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1.
This paper describes an assay procedure for acyclovir quantification in human skin after in vitro transdermal transport experiments. The procedure employs warm distilled water for acyclovir (ACV) extraction and high-performance liquid chromatography (HPLC) as analytical method. The procedure has good reproducibility, sensitivity and specificity, resulting in a reliable method for biopharmaceutical studies of ACV distribution in skin tissue. The chromatographic conditions set up, using distilled water as mobile phase, makes the analytical procedure simple and easy to perform. 相似文献
2.
In Fifth Generation (5G) Heterogeneous Mobile Networks (HetNets), deploying dense small cell networks makes user association more challenging. The process of collecting cell load information from the User Equipments (UEs) and broadcasting the feedback message involves significant overhead and time complexity. Moreover, the UEs may not know the optimum cell to reselect, satisfying its data rate requirements. In order to overcome these drawbacks, in this paper, we propose to design an Hierarchical and Hybrid Cell Load Balancing (HHCLB) technique using Selective Handoff. In this technique, the UEs of each cell are grouped into clusters depending on their proximity distance. Each cluster contains a cluster controller (CC) which is in charge of determining the intra-cell load and redirecting the cell-reselection request of a UE. If the data rate of any UE in a cluster becomes less than its required rate, then the cell reselection process is performed. By simulation results, it is shown that load balancing can be done proactively (implicitly) by the CCs when the load is unbalanced or can be done on demand (explicitly) when a UE send a request for cell reselection. In the case of Macro cells, HHCLB attains 71% higher throughput for low load scenario and 59% higher throughput for high load scenario. Similarly, in the case of Femto cells, HHCLB attains 19% higher throughput for low load scenario and 27% higher throughput for high load scenario. 相似文献
3.
Fatos Xhafa Leonard Barolli Santi Caballé Raul Fernández 《The Journal of supercomputing》2010,53(1):45-65
With the fast development of IT technologies, virtual organizations are more and more present in the current collaborative
work and learning activity. For instance, many subjects in virtual distance learning are organized as online groups of students,
who use groupware tools to complete their learning tasks. In this paper, we address the efficient management of peer groups
in JXTA-based P2P systems as a key issue in many P2P applications that use peer group as a unit such as for remote execution
of tasks in parallel and distributed applications. From this perspective, we consider peer grouping as the basis in the development
of groupware tools in P2P systems. 相似文献
4.
Santi CaballéAuthor Vitae Thanasis DaradoumisAuthor VitaeFatos XhafaAuthor Vitae Angel JuanAuthor Vitae 《Computers in human behavior》2011,27(4):1372-1381
Learning and knowledge building have become critical competences for people in the knowledge society era. In this paper, we propose a sociolinguistic dialogue model for understanding how learning evolves and how cognitive process is constructed in on-line discussions. The knowledge extracted from this model is used to assess participation behavior, knowledge building and performance. The ultimate purpose is to provide effective feedback, evaluation and monitoring to the discussion process. Seven hundred students from the Open University of Catalonia in Spain participated in this study. Results showed that learning and knowledge building may be greatly enhanced by presenting selected knowledge to learners as for their particular skills exhibited during interaction. In addition, this valuable provision of information is used as a meta cognitive tool for tutors and moderators for monitoring and evaluating the discussion process more conveniently. This contribution presents our conceptual model for interaction management as well as key design guidelines and evaluation results. Implications of this study are remarked and further research directions are proposed. 相似文献
5.
Santi Chillemi Author VitaeMichele Barbi Author Vitae Angelo Di GarboAuthor Vitae 《Neurocomputing》2011,74(8):1159-1164
The transmission of excitatory inputs by a network of coupled pyramidal cells is investigated by means of numerical simulations. The pyramidal cell models are coupled by excitatory synapses and each one receives an excitatory pulse at a random time extracted from a Gaussian distribution. Moreover, each cell model is injected with a noisy current. It was found that the excitatory coupling promotes the transmission of the synaptic inputs on a time scale of a few ms. 相似文献
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8.
