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1.
Sushama Mishra B K Mishra D K Chokappa D O Shah C Manohar 《Bulletin of Materials Science》1994,17(6):1103-1108
It is conjectured that anionic-cationic surfactant combination can be regarded as equivalent to a double chain surfactant
and using molecular packing considerations it is shown that vesicles, viscoelastic solutions and liquid crystals can be designed
by the proper choice of chain lengths of the pair. Using these concepts new systems are designed, from mixtures of cetyltrimethyl
ammonium bromide and sodium alkyl sulfonates, to produce both viscoelastic gels and vesicles. 相似文献
2.
Sushama Gomare Hyun A. Kim Jeong Hyub Ha Min Woo Lee Jong Moon Park 《Korean Journal of Chemical Engineering》2011,28(5):1252-1259
This study was conducted to isolate microorganisms from the gut of the marine turban shell, Batillus cornutus, which inhabits the mainland of South Korea and primarily feeds on brown algae. We were interested in isolating such gut
bacteria by considering their potential to produce the polysaccharidases required for digestion of brown seaweeds and isolated
three different bacteria from the gut of Batillus cornutus. The isolated bacteria were identified as Bacillus sp. JMP-A, Bacillus sp. JMP-B and Staphylococcus sp. JMP-C. The organisms were evaluated for their ability to produce polysaccharidases such as cellulase, alginate lyase,
laminarinase and kelp-lyase. Bacillus sp. JMP-A and Bacillus sp. JMP-B showed a clear zone of CMC hydrolysis with a radius 1.10 (±0.057) and 3.88 cm (±0.088), respectively, whereas Staphylococcus sp. JMP-C showed no zone of CMC hydrolysis. SEM analysis confirmed that the ability of the bacterial isolates to degrade
kelp differs and is correlated with kelp-lyase production. The cell free extract of the Bacillus sp. JMP-A isolate showed the highest activities of CM-cellulase, α-cellulase, laminarinase and kelp-lyase, which were 22.76, 27.10, 66.59 and 64.36 U/mg, respectively. Meanwhile, the amount
of sugars released was higher during the saccharification of kelp by dialyzed intracellular enzymes of the bacterial isolates
than when dialyzed extracellular enzyme was used. Experimental results of dialyzed enzymatic saccharification of the kelp
demonstrated that use of partially purified enzymes was effective for glucose production. 相似文献
3.
Shaheen Sultana Sushama Talegaonkar Raisuddin Ali Gaurav Mittal Aseem Bhatnagar Farhan J. Ahmad 《Powder Technology》2011,211(1):1-9
The purpose of this research work was to formulate and evaluate alpha ketoglutarate nanoparticles as dry powder inhaler for treatment of cyanide poisoning. Non-polymeric particles were prepared by nano-precipitation technique using various stabilizers. Selection of co-solvent and stabilizer was a key to produce stabilized particles. A combination of lutrol F68 and PVA as a crystal growth inhibitor seems to be best in achieving minimum particle size of 110.2 nm. On the basis of preliminary trials a Box-Behnken statistical design was employed to study the effect of independent variables, drug concentration (X1), stirring speed (X2), stirring time (X3), PVA concentration (X4), poloxomer concentration (X5) and volume of co-solvent (X6) on average particle size. Particle size varied from 110 to 875 nm depending upon the significant terms. Optimized formulation was predicted at drug concentration (50 μg/ml), stirring speed (640 rpm), stirring time (1 min), PVA concentration (1%), poloxomer concentration (1.69%) and volume of co-solvent (30 ml) with 104.6% experimental validity. The nanosized particles were further characterized by X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), Nuclear Magnetic Resonance (NMR) and Fourier Transform Infrared Spectroscopy (FT-IR) analysis. The results of particle characterization indicate that there was no physical disparity when compared with the commercial α-KG sample. 相似文献
4.
5.
