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排序方式: 共有539条查询结果,搜索用时 31 毫秒
1.
Rizwan Ullah Khan Haojie Yu Li Wang Lisong Teng Zain-ul-Abdin Ahsan Nazir Shah Fahad Tarig Elshaarani Fazal Haq Di Shen 《应用聚合物科学杂志》2020,137(46):49424
The development of safe drug carriers is cardinal in cancer therapy, which can target the cancer cells and release the loaded drug on-demand without damaging the healthy cells of the body. In our work, we synthesized three different biodegradable polymers, poly[(ethyl aminobezoate) (ethyl glycinato) phosphazenes] (PABGPs), in different mole ratio of side groups. The successful synthesis of these PABGPs was confirmed by 1H NMR, 31P NMR, FT-IR, and gel permeation chromatography. These PABGPs were fabricated into drug (camptothecin, CPT, a hydrophobic anticancer drug) loaded nanoparticles. These drug-loaded nanoparticles showed good drug release behaviors under normal physiological conditions (pH 7.4 and temperature 37°C). These PABGPs-based nanoparticles may find their application as effective drug carriers for cancer therapy. 相似文献
2.
Thrombolytic therapy for unstable angina has not gained acceptance as a primary treatment for unstable angina (UA) despite the evidence showing a reduction in mortality when these agents are given for myocardial infarction. The purpose of this review is to examine the clinical value of thrombolytic therapy for UA. The multiple lines of evidence supporting intracoronary thrombus formation as a key mechanism in the pathogenesis of UA are reviewed. Studies examining the effect of thrombolytic therapy on angiographic endpoints have shown little effect on the extent of luminal narrowing, but do reveal a decrease in angiographically detected thrombus. Twelve randomized, controlled trials of thrombolytic agents in 611 UA patients with predefined clinical endpoints have been published. These trials varied widely in design and adjunctive therapy both in treated and control grops. Review of these trials show a tendency to fewer clinical events such as death, infarction, and need for revascularization in treated patients, with a corresponding increase in bleeding complications. Clinical efficacy of thrombolytic therapy cannot be excluded by the available data, perhaps in part because of insufficient numbers of patients treated. Determination of the net clinical value of thrombolytic therapy must await larger and more definitive trials. 相似文献
3.
Shafeeque G. Ansari Mushtaq Ahmad Dar Young-Soon Kim Hyung-Kee Seo Gil-Sung Kim Rizwan Wahab Zubaida A. Ansari Jae-Myung Seo Hyung-Shik Shin 《Korean Journal of Chemical Engineering》2008,25(3):593-598
A comparative study for the nucleation of diamond was carried out using surface treatment like (i) surface scratching with
1 μm diamond paste and (ii) surface etching using chlorine plasma at different RF powers (50, 100 and 150 W). Atomic force
microscopic study shows variation in roughness from 31 nm to 110 nm. Scratching results in random scratches, whereas plasma
etches a surface uniformly. Scanning electron microscopic observations show well faceted crystallites with a predominance
of angular shaped grains corresponding to 〈100〉 and 〈110〉 crystallite surfaces for the scratched as well as plasma etched
substrate. Surface etching at 150 W plasma power results in a better growth in comparison with 50 and 100 W plasma powers.
Chlorine-radical is found responsible for the changes in the growth morphology. Raman spectroscopy shows a sharp peak at 1,332
cm−1 and a peak at ∼1,580 cm−1 for both samples. 相似文献
4.
In many data analysis problems, it is useful to consider the data as generated from a set of unknown (latent) generators or sources. The observations we make of a system are then taken to be related to these sources through some unknown function. Furthermore, the (unknown) number of underlying latent sources may be less than the number of observations. Recent developments in independent component analysis (ICA) have shown that, in the case where the unknown function linking sources to observations is linear, such data decomposition may be achieved in a mathematically elegant manner. In this paper, we extend the general ICA paradigm to include a very flexible source model, prior constraints and conditioning on sets of intermediate variables so that ICA forms one part of a hierarchical system. We show that such an approach allows for efficient discovery of hidden representation in data and for unsupervised data partitioning. 相似文献
5.
Influence of ferrite-martensite microstructural morphology on tensile properties of dual-phase steel 总被引:3,自引:0,他引:3
The influence of ferrite-martensite microstructural morphology, volume fraction of martensite, epitaxial ferrite on the tensile behaviour of dual-phase steels, was studied. It was observed that increasing the martensite content and its aspect ratio raised tensile strength and ductility. Epitaxial ferrite in rolled material strongly reduced the strength and improved the ductility, suggesting that substructure strengthening of material, as well as increased stress transfer to the hard phase, contribute to the strength of thermo-mechanically processed material. Mettallographic analysis of deformed samples revealed that void nucleation occurs predominantly along the ferrite-martensite interface. The void density in the necked region increased towards the fracture surface in all samples and was higher for samples which exhibited localized necking. 相似文献
6.
