal histology. In conclusion the measurement of serum iPTH is a useful screening tool for the detection of hyperparathyroid bone disease which can be confirmed by the finding of a raised serum BAP or parathyroid enlargement. For definitive diagnosis, however, the gold standard remains bone biopsy and at present one cannot recommend any non-invasive method as an adequate substitute. 相似文献
2.
Staub Adrian; Rayner Keith; Pollatsek Alexander; Hy?n? Jukka; Majewski Helen 《Canadian Metallurgical Quarterly》2007,33(6):1162
Readers' eye movements were monitored as they read sentences containing noun-noun compounds that varied in frequency (e.g., elevator mechanic, mountain lion). The left constituent of the compound was either plausible or implausible as a head noun at the point at which it appeared, whereas the compound as a whole was always plausible. When the head noun analysis of the left constituent was implausible, reading times on this word were inflated, beginning with the first fixation. This finding is consistent with previous demonstrations of very rapid effects of plausibility on eye movements. Compound frequency did not modulate the plausibility effect, and all disruption was resolved by the time readers' eyes moved to the next word. These findings suggest (contra Kennison, 2005) that the parser initially analyzes a singular noun as a head instead of a modifier. In addition, the findings confirm that the very rapid effect of plausibility on eye movements is not due to strategic factors, because in the present experiment, unlike in previous demonstrations, this effect appeared in sentences that were globally plausible. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
Readers' eye movements were monitored as they read sentences containing lexically ambiguous words. The ambiguous words were either biased (one strongly dominant interpretation) or nonbiased. Readers' gaze durations were longer on nonbiased than biased words when the disambiguating information followed the target word. In Experiment 1, reading times on the disambiguating word did not differ whether the disambiguation followed the target word immediately or occurred several words later. In Experiment 2, prior disambiguation eliminated the long gaze durations on nonbiased target words but resulted in long gaze durations on biased target words if the context demanded the subordinate meaning. The results indicate that successful integration of one meaning with prior context terminates the search for alternative meanings of that word. This results in selective (single meaning) access when integration of a dominant meaning is fast (due to a biasing context) and identification of a subordinate meaning is slow (a strongly biased ambiguity with low-frequency meaning). (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Summary A procedure is described for isolating two nitrogen-free toxins from tung kernels and from press cake. Chick-feeding tests
were used to determine which fraction was toxic at every separation. Both substances were highly toxic as 10-mg. doses killed
4-day old chicks. These substances were shown by chromatography on glass paper to be different and chromatography homogeneous,
but also unstable. The elementary composition, hydroxyl content, saponification value, and specific rotation for the two toxins
are given.
One of the laboratories of the Southern Utilization Research and Development Division, Agricultural Research Service, U, S.
Department of Agriculture. 相似文献
5.
P. H. Eaves H. P. Dupuy L. L. Holzenthal E. T. Rayner L. E. Brown 《Journal of the American Oil Chemists' Society》1968,45(4):293-295
Two simple but effective pilot-plant processes were developed to produce Halphen-negative cottonseed oil. Both involve treatment
of the oil with cottonseed fatty acids in a conventional batch type of deodorizer in conjunction with deodorization. In one
process, in which the acids were added to the oil, the cyclopropenoids were inactivated in as short a time as 5 min after
the oil reached the maximum temperature of 450–455 F. In the other, in which the acids were generated in situ, the oil did
not become Halphennegative until about an hour and 45 min after it reached maximum temperature. The excess acids produced
by both methods were readily removed during conventional deodorization. In contrast, deodorization alone reduced the cyclopropenoid
content of the oil to a low level (0.02%) but did not render it Halphen-negative even after 3 hr at maximum temperature.
These new processes are directly applicable for use by refineries that have the batch type of deodorizers. For refineries
that operate continuous or semicontinuous deodorizers, it should be relatively simple to design preheating vessels or heat
exchangers to inactivate partially or completely the cyclopropenoids before deodorization.
Presented at the AOCS Meeting, New Orleans, May 1967.
So. Utiliz. Res. Dev. Div., ARS, USDA. 相似文献
6.
