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排序方式: 共有175条查询结果,搜索用时 31 毫秒
1.
Abidur Rahman Makoto Kobayashi Kotaro Sugimoto Yuta Endo Manabu Kojima Shigenori Furukawa Takafumi Watanabe Shu Soeda Yuko Hashimoto Keiya Fujimori Hideki Chiba 《International journal of molecular sciences》2021,22(7)
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Methods: We generated a monoclonal Ab (mAb) against human/mouse CLDN12 and verified its specificity. By performing immunohistochemical staining and semiquantification, we evaluated the relationship between CLDN12 expression and clinicopathological parameters in tissues from 138 cases of cervical cancer. Results: Western blot and immunohistochemical analyses revealed that the established mAb selectively recognized the CLDN12 protein. Twenty six of the 138 cases (18.8%) showed low CLDN12 expression, and the disease-specific survival (DSS) and recurrence-free survival rates were significantly decreased compared with those in the high CLDN12 expression group. We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively). Conclusions: It can be concluded that a reduced CLDN12 expression predicts a poor outcome for cervical cancer. The novel anti-CLDN12 mAb could be a valuable tool to evaluate the biological relevance of the CLDN12 expression in diverse cancer types and other diseases. 相似文献
2.
D. Xu T. Enoki T. Suemitsu Y. Umeda H. Yokoyama Y. Ishii 《Journal of Electronic Materials》1998,27(7):L51-L53
We have achieved a self-controlled asymmetrical etching in metalorganic chemical vapor deposition-grown InAlAs/InGaAs heterostructures,
which can be suitable for fabricating modulation-doped field-effect transistors (MODFETs) with gate-groove profiles for improved
performance. The technology is based on electrochemical etching phenomena, which can be effectively controlled by using different
surface metals for ohmic electrodes. When surface metals of Pt and Ni are deposited on the source and the drain, respectively,
the higher electrode potential of Pt results in slower etching on the source side than on the drain side. Thus, asymmetry
of gate grooves can be formed by wet-chemical etching with citric-acid-based etchant. This represents a new possibility to
conduct “recess engineering” for InAlAs/InGaAs MODFETs. 相似文献
3.
Tetsuya Suemitsu Yoshino K. Fukai Hiroki Sugiyama Kazuo Watanabe Haruki Yokoyama 《Microelectronics Reliability》2002,42(1):47-52
The reliability of InP-based HEMTs is studied, focussing on how it is affected by the doped layer material and gate recess structure. Bias-and-temperature stress tests reveal that fluorine-induced donor passivation in the recess region, formed adjacent to the gate electrode, causes the source resistance (Rs) to increase at large drain bias voltages. The increase in Rs can be prevented by using InP or InAlP as the carrier supply layer material instead of InAlAs. On the other hand, the increase in the drain resistance (Rd) does not depend on the material of the carrier supply layer, which suggests that a mechanism different from that in the case of Rs should be considered. It is also found that a deep gate recess suppresses the increase in Rd after long-term stressing. 相似文献
4.
The absorption spectrum of poly(3-alkylthiophene) gel changes drastically in association with a volume instability upon changing the solvent composition and also the temperature. In the expanded state in chloroform and at high temperature, the photoluminescence is much enhanced compared with the shrunken state in ethanol and at low temperature. This gel chromism and anomalous luminescence are discussed in terms of the change of effective conjugation length induced by the steric hindrance and the dynamics of the photoexcited species. 相似文献
5.
We observed change in distance between two droplets in each step after application of large multi-step shear strains. Experiments were performed using a sliding plate apparatus. Large step shear strains were applied to two polyisobutylene droplets in poly(dimethyl siloxane) matrix in the same plane between the plates. The distance between the two droplets decreases with increasing the total shear strain, which is given by the product of the step strain magnitude and the number of application of the step strains. The two droplets coalesce when the distance becomes less than the diameter of the droplets. The slope for plots of the distance versus the total strain is independent of the step strain magnitude. This indicates that the effect per unit strain on the distance is the same, irrespective of the strain magnitude. It is suggested that a stronger hydrodynamic interaction between the droplets is the main cause for the droplet approach. 相似文献
6.
