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1.
Metabolic side-effects of antihypertensive drugs may increase the risk of coronary heart disease despite an adequate blood pressure reduction. Since combinations of different antihypertensive drugs are often necessary and frequently used, we performed a randomized study comparing the effects of a fixed combination of hydrochlorothiazide and sotalol (group A), or hydrochlorothiazide and captopril (group B) on blood pressure and on lipid and glucose metabolism in 40 men with essential hypertension over 1 year. Significant blood pressure reductions (p < 0.001) were achieved in both treatment groups: from 160/105 to 128/88 mmHg in group A (mean doses: hydrochlorothiazide 33 and sotalol 197 mg) and from 162/106 to 135/89 mmHg in group B (hydrochlorothiazide 33 and captopril 64 mg) after 12 months, respectively. No significant changes in body weight were observed in either treatment group. Triglycerides increased (p < 0.05) in both treatment groups (from 183 to 262 mg/dl in A, and from 160 to 196 mg/dl in B) and HDL cholesterol decreased (p < 0.001 and < 0.05) in both groups (from 45.1 to 35.7 mg/dl in A, and from 49.3 to 46.3 mg/dl in B), whereas LDL cholesterol increased significantly (p < 0.05) only in group A from 153 to 164 mg/dl. No significant changes were observed in total cholesterol nor in lipoprotein(a) concentrations in either treatment group. Fasting plasma glucose and hemoglobin A1 increased significantly (p < 0.05) only in group A after 1 year of treatment (from 91.6 to 98.0 mg/dl, and from 6.3 to 6.9%, respectively). Serum levels of creatinine and potassium decreased, and uric acid increased significantly under either combination. Our data show that the diuretic/beta-blocker combination has adverse effects on lipid and glucose metabolism after long-term therapy. The effects of the diuretic/ACE inhibitor combination on lipid metabolism are less pronounced and there are no adverse effects on glucose metabolism. However, the ACE inhibitor component could not completely counteract the metabolic effects of the diuretic. Both combinations have no effects on Lp(a). We conclude that the combination of hydrochlorothiazide with an ACE inhibitor has a better metabolic profile for the treatment of essential hypertension than the combination with a beta-blocker.  相似文献   
2.
Given a planar setS ofn points,maxdominance problems consist of computing, for everyp S, some function of the maxima of the subset ofS that is dominated byp. A number of geometric and graph-theoretic problems can be formulated as maxdominance problems, including the problem of computing a minimum independent dominating set in a permutation graph, the related problem of finding the shortest maximal increasing subsequence, the problem of enumerating restricted empty rectangles, and the related problem of computing the largest empty rectangle. We give an algorithm for optimally solving a class of maxdominance problems. A straightforward application of our algorithm yields improved time bounds for the above-mentioned problems. The techniques used in the algorithm are of independent interest, and include a linear-time tree computation that is likely to arise in other contexts.The research of this author was supported by the Office of Naval Research under Grants N00014-84-K-0502 and N00014-86-K-0689, and the National Science Foundation under Grant DCR-8451393, with matching funds from AT&T.This author's research was supported by the National Science Foundation under Grant DCR-8506361.  相似文献   
3.
Farouk  M.  Slibi  Dhia-Aldin  Abd El-Fattah  Z. M.  Atallah  M.  El-Sherbiny  M. A.  Hassan  Moukhtar A. 《SILICON》2021,13(9):3003-3010
Silicon - Melt-quenching technique was used to prepare borosilicate glasses of composition xSiO2- (75-x) B2O3–24.7Li2O-0.3Cr2O3 (x = 0, 10, 20, 30, 40 and 50&nbsp;mol%). With...  相似文献   
4.
Multimedia Tools and Applications - Automated segmentation has an essential role in detecting several diseases, such as skin lesions. In segmentation, the active contour (AC) is an efficient method...  相似文献   
5.
