Probabilistic Weibull behavior and mechanical properties of MEMS brittle materials

The objective of this work is to present a brief overview of a probabilistic design methodology for brittle structures, review the literature for evidence of probabilistic behavior in the mechanical properties of MEMS (especially strength), and to investigate whether evidence exists that a probabilistic Weibull effect exists at the structural microscale. Since many MEMS devices are fabricated from brittle materials, that raises the question whether these miniature structures behave similar to bulk ceramics. For bulk ceramics, the term Weibull effect is used to indicate that significant scatter in fracture strength exists, hence requiring probabilistic rather than deterministic treatment. In addition, the material's strength behavior can be described in terms of the Weakest Link Theory (WLT) leading to strength dependence on the component's size (average strength decreases as size increases), and geometry/loading configuration (stress distribution). Test methods used to assess the mechanical properties of MEMS, especially strength, are reviewed. Four materials commonly used to fabricate MEMS devices are reviewed in this report. These materials are polysilicon, single crystal silicon (SCS), silicon nitride, and silicon carbide.     

Effect of thermal treatment on ZnO substrate for epitaxial growth

ZnO is a highly efficient photon emitter, and has optical and piezoelectric properties that are attractive for a variety of applications in sensors and potentially optoelectronic devices such as emitters. Due to its identical stacking order and close lattice match to GaN, it is also being developed as a substrate material for GaN epitaxy. However, the surface finish of the ZnO is such that much of the damage induced by sawing and follow up mechanical polishing remains. We developed a thermal treatment method to eliminate surface damage on the 0 face of ZnO (0 0 0 1) to prepare it for epitaxial growth. Atomic force microscopy images of ZnO (0 0 0 1) annealed at 1050 °C for 3 h etc. show that residual scratches from mechanical polishing are removed and atomically flat, terrace-like surfaces are attained. In addition, low-temperature photoluminescence and high-resolution X-ray diffraction measurements have been employed to investigate the effect of annealing on ZnO substrates.     

Type synthesis of spatial mechanisms on the basis of spatial single loop structural groupsTypensynthese räumlicher mechanismen auf der grundlage räumlicher einfach geschlossener strukturgruppen

This paper describes the basis for a new method of type synthesis of spatial mechanisms with the use of single-loop structural groups having zero degrees of freedom. Applying the binary system, the value 0 is used for R (revolute) and 1 is used for P (prismatic) pairs. The five-link spatial groups are described by codes both in the binary and decimal systems. All other groups are reduced to the basis of five-link spatial groups. In these cases two-degree-of-freedom and three-degree-of-freedom kinematic pairs are transformed to one-degree-of-freedom pairs, and these transformations are also described by codes in the binary and decimal systems. This method of coding can be programmed for digital computation and applied towards the automatic type synthesis in the design of spatial mechanisms. The system is equally clear for alphanumeric or for graphical display. To the designer it defines the diagram of the mechanism, pointing out the frame, the mobile links, the types of the kinematic pairs and their mutual disposition in the mechanism configuration.     

The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice

IL-4 plays an important role in polarizing inflammation toward a Th2 response. It remains uncertain, however, whether IL-4 also serves to prevent expression of Th1 inflammation. Therefore, using a genetically pure C57BL/6 IL-4-deficient mouse, we studied the role of IL-4 in regulating the production of IFN-gamma and Th1 inflammation in the granulomas of mice infected with Schistosoma mansoni. In contrast to normal animals, IL-4 mutant mice generated smaller liver granulomas that contained fewer eosinophils and no mast cells. Collagenase-dispersed granuloma cells were analyzed by flow cytometry and cultured in vitro to measure cytokine and Ig production. Compared with control granuloma cells, IL-4-/- cells secreted only small quantities of IL-5 and IL-10. Also, there was impaired expression of the IL-4-dependent molecules IgE and IgG1 as well as B cell surface class II and CD23. Yet the granulomas of IL-4 -/- animals produced little IFN-gamma, IgG2a, or other molecules associated with Th1 inflammation even after Ag or anti-CD3 stimulation. Splenocytes from IL-4 -/- animals stimulated with schistosome Ag also failed to produce a Th1 response. Our data show that most aspects of the Th2 response in murine schistosomiasis are highly dependent on IL-4 production. But in the absence of IL-4, neither the natural local granulomatous response to schistosome ova nor the systemic response to soluble egg Ag switches to the type 1 phenotype. Thus the production of IL-4 early in the inflammatory response is not the only factor preventing Th1 expression in inflammation.     

