Preparation and surface- active properties of polyoxyethylene-glycol (600) monoesters of fatty acids

Polyoxyethyleneglycol (PEG-600) monoesters of undecylenic, lauric, myristic, palmitic, stearic, oleic, ricinoleic and 12-hydroxystearic acids were prepared in 80-85% yield by reacting PEG with boric acid, esterifying the resultant borate with fatty acid, and selectively hydrolyzing the borate ester; their surface active properties were evaluated. Increase in acyl chain length increased the surface tension. The presence of a double bond or hydroxyl group in C₁₈ series improved the wetting and emulsifying proper-ties. Unsaturation in the fatty acid chain reduced the foaming power.     

Intelligent actor mobility in wireless sensor and actor networks

In wireless sensor and actor network research, the commonly used mobility models for a mobile actor are random walk model, random waypoint mobility model, or variants thereof. For a fully connected network, the choice of mobility model for the actor is not critical because, there is at least one assured path from the sensor nodes to the actor node. But, for a sparsely connected network where information cannot propagate beyond a cluster, random movement of the actor may not be the best choice to maximize event detection and subsequent action. This paper presents static and dynamic intelligent mobility models that are based on the inherent clusters’ information of a sparsely connected network. Simulation results validate the idea behind the intelligent mobility models and provide insights into the applicability of these mobility models in different application scenarios.     

更大温度范围的钽电容器

汽车电子应用不断增多,从驾驶室娱乐、安全气囊、ABS到发动机.它们各自由于在车内位置不同而要求不同,由此对工作温度、过程电压和可靠性提出了多种要求.     

Characteristics and composition of indian wood apple seed and oil

Indian wood apple seed (Feronia elephantum Correa) constituting 6% (dry weight basis) of the fruit, contains 34% oil and 28% protein. The kernel comprises 62% of the seed. The oil is yellow with an iodine value 131, saponification value 192, unsaponifiable matter 1%. Fatty acid profile of oil by GLC is: palmitic 19.3, stearic 7.3, oleic 27.2, linoleic 19.8 and linolenic 26.4%.     

Empirical evaluation of the delivery risk of extended supply chains

The rise in global sourcing has led to extended supply chains. Extended supply chains generally have more mode changes, border crossings, rail classification yards, port congestion and so forth, that all lead to more delivery disruption risk. To test this assertion, we perform an empirical assessment of the inbound supply chain disruption risk at a major manufacturer that imports components from over three dozen different countries. Although delivery disruption risk can be mitigated with effort, we observe that delivery disruption risk increases with distance. Based on industrial data, we quantify the increase in delivery disruption with international versus domestic suppliers and intercontinental versus continental suppliers.     

Separation and identification of isomeric conjugated fatty acids by high-performance liquid chromatography with photodiode array detection

A simple, high-performance liquid chromatographic method is described for the separation of tetraenoic, trienoic and dienoic conjugated fatty acids on a Zorbax ODS reversed-phase column using acetonitrile/tetrahydrofuran (95∶5, vol/vol) at a flow rate of 1.2 mL/min as mobile phase. Also described is the separation of the isomeric conjugated fatty acids with acetonitrile/water/tetrahydrofuran (90∶90∶1, by vol) as mobile phase. The simultaneous detection and identification of the separated geometrical isomers in the eluant was accomplished using photodiode array detection.     

Changes in fatty acids during maturation of Coriandrum sativum seeds

Changes in fatty acids were studied during maturation ofCoriandrum sativumseeds. The seeds matured in 50 days after flowering. Lipid synthesis proceeded at a steady rate up to 40 days after flowering. Reductive ozonolysis of the monoenes followed by gas liquid Chromatographic analysis of the aldehydic fragments as dioxolanes of 1,3-propanediol was employed to estimate petroselenate (octadeca-cis-6-enoate) in the presence of oleate (octadeca-cis-9-enoate). Petroselenic acid was the major fatty acid at all stages.     

Effects of Subtoxic Concentrations of Atrazine,Cypermethrin, and Vinclozolin on microRNA-Mediated PI3K/Akt/mTOR Signaling in SH-SY5Y Cells

Endocrine-disrupting chemicals (EDCs) are different natural and synthetic chemicals that may interfere with several mechanisms of the endocrine system producing adverse developmental, metabolic, reproductive, and neurological effects in both human beings and wildlife. Among pesticides, numerous chemicals have been identified as EDCs. MicroRNAs (miRNAs) can regulate gene expression, making fine adjustments in mRNA abundance and regulating proteostasis. We hypothesized that exposure to low doses of atrazine, cypermethrin, and vinclozolin may lead to effects on miRNA expression in SH-SY5Y cells. In particular, the exposure of SH-SY5Y cells to subtoxic concentrations of vinclozolin is able to downregulate miR-29b-3p expression leading to the increase in the related gene expression of ADAM12 and CDK6, which may promote a pro-oncogenic response through the activation of the PI3K/Akt/mTOR pathway and counteracting p53 activity. A better understanding of the molecular mechanisms of EDCs could provide important insight into their role in human disease.     

Single-Cell Analysis to Better Understand the Mechanisms Involved in MS

Multiple sclerosis is a chronic and inflammatory disease of the central nervous system. Although this disease is widely studied, many of the precise mechanisms involved are still not well known. Numerous studies currently focusing on multiple sclerosis highlight the involvement of many major immune cell subsets, such as CD4+ T cells, CD8+ T cells and more recently B cells. However, our vision of its pathology has remained too broad to allow the proper use of targeted therapeutics. This past decade, new technologies have emerged, enabling deeper research into the different cell subsets at the single-cell level both in the periphery and in the central nervous system. These technologies could allow us to identify new cell populations involved in the disease process and new therapeutic targets. In this review, we briefly introduce the major single-cell technologies currently used in studies before diving into the major findings from the multiple sclerosis research from the past 5 years. We focus on results that were obtained using single-cell technologies to study immune cells and cells from the central nervous system.