Aziz Romila Anwar Muhammad Waqas Jamal Muhammad Hasan Bajwa Usama Ijaz 《Neural computing & applications》2021,33(21):14707-14721
Neural Computing and Applications - Detecting and correcting misspelled words in a written text are of great importance in many natural language processing applications. Errors can be broadly... 相似文献
7.
Shaikh Mohd Rizwan Uddin Loan Sajad A. Alharbi Abdullah G. 《Journal of Computational Electronics》2021,20(6):2360-2368
Journal of Computational Electronics - In this work, a Schottky junction on the drain side employing low workfunction (WF) metal is proposed as a method to suppress the OFF-state leakage in... 相似文献
8.
Ratnayake WM Plouffe L Hollywood R L'Abbé MR Hidiroglou N Sarwar G Mueller R 《Lipids》2000,35(4):409-420
In recent studies, the life span of stroke-prone spontaneously hypertensive (SHRSP) rats was altered by a variety of dietary
fats. It was relatively shorter in rats fed canola oil as the sole source of fat. The present study was performed to find
out whether the fatty acid profile and the high content of sulfur compounds in canola oil could modulate the life span of
SHRSP rats. SHRSP rats (47 d old, n=23/group) were matched by body weight and systolic blood pressure and fed semipurified diets containing 10% canola oil, high-palmitic
canola oil, low-sulfur canola oil, soybean oil, high-oleic safflower oil, a fat blend that mimicked the fatty acid composition
of canola oil, or a fat blend high in saturated fatty acids. A 1% sodium chloride solution was used as drinking water to induce
hypertension. After consuming the diets for 37 d, five rats from each dietary group were killed for collection of blood and
tissue samples for biochemical analysis. The 18 remaining animals from each group were used for determining their life span.
The mean survival time of SHRSP rats fed canola oil (87.4±4.0 d) was not significantly different (P>0.05) from those fed low-sulfur canola oil (89.7±8.5 d), suggesting that content of sulfur in canola oil has no effect on
the life span of SHRSP rats. The SHRSP rats fed the noncanola oil-based diets lived longer (mean survival time difference
was 6–13 d, P<0.05) than those fed canola and low-sulfur canola oils. No marked differences in the survival times were observed among the
noncanola oil-based groups. The fatty acid composition of the dietary oils and of red blood cells and liver of SHRSP rats
killed after 37 d of treatment showed no relationship with the survival times. These results suggest that the fatty acid profile
of vegetable oils plays no important role on the life span of SHRSP rat. However, phytosterols in the dietary oils and in
liver and brain were inversely correlated with the mean survival times, indicating that the differential effects of vegetable
oils might be ascribed, at least partly, to their different phytosterol contents. 相似文献
9.
Fuzzy geographic information systems is a newly emerging field of computational intelligence. It combines fuzzy logic with spatial context. Most of the natural phenomena are fuzzy in nature. They show a degree of uncertainty or vagueness in their extent and attribute, which cannot be expressed by a crisp value. Agriculture is one of the fields of the spatial domain that needs to be described in fuzzy terms. Fertilizer is a key input for the agriculture sector. In this article, the spatial surfaces of fertilizers are developed for the wheat crop using a fuzzy decision support system. The algorithm of our system takes soil nutrients and cropping time as input, applies fuzzy logic on the input values, defuzzifies the fuzzy output to crisp value, and generates a fertilizer surface. The resultant output surface of fertilizer describes the amount of fertilizer needed to cultivate a specific crop in a specified area. The complexity of our algorithm is \(O(mnr)\) , where \(m\) is the height of the raster, \(n\) is the width of the raster, and \(r\) is the number of expert rules. 相似文献
10.
C. Nick S. Quednau R. Sarwar H. F. Schlaak C. Thielemann 《Microsystem Technologies》2014,20(10-11):1849-1857
Microelectrode arrays (MEA) have become an established tool in applied and fundamental research. Low impedance at the interface between tissue and conducting electrodes is of utmost importance for the electrical recording or stimulation of electrophysiological active cells such as cardiac myocytes and neurons. A common way to improve this interface is to increase the electrochemically active surface area of the electrode. In this paper the fabrication of microelectrodes covered with very high aspect ratio (AR > 100) gold nanopillars is presented and electrode biocompatibility is investigated using cell culture experiments. The nanopillar electrodes show decreased impedance over the entire scanned frequency range of 1 Hz–100 kHz and an impedance improvement of up to 89.5 at 1 kHz depending on nanopillar height. Neurons adhere well to the substrate and electrodes and signals with amplitudes up to ten times higher than with conventional gold electrodes were recorded in cell culture experiments. 相似文献