Physiological Imaging Methods for Evaluating Response to Immunotherapies in Glioblastomas

Glioblastoma (GBM) is the most malignant brain tumor in adults, with a dismal prognosis despite aggressive multi-modal therapy. Immunotherapy is currently being evaluated as an alternate treatment modality for recurrent GBMs in clinical trials. These immunotherapeutic approaches harness the patient’s immune response to fight and eliminate tumor cells. Standard MR imaging is not adequate for response assessment to immunotherapy in GBM patients even after using refined response assessment criteria secondary to amplified immune response. Thus, there is an urgent need for the development of effective and alternative neuroimaging techniques for accurate response assessment. To this end, some groups have reported the potential of diffusion and perfusion MR imaging and amino acid-based positron emission tomography techniques in evaluating treatment response to different immunotherapeutic regimens in GBMs. The main goal of these techniques is to provide definitive metrics of treatment response at earlier time points for making informed decisions on future therapeutic interventions. This review provides an overview of available immunotherapeutic approaches used to treat GBMs. It discusses the limitations of conventional imaging and potential utilities of physiologic imaging techniques in the response assessment to immunotherapies. It also describes challenges associated with these imaging methods and potential solutions to avoid them.     

Strong convergence theorems for an infinite family of quasi-nonexpansive mappings and generalized equilibrium problems and variational inequality problems

In this paper, we introduce a new iterative scheme for finding a common element of the set of common fixed points of an infinite family of uniformly continuous quasi-nonexpansive mappings and the set of solutions to a generalized equilibrium problem and the set of solutions to a variational inequality problem in a real Hilbert space. We then prove strong convergence of the scheme to a common element of the three mentioned sets. Our results extend important recent results.     

Optimization of citrus peels D-limonene extraction using solvent-free microwave green technology

Attention is presently drawn to the development of a new and green alternative technique for the extraction of essential oil from citrus plant materials. This study was aimed at the extracting essential oil from orange and lemon peels using solvent-free microwave method. This process uses microwave-assisted hydro-diffusion technique to extract essential oil from citrus peels. Response surface methodology was used to investigate the effect of microwave power (200–1,000?W) and extraction time (10–40?min) on the essential oil yield. The oil extracted was characterized using Fourier transform infrared radiation (FTIR) and Gas chromatography–mass spectrometry analysis to determine the functional groups and chemical components present, respectively. The optimum yield of extract from orange and lemon peels were 3.7 and 2.0%, respectively at corresponding power of 1,000?W and time of 10?min. The analysis of variance results showed that the resulting models for both orange and lemon peels were significant and microwave power had greater influence on the extraction processes at both linear and quadratic levels. The FTIR analysis revealed prominent functional groups of alkenes that majorly constitute limonene compound at 1,642 and 1,643?cm^?1 for orange and lemon peels, respectively. The present process permits fast and efficient extraction, avoids water and solvent consumption, and allows substantial energy savings.     

Comparative physicochemical stability and efficacy study of lipoid S75-biopeptides nanoliposome composite produced by conventional and direct heating methods

Liposomes are used as effective nanodelivery devices to improve the physicochemical stability and biological efficacy of the encapsulated peptides and proteins. In this study, nanoliposome composite of lipoid S75-entrapped angiotensin I-converting enzyme (ACE)-inhibitory biopeptides was prepared by conventional (BLS75-CM) and direct heating (BLS75-DHM) methods. The nanoliposomes (BLS75-CM and BLS75-DHM) were stored at 4^°C for 8 weeks and evaluated for physicochemical stability in terms of particle size, polydispersity index (pdi), zeta potential, and encapsulation efficiency (EE). These were also studied for residual ACE-inhibitory efficacy following their digestion under simulated gastrointestinal tract condition. The BLS75-CM was found to maintain higher physicochemical stability in terms of particle size, pdi, and zeta potential compared to BLS75-DHM. However, the BLS75-DHM indicated higher EE and efficacy with greater residual ACE-inhibitory activity of 47.37% compared to 44.18% and 36.84% that were obtained for the digested BLS75-CM and digested biopeptides without encapsulation, respectively. In vitro release study showed a cumulative biopeptides release of 66.41% and 69.00% from BLS75-CM and BLS75-DHM, respectively. The results of transmission electron microscopy showed spherical appearance of the nanoliposome capsules while Fourier Transform Infrared spectroscopy indicated the presence of ionic complexation and hydrogen bonds between the biopeptides and their phospholipid matrix.     

