全文获取类型
收费全文 | 2958篇 |
免费 | 262篇 |
国内免费 | 17篇 |
专业分类
电工技术 | 53篇 |
综合类 | 11篇 |
化学工业 | 760篇 |
金属工艺 | 133篇 |
机械仪表 | 164篇 |
建筑科学 | 76篇 |
矿业工程 | 10篇 |
能源动力 | 126篇 |
轻工业 | 245篇 |
水利工程 | 6篇 |
石油天然气 | 15篇 |
无线电 | 507篇 |
一般工业技术 | 565篇 |
冶金工业 | 173篇 |
原子能技术 | 28篇 |
自动化技术 | 365篇 |
出版年
2023年 | 27篇 |
2022年 | 50篇 |
2021年 | 77篇 |
2020年 | 58篇 |
2019年 | 72篇 |
2018年 | 93篇 |
2017年 | 99篇 |
2016年 | 115篇 |
2015年 | 107篇 |
2014年 | 129篇 |
2013年 | 224篇 |
2012年 | 199篇 |
2011年 | 221篇 |
2010年 | 163篇 |
2009年 | 184篇 |
2008年 | 143篇 |
2007年 | 136篇 |
2006年 | 120篇 |
2005年 | 125篇 |
2004年 | 92篇 |
2003年 | 83篇 |
2002年 | 85篇 |
2001年 | 59篇 |
2000年 | 58篇 |
1999年 | 63篇 |
1998年 | 65篇 |
1997年 | 73篇 |
1996年 | 57篇 |
1995年 | 38篇 |
1994年 | 28篇 |
1993年 | 22篇 |
1992年 | 6篇 |
1991年 | 18篇 |
1990年 | 7篇 |
1989年 | 16篇 |
1988年 | 23篇 |
1987年 | 4篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 9篇 |
1983年 | 7篇 |
1982年 | 6篇 |
1981年 | 5篇 |
1980年 | 8篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1973年 | 8篇 |
排序方式: 共有3237条查询结果,搜索用时 15 毫秒
1.
Ji Hye Yang Sae Kwang Ku IL Je Cho Je Hyeon Lee Chang-Su Na Sung Hwan Ki 《International journal of molecular sciences》2021,22(4)
Hepatic fibrosis occurs when liver tissue becomes scarred from repetitive liver injury and inflammatory responses; it can progress to cirrhosis and eventually to hepatocellular carcinoma. Previously, we reported that neoagarooligosaccharides (NAOs), produced by the hydrolysis of agar by β-agarases, have hepatoprotective effects against acetaminophen overdose-induced acute liver injury. However, the effect of NAOs on chronic liver injury, including hepatic fibrosis, has not yet been elucidated. Therefore, we examined whether NAOs protect against fibrogenesis in vitro and in vivo. NAOs ameliorated PAI-1, α-SMA, CTGF and fibronectin protein expression and decreased mRNA levels of fibrogenic genes in TGF-β-treated LX-2 cells. Furthermore, downstream of TGF-β, the Smad signaling pathway was inhibited by NAOs in LX-2 cells. Treatment with NAOs diminished the severity of hepatic injury, as evidenced by reduction in serum alanine aminotransferase and aspartate aminotransferase levels, in carbon tetrachloride (CCl4)-induced liver fibrosis mouse models. Moreover, NAOs markedly blocked histopathological changes and collagen accumulation, as shown by H&E and Sirius red staining, respectively. Finally, NAOs antagonized the CCl4-induced upregulation of the protein and mRNA levels of fibrogenic genes in the liver. In conclusion, our findings suggest that NAOs may be a promising candidate for the prevention and treatment of chronic liver injury via inhibition of the TGF-β/Smad signaling pathway. 相似文献
2.
Hong Sae Jin Park Nam Il Hwang Dae Keun Yi Tae Gyu Eum Hyang Lan 《Food science and biotechnology》2022,31(6):669-679
Food Science and Biotechnology - Various hilling materials (rice hulls, pine sawdust, and perlite) were compared to produce sprout vegetables using beach silvertop (Glehnia littoralis Fr. Schm. ex... 相似文献
3.
4.
In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria 下载免费PDF全文
Su Chul Jang Sae Rom Kim Yae Jin Yoon Kyong‐Su Park Ji Hyun Kim Jaewook Lee Oh Youn Kim Eun‐Jeong Choi Dae‐Kyum Kim Dong‐Sic Choi Yoon‐Keun Kim Jaesung Park Dolores Di Vizio Yong Song Gho 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(4):456-461
Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo. 相似文献
5.
6.
7.
To determine three‐dimensional fiber orientation states in injection‐molded short‐fiber composites, a confocal laser scanning microscope (CLSM) is used. Since the CLSM optically sections the specimen, more than two images of the cross sections on and below the surface of the composite can be obtained. Three‐dimensional fiber orientation states can be determined by using geometric parameters of fiber images obtained from two parallel cross sections. For experiments, carbon‐fiber‐reinforced polystyrene is examined by the CLSM and geometric parameters of fibers on each cross‐sectional plane are measured by an image analysis. In order to describe fiber orientation states compactly, orientation tensors are determined at different positions of the prepared specimen. Three‐dimensional orientation states are obtained without any difficulty by determining the out‐of‐plane angles utilizing fiber images on two parallel planes acquired by the CLSM. Orientation states are different at different positions and show the shell–core structure along the thickness of the specimen. Fiber orientation tensors are predicted by a numerical analysis and the numerically predicted orientation states show good agreement with measured ones. However, some differences are found at the end of cavity. They may result from the fountain flow effects, which are not considered in the numerical analysis. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 500–509, 2003 相似文献
8.
As packet cellular networks are expected to support multimedia services, the authors incorporate the multimedia QoS requirements into the design of a new scheduling algorithm. The proposed wireless-adaptive fair scheduling tries to allocate time slots for each user with fair share by considering the varying channel condition while reflecting the stream requirements and achieving high throughput. 相似文献
9.
K Ku K Nakayama Y Saitoh S Nosaka T Kitano T Hanada H Nagami K Yamada K Minami 《Canadian Metallurgical Quarterly》1997,64(2):399-403
Forty-eight Russell's viper bite patients (40 males, 8 females), age ranging from 16-76 years were studied. Out of 48 patients, 14 were found to have a prolonged whole blood clotting time test (WBCT) (i.e. incoagulable blood) (Group 1); 23 had a normal WBCT (i.e. clotted blood) (Group II); and 11 patients had a normal WBCT on admission which changed to non-clotting during the clinical course (Group III). Four patients from group I developed hypotension and 2 expired. The serum cortisol concentration (mean +/- SEM) on admission among groups I and II were 639 +/- 45.6 and 424 +/- 33.2 nmol/l respectively. The blood cortisol level in 35 subjects (controls) were 370.7 +/- 17.7 nmol/l (mean +/- SEM). There was a significant rise of blood cortisol in patients with incoagulable blood when compared to controls at the time of admission to the hospital (p < 0.05); but there was no significant difference among those patients with clotted blood. A much higher mean serum cortisol level was observed in 4 patients with hypotension as compared to 10 patients without shock. These patients with hypotension according to our study shown to have a favorable response to steroid therapy and eventually recovered. Whether higher doses of steroid in addition to antiserum confer extra benefit in suppressing nonspecific venom effects on the pituitary and/or adrenal is not known. 相似文献
10.