Design and evaluation of a multimedia storage server for mixed traffic

The relative simplicity of access to digital communications nowadays and the simultaneous increase in the available bandwidth are leading to the definition of new telematic services, mainly oriented towards multimedia applications and interactivity with the user. In the near future, a decisive role will be played in this scenario by the providers of interactive multimedia services of the on-demand type, which will guarantee the end user a high degree of flexibility, speed and efficiency. In this paper, some of the technical aspects regarding these service providers are dealt with, paying particular attention to the problems of storing information and managing service requests. More specifically, the paper presents and evaluates a new storage technique based on the use of disk array technology, which can manage both typical multimedia connections and traditional requests. The proposed architecture is based on the joint use of the partial dynamic declustering and the information dispersal algorithm, which are employed for the allocation and retrieval of the data stored on the disk array. We also define efficient strategies for request management in such a way as to meet the time constraints imposed by multimedia sessions and guarantee good response times for the rest of the traffic. The system proposed is then analyzed using a simulation approach.     

Critical Role for the Protons in FRTL-5 Thyroid Cells: Nuclear Sphingomyelinase Induced-Damage

Proliferating thyroid cells are more sensitive to UV-C radiations than quiescent cells. The effect is mediated by nuclear phosphatidylcholine and sphingomyelin metabolism. It was demonstrated that proton beams arrest cell growth and stimulate apoptosis but until now there have been no indications in the literature about their possible mechanism of action. Here we studied the effect of protons on FRTL-5 cells in culture. We showed that proton beams stimulate slightly nuclear neutral sphingomyelinase activity and inhibit nuclear sphingomyelin-synthase activity in quiescent cells whereas stimulate strongly nuclear neutral sphingomyelinase activity and do not change nuclear sphingomyelin-synthase activity in proliferating cells. The study of neutral sphingomyelinase/sphingomyelin-synthase ratio, a marker of functional state of the cells, indicated that proton beams induce FRTL-5 cells in a proapoptotic state if the cells are quiescent and in an initial apoptotic state if the cells are proliferating. The changes of cell life are accompanied by a decrease of nuclear sphingomyelin and increase of bax protein.     

Advanced Modeling of Food Convective Drying: A Comparison Between Artificial Neural Networks and Hybrid Approaches

In the present paper, three different approaches are proposed to model the convective drying of food. The performance of thin-layer, pure neural network and hybrid neural model is compared in a wide range of operating conditions, with two different vegetables, available either as cylinders or as slabs with different characteristic dimensions. It was found that the thin-layer model was adequate to describe food drying behavior, but it could be applied only as a fitting procedure. Pure neural models gave accurate predictions in some situations, but exhibited poor performance when tested outside the range of operating conditions exploited during their development. Finally, it was shown that hybrid neural models, formulated as a combination of both theoretical and neural network models, are capable of offering the most accurate predictions of system behavior with average relative errors never exceeding 10%, even in operating conditions unexploited during the definition of the neural part of the model. The results obtained proved that the hybrid neural paradigm is a novel and efficient modeling technique that could be used successfully in food processing, thus allowing drying process optimization to be achieved, and efficient and fast on-line controllers to be implemented.     

Obesity and Male Reproduction: Do Sirtuins Play a Role?

Obesity is a major current public health problem of global significance. A progressive sperm quality decline, and a decline in male fertility, have been reported in recent decades. Several studies have reported a strict relationship between obesity and male reproductive dysfunction. Among the many mechanisms by which obesity impairs male gonadal function, sirtuins (SIRTs) have an emerging role. SIRTs are highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases that play a role in gene regulation, metabolism, aging, and cancer. SIRTs regulate the energy balance, the lipid balance, glucose metabolism, and adipogenesis, but current evidence also indicates a role for SIRTs in male reproduction. However, the majority of the studies have been conducted in animal models and very few have been conducted with humans. This review shows that SIRTs play an important role among the molecular mechanisms by which obesity interferes with male fertility. This highlights the need to deepen this relationship. It will be of particular interest to evaluate whether synthetic and/or natural compounds capable of modifying the activity of SIRTs may also be useful for the treatment of obesity and its effects on gonadal function. Although few studies have explored the role of SIRT activators in obesity-induced male infertility, some molecules, such as resveratrol, appear to be effective in modulating SIRT activity, as well as counteracting the negative effects of obesity on male fertility. The search for strategies to improve male reproductive function in overweight/obese patients is a challenge and understanding the role of SIRTs and their activators may open new interesting scenarios in the coming years.     

