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1.
H. R. Spiegel J. Juilfs U. Neubert K. J. Euler J. W. Beck D. Besdo H. Winter H. Becker W. Neuberger R. Jung K. Herfort H. Bühler H. Göppl H. W. Hahnemann W. Siegel 《Forschung im Ingenieurwesen》1970,36(2):64-68
Ohne Zusammenfassung
VDI 相似文献
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In this report we present for the first time strong evidence for autosomal-dominant inheritance of grant liver hemangiomas. Furthermore, we review the current literature about incidence, pathogenesis, clinics, as well as diagnostic and therapeutic aspects of LH. A large family of Italian origin is described where three female patients in three successive generations suffered from large symptomatic LH. In addition, two other female relatives exhibited asymptomatic LH on sonographic scans. The restriction of the disease to the female gender could be explained by a sex-dependent difference in penetrance or expressivity of a presumable "liver-hemangioma" gene, or by known proliferative factors such as female sex hormones. We also observed an increased incidence of adenomas of the thyroidea among members with or without LH of the presented family. This uncommon familial association has also not yet been described and its genetic aspects are discussed. 相似文献
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Sphingolipid metabolism and cell growth regulation 总被引:2,自引:0,他引:2
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Leber’s Hereditary Optic Neuropathy (LHON) is the most common primary mitochondrial DNA disorder. It is characterized by bilateral severe central subacute vision loss due to specific loss of Retinal Ganglion Cells and their axons. Historically, treatment options have been quite limited, but ongoing clinical trials show promise, with significant advances being made in the testing of free radical scavengers and gene therapy. In this review, we summarize management strategies and rational of treatment based on current insights from molecular research. This includes preventative recommendations for unaffected genetic carriers, current medical and supportive treatments for those affected, and emerging evidence for future potential therapeutics. 相似文献
6.
Mouchtaris A. Van der Spiegel J. Mueller P. 《IEEE transactions on audio, speech, and language processing》2006,14(3):952-963
The objective of voice conversion algorithms is to modify the speech by a particular source speaker so that it sounds as if spoken by a different target speaker. Current conversion algorithms employ a training procedure, during which the same utterances spoken by both the source and target speakers are needed for deriving the desired conversion parameters. Such a (parallel) corpus, is often difficult or impossible to collect. Here, we propose an algorithm that relaxes this constraint, i.e., the training corpus does not necessarily contain the same utterances from both speakers. The proposed algorithm is based on speaker adaptation techniques, adapting the conversion parameters derived for a particular pair of speakers to a different pair, for which only a nonparallel corpus is available. We show that adaptation reduces the error obtained when simply applying the conversion parameters of one pair of speakers to another by a factor that can reach 30%. A speaker identification measure is also employed that more insightfully portrays the importance of adaptation, while listening tests confirm the success of our method. Both the objective and subjective tests employed, demonstrate that the proposed algorithm achieves comparable results with the ideal case when a parallel corpus is available. 相似文献
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Jie Yuan Ning Song Nabil Farhat Jan Van der Spiegel 《Analog Integrated Circuits and Signal Processing》2009,59(3):287-300
The clustering of spatio-temporal patterns are essential for many applications. Established from the biological analogy of
the cortex, the parametrically coupled logistic map network (PCLMN) provides a viable solution to the clustering problem.
To engineer for a single-chip spatio-temporal pattern clustering system, the highly modular PCLMN is designed in analog circuit.
In this paper, the 0.6 μm 5 V CMOS design of the processing element is presented. The analog design employs self-calibration
techniques to improve the accuracy and robustness of the nonlinear circuits. A fabricated element covers a die area of 0.55
mm2, and consumes 240 mW power at 5 V supply. After calibration, simulation and testing results show that the element fulfills
the system-level requirement of the Cort-X model for driving signals up to 1 MHz. 相似文献
10.
Hill Clara E.; Helms Janet E.; Spiegel Sharon B.; Tichenor Victoria 《Canadian Metallurgical Quarterly》1988,35(1):27
We developed a measure of client reactions to therapist interventions. The 21 categories of the measure were divided into 14 positive and 7 negative reactions, which differed significantly from each other on client helpfulness ratings. Preliminary validity data indicated that therapist intentions were related to client reactions more for successful cases than unsuccessful cases, pretreatment symptomatology was highly predictive of which reactions the clients reported, there were some predictable changes in reactions across time in treatment, and within-case correlations of reactions with client-rated session depth and smoothness indicated some similarities across cases. We discuss the case-specific nature of client reactions, methodological issues, and the need for greater therapist awareness of client reactions. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献