Internet addiction is “an individual’s inability to control their Internet use, which in turn leads to feelings of distress and functional impairment of daily activities” [Shapira, N., Lessig, M., Goldsmith, T., Szabo, S., Lazoritz, M., Gold, M. et al. (2003). Problematic Internet use: Proposed classification and diagnostic criteria. Depression and Anxiety, 17(4), 207–216]. Previous research in this field has offered inconclusive data on whether Internet addiction can be classified as a disorder. This study provides an in-depth and comprehensive analysis of internet addiction through a meta-synthesis of qualitative studies on excessive Internet use published during the period of 1996–2006. Several constructs pertaining to the domain of Internet addiction have been identified and a theoretical model of Internet addiction has been proposed.  相似文献   
6.
Given a set of n intervals representing an interval graph, the problem of finding a maximum matching between pairs of disjoint (nonintersecting) intervals has been considered in the sequential model. In this paper we present parallel algorithms for computing maximum cardinality matchings among pairs of disjoint intervals in interval graphs in the EREW PRAM and hypercube models. For the general case of the problem, our algorithms compute a maximum matching in O( log 3 n) time using O(n/ log 2 n) processors on the EREW PRAM and using n processors on the hypercubes. For the case of proper interval graphs, our algorithm runs in O( log n ) time using O(n) processors if the input intervals are not given already sorted and using O(n/ log n ) processors otherwise, on the EREW PRAM. On n -processor hypercubes, our algorithm for the proper interval case takes O( log n log log n ) time for unsorted input and O( log n ) time for sorted input. Our parallel results also lead to optimal sequential algorithms for computing maximum matchings among disjoint intervals. In addition, we present an improved parallel algorithm for maximum matching between overlapping intervals in proper interval graphs. Received November 20, 1995; revised September 3, 1998.  相似文献   
7.
This paper presents a performance analysis of a recently proposed preamble-based reduced-complexity (RC) two-stage synchronization technique. The preamble, composed of two identical subsequences, is first used to determine an uncertainty interval based on Cox and Schmidl algorithm. Then, a differential correlation-based metric is carried using a new sequence obtained by element wise multiplication of the preamble subsequence and a shifted version of it. This second step is performed to fine tune the coarse time estimate, by carrying the differential correlation-based metric over the uncertainty interval of limited width around the coarse estimate, thus leading to low computational load. In this paper, we first discuss some complexity issues of the RC approach compared to previously proposed algorithms. Then, we study the effect of the training sequence class and length choices on the synchronization performance in the case of multipath channels. The impact of the uncertainty interval width on the trade-off between performance and complexity is also studied. The two-stage approach was found to provide almost equal performance to those obtained by the most efficient differential correlation-based benchmarks. However, it has a very reduced computational load, equivalent to that of sliding correlation-based approaches.  相似文献   
8.
3D computer graphics models and digitally-controlled manufacturing have come together to enable the design, visualization, simulation, and automated creation of complex 3D objects. In our work, we propose and implement a framework for designing computer graphics objects and digitally manufacturing them such that no adversary can make imitations or counterfeit copies of the physical object, even if the adversary has a large number of original copies of the object, knowledge of the original object design, and has manufacturing precision that is comparable to or superior to that of the legitimate creator of the object. Our approach is to design and embed a signature on the surface of the object which acts as a certificate of genuinity of the object. The signature is detectable by a signature-reading device, based on methods in computer graphics and computer vision, which contains some of the secret information that was used when marking the physical object. Further, the compromise of a signature-reading device by an adversary who is able to extract all its secrets, does not enable the adversary to create counterfeit objects that fool other readers, thereby still enabling reliable copy detection. We implemented a prototype of our scheme end-to-end, including the production of the physical object and the genuinity-testing device.  相似文献   
9.
This paper presents a tool capable of automatically compiling the circuit of a direct-conversion receiver at the schematics level based on system specifications that include the frequency of operation, gain, noise figure, IIP2 and IIP3 linearity. The front-end of a direct-conversion receiver is built using inductive source degeneration (LSD) LNA and double-balanced source-degenerated Gilbert Cell mixers with charge injection. The tool uses power constrained noise and linearity optimization vector-space algorithms that automatically size the transistors, passive components, and find the optimum biasing points. The solution generated by the tool is automatically read by Agilent ADS where the blocks are easily fine-tuned and validated before layout. Case studies involving WiMAX, UMTS, GSM, Bluetooth and WLAN are presented to reveal the capabilities of the tool in reducing the design time.  相似文献   
10.
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