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1.
Comparative characterization of particle emissions from asbestos and non-asbestos cement roof slates
Prasauskas Tadas Martuzevicius Dainius Krugly Edvinas Kliucininkas Linas Kireitseu Maksim Zerrath Axel 《Building and Environment》2011
The first aim of this study was to characterise total and size-fractionated particulate matter (PM) aerosol, including fibres, released from the processing operations of cement roofing slates. The second aim was to compare particle emissions from asbestos-cement and non-asbestos cement sheets, with respect to total and size-fractionated particulate matter as well as fibres emissions. Asbestos and cellulose-based cement sheets were compared during slate treatment processes, namely crushing, rubbing, rasping and scrubbing. Generated PM and fibres were classified by a variety of methods (PM2.5 and PM10 cyclones, aerodynamic particle spectrometer and optical particle counter). A substantial variation in the mass of generated particles has been noticed, both within each PM fraction and between different treatment processes. The PM10/PMtotal concentration ratio ranged from 70 to 98% and PM2.5/PMtotal ratio equalled to ∼20%. The new generation non-asbestos sheets produced three times higher PM emissions than asbestos-cement sheets during crushing operation. Particle size distribution of number concentrations was mostly bimodal (two modes at 0.5 and 2.5 μm). With respect to fibres, the release of cellulose fibres from non-asbestos slates was from 1.8 to 13 times lower in comparison with asbestos fibres. At the same time, cellulose fibre length was 1.4–1.6 times lower. Hence, new generation non-asbestos roofing slates were proved to be less hazardous from the point of view of fibre release, but more hazardous with respect to total particle release. 相似文献
2.
Rokas Lukosevicius Simonas Juzenas Violeta Salteniene Ugne Kulokiene Justina Arstikyte Georg Hemmrich-Stanisak Andre Franke Alexander Link Paulius Ruzgys Saulius Satkauskas Henrikas Pauzas Tadas Latkauskas Gediminas Kiudelis Francesc Balaguer Juozas Kupcinskas Jurgita Skieceviciene 《International journal of molecular sciences》2022,23(4)
Regulatory changes occurring early in colorectal cancer development remain poorly investigated. Since the majority of cases develop from polyps in the adenoma-carcinoma transition, a search of early molecular features, such as aberrations in miRNA expression occurring prior to cancer development, would enable identification of potentially causal, rather than consequential, candidates in the progression of polyp to cancer. In the current study, by employing small RNA-seq profiling of colon biopsy samples, we described differentially expressed miRNAs and their isoforms in the adenoma-carcinoma transition. Analysis of healthy-adenoma-carcinoma sequence in an independent validation group enabled us to identify early deregulated miRNAs including hsa-miR-1246 and hsa-miR-215-5p, the expressions of which are, respectively, gradually increasing and decreasing. Loss-of-function experiments revealed that inhibition of hsa-miR-1246 lead to reduced cell viability, colony formation, and migration rate, thereby indicating an oncogenic effect of this miRNA in vitro. Subsequent western blot and luciferase reporter assay provided evidence of hsa-miR-1246 being involved in the regulation of target AXIN2 and CFTR genes’ expression. To conclude, the present study revealed possible involvement of hsa-miR-1246 in early colorectal cancer development and regulation of tumor suppressors AXIN2 and CFTR. 相似文献
3.
Tadas Malinauskas Ingrida Vilionskiene Juozas V Grazulevicius Vytautas Getautis Jose A Reina Jonas Sidaravicius 《Polymer International》2008,57(10):1159-1164
BACKGROUND: Carbazole derivatives are well known to exhibit interesting electro‐ and photo‐active properties due to their hole‐transporting ability, strong absorption in the ultraviolet spectral region and blue‐light emission. One of the most widely studied materials among carbazole‐containing oligomers is poly[9‐(2,3‐epoxypropyl)carbazole] (PEPK). The main field of application of this oligomer is electrophotographic microfilming. It is also used for the manufacture of multicolour slides and in the photothermoplastic recording of information. Unfortunately, due to its high ionization potential, which reaches 5.86 eV, the possibilities of application of this compound in optoelectronic devices are rather limited. RESULTS: PEPK‐based charge transporting oligomers, incorporating hydrazone moieties, are reported. The oligomers were prepared by chemical modification of PEPK. The materials obtained were examined using various techniques including differential scanning calorimetry and ultraviolet, infrared and NMR spectroscopy. Electron photoemission spectra of layers of the synthesized oligomers showed ionization potentials (Ip) in the range 5.4–5.5 eV. CONCLUSION: The synthesized oligomers possess a larger π‐conjugated system and show ionization potentials of ca 5.4 eV. Therefore, they are more suitable for use in optoelectronic devices with quicker photoresponse than unmodified PEPK. Copyright © 2008 Society of Chemical Industry 相似文献
4.
