Paediatric gastro-oesophageal reflux: prognostic indicators from pH monitoring

The original diagnostic 24 hour pH monitoring data in 57 children with gastro-oesophageal reflux (GOR) were retrospectively reviewed after a minimum of one year follow up. The tracings of children who responded to medical treatment were compared with those who failed to respond and required a fundoplication. Children with GOR secondary to oesophageal atresia/tracheo-oesophageal fistula and neurological conditions (n = 12) were analysed separately from those with primary GOR (n = 45). Children with primary GOR requiring a fundoplication (n = 9) had increased daytime reflux. The percentage time pH < 4 was the best discriminator (21% v 7%) with a threshold of 18% giving a 92% specificity and a 70% sensitivity. For children with secondary GOR the percentage time pH < 4 at night was significantly higher (29% v 3.7%) in those requiring a fundoplication (n = 5). A threshold of 18% gave an 80% specificity and an 86% sensitivity. These results show that both daytime and night time pH monitoring data can be of prognostic value in different subgroups of children with GOR. A percentage time pH < 4 of greater than 18% was a useful threshold to apply when evaluating the pH monitoring data.     

Effect of near-critical swirl on the Burke-Schumann reaction sheet

The influence of swirl on the shape of the Burke-Schumann reaction sheet in a straight cylindrical pipe is investigated by asymptotic and numerical means. Attention is confined to swirl levels that are near the critical value at which vortex breakdown occurs. A high-Reynolds-number, laminar, isothermal, low-Mach-number reacting flow is considered. An asymptotic analysis is developed to study the nonlinear interaction between near-critical swirl and mixture fraction distribution within the flow. It is first shown that leading-order perturbation of the velocity field from the columnar state, generated by the interaction of near-critical swirl and low viscosity, can be described by a nonlinear reduced-order model. This flow perturbation is computed, and then employed to determine the correction to the classical Burke-Schumann solution. Under lean conditions of reaction the reaction sheet becomes shorter and more compact as swirl is increased. For rich conditions of reaction, increasing swirl first causes the reaction-sheet length to decrease, and then increase after vortex breakdown has appeared. Numerical simulations of the flow and reaction-zone shape are substantiated by, and supplement, the asymptotic results.     

Robust H∞ stabilization via parametrized Lyapunovbounds

The parametrized Lyapunov bounding technique of Haddad and Bernstein (1991, 1993, 1995) is extended to include an H_∞ -disturbance attenuation constraint. The results presented in this paper provide a framework for designing fixed-order (i.e., full- and reduced-order) controllers that guarantee robust H₂ and H_∞ performance in the presence of structured constant real parameter variations in the state space model     

Robust controller synthesis via shifted parameter-dependentquadratic cost bounds

Parameterized Lyapunov bounds and shifted quadratic guaranteed cost bounds are merged to develop shifted parameter-dependent quadratic cost bounds for robust stability and robust performance. Robust fixed-order (i.e., full- and reduced-order) controllers are developed based on new shifted parameter-dependent bounding functions. A numerical example is presented to demonstrate the effectiveness of the proposed approach     

Effects of partial hydrogenation, epoxidation, and hydroxylation on the fuel properties of fatty acid methyl esters

The properties of biodiesel depend on the chemical structure of individual fatty acid methyl esters (FAME). In this work the chemical structure of fatty acid chains was modified by catalytic hydrogenation, epoxidation and hydroxylation under controlled conditions. Hydrolysis of ester functionality or oxidation of fatty acid chain was not observed during these reactions. The properties of hydrogenated FAME strongly depend on the hydrogenation time. The total saturated fatty acid (SFA) percentage increased from 29.3% to 76.2% after 2 h of hydrogenation. This hydrogenated FAME showed higher oxidation stability and higher cetane number but poor cold flow properties. Formation of trans FAME was observed during hydrogenation. Both hydroxylation and epoxidation resulted in a decrease of unsaturated fatty acid methyl ester (UFA) fraction. The percentages of total unsaturated FAME decreased 39% in the epoxidation reaction and 44% in the hydroxylation reaction. The addition of hydroxyl groups to the unsaturated regions of the fatty acid chain yields biodiesel with better cold flow properties, increased lubricity and slightly increased oxidative stability. However, epoxy FAME shows some interesting properties such as higher oxidation stability, higher cetane number and acceptable cold flow properties, which met the limits of ASTM D6751 biodiesel specifications.     

