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排序方式: 共有1316条查询结果,搜索用时 15 毫秒
1.
Hasrul Abdi Hasibuan Azis Boing Sitanggang Nuri Andarwulan Purwiyatno Hariyadi 《International Journal of Food Science & Technology》2021,56(9):4549-4558
This research aimed to produce triacylglycerols fraction rich in palmitic acid (PA) at the sn-2 position from hard palm stearin (HPS) through acetone fractionation. Fractionations were done at HPS-to-acetone ratios of 1:3, 1:5 and 1:7 (w/v) and at temperatures of 25, 30 and 35 °C for 3 h. Triacylglycerols with PA at the sn-2 position, such as tripalmitoylglycerol (PPP) and dipalmitoyl-stearoyl-glycerol (PPS), were concentrated in the solid fraction, obtained after separation by filtration. The optimal fractionation conditions were at a HPS-to-acetone ratio of 1:5 (w/v) and 30 °C. The total PPP and PPS content was more than 91%, with a corresponding yield of more than 59%. Triacylglycerols obtained were composed of more than 91% PA in which 88% were at the sn-2 position. Conclusively, the solvent fractionation is a suited alternative method for the preparation of triacylglycerols used for the enzymatic synthesis of 1,3-dioleoyl-2-palmitoylglycerol which is the main triacylglycerol for human milk fat substitute. 相似文献
2.
Fatemeh Abdi 《Optimization methods & software》2019,34(1):25-36
In this paper, we propose a globally convergent BFGS method to solve Variational Inequality Problems (VIPs). In fact, a globalization technique on the basis of the hyperplane projection method is applied to the BFGS method. The technique, which is independent of any merit function, is applicable for pseudo-monotone problems. The proposed method applies the BFGS direction and tries to reduce the distance of iterates to the solution set. This property, called Fejer monotonicity of iterates with respect to the solution set, is the basis of the convergence analysis. The method applied to pseudo-monotone VIP is globally convergent in the sense that subproblems always have unique solutions, and the sequence of iterates converges to a solution to the problem without any regularity assumption. Finally, some numerical simulations are included to evaluate the efficiency of the proposed algorithm. 相似文献
3.
Dr. Blijke S. Kroezen Gabriele Conti Benedetta Girardi Dr. Jonathan Cramer Dr. Xiaohua Jiang Dr. Said Rabbani Jennifer Müller Maja Kokot Enrico Luisoni Prof. Daniel Ricklin Dr. Oliver Schwardt Prof. Beat Ernst 《ChemMedChem》2020,15(18):1706-1719
Siglecs are members of the immunoglobulin gene family containing sialic acid binding N-terminal domains. Among them, Siglec-8 is expressed on various cell types of the immune system such as eosinophils, mast cells and weakly on basophils. Cross-linking of Siglec-8 with monoclonal antibodies triggers apoptosis in eosinophils and inhibits degranulation of mast cells, making Siglec-8 a promising target for the treatment of eosinophil- and mast cell-associated diseases such as asthma. The tetrasaccharide 6’-sulfo-sialyl Lewisx has been identified as a specific Siglec-8 ligand in glycan array screening. Here, we describe an extended study enlightening the pharmacophores of 6’-sulfo-sialyl Lewisx and the successful development of a high-affinity mimetic. Retaining the neuraminic acid core, the introduction of a carbocyclic mimetic of the Gal moiety and a sulfonamide substituent in the 9-position gave a 20-fold improved binding affinity. Finally, the residence time, which usually is the Achilles tendon of carbohydrate/lectin interactions, could be improved. 相似文献
4.
Performance comparison of space-time block coded and cyclic delay diversity MC-CDMA systems 总被引:1,自引:0,他引:1
Spatial diversity is a widely applied technique for enhancing wireless system performance since it greatly reduces the detrimental effects of multipath fading. Space-time block codes have been considered the best choice for transmit diversity in narrowband environments, but their use in broadband channels is questionable due to their inability to pick up multipath diversity. However, when used in conjunction with an MC-CDMA system, they achieve not only full spatial but also variable multipath diversity depending on the employed spreading. In comparison, cyclic delay diversity is an attractive approach to achieve spatial and multipath diversity. Its simplicity and conformability with current standards makes it desirable for multicarrier systems. Previous studies suggest that CDD is only advantageous with an outer channel code for OFDM systems. In this article, we compare STBCs and CDD applied to an MC-CDMA system in terms of complexity and performance. It is shown that for an MC-CDMA system, CDD benefits from spreading and channel coding that makes it very competitive with STBCs, particularly since it is applicable to any number of transmit antennas with no loss in rate. 相似文献
5.
Steeves G.M. Elezzabi A.Y. Teshima R. Said R.A. Freeman M.R. 《Quantum Electronics, IEEE Journal of》1998,34(8):1415-1418
A lumped element circuit model for the operation of a junction mixing scanning tunneling microscope (JM-STM) is presented. Fits from this model show excellent agreement with experimental results in the picosecond time regime. The tip sample capacitance employed in the model was calculated to be 33 fF, using the method of images. By varying the capacitance, various tip/sample geometries can be investigated. Testing the response of the model tunnel junction, for faster electrical pulses, suggests how the JM-STM can be pushed into the femtosecond time regime 相似文献
6.
