A facile and efficient method for preparation of chiral supported poly(styrene–divinylbenzene) copolymers

A new and efficient method for preparation of optically active poly(styrene–divinylbenzene) copolymers (PS-DVB) is presented here. This is carried out by Friedel–Crafts acylation reaction of chiral N-phthaloyl -leucine acid chloride with PS-DVB beads in the presence of aluminum chloride as Lewis acid catalyst and 1,2-dichloroethane as the solvent at ambient temperature. Reagents’ amounts and reaction conditions are mentioned and four samples with different amounts of functionality have been prepared. Final products were characterized by FT-IR and elemental analysis. The results obtained confirm that the above modification in preparation of chiral supported PS-DVB has been achieved well and in moderate yield.     

A particle swarm optimization for a fuzzy multi-objective unrelated parallel machines scheduling problem

This paper proposes a novel multi-objective model for an unrelated parallel machine scheduling problem considering inherent uncertainty in processing times and due dates. The problem is characterized by non-zero ready times, sequence and machine-dependent setup times, and secondary resource constraints for jobs. Each job can be processed only if its required machine and secondary resource (if any) are available at the same time. Finding optimal solution for this complex problem in a reasonable time using exact optimization tools is prohibitive. This paper presents an effective multi-objective particle swarm optimization (MOPSO) algorithm to find a good approximation of Pareto frontier where total weighted flow time, total weighted tardiness, and total machine load variation are to be minimized simultaneously. The proposed MOPSO exploits new selection regimes for preserving global as well as personal best solutions. Moreover, a generalized dominance concept in a fuzzy environment is employed to find locally Pareto-optimal frontier. Performance of the proposed MOPSO is compared against a conventional multi-objective particle swarm optimization (CMOPSO) algorithm over a number of randomly generated test problems. Statistical analyses based on the effect of each algorithm on each objective space show that the proposed MOPSO outperforms the CMOPSO in terms of quality, diversity and spacing metrics.     

Business process management with the user requirements notation

A number of recent initiatives in both academia and industry have sought to achieve improvements in e-businesses through the utilization of Business Process Management (BPM) methodologies and tools. However there are still some inadequacies that need to be addressed when it comes to achieving alignment between business goals and business processes. The User Requirements Notation (URN), recently standardized by ITU-T, has some unique features and capabilities beyond what is available in other notations that can help address alignment issues. In this paper, a URN-based framework and its supporting toolset are introduced which provide business process monitoring and performance management capabilities integrated across the BPM lifecycle. The framework extends the URN notation with Key Performance Indicators (KPIs) and other concepts to measure and align processes and goals. An example process for controlling access to a healthcare data warehouse is used to illustrate and evaluate the framework. Early results indicate the feasibility of the approach.     

Mechanism study of silver nanoparticle production using Neurospora intermedia

Elucidation of the molecular mechanism of silver nanoparticle (AgNP) synthesis is necessary to control nanoparticle size, shape, and monodispersity. In this study, the mechanism of AgNP formation by Neurospora intermedia was investigated. The higher production rate of AgNP formation using a culture supernatant heat‐treated at 100° and 121°C relative to that with an un‐treated culture supernatant indicated that the native form of the molecular species is not essential. The effect of the protein molecular weight (MW) on the nanoparticle size distribution and average size was studied by means of ultraviolet–visible spectroscopy and dynamic light scattering. Using un‐treated and concentrated cell‐free filtrate passed through 10 and 20 kDa cut‐off filters led to the production of AgNPs with average sizes of 25, 30, and 34 nm, respectively. Also, using the permeate fraction of cell‐free filtrate passed through a 100 kDa cut‐off filter led to the formation of the smallest nanoparticles with the narrowest size distribution (average size of 16 nm and polydispersity index of 0.18). Sodium dodecyl sulphate polyacrylamide gel electrophoresis analysis of the fungal extracellular proteins showed two notable bands with the MWs of 15 and 23 kDa that are involved in the reduction and stabilisation of the nanoparticles, respectively.Inspec keywords: silver, nanoparticles, nanofabrication, proteins, molecular weight, ultraviolet spectra, visible spectra, cellular biophysics, electrophoresis, molecular biophysicsOther keywords: Neurospora intermedia, molecular mechanism, silver nanoparticle synthesis, nanoparticle shape, nanoparticle monodispersity, AgNP formation, untreated culture supernatant, molecular species, protein molecular weight, MW, nanoparticle size distribution, ultraviolet‐visible spectroscopy, dynamic light scattering, untreated cell‐free filtrate, concentrated cell‐free filtrate, cut‐off filters, permeate fraction, polydispersity index, Sodium dodecyl sulphate polyacrylamide gel electrophoresis analysis, fungal extracellular proteins, nanoparticle reduction, nanoparticle stabilisation, temperature 100 degC, temperature 121 degC, size 25 nm, size 30 nm, size 34 nm, size 16 nm, Ag     

