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1.
The effect of actinomycin-D (AMD) on radiation damage repair was studied in plateau phase V79 Chinese hamster cells. Sublethal radiation damage repair, as demonstrated by survival fluctuations following two x-ray exposures separted by time, was observed in our plateau phase cells. Plateau phase cells exposed to 0.01-0.04 mug/ml AMD (a nontoxic regimen to 8 hours) between x-ray exposures were less able to repair sublethal damage. If plateau phase cells were plated at low dilutions into fresh medium (conditions for resuming exponential growth) immediately after the first x-ray dose, and exposed to 0.01--0.04 mug/ml AMD until the second dose, inhibition of sublethal damage repair and additional cell killing were observed particularly at 0.04 mug/ml AMD. It is suggested that radiation-drug damage interactions should be studied in plateau phase cells and in cells resuming exponential growth after plateau phase (possibly analogous to "recruitment"), as well as in exponential phase cultures. 相似文献
2.
Giacomo Lazzarino Valentina Di Pietro Marco Rinaudo Zsuzsanna Nagy Nicholas M. Barnes Lars Bruce Stefano Signoretti Renata Mangione Miriam Wissam Saab Barbara Tavazzi Antonio Belli Giuseppe Lazzarino Angela Maria Amorini Ann Logan 《International journal of molecular sciences》2022,23(15)
In a previous study, we found that administration of ILB®, a new low molecular weight dextran sulphate, significantly improved mitochondrial functions and energy metabolism, as well as decreased oxidative/nitrosative stress, of brain tissue of rats exposed to severe traumatic brain injury (sTBI), induced by the closed-head weight-drop model of diffused TBI. Using aliquots of deproteinized brain tissue of the same animals of this former study, we here determined the concentrations of 24 amino acids of control rats, untreated sTBI rats (sacrificed at 2 and 7 days post-injury) and sTBI rats receiving a subcutaneous ILB® administration (at the dose levels of 1, 5 and 15 mg/kg b.w.) 30 min post-impact (sacrificed at 2 and 7 days post-injury). Additionally, in a different set of experiments, new groups of control rats, untreated sTBI rats and ILB®-treated rats (administered 30 min after sTBI at the dose levels of 1 or 5 mg/kg b.w.) were studied for their neurocognitive functions (anxiety, locomotor capacities, short- and long-term memory) at 7 days after the induction of sTBI. Compared to untreated sTBI animals, ILB® significantly decreased whole brain glutamate (normalizing the glutamate/glutamine ratio), glycine, serine and γ-aminobutyric acid. Furthermore, ILB® administration restored arginine metabolism (preventing nitrosative stress), levels of amino acids involved in methylation reactions (methionine, L-cystathionine, S-adenosylhomocysteine), and N-acetylaspartate homeostasis. The macroscopic evidences of the beneficial effects on brain metabolism induced by ILB® were the relevant improvement in neurocognitive functions of the group of animals treated with ILB® 5 mg/kg b.w., compared to the marked cognitive decline measured in untreated sTBI animals. These results demonstrate that ILB® administration 30 min after sTBI prevents glutamate excitotoxicity and normalizes levels of amino acids involved in crucial brain metabolic functions. The ameliorations of amino acid metabolism, mitochondrial functions and energy metabolism in ILB®-treated rats exposed to sTBI produced significant improvement in neurocognitive functions, reinforcing the concept that ILB® is a new effective therapeutic tool for the treatment of sTBI, worth being tested in the clinical setting. 相似文献
3.
4.
In this paper, data are reported for the behaviour of some charcoals during combustion and devolatilization in a thermal analyser. 相似文献
5.
Scientometrics - Open Access (OA) initiatives and knowledge infrastructure represent vital elements for both producing significant changes in scholarly communication and reducing limitations of... 相似文献
6.
C Clayton M Adams R Almeida T Baltz M Barrett P Bastien S Belli S Beverley N Biteau J Blackwell C Blaineau M Boshart F Bringaud G Cross A Cruz W Degrave J Donelson N El-Sayed G Fu K Ersfeld W Gibson K Gull A Ivens J Kelly L Vanhamme 《Canadian Metallurgical Quarterly》1998,97(1-2):221-224
We investigated the effect of chronic ethanol administration and its withdrawal on the polypeptide levels of NMDA receptor subunits such as NR1, NR2A, and NR2B in the rat cerebral cortex and hippocampus using Western blot analysis technique. Our results indicate that chronic ethanol treatment upregulates NMDA receptor subunits NR1, NR2A, and NR2B ( approximately 35%). At 48 h of last dose of ethanol administration, the protein content returned to almost control level, thereby demonstrating the reversibility of the changes. 相似文献
7.
