Lung volume reduction surgery (LVRS) improves exercise capacity and relieves dyspnoea in patients with smoker's emphysema (SE). It is unclear, however, whether LVRS similarly improves lung function in alpha1-antitrypsin-deficiency emphysema (alpha1 E). To address this question, this study prospectively compared the intermediate-term functional outcome in 12 consecutive patients with advanced alpha1E and 18 patients with SE who underwent bilateral LVRS. Before surgery there were no statistically significant differences between the two groups in the six-minute walking distance, dyspnoea score, respiratory mechanics or lung function data, except for the forced expiratory volume in one second, which was lower in the deficient group (24 versus 31% of the predicted value; p<0.05). In both groups, bilateral LRVS produced significant improvements in dyspnoea, the six-minute walking distance, lung function and respiratory mechanics. In the alpha1E group, the functional data, with the exception of the six-minute walking distance, returned to baseline at 6-12 months postoperation and showed further deterioration at 24 months. The functional status of the SE group remained significantly improved over this period. In conclusion, the functional improvements resulting from bilateral lung volume reduction surgery are sustained for at least 2 yrs in most patients with smoker's emphysema, but this type of surgery offers only short-term benefits for most patients with alpha1E. 相似文献
Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan sulfate glycosaminoglycan (HS GAG) and its accumulation in tissues. MPS IIIA represents a significant proportion of childhood dementias. This condition generally leads to patient death in the teenage years, yet no effective therapy exists for MPS IIIA and a complete understanding of the mechanisms of MPS IIIA pathogenesis is lacking. Here, we employ targeted CRISPR/Cas9 mutagenesis to generate a model of MPS IIIA in the zebrafish, a model organism with strong genetic tractability and amenity for high-throughput screening. The sgshΔex5−6 zebrafish mutant exhibits a complete absence of Sgsh enzymatic activity, leading to progressive accumulation of HS degradation products with age. sgshΔex5−6 zebrafish faithfully recapitulate diverse CNS-specific features of MPS IIIA, including neuronal lysosomal overabundance, complex behavioural phenotypes, and profound, lifelong neuroinflammation. We further demonstrate that neuroinflammation in sgshΔex5−6 zebrafish is largely dependent on interleukin-1β and can be attenuated via the pharmacological inhibition of Caspase-1, which partially rescues behavioural abnormalities in sgshΔex5−6 mutant larvae in a context-dependent manner. We expect the sgshΔex5−6 zebrafish mutant to be a valuable resource in gaining a better understanding of MPS IIIA pathobiology towards the development of timely and effective therapeutic interventions. 相似文献
Recently, several standards have emerged for ontology markup languages that can be used to formalize all kinds of knowledge.
However, there are no widely accepted standards yet that define APIs to manage ontological data. Processing ontological information
still suffers from the heterogeneity imposed by the plethora of available ontology management systems. Moreover, ubiquitous
computing environments usually comprise software components written in a variety of different programming languages, which
makes it particularly difficult to establish a common ontology management API with programming language agnostic semantics.
We implemented an ontological Knowledge Base Server, which can expose the functionality of arbitrary off-the-shelf ontology
management systems via a formally specified and well defined API. A case study was carried out in order to demonstrate the
feasibility of our approach to use a formally specified ontology management API to implement a registry for ubiquitous computing
systems. 相似文献
The rapid advances in Artificial Intelligence and Robotics will have a profound impact on society as they will interfere with the people and their interactions. Intelligent autonomous robots, independent if they are humanoid/anthropomorphic or not, will have a physical presence, make autonomous decisions, and interact with all stakeholders in the society, in yet unforeseen manners. The symbiosis with such sophisticated robots may lead to a fundamental civilizational shift, with far-reaching effects as philosophical, legal, and societal questions on consciousness, citizenship, rights, and legal entity of robots are raised. The aim of this work is to understand the broad scope of potential issues pertaining to law and society through the investigation of the interplay of law, robots, and society via different angles such as law, social, economic, gender, and ethical perspectives. The results make it evident that in an era of symbiosis with intelligent autonomous robots, the law systems, as well as society, are not prepared for their prevalence. Therefore, it is now the time to start a multi-disciplinary stakeholder discussion and derive the necessary policies, frameworks, and roadmaps for the most eminent issues.