Camilla Isgr Ludovica Spagnuolo Elisa Pannucci Luigi Mondello Luca Santi Laura Dugo Anna Maria Sardanelli 《International journal of molecular sciences》2022,23(21)
Sumac, Rhus coriaria L., is a Mediterranean plant showing several useful properties, such as antioxidant and neuroprotective effects. Currently, there is no evidence about its possible neuroprotective action in Parkinson’s disease (PD). We hypothesized that sumac could modulate mitochondrial functionality in fibroblasts of familial early-onset PD patients showing PARK2 mutations. Sumac extract volatile profile, polyphenolic content and antioxidant activity have been previously characterized. We evaluated ROS and ATP levels on sumac-treated patients’ and healthy control fibroblasts. In PD fibroblasts, all treatments were effective in reducing H2O2 levels, while patients’ ATP content was modulated differently, probably due to the varying mutations in the PARK2 gene found in individual patients which are also involved in different mitochondrial phenotypes. We also investigated the effect of sumac extract on THP-1-differentiated macrophages, which show different embryogenic origin with respect to fibroblasts. In THP-1 macrophages, sumac treatment determined a reduction in H2O2 levels and an increase in the mitochondrial ATP content in M1, assuming that sumac could polarize the M1 to M2 phenotype, as demonstrated with other food-derived compounds rich in polyphenols. In conclusion, Rhus coriaria L. extracts could represent a potential nutraceutical approach to PD. 相似文献
9.
Anthocyanin composition and extractability in berry skin and wine of Vitis vinifera L. cv. Aglianico
Manfra M De Nisco M Bolognese A Nuzzo V Sofo A Scopa A Santi L Tenore GC Novellino E 《Journal of the science of food and agriculture》2011,91(15):2749-2755
BACKGROUND: The present article reports the anthocyanin content in the berry skin and wine of the Italian red grape cultivar Aglianico (clone VCR11 grafted onto 1103 Paulsen), one of the most ancient vines and famous for its deep‐red colour. Anthocyanins were extracted from frozen berry skin in an acidified methanol solution. The extraction mixtures, monitored for 120 h, were analysed by high‐performance liquid chromatography. RESULTS: The extraction from berry skin of delphinidin, petunidin and malvidin appeared to be a time‐independent process, whereas the concentration of peonidin increased linearly with time. Peonidin‐O‐acetyl‐glucoside was transferred from skin more slowly than petunidin‐O‐acetyl‐glucoside and malvidin‐O‐acetyl‐glucoside. The anthocyanin composition of the resulting wine showed that the total anthocyanin content was about one‐tenth of the corresponding berry skin content. The ratio acetyl/coumaroyl anthocyanins in the wine was sharply higher than the value in berry skin (0.85 and 0.10, respectively), indicating an enrichment of acetyl derivatives in the wine. CONCLUSION: Levels of single anthocyanins in wine were not always correlated with those detected in grapes, as they were affected by winemaking. The high values of some anthocyanins in Aglianico wine could ameliorate its quality, increasing the chromatic properties, aging stability and product acceptance. Copyright © 2011 Society of Chemical Industry 相似文献
10.
Nowadays, the use of Radio Frequency Identification (RFID) systems in industry and stores has increased. Nevertheless, some
of these systems present privacy problems that may discourage potential users. Hence, high confidence and effient privacy
protocols are urgently needed. Previous studies in the literature proposed schemes that are proven to be secure, but they
have scalability problems. A feasible and scalable protocol to guarantee privacy is presented in this paper. The proposed
protocol uses elliptic curve cryptography combined with a zero knowledge-based authentication scheme. An analysis to prove
the system secure, and even forward secure is also provided.
This work is supported by the Generalitat de Catalunya under Grant No. FIC 2007FIC 00880, and the projects of the Spanish
MCyT MTM2007-66842-C02-02 and TIN2006-15662-C02-02. 相似文献