Organic field-effect transistors as new paradigm for large-area molecular junctions

Self-Assembly Monolayers (SAMs) are considered a promising route for solving technological hindrances (such as bias-stress, contact resistance, charge trapping) affecting the electrical performances of the Organic Field-Effect Transistors (OFETs). Here we use an OFET based on pentacene thin film to investigate the charge transport across conjugated SAMs at the Au/pentacene interface. We synthesized a homolog series of π-conjugated molecules, termed Tn-C8-SH, consisting of a n-unit oligothienyl Tn (n = 1…4) bound to an octane-1-thiol (C8-SH) chain that self-assembles on the Au electrodes. The multi-parametric response of such devices yields an exponential behavior of the field-effect mobility (μ), current density (J), and total resistivity (R), due to the SAM at the charge injection interface (i.e. Au-SAM-pentacene). The surface treatment of the OFETs induces a clear stabilization of different parameters, like sub-threshold slope and threshold voltage, thanks to standardized steps in the fabrication process.     

New strong convergence method for the sum of two maximal monotone operators

Optimization and Engineering - This paper aims to obtain a strong convergence result for a Douglas–Rachford splitting method with inertial extrapolation step for finding a zero of the sum of...     

Construction programme management theory and practice: Contextual and pragmatic approach

The combination of the economic pressures, maturity and limitations of project management and the dynamic nature of the construction industry clients’ requirements has triggered the need for the adoption and implementation of programme management as a de facto means of aligning, coordinating and managing a portfolio of construction projects to deliver benefits that would not be achievable if the projects were managed independently. Despite the benefits achievable in the practice of programme management, the awareness and understanding of its practice in the construction industry remains vague as a result of a lack of clarity and inconsistencies associated with its definitions. To fully understand the core essence of programme management, it is imperative that its quintessential definition, practice and context are clearly understood and documented. This research is based on a pragmatic synthesis of literature review and industrial questionnaire survey which establishes the relationship, similarities and differences between programme management and project management and subsequently draws comparisons of the practices relevant to programmes between programme and non-programme organisations. The research further highlights the implications of unawareness and lack of understanding that can affect the effective implementation and practice of programme management in the UK construction environment.     

Background Radiation Measurement and the Assessment of Radiological Impacts due to Natural Radioactivity Around Itakpe Iron-Ore Mines

Mining activity and metal extraction processes have been identified as one of the major pathways through which natural radionuclides are accumulated in the terrestrial environment. Exposure to excessive radiation from natural radionuclides can cause deleterious health hazards to man. In this study therefore, the activity concentrations of primordial radionuclides (⁴⁰K, ²³⁸U and ²³²Th) were measured in rock, soil, tailings and water samples collected from abandoned iron ore mines in order to estimate the radiological impacts associated with the previous mining and metal extraction activities within the environment of abandoned Itakpe iron-ore mines. Gamma spectrometry utilizing a well calibrated NaI(Tl) detector was employed for the measurements. Results show that the average activity concentrations of ⁴⁰K, ²³⁸U and ²³²Th are 1084?±?581, 11.0?±?7.7 and 5.0?±?1.8 Bq kg^?1 respectively for rock samples and 415.6?±?197.5, 12.8?±?5.7 and 8.8?±?5.8 Bq kg^?1, respectively for soil samples. The activity concentrations of the three radionuclides are much lower in water samples compared to rocks and soil. Radiological hazard indices calculated from the activity concentrations show that the mining activities have little or no negative impacts on the environment as the radiological risk indices obtained are all lower than their permissible limits.     

Approximation of solutions of generalized equations of Hammerstein type

Let $H$ be a real Hilbert space. For each $i=1,2,\dots ,m$, let $F_i,K_i:H\to H$ be bounded and monotone mappings. Assume that the generalized Hammerstein equation $u+{\sum }_{i=1}^m{K}_i{F}_{i}u=0$ has a solution in $H$. We construct a new explicit iterative sequence and prove strong convergence of the sequence to a solution of the generalized Hammerstein equation.