COVID-19 and Lung Mast Cells: The Kallikrein–Kinin Activation Pathway

Mast cells (MCs) have relevant participation in inflammatory and vascular hyperpermeability events, responsible for the action of the kallikrein–kinin system (KKS), that affect patients inflicted by the severe form of COVID-19. Given a higher number of activated MCs present in COVID-19 patients and their association with vascular hyperpermeability events, we investigated the factors that lead to the activation and degranulation of these cells and their harmful effects on the alveolar septum environment provided by the action of its mediators. Therefore, the pyroptotic processes throughout caspase-1 (CASP-1) and alarmin interleukin-33 (IL-33) secretion were investigated, along with the immunoexpression of angiotensin-converting enzyme 2 (ACE2), bradykinin receptor B1 (B1R) and bradykinin receptor B2 (B2R) on post-mortem lung samples from 24 patients affected by COVID-19. The results were compared to 10 patients affected by H1N1pdm09 and 11 control patients. As a result of the inflammatory processes induced by SARS-CoV-2, the activation by immunoglobulin E (IgE) and degranulation of tryptase, as well as Toluidine Blue metachromatic (TB)-stained MCs of the interstitial and perivascular regions of the same groups were also counted. An increased immunoexpression of the tissue biomarkers CASP-1, IL-33, ACE2, B1R and B2R was observed in the alveolar septum of the COVID-19 patients, associated with a higher density of IgE⁺ MCs, tryptase⁺ MCs and TB-stained MCs, in addition to the presence of intra-alveolar edema. These findings suggest the direct correlation of MCs with vascular hyperpermeability, edema and diffuse alveolar damage (DAD) events that affect patients with a severe form of this disease. The role of KKS activation in events involving the exacerbated increase in vascular permeability and its direct link with the conditions that precede intra-alveolar edema, and the consequent DAD, is evidenced. Therapy with drugs that inhibit the activation/degranulation of MCs can prevent the worsening of the prognosis and provide a better outcome for the patient.     

IP世界的语音安全

2004年发生的一起黑客入侵事件仍不断被人们提起。一名入侵者侵入一个主要网络并截获了许多计算机的编程指令,其中包括那些为美国军方、NASA和研究实验室服务的计算机。《纽约时报》在谈到这个事件时称:“……该案例显示侵入通过互联网连接的计算机,甚至包括复杂的公司和政府网络,是多么的容易,同时也显示追查肇事者的难度有多么大。”对于我们这些整天冥思苦想着如何保护机构免遭安全漏洞攻击的人来说,这一案例也让我们思考,如何加强防御来应对破坏性日趋严重的漏洞攻击。入侵者寻找之前不为人知的漏洞,藉此突破一个机构的防御系统,实施…     

An optimal decision-making approach for the management of radiotherapy patients

In this paper, novel integer programming formulations are developed for solving the optimal scheduling of patients waiting for radiotherapy treatment. In this specific clinical domain, the suitable management and control of a patients’ waiting list strongly affect both the quality of the therapeutical outcome, in terms of effectiveness, and the cost-saving use of the overall therapeutical resources, in terms of efficiency. The proposed models allow the best scheduling strategy to be devised by taking into account the quality of the health care service offered to the patient as well as the status and the preferences of the patient. The computational experiments, carried out on realistic scenarios and considering real data, are very promising and show the efficiency and robustness of the proposed models to address the problem under consideration.     

Bio-ethanol production by fermentation of ricotta cheese whey as an effective alternative non-vegetable source

The aim of the present paper is to investigate the feasibility of bio-ethanol production by batch fermentation of ricotta cheese whey (“Scotta”), a dairy industry waste characterized by lactose concentration ranging from 4.5% to 5.0% (w/w) and, with respect to traditional (raw) whey, by much lower protein content. Scotta, therefore, could represent an effective non-vegetable source for renewable energy production. The microrganism used to carry out the fermentation processes was the yeast Kluyveromyces marxianus. Preliminary experiments, performed in aerobic conditions on different volumes of scotta, have shown the actual growth of the yeast. The subsequent fermentation experiments were carried out, in anaerobic conditions, on three different substrates: scotta, raw cheese whey and deproteinized whey. The experimental data have demonstrated the process feasibility: scotta is an excellent substrate for fermentation and exhibits better performance with respect to both raw cheese whey and deproteinized whey. Complete lactose consumption, indeed, was observed in the shortest time (13 h) and with the highest ethanol yield (97% of the theoretical value).