Belli F. Jedrzejowicz P. 《IEEE transactions on pattern analysis and machine intelligence》1991,17(3):310-312
An approach to the optimization of software reliability is proposed. The emphasis is put on the software redundancy to achieve fault tolerance, i.e. the results of the optimization process are used to determine the optimal structure of the software to be developed. Two optimization models are formulated covering, respectively, modified recovery block scheme and multiversion programming approaches. Both cases are illustrated by simple examples. The models show that it is possible to formulate and solve some software related reliability optimization problems. They further show that the concept of redundancy to achieve fault tolerance (basic for the traditional theory of reliability) can be used in the field of software reliability optimization 相似文献
8.
LS Belli L de Carlis G Rondinara AB Alberti G Bellati A De Gasperi D Forti G Idèo 《Canadian Metallurgical Quarterly》1998,27(6):1524-1529
Maintenance of adequate immunosuppression and avoidance of side-effects are the goals of long-term management of all organ-transplanted patients. We here report the final results of a prospective, randomized trial comparing early cyclosporine monotherapy versus double-drug therapy (cyclosporine and steroids) in adult liver transplantation patients. One hundred four patients were randomized 3 months after transplantation either to continue (Group I = 50 patients) or to stop steroids (Group II = 54 patients). Patients on a double-drug regimen were maintained long term on methylprednisolone at a dose of 0.1 mg/kg/d. Target cyclosporine trough levels were between 150 and 250 ng/mL in both groups. Our main points of interest were the prevalence of acute and chronic rejections and steroid-related side-effects in the two groups of patients. Mean follow-up was 41 +/- 16 months (range, 4-68 months). Patient actuarial survival 2 and 5 years after randomization was similar in the two groups (82% vs. 83% and 82% vs. 77%). The prevalence of acute rejections after randomization was, respectively, 8% and 4%. A single episode of chronic rejection was observed only in a patient on long-term steroid therapy. Side-effects of steroid therapy were less frequent in patients weaned off steroids, and when considering hypertension and diabetes, the differences between the two groups were statistically significant. Early cyclosporine monotherapy is a safe undertaking in liver transplantation because it allows a significant reduction of steroid-related side-effects without increasing the risk of acute and chronic rejection. After 5 years, patient survival was similar in patients with or without steroids. 相似文献
9.
Adaptive response: modelling and experimental studies 总被引:1,自引:0,他引:1
Esposito G Campa A Pinto M Simone G Tabocchini MA Belli M 《Radiation protection dosimetry》2011,143(2-4):320-324
Adaptive response (AR) is a term that has been generally accepted to describe the ability of a low 'priming' radiation dose to decrease the cell response to a subsequent higher 'challenging' dose. The main proposed mechanisms to explain AR are: increased efficiency of DNA repair and induction of antioxidant enzymes. A model that considers a modulation of the efficiency of DNA repair activity and of the level of antioxidant enzymes, starting from the framework of a lethal-potentially lethal (LPL) model is proposed. The LPL model has been extended with the inclusion of the dynamic variables representing the efficiency of repair, the levels of radiation induced radicals and of antioxidant enzymes. The model used here is able to describe the protective effect of a priming dose. Moreover, in agreement with the data in the literature, the simulations show that the AR happens in given priming dose and priming dose-rate ranges only, and requires at least 4 h to develop. In order to get more insights into the role of cell-cell communication as factors affecting the AR, experimental studies were planned using sparse or confluent AG1522 cell monolayer. The results obtained after gamma irradiation suggest that cell density is a crucial factor for observing an AR. 相似文献
10.
Belli Robert F.; Windschitl Paul D.; McCarthy Thomas T.; Winfrey Steve E. 《Canadian Metallurgical Quarterly》1992,18(2):356
Suggests that detecting memory impairment with the modified test relies on long retention intervals that provide the necessary forgetting of event information for impairing effects of postevent misinformation to occur. 288 Ss were tested in 4 experiments that presented event items centrally, introduced verbal postevent items to a misled condition, and used the modified test, but differed by using either short (15 min) or long (5–7 days) retention intervals. As evidenced by poorer misled than control test performances, memory impairment only occurred with long retention intervals. Retrieval- and storage-based versions of memory-impairment hypotheses are assessed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献