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排序方式: 共有141条查询结果,搜索用时 31 毫秒
1.
Onno B. Bleijerveld Ya-Nan Zhang Serap Beldar Imo E. Hoefer Siu K. Sze Gerard Pasterkamp Dominique P. V. de Kleijn 《Proteomics. Clinical applications》2013,7(7-8):490-503
Cardiovascular disease (CVD) is the leading cause of death and loss of productive life years in the world. The underlying syndrome of CVD, atherosclerosis, is a complex disease process, which involves lipid metabolism, inflammation, innate and adaptive immunity, and many other pathophysiological aspects. Furthermore, CVD is influenced by genetic as well as environmental factors. Early detection of CVD and identification of patients at risk are crucial to reduce the burden of disease and to allow personalized treatment. As established risk factors fail to accurately predict which part of the population is likely to suffer from the disease, novel biomarkers are urgently needed. Proteomics can play a significant role in identifying these biomarkers. In this review, we describe the progress made in proteome profiling of the atherosclerotic plaque and several novel sources of potential biomarkers, including circulating cells and plasma extracellular vesicles. The importance of longitudinal biobanking in biomarker discovery is highlighted and exemplified by several plaque proteins identified in the biobank study Athero-Express. Finally, we discuss the PTMs of proteins that are involved in atherosclerosis, which may become one of the foci in the ongoing quest for biomarkers through proteomics of plaque and other matrices relevant to the progression of atherosclerosis. 相似文献
2.
In many wireless sensor network (WSN) applications, the location of a sensor node is crucial for determining where the event or situation of interest occurred. Therefore, localization is one of the critical challenges in WSNs. Mobile anchor node assisted localization (MANAL) is one of the promising solutions for the localization of statically deployed sensors. The main problem in MANAL localization is that the path planning of the mobile anchor (MA) node should be done so that the localization error in the network will be minimal and that all unknown nodes in the network are covered. This paper proposes a new path planning approach called nested hexagons curves (NHexCurves) for MANAL. NHexCurves guarantees that it will receive messages from at least three non-collinear anchors to locate all unknown nodes in the network. The proposed model has compared six different path planning schemes in the literature using weighted centroid localization (WCL). In these comparisons, first of all, localization errors of the models are compared using some statistical concepts. Second, the variation of the localization error according to parameters such as resolution (R) and the standard deviation of noise (σ) is observed. Then, with similar approaches, the standard deviation of errors, localization ratio, scalability performances, and finally, path lengths of the models are examined. The simulation results show that the NHexCurves static path planning model proposed in this study stands out compared to other models with high localization error and localization ratio performance, especially at low resolutions, due to its path design. At the same time, the lowest error values according to σ are obtained with the proposed model among all models considered. 相似文献
3.
This paper aims the adsorption of boron from aqueous solution onto Siral 30 and Pural using 23 full factorial design. The effect of individual variables and their interactional effects for boron adsorption were also determined. From the statistical analysis, it is inferred that as pH and temperature increased boron adsorption from aqueous solution decreased. Siral 30 was found to be more efficient adsorbent than Pural. The unimportant factor affecting boron adsorption from aqueous solution was also verified by using Fisher adequacy test. At the 90% confidence level, the type of adsorbent, temperature and type of adsorbent–temperature interaction was effective on boron adsorption from aqueous solution. The experimental results were fitted to the Langmuir, Freundlich and Dubinin–Radushkevich (DR) equations to find out adsorption capacities. In most cases, the results indicate that Freundlich and DR equations are well described with the sorption data. The adsorption capacity values of Siral 30 calculated from Freundlich and DR equation was greater than that of Pural. The thermodynamic parameters were also estimated and the adsorption process was not spontaneous nature. 相似文献
4.
5.
Metalloporphyrazines with a 2-methyl-2-pentenyl group fused to each pyrrole unit were synthesized starting with the corresponding unsaturated dicarbonitrile derivative. The new compounds were characterized by elemental analysis together with FTIR, 1H-NMR, and UV-Vis spectroscopy and via voltammetric and spectrochemical methods. Electrochemical and spectroelectrochemical measurements demonstrate that while metal-free and magnesium porphyrazines gave common porphyrazine (Pz) ring-based electron-transfer reactions, incorporating redox active metal center, CoII, into the porphyrazine core extended the redox activity of the ring system with reversible metal-based reduction and oxidation couples of the metal center in addition to the common Pz ring-based electron transfer processes. The unsaturated functional groups of the porphyrazines did not alter the common electrochemical behavior of the complexes. An in situ electrocolorimetric method, based on the 1931 CIE (Commission Internationale de l’Eclairage) system of colorimetry, was applied to investigate the color of the electro-generated anionic and cationic forms of the complexes for possible electrochromatic applications. 相似文献
6.
Food Science and Biotechnology - In this study, lactic acid bacteria diversity during the fermentation of homemade and commercially prepared Tarhana, a traditional fermented cereal food from... 相似文献
7.