Shaheen Sultana Sushma Talegaonkar Bhaskar Ray Harvinder Singh F. J. Ahmad Gaurav Mittal 《Drug development and industrial pharmacy》2018,44(7):1171-1184
Introduction: In this study, different nifedipine-loaded formulations were prepared to treat pylorospasm, a sphincter muscle disorder characterized by delayed gastric emptying process. The efficacy of formulation was evaluated in patients by subjective assessment, gamma scintigraphic approaches, and confocal microscopy.Methods: Nifedipine-loaded different formulations such as sucrose bead, pellets, and microparticles (slugging method, ionotropic gelation, and chemical denaturation) were designed. The studies were performed on 50 subjects, of which 30 subjects were treated with optimized nifedipine loaded microcapsules while 20 subjects were given capsule becosule-Z as a control. The efficacy of formulation was assessed by comparing symptoms like dyspepsia, abdominal pain, abdominal fullness, poor appetite, nausea, vomiting, and irregular motion. The effectiveness of formulation was also assessed by gamma scintigraphic studies by determining the rate of emptying of a radioactivity labeled standard meal from patients’ stomach into the duodenum. Confocal microscopy was used to assess targeting potential of developed formulation.Results: Drug-loaded alginate-chitosan microcapsules were found to be satisfactory, in terms of controlled drug release, surface morphology, and bioadhesive properties and thus selected for in vivo studies. Clinical studies revealed the efficacy of formulation in abolishing various GI symptoms at high altitude. Associated symptoms such as dyspepsia, abdominal pain, poor appetite, nausea, vomiting, and irregular motion were recovered by 75, 62, 76.5, 86.7, 85.7, and 37.5%, respectively in nifedipine-treated patients. In comparison, 73.7, 40, 33.3, 40, 20, and 0% recoveries were observed in patients given control treatment only. Gamma Scintigraphic studies in lab also revealed 2.425?±?0.245 (p?.05) times improvement in gastric emptying rate in patients with diabetic gastroparesis. Confocal analysis showed better targeting and penetration in pyloric region when formulation was administered in form of high-density microcapsules.Conclusions: Results strongly suggest that nifedipine loaded mucoadhesive formulation has a targeting potential which accelerates gastric emptying process in gastroparesis patients, and thus the formulation might prove useful as a potent prokinetic agent. 相似文献
6.
Gamma radiation inactivation of phytohemagglutinin (PHA) of red kidney bean in purified form as well as in seeds in different moisture conditions was demonstrated at different doses viz. 1, 10, 30, 50, 100 and 200 kGy. Irradiation of PHA in dry state (99.5% dry) or in 50% moisture condition showed structural intactness as studied by SDS–PAGE, size exclusion chromatography (SEC), fluorescence measurement, CD spectroscopy below 30 kGy, while a 50% reduction in hemagglutinin and mitogenic activity was observed in the dose range of 30–50 kGy. Radiation inactivation of purified PHA was more pronounced when irradiated in aqueous solution form resulting in complete destruction of secondary and tertiary structure as well as function at a dose of 10 kGy. Radiation processing of dry and soaked seeds of kidney bean exhibited 50% loss in functional activity of PHA at the doses of 50 and 30 kGy, respectively. Practicality of implication of the radiation processing for inactivation of this antinutrient in legume seeds is discussed. 相似文献
7.
Jyoti M. Ghushe Sushama M. Giripunje Subhash B. Kondawar 《Journal of Inorganic and Organometallic Polymers and Materials》2016,26(2):370-375
The n-type vertically aligned metal doped ZnO nanorods (NRs) and p-type proton acid doped polyaniline (PANI) inorganic/organic heterojunction diodes have been fabricated. Aluminium (Al) and iron (Fe) doped ZnO NRs were grown on seed ZnO layer on fluorine doped tin oxide coated glass substrates by high temperature chemical bath deposition method. The elemental analysis using EDAX confirm doping of Al and Fe in ZnO. The morphology of doped ZnO nanorods and ZnO/PANI heterojunction exhibit well defined uniform nanorod arrays and interface between nanorods and polyaniline matrix respectively. The dark current–voltage curves confirmed the rectifying diode like behaviors of the heterojunctions, whereas under illumination, the junction revealed good sensitivity to UV and visible range with increased current densities. The highest ideality factor and lowest barrier height was found for FeZnO/PANI heterojunction under dark and under light compared to that of ZnO/PANI, AlZnO/PANI. This research is innovative with respect to low cost synthesis of efficient and sensitive hybrid p–n junction diodes and possibly serves as the building blocks for future optoelectronic applications. 相似文献
8.