The visualization of ontologies is a challenging task especially if they are large. In this paper we propose a visualization approach which is based on star-like graphs of variable radius which enables users to gradually explore and navigate through the entire ontology without overloading them. The star-like graphs are visualized using a Force Directed Placement algorithm (FDP) specially suited for RDF schemas whose configuration parameters can be adjusted interactively by the end-user via an intuitive on-screen tool bar. In addition, and since each star-like graph exhibits different graph features, we propose a novel automatic configuration method for the FDP algorithm parameters that is based on a number of quality metrics (area density and verticality of subclass hierarchies) and corresponding corrective actions. The experimental evaluation showed the quality of the yielded layout is significantly improved and the proposed approach is acceptably fast for real-time exploration. The user study showed that users prefer these views and perform various very common tasks faster. 相似文献
Urban neighbourhoods and open spaces are strongly related to bioclimatic techniques and practices. The procedure of a bioclimatic study is presented by the use of simulation tools. Routes linking archaeological monuments in the Greek city of Arta are characterised of decreased human thermal comfort conditions during summer time. The employment of computational fluid dynamics has contributed to the understanding of what interventions should be made at the urban populated routes in order to succeed the defined environmental thermal-related targets. The proposed rehabilitation explains what the interventions would contribute to the improvement of the local environment. 相似文献
Single-Instruction Multiple-Data (SIMD) instructions provide an inexpensive way to exploit the Data-Level Parallelism in multimedia applications. However, the performance improvement obtained by employing SIMD instructions is often limited because frequently many overhead instructions are required to bring data in a form amenable to SIMD processing. In this paper, we employ two techniques to overcome this limitation. The first technique, extended subwords, uses four extra bits for every byte in a media register. This allows many SIMD operations to be performed without overflow and avoids packing/unpacking conversion overhead. The second technique, Matrix Register File (MRF), allows flexible row-wise as well as column-wise access to the register file. It is useful for many two-dimensional multimedia algorithms such as the (I) Discrete Cosine Transform, 2 × 2 Haar Transform, and pixel padding. In addition, we propose a few new media instructions. Experimental results obtained by extending the SimpleScalar toolset show that these techniques improve performance by up to a factor of 4.5 compared to a conventional SIMD instruction set extension. 相似文献
In this paper, we study the performance impact of dynamic hardware reconfigurations for current reconfigurable technology.
As a testbed, we target the Xilinx Virtex II Pro, the Molen experimental platform and the MPEG2 encoder as the application.
Our experiments show that slowdowns of up to a factor 1000 are observed when the configuration latency is not hidden by the
compiler. In order to avoid the performance decrease, we propose an interprocedural optimization that minimizes the number
of executed hardware configuration instructions taking into account constraints such as the “FPGA-area placement conflicts”
between the available hardware configurations. The presented algorithm allows the anticipation of hardware configuration instructions
up to the application’s main procedure. The presented results show that our optimization produces a reduction of 3 to 5 order
of magnitude of the number of executed hardware configuration instructions. Moreover, the optimization allows to exploit up
to 97% of the maximal theoretical speedup achieved by the reconfigurable hardware execution. 相似文献
Given a set of connection requests (calls) in a communication network, the call control problem is to accept a subset of the requests and route them along paths in the network such that no edge capacity is violated, with the goal of rejecting as few requests as possible. We investigate the complexity of parameterized versions of this problem, where the number of rejected requests is taken as the parameter. For the variant with pre-determined paths, the problem is fixed-parameter tractable in arbitrary graphs if the link capacities are bounded by a constant, but W[2]-hard if the link capacities are arbitrary. If the paths are not pre-determined, no FPT algorithm can exist even in series-parallel graphs unless . Our main results are new FPT algorithms for call control in tree networks with arbitrary edge capacities and in trees of rings with unit edge capacities in the case that the paths are not pre-determined. 相似文献
A switchable electrode, which relies on an indium‐tin oxide conductive substrate coated with a self‐assembled monolayer terminated with an anthraquinone group (AQ), is reported as an electrowetting system. AQ electrochemical features confer the capability of yielding a significant modulation of surface wettability as high as 26° when its redox state is switched. Hence, an array of planar electrodes for droplets actuation is fabricated and integrated in a microfluidic device to perform mixing and dispensing on sub‐nanoliter scale. Vehiculation of cells across microfluidic compartments is made possible by taking full advantage of surface electrowetting in culture medium. 相似文献