Ultraviolet (UV) and Hydrogen Peroxide Activate Ceramide-ER Stress-AMPK Signaling Axis to Promote Retinal Pigment Epithelium (RPE) Cell Apoptosis

Ultraviolet (UV) radiation and reactive oxygen species (ROS) impair the physiological functions of retinal pigment epithelium (RPE) cells by inducing cell apoptosis, which is the main cause of age-related macular degeneration (AMD). The mechanism by which UV/ROS induces RPE cell death is not fully addressed. Here, we observed the activation of a ceramide-endoplasmic reticulum (ER) stress-AMP activated protein kinase (AMPK) signaling axis in UV and hydrogen peroxide (H₂O₂)-treated RPE cells. UV and H₂O₂ induced an early ceramide production, profound ER stress and AMPK activation. Pharmacological inhibitors against ER stress (salubrinal), ceramide production (fumonisin B1) and AMPK activation (compound C) suppressed UV- and H₂O₂-induced RPE cell apoptosis. Conversely, cell permeable short-chain C6 ceramide and AMPK activator AICAR (5-amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide) mimicked UV and H₂O₂’s effects and promoted RPE cell apoptosis. Together, these results suggest that UV/H₂O₂ activates the ceramide-ER stress-AMPK signaling axis to promote RPE cell apoptosis.     

A Fast Hidden-line Removal Algorithm for 3-Dimensional Buildings

ＡＦＡＳＴＨＩＤＤＥＮ－ＬＩＮＥＲＥＭＯＶＡＬＡＬＧＯＲＩＴＨＭＦＯＲ３－ＤＩＭＥＮＳＩＯＮＡＬＢＵＩＬＤＩＮＧＳＱｉｎＫａｉｈｕａｉ；ＴｏｎｇＧｅｌｉａｎｇ；ＺｈａｎｇＮａｎ；ＣｈｅｎＤａｉｌｉｎ；ＬｉＹｕｎｇｕｉ；ＳｈｅｎＷｅｎｄｕＡＦＡＳＴＨＩ...     

基于OpenCV与SVM的车牌识别方法

为了提高车牌识别效率,论文提出了一种基于OpenCV与SVM的车牌识别方法.用Canny算子获取图像边缘轮廓信息,基于SURF算法对车牌进行特征提取,并结合HSV颜色空间来定位车牌位置;基于垂直投影方法来提取车牌字符特征,再利用SVM算法实现对车牌字符的识别.该方法利用计算机视觉库OpenCV实现,利用OpenCV封装的SURF算法和SVM算法实现车牌识别,实验表明,该方法有较高的识别效率.     

钢筋砼粘结锚固性能的试验研究

本文通过试验观察了粘结锚固机理，从试验数据统计回归和应力状态分析建立了全过程τ－ｓ本构方程。应用计算机模拟试验探讨了锚固强度变化规律和临界锚长、极限锚长。通过可靠度分析建议了设计的锚固长度。     

Numerical simulation of non-Archie electrophysical property of saturated rock with lattice Boltzmann method

The electrophysical property of saturated rocks is very important for reservoir identification and evaluation. In this paper, the lattice Boltzmann method （LBM） was used to study the electrophysical property of rock saturated with fluid because of its advantages over conventional numerical approaches in handling complex pore geometry and boundary conditions. The digital core model was constructed through the accumulation of matrix grains based on their radius distribution obtained by the measurements of core samples. The flow of electrical current through the core model saturated with oil and water was simulated on the mesoscopic scale to reveal the non-Archie relationship between resistivity index and water saturation （I-Sw）. The results from LBM simulation and laboratory measurements demonstrated that the I-Sw relation in the range of low water saturation was generally not a straight line in the log-log coordinates as described by the Archie equation. We thus developed a new equation based on numerical simulation and physical experiments. This new equation was used to fit the data from laboratory core measurements and previously published data. Determination of fluid saturation and reservoir evaluation could be significantly improved by using the new equation.     

计算机在建筑工程设计相容性和一致性检查中的应用

本文对建筑工程设计中相容性和一致性检查内容做了较全面的论述,阐述了用计算机进行相容性和一致性检查的必要性和重要性,提出了它们的实现方法和过程。     

反坦克导弹的无线扩频指令传输制导技术

提出采用无线扩频通信原理,探索新型的无线扩频指令传输代替有线指令传输技术的可行性。着重研究反坦克导弹无线扩频指令传输系统、扩频传输数学与物理模型,以及扩频通信模块实际应用中的直扩相关匹配接收、抗干扰分析与弹上通信设计等关键技术。     

大型贮煤场网壳结构风压分布的数值模拟

使用计算流体力学软件ANSYS-CFX,对广东某贮煤场大型网壳在风作用下的表面风压分布进行了数值模拟并对其结果进行分析,结果表明风压分布及体型系数等符合理论分析,建筑物所采用的体型较合理,能有效降低风对建筑的不利影响。     

Sensory Evaluation of Sherry Vinegar: Traditional Compared to Accelerated Aging With Oak Chips

ABSTRACT: The aim of this work was to describe the sensory profile of wine vinegars aged with oak chips (accelerated aging) compared with those elaborated by a traditional method (sherry vinegar). Two types of oak chips (American and French) were used to perform sample infusions. The chips were subjected to toasting to simulate the heating effect during oak board bending in cask construction. Ten sensory parameters were selected to describe the vinegars with 11 trained panelists. Sensory profiles were compared and sensorial differences observed among the samples analyzed. These differences are largely associated with the pungent sensation rather than the sensory attributes generated from the oak wood.