Sushama R. Deasi Lyod V. Allen Jr. Robert B. Greenwood M. L. Stiles Donald Parker 《Drug development and industrial pharmacy》1989,15(5):671-689
Various prednisone (Pd), griseofulvin (Gr), and primidone (Pr) solid dispersions mady by the fusion method utilizing diffent carriers and drug: carrier ratios were evaluated. Citric acid (CA), succinic acid (SA) and tartaric acid (TA) were employed in various ratios with sodium bicarbonate (SB) as carriers for the respective drugs.
CA:SB was the most effective carrier for releasing Pd and Pr, and SA:SB was found to be the best carrier for Gr. Results showed that there was an increase in in dissolution rate as the proportion of SB increased in the carrier system. 相似文献
CA:SB was the most effective carrier for releasing Pd and Pr, and SA:SB was found to be the best carrier for Gr. Results showed that there was an increase in in dissolution rate as the proportion of SB increased in the carrier system. 相似文献
9.
Shirshendu Dey Sushama Pethkar Suguna D. Adyanthaya Murali Sastry C. V. Dharmadhikari 《Bulletin of Materials Science》2008,31(3):309-312
A new methodology to anchor λ-DNA to silanized n-Si(111) surface using Langmuir Blodget trough was developed. The n-Si (111) was silanized by treating it with low molecular weight octyltrichlorosilane in toluene. Scanning tunneling microscopy
(STM) image of λ-DNA on octyltrichlorosilane deposited Si substrate shows areas exhibiting arrayed structures of 700 nm length and 40 nm spacing.
Scanning tunneling spectroscopy (STS) at different stages depict a broad distribution of defect states in the bandgap region
of n-Si(111) which presumably facilitates tunneling through otherwise insulating DNA layer. 相似文献
10.
Sanjib Mondal Chiranjib Ghosh S.M.M. Dhar Dwivedi Anupam Ghosh Sushama Sushama Subhananda Chakrabarti Aniruddha Mondal 《Ceramics International》2021,47(10):14879-14891
Glancing angle deposition (GLAD) was employed to synthesise plasmonic Silver (Ag) nanoparticles (NPs) on the chemically prepared Erbium-doped Titanium dioxide (Er:TiO2) thin films (TFs). The impact of using Ag NPs on the morphological, optical, and electrical aspects of Er:TiO2 TFs were sequentially analysed. From the field emission scanning electron microscopy (FESEM) image, the Ag NPs appeared spherical and uniformly distributed on the Er:TiO2 TFs. The size (diameter) of the maximum number of Ag NPs was ~15 nm (calculated from FESEM image). Energy dispersive X-ray (EDX) spectra assured the presence of Ag NPs on the TFs. X-ray diffraction (XRD) pattern for Ag NPs decorated Er:TiO2 TFs closely resembled the face centred cubic crystal structure of Ag NPs and body centred tetragonal Ag–O compound. The optical spectroscopy (UV–visible diffuse reflectance and photoluminescence) elucidated that the absorption of light was significantly enhanced in the UV–visible spectral range for the TFs in which Ag NPs were sandwiched between Er:TiO2 TF layers (Er:TiO2/Ag NPs/Er:TiO2). The Schottky contact-based Au/Er:TiO2/Si photodetector (PD) and Au/Er:TiO2/Ag NPs/Er:TiO2/Si (plasmonic) PD were constructed. The plasmonic PD offered a better photo-responsivity of ~4.5 fold higher as compared to Er:TiO2 TF-based PD upon 380 nm illumination under ?6 V bias. An increase in detectivity and a decrease in noise equivalent power was observed for the plasmonic device compared to Er:TiO2 device in the UV region. A theoretical approach had been adopted to calculate the wavelength-dependent responsivity for both devices. Further, the important parameters like photoconductive gain, electron transit time and electron mobility were calculated by simulating the experimental responsivity curves of the devices. These parameters exhibited improvement in the UV regime for the plasmonic PD. The fast temporal response with short rise and decay time proves the excellent efficiency of the plasmonic UV PD. 相似文献