Fracture Assessment of U-Notched Graphite Plates Under Tension

The experimentally obtained tensile load-bearing capacity of fifteen U-notched polycrystalline graphite plates reported in literature was theoretically estimated by means of two well-known brittle fracture models, namely the mean stress (MS) and the point stress (PS) criteria. The results showed that while the mean discrepancies between the experimental and the theoretical results for both the models are very good and approximately equal, the discrepancies are significantly different for various notch tip radii. Meanwhile, the results of MS and PS criteria were compared with the results of the strain energy density (SED) criterion reported in literature. Relatively similar value of mean discrepancy was also obtained for the SED model. It was demonstrated in this research that for small values of the notch tip radius, the MS model is the most appropriate failure criterion while the PS and SED criteria are much better models for medium radii. Moreover, for large notch tip radii, the MS and PS criteria are better choices for tensile fracture assessment of U-notched graphite plates than the SED criterion.     

Thermal Analysis of Non-linear Convective–Radiative Hyperbolic Lumped Systems with Simultaneous Variation of Temperature-Dependent Specific Heat and Surface Emissivity by MsDTM and BPES

With the advent of temperatures near absolute zero, it is often claimed that at very low temperatures the effect of thermal wave propagation must be included by the hyperbolic heat conduction equation (HHCE). In this paper the non-linear convective–radiative HHCE is investigated. Opposite to common numerical analyses, analytical expressions are obtained for the temperature variations by the multi-step differential transformation method. Some conclusions about alteration of the specific heat of the material, temperature steeping, and Vernotte number have been formulated.     

Failure Analysis and Repair of a Catastrophically Damaged Gas Turbine Compressor Disk Using SEM Technique and CFD Analysis

During a major overhaul of an 85?MW gas turbine unit in Iran-Rey power plant, 39 cracks were detected with different lengths and locations on the compressor disk of stage 11. All of the cracks initiated from the dovetail regions. Preliminary visual inspections and further micro-fractography using the scanning electron microscope demonstrated that the fretting fatigue phenomenon was the main cause of failure. Four repair methods were suggested to restart the unit. The first one was to remove all of the cracks from the disk by machining, or the so-called blending. The second, third, and fourth ways were to remove the entire rotor blades of stage 11, to remove the entire rotor and stator blades of the stage 11 simultaneously, and to remove those rotor blades of stage 11 corresponding to the damaged dovetails, respectively. Although the first way of solution was initially carried out on the damaged disk, the first author offered that restarting the unit with the blended disk is not reliable enough because of the presence of a large number of repair points on the disk. Using the numerical investigations based on the computational fluid dynamics, it was found that only the second suggestion (i.e., removing the entire rotor blades of the stage 11) might be applicable. Ultimately, the entire stage 11 rotor blades were removed from the blended disk, and the gas turbine unit was successfully restarted without encountering abnormal operation. Although the performed process resulted in approximately 20% output power loss compared with the unit's power before the blades' removal, the unit was quickly restored to be ready to restart, and the electric power could be generated during the period of peak consumption.     

A Review on the Role of miR-149-5p in the Carcinogenesis

miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the “guide” and the sister “passenger” strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.     

Potency of Different Carbon Sources in Reduction of Microsilica to Synthesize SiC from Mechanically Activated Powder Mixtures

In the present study, the influences of three different types of carbon (carbon black, graphite, and petroleum coke) on SiC synthesis via mechanical activation and sintering were evaluated. In this regard, the phase components, morphology, and the formation mechanism were investigated. SiC nanoparticles were detected to be formed after 4 h of milling and sintering at 1450°C, regardless of the sources of carbon. The carbon types exert their effects on the morphology of the as‐synthesized particles, where carbon black leads to form rod‐like SiC particles and the other two carbon types result in semi‐spherical SiC particles. This is due to the dominant mechanism in the mentioned process. The rod‐like particles obtained from the carbon black‐containing powder were synthesized via the VSL mechanism, whereas the solid‐state reactions occurred to form the SiC particles in the graphite‐ or petroleum coke‐containing samples. In the VSL mechanism, any increase in the milling time leads to facilitate the SiC formation due to entrance of Fe debris, whereas in the other samples (graphite or petroleum coke) the procedure is reversed.