We propose a new image multiresolution transform that is suited for both lossless (reversible) and lossy compression. The new transformation is similar to the subband decomposition, but can be computed with only integer addition and bit-shift operations. During its calculation, the number of bits required to represent the transformed image is kept small through careful scaling and truncations. Numerical results show that the entropy obtained with the new transform is smaller than that obtained with predictive coding of similar complexity. In addition, we propose entropy-coding methods that exploit the multiresolution structure, and can efficiently compress the transformed image for progressive transmission (up to exact recovery). The lossless compression ratios are among the best in the literature, and simultaneously the rate versus distortion performance is comparable to those of the most efficient lossy compression methods. 相似文献
7.
Thick films of polyvinyl alcohol (PVA) containing very finemetallic powder, copper (Cu), iron (Fe) and aluminum (Al) 2.5% by weight,were prepared by the casting method. The temperature dependence of Young'smodulus at constant stress, the stress dependence of Young's modulus(Y), the stress dependence of dielectric constant (ε) and stressdependence of phonon velocity, were studied. It was found that Young'smodulus (Y) of the pure sample has the lowest value and that of PVA + Alhas the highest value. This can be explained on the basis that Ydepends on the ratio between the energy of molecular interactions andthe energy of thermal motion of the sample units. We also found that thedielectric constant increases with the addition of metallic powder, andwith an increasing applied stress. The phonon velocity increased withincreasing stress. The increase of stress decreases imperfectionsleading to the increased phonon velocity. The electronic absorptionspectra of PVA is not affected by doping Al and Fe, whereas the PVA dopedwith Cu shows a shift of the absorption maxima toward a longer wavelength.The instantaneous elastic behavior may be observed only at lowtemperatures and very short creep times. 相似文献
8.
E Elstner M Linker-Israeli J Le T Umiel P Michl JW Said L Binderup JC Reed HP Koeffler 《Canadian Metallurgical Quarterly》1997,99(2):349-360
Patients with acute promyelocytic leukemia (APL) usually relapse after all-trans retinoic acid (RA) treatment because this therapy fails to eradicate the malignant clone. Our data showed that KH 1060 and other 20-epi vitamin D3 analogs alone were potent inhibitors of clonal growth of NB4 cells, an APL cell line (ED50, approximately 5 x 10(-11) M). The combination of KH 1060 and 9-cis-RA synergistically and irreversibly enhanced this effect. Neither KH 1060 nor 9-cis-RA (10(-6) M, 3 d) were strong inducers of differentiation of NB4 cells. However, 98% of the cells underwent differentiation to a mature phenotype with features of both granulocytes and monocytes after exposure to a combination of both compounds. Apoptosis only increased after incubation of NB4 cells with 9-cis-RA alone (28%) or with a combination of 9-cis-RA plus KH1060 (32%). Immunohistochemistry showed that the bcl-2 protein decreased from nearly 100% of the wild-type NB4 cells to 2% after incubation with a combination of KH 1060 and 9-cis-RA, and the bax protein increased from 50% of wild-type NB4 cells to 92% after culture with both analogs (5 x 10(-7) M, 3 d). Western blot analysis paralleled these results. Studies of APL cells from one untreated individual paralleled our results with NB4 cells. Taken together, the data demonstrated that nearly all of the NB4 cells can be irreversibly induced to differentiate terminally when exposed to the combination of KH 1060 and 9-cis-RA. 相似文献
9.
In this paper a hybrid finite element method is applied in evaluation of the stress intensity factors K
I
and K
II
of unidirectional fiber reinforced composites. In order to satisfy the stress singularity at the crack tip a singular super-element based on a modified complementary energy principle is developed. The stress and displacement fields in the super-element are expressed in terms of polynomials of two complex variables 1 and 2 in the transformed -plane. The stiffness matrix of the super-element was determined by using a line integral along the boundary of the super-element. The displacement vector was expressed in terms of the element nodal displacement vector {q} and a properly selected shape function defined along the element boundary.Numerical results for K
I
and K
II
of glass-epoxy and graphite-epoxy unidirectional composites with cracks along the diameter of a circular cut out as well as elliptical cut outs were evaluated
Résumé On applique, dans la présente étude, une méthode d'éléments finis hybrides à l'évaluation des facteurs d'intensité de contrainte KI et KII pour des composites renforcés de fibres unidirectionnelles. Pour tenir compte de la singularité de la contrainte à l'extrémité de la fissure, on développe un super élément singulier en se basant sur un principe modifié d'énergie complémentaire. Les champs de contraintes et de déplacements dans le super-élément sont exprimés sous forme polynormale de deux variables complexes 1, et 2 dans le plan de la transformée. La matrice de rigidité du super élément est, quant à elle, définie en utilisant une intégrale linéaire le long du contour de l'élément. Le vecteur de déplacement est exprimé par un vecteur (9) de déplacement nodal de l'élément, et par une fonction de forme appropriée, définie le long du contour de l'élément.On évalue les résultats numériques pour KI et KII, correspondant à des composites à fibres unidirection-nelles de types verre-epoxy et graphite-epoxy, oú des fissures se situeraient sur le diamètre de découpes circulaires et elliptiques相似文献
10.
Haddaji Younesse Hamdane Hasna Majdoubi Hicham Mansouri Said Allaoui Driss El bouchti Mehdi Tamraoui Youssef Manoun Bouchaib Oumam Mina Hannache Hassan 《SILICON》2021,13(7):2389-2400
Silicon - Geopolymers produced with metakaolin (MK) and thermally untreated phosphate sludge (PS) are beneficial and environmentally advantageous materials, but their fragility limits its... 相似文献