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排序方式: 共有410条查询结果,搜索用时 15 毫秒
1.
Mie Kurosawa Yosuke Shikama Masae Furukawa Rieko Arakaki Naozumi Ishimaru Kenji Matsushita 《International journal of molecular sciences》2021,22(5)
Immunosenescence is characterized by age-associated changes in immunological functions. Although age- and autoimmune-related sialadenitis cause dry mouth (xerostomia), the roles of immunosenescence and cellular senescence in the pathogenesis of sialadenitis remain unknown. We demonstrated that acquired immune cells rather than innate immune cells infiltrated the salivary glands (SG) of aged mice. An analysis of isolated epithelial cells from SG revealed that the expression levels of the chemokine CXCL13 were elevated in aged mice. Senescence-associated T cells (SA-Ts), which secrete large amounts of atypical pro-inflammatory cytokines, are involved in the pathogenesis of metabolic disorders and autoimmune diseases. The present results showed that SA-Ts and B cells, which express the CXCL13 receptor CXCR5, accumulated in the SG of aged mice, particularly females. CD4+ T cells derived from aged mice exhibited stronger in vitro migratory activity toward CXCL13 than those from young mice. In a mouse model of Sjögren’s syndrome (SS), SA-Ts also accumulated in SG, presumably via CXCL12-CXCR4 signaling. Collectively, the present results indicate that SA-Ts accumulate in SG, contribute to the pathogenesis of age- and SS-related sialadenitis by up-regulating chemokines in epithelial cells, and have potential as therapeutic targets for the treatment of xerostomia caused by these types of sialadenitis. 相似文献
2.
3.
Cold-rolling texture and partially recrystallized texture of polycrystalline 3 pct Si-Fe were investigated using high-resolution
electron backscattered diffraction (EBSD) method. From the measurement on a deformed grain with {211}〈011〉∼{111}〈011〉 orientations,
deformation bands with {12 4 1}〈014〉 orientation were found. It turned out that the orientation rotation relationship between
deformation bands and surrounding deformed grain can be explained by the activation of the slip system, which has a common
slip plane with an adjacent grain. Oriented nucleation of recrystallized grains with {12 4 1}〈014〉 orientation was observed
in a deformed grain with {211}〈011〉∼{111}〈011〉 orientation. Exactly the same orientation relationship that was observed between
deformed grain and the deformation bands was also observed between the deformed grain and the recrystallized grain. A hypothesis
that recrystallization nuclei are generated directly from the deformation bands formed by an activation of the slip system
that has a common slip plane of neighboring deformed grains was proposed from the present experimental results. 相似文献
4.
A high-speed bilevel reproduction algorithm, called modified error diffusion (MED) algorithm, has been developed to provide high-quality halftoning images for continuous tone images and has been implemented in a CMOS LSI chip. The chip has been designed with standard-cell 1.5-μm CMOS technology using an optimum layout design. The chip has achieved a maximum processing speed of 60 ns/pixel 相似文献
5.
The microporous polypropylene sheets were prepared by biaxially stretching polypropylene sheets containing CaCO3 filler (particle size, 0.08–3.0 μm), when the CaCO3 filler content was 59% by weight and the stretching ratio was 2.8 × 1.8. The microstructure of the sheets were investigated in relation to the CaCO3 particle size by a N2 gas permeation method. (1) Effective porosity increases with decreasing mean particle size of filler. (2) The tortuosity factor of the pore is in the range of 25–40 and becomes relatively smaller with decreasing mean particle size of filler. (3) The equivalent pore size becomes relatively smaller with decreasing mean particle size of filler. 相似文献
6.
7.
Takashi Kato Tadahiro Kurosawa Takashi Nakamura 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》2002,480(2-3):571-590
A simple phenomenological analysis using the moving source model has been performed on the neutron energy spectra produced by bombarding thick targets with high energy heavy ions which have been systematically measured at the Heavy-Ion Medical Accelerator (HIMAC) facility (located in Chiba, Japan) of the National Institute of Radiological Sciences (NIRS). For the bombardment of both heavy ions and protons in the energy region of 100–500 MeV per nucleon, the moving source model incorporating the knock-on process could be generally successful in reproducing the measured neutron spectra within a factor of two margin of accuracy. This phenomenological analytical equation is expressed having several parameters as functions of atomic number Zp, mass number Ap, energy per nucleon Ep for projectile, and atomic number ZT, mass number AT for target. By inputting these basic data for projectile and target into this equation we can easily estimate the secondary neutron energy spectra at an emission angle of 0–90° for bombardment with heavy ions and protons in the aforementioned energy region. This method will be quite useful to estimate the neutron source term in the neutron shielding design of high energy proton and heavy ion accelerators. 相似文献
8.
Eiichi Haginomori Kenji Yoshimura Shunichi Kobayashi Sadanori Kaneko Takeshi Yokota Masayuki Ishikawa 《Electrical Engineering in Japan》1994,114(4):50-61
To cope with the high rate of increase of power demand in the main industrialized districts in Japan, 550-kV transmission systems covering the districts have been reinforced, with most of the main power plants connected directly to these systems. Through 550-/300-kV substations, the majority of power to the districts is supplied by 300-kV systems. To limit the excess short-circuit capacity in the 300-kV systems, they tend to be reconstructed as so-called radial networks. In radial networks with high short-circuit capacity and relatively small number of transmission lines connected to the substation busbars, the rate of rise of TRV can be far higher than standard value. This paper analyzes the transient recovery voltages (TRV) in such extra-high-voltage radial networks in Japan, together with the relevant stresses to circuit-breakers during fault clearings. Future system conditions have also been introduced. As the typical rate of rise of the TRV values, more than twice that of today's standard ones are probable. 相似文献
9.
Shunichi Hasegawa Takahiro Nishiwaki Hitoe Habuchi Shoji Nitta Shuichi Nonomura 《Fullerenes, Nanotubes and Carbon Nanostructures》1995,3(3):313-325
The CPM spectra of fullerene films was measured to obtain the below gap absorption. The optical energy gap Eo was obtained by using the Tauc's plots. Eo did not change greatly with intercalated impurities. The absorption due to intercalated impurities was found below 1.6eV. 相似文献
10.
Kurosawa T 《Applied optics》1986,25(21):3816-3824
The relative changes in refractive index of the amplifying medium in a waveguide CO2 laser have been measured as a function of the inlet and outlet pressures, discharge current, gas flow rate, and intracavity power using an interferometric technique. The experiments have been made for two gas mixing ratios over a wide range of the inlet pressure. Saturated phenomena of the refractive index have been observed for increasing inlet pressure. The output power and the variation in impedance of the amplifying medium have been simultaneously measured. The dependence of the refractive index on the inlet pressure in the absence of the discharge, the electron density, and the estimation of errors in measurements are discussed. 相似文献