In this study, the functional monomers, N‐methacryloyl‐l ‐aspartic acid and N‐methacryloyl‐l ‐cysteine were synthesized through a reaction between appropriate amino acids and methacryloyl chloride. Then, Pb(II) or Cd(II) ion‐imprinted 2‐hydroxyethyl methacrylate based cryogels were prepared by free radical polymerization method under partially frozen conditions. Following the characterization of matrices, adsorption of heavy metal ions was examined in batch mode from aqueous solution considering several parameters affecting the adsorption performance. The actual adsorption capacities were 44.5, 65.3, and 86.7 mg/g for Cd‐1, Cd‐2, and Cd‐3 cryogels meanwhile those were 41.9, 86.3, and 122.7 mg/g for Pb‐1, Pb‐2, and Pb‐3 cryogels, respectively at optimum pH: 5.5. By increasing temperature, adsorption capabilities of both cryogels were inhibited because of the electrostatic nature of coordinated covalent bonds and collapsing of coordination spheres. The adsorption process was very fast, the equilibrium adsorption was achieved in about 60 min, which was directly related to macroporous structure and interconnected flow‐channels of cryogels. Kinetics and adsorption isotherms were also studied. Langmuir isotherms and pseudo‐second order kinetic model were well suited to adsorption data, which also indicated that the process occurred without any diffusion restrictions or steric hindrances. Finally, the competitive adsorption studies were performed using multi‐ion containing synthetic wastewater to show whether the cryogels developed are suitable for specific heavy metal recycling or not. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43095. 相似文献
8.
Raman Spectroscopic Barcode Use for Differentiation of Vegetable Oils and Determination of Their Major Fatty Acid Composition
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Serap Durakli Velioglu Elif Ercioglu H. Tumay Temiz H. Murat Velioglu Ali Topcu Ismail H. Boyaci 《Journal of the American Oil Chemists' Society》2016,93(5):627-635
In this study, differentiation of vegetable oils and determination of their major fatty acid (FA) composition were performed using Raman spectral barcoding approach. Samples from seven different sources (sunflower, corn, olive, canola, mustard, soybean and palm) were analyzed using Raman spectroscopy. Second derivative of the spectral data was utilized to generate unique barcodes of oils. Chemometric analyses, namely, principal component analysis (PCA) and partial least square (PLS) methods were used for data analysis. PCA was applied for classification of the samples according to the differences in their levels arising from their barcode data. A successful differentiation based on second derivative barcodes of Raman spectra (2D‐BRS) of vegetable oils was obtained. In addition, PLS method was applied on 2D‐BRS in order to determine the major FA composition of these samples. Coefficient of determination values for palmitic, stearic, oleic, linoleic, α‐linolenic, cis‐11 eicosenoic, erucic and nervonic acids were in the range of 0.970–0.989. Limit of detection and limit of quantification values were found to be satisfactory (0.09–8.09 and 0.30–26.95 % in oil) for these fatty acids . Advantages of both chemometric analysis and spectral barcoding approach have been utilized in the present study. Taking the second derivative of the Raman spectra has minimized background variability and sensitivity to intensity fluctuations. Spectral conversion to the barcodes has further increased the quality of information obtained from Raman spectra and also made it possible to improve the visualization of the data. Converting Raman spectra of oils into barcodes enables simpler presentation of the valuable information, and still allows further analysis such as classification of vegetable oils and prediction of their major fatty acids with high accuracy. 相似文献
9.
Dye‐affinity adsorption is increasingly used for protein separation. Hollow‐fibres have advantages as adsorbents in comparison to conventional bead supports because they are not compressible and can eliminate internal diffusion limitations. The aim of this study was to explore in detail the performance of polyamide hollow‐fibres to which Reactive Green HE‐4BD was attached for adsorption of lysozyme. The hollow‐fibre was characterized by scanning electron microscopy. These dye‐carrying hollow‐fibres (26.3 µmol g?1) were used in the lysozyme adsorption–elution studies. The effect of initial concentration of lysozyme and medium pH on the adsorption efficiency of dye‐attached hollow‐fibres was studied in a batch system. The non‐specific adsorption of lysozyme on the polyamide hollow‐fibres was 1.8 mg g?1. Reactive Green HE‐4BD attachment significantly increased the lysozyme adsorption up to 41.1 mg g?1. Langmuir adsorption model was found to be applicable in interpreting lead adsorption by Reactive Green HE‐4BD attached hollow fibres. Significant amount of the adsorbed lysozyme (up to 95%) was eluted in 1 h in the elution medium containing 1.0 M NaSCN at pH 8.0. In order to determine the effects of adsorption conditions on possible conformational changes of lysozyme structure, fluorescence spectrophotometry was employed. We concluded that polyamide dye‐affinity hollow‐fibres can be applied for lysozyme adsorption without causing any significant conformational changes. Repeated adsorption–elution processes showed that these dye‐attached hollow‐fibres are suitable for lysozyme adsorption. © 2001 Society of Chemical Industry 相似文献
10.
The aim of this study was to show the hemocompatibility, cytotoxicity, and genotoxicity of nanocomposites that were synthesized with different molecular weights of poly(methyl methacrylate) (PMMA) and different concentrations of nanohydroxyapatite (nHAp). Different techniques to characterize the nanocomposites were used. The cytotoxicity and genotoxic effects of the polymers and nanocomposites on human lymphocytes were determined by acid phosphatase assay, viability test, and comet assay. Moreover, hemocompatibility test was performed. It was found that all of the PMMA/nHAp nanocomposites are highly hemocompatible and biocompatible, none of the nanocomposites showed a cytotoxic effect, and nHAp addition decreased the genotoxicity. 相似文献