Identification by parameter bounds in adaptive control

Approximate solutions are suggested for receding horizon dual control to guarantee acceptable control performance of a plant with large a priori parameter uncertainties under poor excitation by the output reference and to satisfy the requirement of very fast adaptation using knowledge available on sensor and performance in industrial applications of adaptive control. the aim of the paper is to present several levels of interaction between on-line identification and control performance using parameter bounds. an interesting theorem shows that parameter bounding is a necessary part of the solution of the dual control problem. Starting from the complete separation of identification and control, various approximations are presented at different levels of optimality. Finally, the exact solution of the dual control problem is found for static gain adaptation, which implicitly involves a parameter-bounding identification procedure.     

PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study

Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI.     

“Those found responsible have been sacked”: some observations on the usefulness of error

Erik Hollnagel’s body of work in the past three decades has molded much of the current research approach to system safety, particularly notions of “error”. Hollnagel regards “error” as a dead-end and avoids using the term. This position is consistent with Rasmussen’s claim that there is no scientifically stable category of human performance that can be described as “error”. While this systems view is undoubtedly correct, “error” persists. Organizations, especially formal business, political, and regulatory structures, use “error” as if it were a stable category of human performance. They apply the term to performances associated with undesired outcomes, tabulate occurrences of “error”, and justify control and sanctions through “error”. Although a compelling argument can be made for Hollnagel’s view, it is clear that notions of “error” are socially and organizationally productive. The persistence of “error” in management and regulatory circles reflects its value as a means for social control.     

Visually Perceived Distance Judgments: Tablet-Based Augmented Reality Versus the Real World

Does visually perceived distance differ when objects are viewed in augmented reality (AR), as opposed to the real world? What are the differences? These questions are theoretically interesting, and the answers are important for the development of many tablet- and phone-based AR applications, including mobile AR navigation systems. This article presents a thorough literature review of distance judgment experimental protocols, and results from several areas of perceptual psychology. In addition to distance judgments of real and virtual objects, this section also discusses previous work in measuring the geometry of virtual picture space and considers how this work might be relevant to tablet AR. Then, the article presents the results of two experiments. In each experiment, observers bisected egocentric distances of 15 and 30 m in tablet-based AR and in the real world, in both indoor corridor and outdoor field environments. In AR, observers bisected the distances to virtual humans, while in the real world, they bisected the distances to real humans. This is the first reported research that directly compares distance judgments of real and virtual objects in a tablet AR system. Four key findings were: (1) In AR, observers expanded midpoint intervals at 15 m, but compressed midpoints at 30 m. (2) Observers were accurate in the real world. (3) The environmental setting—corridor or open field—had no effect. (4) The picture perception literature is important in understanding how distances are likely judged in tablet-based AR. Taken together, these findings suggest the depth distortions that AR application developers should expect with mobile and especially tablet-based AR.     

Using cognitive artifacts to understand distributed cognition

Studies of patient safety have identified gaps in current work including the need for research about communication and information sharing among healthcare providers. They have also encouraged the use of decision support tools to improve human performance. Distributed cognition is the shared awareness of goals, plans, and details that no single individual grasps. Cognitive artifacts are objects such as: schedules, display boards, lists, and worksheets that form part of a distributed cognition. Cognitive artifacts that are related to operating room (OR) scheduling include: the availabilities sheet, master schedule, OR graph, and OR board. All provide a "way in" to understand how teams in the acute care setting dynamically plan and manage the balance between demand for care and the resources available to provide it. This work has import for the way that information technology supports the organization, management, and use of healthcare resources. Better computer-supported cognitive artifacts will benefit patient safety by making teamwork processes, planning, communications, and resource management more resilient.