Salt sensitivity is probably caused by either a hereditary or acquired defect of salt excretion by the kidney, and it is reasonable to consider that this is the basis for differences in hypertension between black and white people. Dopamine acts in an autocrine/paracrine fashion to promote natriuresis in the proximal tubule and thick ascending loop of Henle. G-protein receptor kinases (or GRKs) are serine and threonine kinases that phosphorylate G protein-coupled receptors in response to agonist stimulation and uncouple the dopamine receptor from its G protein. This results in a desensitisation process that protects the cell from repeated agonist exposure. GRK4 activity is increased in spontaneously hypertensive rats, and infusion of GRK4 antisense oligonucleotides attenuates the increase in blood pressure (BP). This functional defect is replicated in the proximal tubule by expression of GRK4 variants namely p.Arg65Leu, p.Ala142Val and p.Val486Ala, in cell lines, with the p.Ala142Val showing the most activity. In humans, GRK4 polymorphisms were shown to be associated with essential hypertension in Australia, BP regulation in young adults, low renin hypertension in Japan and impaired stress-induced Na excretion in normotensive black men. In South Africa, GRK4 polymorphisms are more common in people of African descent, associated with impaired Na excretion in normotensive African people, and predict blood pressure response to Na restriction in African patients with mild to moderate essential hypertension. The therapeutic importance of the GRK4 single nucleotide polymorphisms (SNPs) was emphasised in the African American Study of Kidney Disease (AASK) where African-Americans with hypertensive nephrosclerosis were randomised to receive amlodipine, ramipril or metoprolol. Men with the p.Ala142Val genotype were less likely to respond to metoprolol, especially if they also had the p.Arg65Leu variant. Furthermore, in the analysis of response to treatment in two major hypertension studies, the 65Leu/142Val heterozygote predicted a significantly decreased response to atenolol treatment, and the 65Leu/142Val heterozygote and 486Val homozygote were associated in an additive fashion with adverse cardiovascular outcomes, independent of BP. In conclusion, there is considerable evidence that GRK4 variants are linked to impaired Na excretion, hypertension in animal models and humans, therapeutic response to dietary Na restriction and response to antihypertensive drugs. It may also underlie the difference in hypertension between different geographically derived population groups, and form a basis for pharmacogenomic approaches to treatment of hypertension. 相似文献
7.
Staub Adrian; Grant Margaret; Clifton Charles Jr.; Rayner Keith 《Canadian Metallurgical Quarterly》2011,37(5):1326
In this brief rejoinder, we respond to Farmer, Monaghan, Misyak, and Christiansen (2011). We argue that the data still do not support the claim that reading time is affected by the phonological typicality of a word for its part of speech. We also question Farmer et al.'s claim that interleaving syntactic structures in an experiment modifies grammatically based syntactic expectations. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
8.
Investigations of biofilms in domestic environments are sparsely represented in the literature. In this study, samples of various household surfaces, including food, laundry and kitchen items, were analyzed for evidence of biofilm presence. Visualization of the surfaces was carried out using cryostage scanning electron microscopy (CSEM) and light microscopy. Qualitative evidence of the presence of biofilm formation was obtained from all of the sample groups analyzed, suggesting the widespread existence of microorganisms in biofilms on domestic surfaces. This suggests that biofilms may be important in household hygiene, and highlights the need for standardized, approved biofilm methods suitable for consumer products testing. 相似文献
9.
An efficient method of achieving flexibility in the length of discrete convolutions, computed using Fourier and Fourier-like fast transform algorithms, is described. Then this method is extended to discrete multidimensional convolutions computed using polynomial transforms. 相似文献
10.
Rayner PJ Whatmore RW 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》2001,48(3):683-690
This paper describes the design, construction, and performance of a piezoelectric motor that uses the travelling B08 mode of an 80-mm diameter circular membrane to drive a rotor by frictional contact. The motor is of a thin planar design, giving high torque of up to 0.33 Nm at low speed and has been developed as a design that can be made with lithographic techniques for miniaturization. Investigations of the free stator with a vibration pattern imager and impedance analyser gave the resonance frequency, mode, and electromechanical coupling of the stator. Motor speed as a function of frequency for a constant voltage and performance charts of speed, output power, and efficiency against torque are presented for a particular input voltage and rotor pre-load. The effects of two different lead zirconate titanate (PZT) ring dimensions have been investigated. Excitation of the B09 mode has been observed, incommensurate with the piezoelectric excitation of the stator. This is discussed with relation to edge-clamping of the stator. Single standing wave motoring was observed, believed to arise from asymmetry of the stator and its perturbation of the B08 resonance mode. Sources of power loss, including frame vibration and friction interface slip, are considered and discussed 相似文献