全文获取类型
收费全文 | 183篇 |
免费 | 4篇 |
专业分类
电工技术 | 2篇 |
化学工业 | 39篇 |
机械仪表 | 5篇 |
建筑科学 | 26篇 |
能源动力 | 1篇 |
轻工业 | 30篇 |
水利工程 | 1篇 |
无线电 | 15篇 |
一般工业技术 | 16篇 |
冶金工业 | 34篇 |
自动化技术 | 18篇 |
出版年
2022年 | 4篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 3篇 |
2014年 | 2篇 |
2013年 | 9篇 |
2012年 | 7篇 |
2011年 | 2篇 |
2010年 | 8篇 |
2009年 | 8篇 |
2008年 | 5篇 |
2007年 | 13篇 |
2006年 | 11篇 |
2005年 | 4篇 |
2004年 | 11篇 |
2003年 | 8篇 |
2002年 | 6篇 |
2001年 | 3篇 |
2000年 | 6篇 |
1999年 | 1篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 5篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 7篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1964年 | 1篇 |
1957年 | 2篇 |
排序方式: 共有187条查询结果,搜索用时 15 毫秒
1.
2.
With youth participation in sports at an all-time high, youths have become more vulnerable to the silent epidemic of concussion. Psychologists should become aware of the alarming frequency of mild concussion and the subtle effects of concussion, which often go unnoticed or result in misdiagnosis. This article provides a basic survey of the research and literature on this topic, a simplified knowledge base for understanding updated assessment and management techniques, and a discussion of the important role psychologists can play in educating the public and their patients. Practitioners can become more aware of this developing practice opportunity. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
4.
Mick Donegan Jeffrey D. Morris Fulvio Corno Isabella Signorile Adriano Chió Valentina Pasian Alessandro Vignola Margret Buchholz Eva Holmqvist 《Universal Access in the Information Society》2009,8(4):259-275
Gaze-control enables people to control a computer by using eye-gaze to select items on screen. Gaze-control is a necessity
for people who have lost all motor control of their body and only have control over eye movements. In addition, gaze-control
can be the quickest and least tiring option for a far broader group of people with varying disabilities. This paper reports
findings from gaze-control user trials involving users from both groups: people who are totally paralyzed, as well as people
with a wide range of complex disabilities. The trials conducted involved four different centres supporting people with disabilities
in three different European countries. Several gaze-control systems were trialled by a large number of users with varying
needs and abilities. The perceived benefits of gaze-control are described, and recommendations for successful assessment and
implementation of gaze-control are provided. 相似文献
5.
Rosemarie Velik 《Minds and Machines》2010,20(1):1-18
For a long time, emotions have been ignored in the attempt to model intelligent behavior. However, within the last years,
evidence has come from neuroscience that emotions are an important facet of intelligent behavior being involved into cognitive
problem solving, decision making, the establishment of social behavior, and even conscious experience. Also in research communities
like software agents and robotics, an increasing number of researchers start to believe that computational models of emotions
will be needed to design intelligent systems. Nevertheless, modeling emotions in technical terms poses many difficulties and
has often been accounted as just not feasible. In this article, there are identified the main problems, which occur when attempting
to implement emotions into machines. By pointing out these problems, it is aimed to avoid repeating mistakes committed when
modeling computational models of emotions in order to speed up future development in this area. The identified issues are
not derived from abstract reflections about this topic but from the actual attempt to implement emotions into a technical
system based on neuroscientific research findings. It is argued that besides focusing on the cognitive aspects of emotions,
a consideration of the bodily aspects of emotions—their grounding into a visceral body—is of crucial importance, especially
when a system shall be able to learn correlations between environmental objects and events and their “emotional meaning”. 相似文献
6.
Rory A Cooper Michael L Boninger Donald M Spaeth Dan Ding Songfeng Guo Alicia M Koontz Shirley G Fitzgerald Rosemarie Cooper Annmarie Kelleher Diane M Collins 《IEEE transactions on neural systems and rehabilitation engineering》2006,14(4):438-455
With about 2.2 million Americans currently using wheeled mobility devices, wheelchairs are frequently provided to people with impaired mobility to provide accessibility to the community. Individuals with spinal cord injuries, arthritis, balance disorders, and other conditions or diseases are typical users of wheelchairs. However, secondary injuries and wheelchair-related accidents are risks introduced by wheelchairs. Research is underway to advance wheelchair design to prevent or accommodate secondary injuries related to propulsion and transfer biomechanics, while improving safe, functional performance and accessibility to the community. This paper summarizes research and development underway aimed at enhancing safety and optimizing wheelchair design. 相似文献
7.
Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity 下载免费PDF全文
Dr. Sudhir Landge Dr. Vasanthi Ramachandran Dr. Anupriya Kumar Dr. João Neres Kannan Murugan Dr. Claire Sadler Dr. Mick D. Fellows Vaishali Humnabadkar Dr. Prakash Vachaspati Dr. Anandkumar Raichurkar Sreevalli Sharma Sudha Ravishankar Supreeth Guptha Dr. Vasan K. Sambandamurthy Dr. Tanjore S. Balganesh Dr. Bheemarao G. Ugarkar Dr. V. Balasubramanian Dr. Balachandra S. Bandodkar Dr. Manoranjan Panda 《ChemMedChem》2016,11(3):331-339
Nitroarenes are less preferred in drug discovery due to their potential to be mutagenic. However, several nitroarenes were shown to be promising antitubercular agents with specific modes of action, namely, nitroimidazoles and benzothiazinones. The nitro group in these compounds is activated through different mechanisms, both enzymatic and non‐enzymatic, in mycobacteria prior to binding to the target of interest. From a whole‐cell screening program, we identified a novel lead nitrobenzothiazole (BT) series that acts by inhibition of decaprenylphosphoryl‐β‐d ‐ribose 2′‐epimerase (DprE1) of Mycobacterium tuberculosis (Mtb). The lead was found to be mutagenic to start with. Our efforts to mitigate mutagenicity resulted in the identification of 6‐methyl‐7‐nitro‐5‐(trifluoromethyl)‐1,3‐benzothiazoles (cBTs), a novel class of antitubercular agents that are non‐mutagenic and exhibit an improved safety profile. The methyl group ortho to the nitro group decreases the electron affinity of the series, and is hence responsible for the non‐mutagenic nature of these compounds. Additionally, the co‐crystal structure of cBT in complex with Mtb DprE1 established the mode of binding. This investigation led to a new non‐mutagenic antitubercular agent and demonstrates that the mutagenic nature of nitroarenes can be solved by modulation of stereoelectronic properties. 相似文献
8.
Ramona Erber Steffen Spoerl Andreas Mamilos Rosemarie Krupar Arndt Hartmann Matthias Ruebner Juergen Taxis Mareike Wittenberg Torsten E. Reichert Gerrit Spanier Silvia Spoerl 《International journal of molecular sciences》2022,23(1)
Oral cancer often presents with aggressive behavior and a high risk of recurrence and metastasis. For oral squamous cell carcinoma (OSCC), which is the most frequent histological subtype, therapy strategies include surgery, radiation therapy, chemotherapy, immune checkpoint inhibitors, and EGFR inhibitors. Recently, a Trop-2 antibody-drug conjugate (ADC) has been approved in the United States of America for the treatment of advanced triple-negative breast cancer. However, this ADC has also been tested in other solid tumors including head & neck squamous cell carcinoma. The prognostic impact of Trop-2 has already been reported for several cancers. We studied the prognostic influence of Trop-2 protein expression on OSCC patients’ survival. The cohort comprised n = 229 OSCC patients with available archived tumor tissue and corresponding non-neoplastic oral mucosa tissue. Using immunohistochemistry, we investigated Trop-2 expression in both the central and peripheral regions of each tumor and in corresponding non-neoplastic oral mucosa. In patients suffering from OSCC with combined high central and low peripheral Trop-2 expression, five-year overall survival (OS) was 41.2%, whereas 55.6% of OSCC patients who presented lower central and/or higher peripheral tumoral Trop-2 expression were alive after five years (p = 0.075). In multivariate Cox regression, the expression pattern of high central tumoral and lower peripheral Trop-2 expression was significantly correlated with impaired OS (HR = 1.802, 95%-CI: 1.134–2.864; p = 0.013) and recurrence-free survival (RFS) (HR = 1.633, 95%-CI: 1.042–2.560; p = 0.033), respectively, when adjusting for co-variables. Hence, Trop-2 may serve as an independent prognostic biomarker in OSCC. In subsequent studies, the pathophysiological meaning of downregulated Trop-2 expression in the OSCC periphery has to be analyzed. 相似文献
9.
10.
This study examined the effect of four communication modes (computer-based video teleconferencing, computer-based electronic chat, telephone, and face-to-face) on developmental interactions between dyads; specifically on the transmission of psychosocial versus instrumental information. The dyads consisted of undergraduates at a southeastern university. One member of the dyad was an incoming first year student; the second member was an upper division student who served as a developmental coach. The study was experimental in design, which controlled the amount of interaction, the frequency of interaction, and prior acquaintanceship of the dyadic pair. The small amount of variance attributable to communication mode suggests that people matter more than the machines. Specifically, in terms of implementing non-face-to-face developmental programs, it might be more useful to focus on reducing the variability in the coaches’ behaviors through selection or training, than to focus on communication mode. Additionally, independent observers watched and rated the dyadic interactions to provide a third point of view. There was very little overlap between coach and trainee perceptions, although there was considerable agreement between the raters’ and coaches’ ratings. 相似文献