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排序方式: 共有590条查询结果,搜索用时 31 毫秒
1.
Filippo Lococo Massimiliano Paci Cristian Rapicetta Teresa Rossi Valentina Sancisi Luca Braglia Silvio Cavuto Alessandra Bisagni Italia Bongarzone Douglas M. Noonan Adriana Albini Sally Maramotti 《International journal of molecular sciences》2015,16(8):19612-19630
Assessment of biological diagnostic factors providing clinically-relevant information to guide physician decision-making are still needed for diseases with poor outcomes, such as non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) is a promising molecule in the clinical management of NSCLC. While the EGFR transmembrane form has been extensively investigated in large clinical trials, the soluble, circulating EGFR isoform (sEGFR), which may have a potential clinical use, has rarely been considered. This study investigates the use of sEGFR as a potential diagnostic biomarker for NSCLC and also characterizes the biological function of sEGFR to clarify the molecular mechanisms involved in the course of action of this protein. Plasma sEGFR levels from a heterogeneous cohort of 37 non-advanced NSCLC patients and 54 healthy subjects were analyzed by using an enzyme-linked immunosorbent assay. The biological function of sEGFR was analyzed in vitro using NSCLC cell lines, investigating effects on cell proliferation and migration. We found that plasma sEGFR was significantly decreased in the NSCLC patient group as compared to the control group (median value: 48.6 vs. 55.6 ng/mL respectively; p = 0.0002). Moreover, we demonstrated that sEGFR inhibits growth and migration of NSCLC cells in vitro through molecular mechanisms that included perturbation of EGF/EGFR cell signaling and holoreceptor internalization. These data show that sEGFR is a potential circulating biomarker with a physiological protective role, providing a first approach to the functional role of the soluble isoform of EGFR. However, the impact of these data on daily clinical practice needs to be further investigated in larger prospective studies. 相似文献
2.
Yi‐Hung Chen Ching‐Yuan Chang Wei‐Ling Su Chun‐Yu Chiu Yue‐Hwa Yu Pen‐Chi Chiang Chiung‐Fen Chang Je‐Lueng Shie Chyow‐San Chiou Sally IM Chiang 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(1):68-75
This study investigates the ozonation of CI Reactive Black 5 (RB5) by using the rotating packed bed (RPB) and completely stirred tank reactor (CSTR) as ozone contactors. The RPB, which provides high gravitational force by adjusting the rotational speed, was employed as a novel ozone contactor. The same ozone dosage was separately introduced into either the RPB or the CSTR for the investigation, while the experimental solution was continuously circulated within the apparatus consisting of the RPB and CSTR. The decolorization and mineralization efficiencies of RB5 in the course of ozonation are compared for these two methods. Moreover, the dissolved and off‐gas ozone concentrations were simultaneously monitored for the further analysis. As a result, the ozone mass transfer rate per unit volume of the RPB was significantly higher because of its higher mass transfer coefficient and gas–liquid concentration driving force. Furthermore, ozonation kinetics was found to be independent of the gravitational magnitude of an ozone gas–liquid contactor. Therefore, the results suggest employing RPBs as ozone‐contacting devices with the advantage of volume reduction. The experimental results, which can be used for further modeling of the ozonation process in the RPB, also show the requirement of correct design for the RPB. Consequently, the present study is useful for the understanding of practical application of RPBs. Copyright © 2004 Society of Chemical Industry 相似文献
3.
Sally Cole Johnson 《集成电路应用》2007,(5):41-42
纽约州立大学Buffalo分校电子封装实验室正在为美国海军开发新型的功率电子封装,在一些极端苛刻的工作条件下(比如在军舰和战机上).它们能够解决大电流密度、高温和大的温度梯度所引起的种种问题。这类功率电子封装还有可能很快进入民用产品。 相似文献
4.
The influence of the gaseous phase composition (SiH4 or SiCI4 diluted with argon or hydrogen), used for chemical vapor deposition of silicon onto two different substrates (pure iron or low chromium mild steel) is investigated. Depending on the chosen process, two types of coatings are developed: either a very adherent, non-porous solid solution containing up to 6 to 7 wt. % Si, or a Fe3Si iron silicide (14.35 wt. %). This solid solution coating considerably improves the oxidation resistance properties of steels at temperatures up to 800° C. This beneficial effect was not observed on the corrosion behavior of treated samples in sulfuric acid solutions. In contrast, the Fe3Si iron silicide has the same outstanding corrosion resistance that the silicon-rich cast alloys have in very severe environments such as boiling concentrated sulfuric acid. But this remarkable behavior is certainly limited in other mediums by the open porosity of the coating, inherent to the chemical vapor process. 相似文献
5.