Performance and durability of a generator set CI engine using synthetic and petroleum based fuels for military applications

The long term performance and durability evaluation of a compression ignition (CI) engine of a diesel power generator using ultra-low sulfur diesel (ULSD) and Synthetic Paraffinic Kerosene, (S-8) fuels have been investigated under military specifications. The brake specific fuel consumptions (BSFC) were 0.308 ± 0.013 and 0.267 ± 0.019 kg/kW-h for ULSD and S-8, respectively. The corresponding brake thermal efficiencies (BTE) were 0.287 ± 0.002 and 0.309 ± 0.005. Degradation of engine performance or engine part wear was not observed during these test periods. Analysis of lubricating oil suggests negligible engine part wear. The frequency and power output of the generator, however, were not as stable with S-8 as those with ULSD. These power and frequency instabilities can be attributed to higher volatility and lower density and viscosity of S-8, all of which affect the fuel injection characteristics.     

Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats

Guggul tree or Commiphora mukul is a small thorny herb having remarkable hypocholesterolaemic properties. Its therapeutic effects are because of its biocomponent guggulsterones, especially guggulsterone E and Z. In this research, double emulsion‐based spread was tried to improve the bioavailability of the herb guggul in in vivo rat model. The effect of the different diets with encapsulated and nonencapsulated guggul was evaluated and compared after 6 weeks, based on the final body weight and analysis of organs, serum and faeces of normal and hypercholesterolaemic (H) rats. It was evident from the results that double emulsion‐encapsulated guggul showed better control on weight of H rats (25.98% lower), inhibition of HMG CoA reductase (3.95 times less) activity and reduction in atherosclerotic index (47.2%), as compared to diet with unencapsulated guggul. Encapsulation of guggul also improved faecal excretion of bile acids, lipids and total cholesterol in H and normal rats.     

Probiotic properties of folate producing Streptococcus thermophilus strains

This study aimed at assessing the probiotic potential of two high folate producing Streptococcus thermophilus strains (RD102 and RD104) isolated from Indian fermented milk products by both in vitro and in vivo tests. These strains were able to survive at pH 2.5 and 2% bile with a good bile salt hydrolase activity, cell surface hydrophobicity and sensitivity to most of the clinically important antibiotics. On evaluation for gastrointestinal transit tolerance these showed a viable count of 5 log cfu mL^?1 and 7 log cfu mL^?1, respectively in simulated gastrointestinal juice of pH 2.0 and 2% bile. During the in vivo feeding trial in mice the strains showed a viable count of about 7 log cfu g^?1 faeces and 6 log cfu g^?1 of large intestine, respectively. These strains were hence observed to possess favorable strain specific probiotic properties and have the potential to be a source of novel probiotics.     

Whole grains and resistant starch rich,reduced‐calorie biscuit diet as a hypoglycaemic,hypolipidaemic and insulin stimulator in streptozotocin‐induced diabetic rats

A fibre‐enriched, reduced‐calorie biscuit [formulated biscuit (FB)] was evaluated for its antidiabetic and antilipidaemic potential in streptozotocin‐induced diabetes in Wistar rats against control biscuit (CB) having high calorie and low fibre content. Animals were allocated into five groups: a control group fed with synthetic diet, two diabetes‐induced groups (CBD and FBD) and two nondiabetic groups (CBND and FBND). CBD and CBND were fed with synthetic diet + CB while FBD and FBND were fed with synthetic diet + FB. After 6 weeks of feeding, the change in weight of nondiabetic group fed with FB (+16.20%) was nonsignificantly lower compared to control (+33.01%) and CB‐fed (+34.55%) group. Nonsignificant loss in body weight was observed among diabetic group fed with FB (?11.76%) or CB (?36.88%). Feeding of FB led to a significant decrease in fasting and postprandial blood glucose levels, total cholesterol, triglycerides, LDL‐C, VLDL‐C and atherosclerotic index and increase the HDL‐C. Histological examination showed that feeding of FB was able to partially recover the destroyed β‐cell in STZ‐induced diabetic rats.     

A periodic fixed-structure approach to multirate control

We develop an approach to designing reduced-order multirate controllers. A discrete-time model that accounts for the multirate timing sequence of measurements is presented and is shown to have periodically time-varying dynamics. Using discrete-time stability theory, the optimal projection approach to fixed-order (i.e. full- and reduced-order) dynamic compensation is generalized to obtain reduced-order periodic controllers that account for the multirate architecture. It is shown that the optimal reduced-order controller is characterized by means of a periodically time-varying system of equations consisting of coupled Riccati and Lyapunov equations. In addition, the multirate static output-feedback control problem is considered. For both problems, the design equations are presented in a concise, unified manner to facilitate their accessibility for developing numerical algorithms for practical applications