Shigenori Egusa 《Journal of Materials Science》1988,23(8):2753-2760
Four kinds of polymer matrix composites (filler, E-glass or carbon fibre cloth; matrix, epoxy or polyimide resin) and pure epoxy and polyimide resins were irradiated with 60Co -rays or 2 MeV electrons at room temperature. Mechanical tests were then carried out at 77 K and at room temperature. Following irradiation, the Young's (tensile) modulus of these composites and pure resins remains practically unchanged even at 170 MGy for both test temperatures. The ultimate strength, however, decreases appreciably with increasing dose. The dose dependence of the composite strength depends not only on the combination of fibre and matrix in the composite but also on the test temperature. A relationship is found between the composite ultimate strain and the matrix ultimate strain, thus indicating that the dose dependence of the composite strength is virtually determined by a change in the matrix ultimate strain due to irradiation. Based on this finding, we propose a mechanism of radiation-induced degradation of a polymer matrix composite in order to explain the dose dependence of the composite strength measured at 77 K and at room temperature. 相似文献
7.
Hiroya Oka Yuji Maruki Haruo Suemitsu Takami Matsuo 《International Journal of Control, Automation and Systems》2016,14(5):1270-1279
In this paper, we deal with the control method for rotational movements of a pendulum using a separatrix. We design a controller that attains a homoclinic motion or a heteroclinic motion of the pendulum and the asymptotic stability of the cart by using a kind of forwarding control design. First, we derive a controller that converges to a homoclinic orbit via a Lyapunov function of the pendulum subsystem. Next, we give a nonlinear stabilizing controller via another Lyapunov function of the cart subsystem. Moreover, using the third Lyapunov function and adding a complementary control input, we guarantee that the pendulum converges to the homoclinic orbit and the cart is stabilized. Finally, the simulation and the experiment using the rapid controller prototyping system based on MATLAB/Simulink are performed to demonstrate the forward upward circling and the giant swing of the pendulum. 相似文献
8.
Shigenori Okubo 《国际自动化与计算杂志》2009,6(2):186-191
In this paper, we propose a new state predictive model following control system (MFCS). The considered system has linear time delays. With the MFCS method, we obtain a simple input control law. The bounded property of the internal states for the control is given and the utility of this control design is guaranteed. Finally, an example is given to illustrate the effectiveness of the proposed method. 相似文献
9.
10.
Yan Liu Shigenori Mitsushima Ken-ichiro Ota Nobuyuki Kamiya 《Electrochimica acta》2006,51(28):6503-6509
The electro-oxidation of dimethyl ether (DME) on PtMe/Cs (Me = Ru, Sn, Mo, Cr, Ni, Co, and W) and Pt/C electro-catalysts were investigated in an aqueous half-cell, and compared to the methanol oxidation. The addition of a second metal enhanced the tolerance of Pt to the poisonous species during the DME oxidation reaction (DOR). The PtRu/C electro-catalyst showed the best electro-catalytic activity and the highest tolerance to the poisonous species in the low over-potential range (<0.55 V, 50 °C) among the binary electro-catalysts and the Pt/C, but at the higher potential (>ca. 0.55 V, 50 °C), the Pt/C behaved better than PtRu/C. The apparent activation energy for the DOR decreased in the order: PtRu/C (57 kJ mol−1) > Pt3Sn/C (48 kJ mol−1) ≈ Pt/C (46 kJ mol−1). On the other hand, the activation energy for the MOR showed a different turn, decreased in the following order: Pt/C (43 kJ mol−1) > Pt3Sn/C (35 kJ mol−1) ≈ PtRu/C (34 kJ mol−1). The temperature dependence of the DOR was greater than that of the oxidation of methanol (MOR) on the PtRu/C. 相似文献