TTI hydraulics and erosion control laboratory research field performance of erosion-control blankets
Storm water management issues facing the Texas Department of Transportation in the late 1980s led to the development of a coordinated research program with the Texas Transportation Institute. Researchers developed methodologies for evaluating the field performance of various erosion control technologies of the most widely used products within the Department's construction and maintenance operations. From these methodologies, the Hydraulics and Erosion Control Laboratory was designed and constructed. Currently, participants include private industry (manufacturers of erosion control products), transportation researchers (TTI), and the public sector (TxDOT).The results reported in this paper reflect 2 years of erosion-control blanket research. The study objectives were to determine the effectiveness of erosion-control blankets on the growth of warm-season perennial grasses and their ability to prevent sediment loss in a sloped condition.The laboratory simulates the highway environment with the sloped plots (6 m in width) located on an earthen embankment that is 300 m in length and 6.75 m in height (94 ft. by 22 ft., vertically). A randomized experimental design was replicated on two soil types (sand and clay) for each slope condition (3:1 or 2:1) with a control.In general, the results indicate better combined results relating to sediment retention and vegetation establishment performance for erosion-control blankets on sandy soils (noncohesive) regardless of slope condition (3:1 or 2:1) or material type. A minimum of 50% more sediment was retained on the sandy treatment plots and a 45% more vegetation coverage was achieved compared with the control plots. When analyzed by material type related to performance, excelsior, synthetic blends, and straw/coconut blends performed the best. For clay soils (cohesive), regardless of slope condition (3:1 or 2:1), the combined results indicate a minimum of 75% more sediment was retained and a minimum of 5% more vegetation establishment was achieved compared with the control plots. When analyzed by material type related to performance, excelsior, straw, and straw/coconut blends performed the best. 相似文献
6.
Databases developed independently in a common open distributed environment may be heterogeneous with respect to both data schema and the embedded semantics. Managing schema and semantic heterogeneities brings considerable challenges to learning from distributed data and to support applications involving cooperation between different organisations. In this paper, we are concerned mainly with heterogeneous databases that hold aggregates on a set of attributes, which are often the result of materialised views of native large-scale distributed databases. A model-based clustering algorithm is proposed to construct a mixture model where each component corresponds to a cluster which is used to capture the contextual heterogeneity among databases from different populations. Schema heterogeneity, which can be recast as incomplete information, is handled within the clustering process using Expectation-Maximisation estimation and integration is carried out within a clustering iteration. Our proposed algorithm resolves the schema heterogeneity as part of the clustering process, thus avoiding transformation of the data into a unified schema. Results of algorithm evaluation on classification, scalability and reliability, using both real and synthetic data, demonstrate that our algorithm can achieve good performance by incorporating all of the information from available heterogeneous data. Our clustering approach has great potential for scalable knowledge discovery from semantically heterogeneous databases and for applications in an open distributed environment, such as the Semantic Web. 相似文献
7.
8.
E?cient resource utilization requires that emerging datacenter interconnects support both high performance communication and e?cient remote resource sharing. These goals require that the network be mor... 相似文献
9.
10.
Developing the ability to recognize a landmark from a visual image of a robot's current location is a fundamental problem in robotics. We consider the problem of PAC-learning the concept class of geometric patterns where the target geometric pattern is a configuration ofk points on the real line. Each instance is a configuration ofn points on the real line, where it is labeled according to whether or not it visually resembles the target pattern. To capture the notion of visual resemblance we use the Hausdorff metric. Informally, two geometric patternsP andQ resemble each other under the Hausdorff metric if every point on one pattern is close to some point on the other pattern. We relate the concept class of geometric patterns to the landmark matching problem and then present a polynomial-time algorithm that PAC-learns the class of one-dimensional geometric patterns. We also present some experimental results on how our algorithm performs. 相似文献