Kvar C. L. Black Tadas S. Sileika Ji Yi Ran Zhang José G. Rivera Phillip B. Messersmith 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(1):169-178
Illumination of noble metal nanoparticles at the plasmon resonance causes substantial heat generation, and the transient and highly localized temperature increases that result from this energy conversion can be exploited for photothermal therapy by plasmonically heating gold nanorods (NRs) bound to cell surfaces. Here, plasmonic heating is used for the first time to locally release silver from gold core/silver shell (Au@Ag) NRs targeted to bacterial cell walls. A novel biomimetic method of preparing Au@Ag core–shell NRs is employed, involving deposition of a thin organic polydopamine (PD) primer onto Au NR surfaces, followed by spontaneous electroless silver metallization, and conjugation of antibacterial antibodies and passivating polymers for targeting to gram‐negative and gram‐positive bacteria. Dramatic cytotoxicity of S. epidermidis and E. coli cells targeted with Au@Ag NRs is observed upon exposure to light as a result of the combined antibacterial effects of plasmonic heating and silver release. The antibacterial effect is much greater than with either plasmonic heating or silver alone, implying a strong therapeutic synergy between cell‐targeted plasmonic heating and the associated silver release upon irradiation. The findings suggest a potential antibacterial use of Au@Ag NRs when coupled with light irradiation, which has not been previously described. 相似文献
5.
Buividas R Rosa L Sliupas R Kudrius T Slekys G Datsyuk V Juodkazis S 《Nanotechnology》2011,22(5):055304
The mechanism of the fine ripples, perpendicular to laser polarization, on the surface of (semi)transparent materials with period smaller than the vacuum wavelength, λ, of the incident radiation is proposed and experimentally validated. The sphere-to-plane transformation of nanoplasma bubbles responsible for the in-bulk ripples accounts for the fine ripples on the surface of dielectrics and semiconductors. The mechanism is demonstrated for 4H:SiC and sapphire surfaces using 800 nm/150 fs and 1030 nm/300 fs laser pulses. The ripples are pinned to the smallest possible standing wave cavity inside material of refractive index n. This defines the corresponding period, Λ = (λ/n)/2, of a light standing wave with intensity, E(2), at the maxima of which surface ablation occurs. The mechanism accounts for the fine ripples at the breakdown conditions. Comparison with ripples recorded on different materials and via other mechanisms using femtosecond pulses is presented and application potential is discussed. 相似文献
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7.
Liuliu Du Virpi Leivo Tadas Prasauskas Martin Tubel Dainius Martuzevicius Ulla Haverinen‐Shaughnessy 《Indoor air》2019,29(4):686-697
We assessed 45 multifamily buildings (240 apartments) from Finland and 20 (96 apartments) from Lithuania, out of which 37 buildings in Finland and 15 buildings in Lithuania underwent energy retrofits. Building characteristics, retrofit activities, and energy consumption data were collected, and Indoor Air Quality (IAQ) parameters, including carbon monoxide (CO), nitrogen dioxide (NO2), formaldehyde (CH2O), selected volatile organic compounds (benzene, toluene, ethylbenzene, and xylenes (BTEX), radon, and microbial content in settled dust were measured before and after the retrofits. After the retrofits, heating energy consumption decreased by an average of 24% and 49% in Finnish and Lithuanian buildings, respectively. After the retrofits of Finnish buildings, there was a significant increase in BTEX concentrations (estimated mean increase of 2.5 µg/m3), whereas significant reductions were seen in fungal (0.6‐log reduction in cells/m2/d) and bacterial (0.6‐log reduction in gram‐positive and 0.9‐log reduction in gram‐negative bacterial cells/m2/d) concentrations. In Lithuanian buildings, radon concentrations were significantly increased (estimated mean increase of 13.8 Bq/m3) after the retrofits. Mechanical ventilation was associated with significantly lower CH2O concentrations in Finnish buildings. The results and recommendations presented in this paper can inform building retrofit studies and other programs and policies aimed to improve indoor environment and health. 相似文献
8.
King Hang Aaron Lau Tadas S. Sileika Sung Hyun Park Ana M.L. Sousa Patrick Burch Igal Szleifer Phillip B. Messersmith 《Advanced Materials Interfaces》2015,2(1)
Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N‐substituted glycine) “peptoids” are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platform for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent attention, and a targeted library of zwitterionic peptoid brushes with different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwitterionic brush designs are found to give rise to distinct but subtle differences in properties. The results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes. 相似文献
9.
Zachery R. Reichert Tadas Kasputis Srinivas Nallandhighal Sophia M. Abusamra Amy Kasputis Saloni Haruray Yugang Wang Shamara Williams Udit Singhal Ajjai Alva Frank C. Cackowski Megan E. V. Caram Phillip L. Palmbos Sarah E. Yentz David C. Smith Joshi J. Alumkal Todd M. Morgan 《International journal of molecular sciences》2022,23(1)
The substantial biological heterogeneity of metastatic prostate cancer has hindered the development of personalized therapeutic approaches. Therefore, it is difficult to predict the course of metastatic hormone-sensitive prostate cancer (mHSPC), with some men remaining on first-line androgen deprivation therapy (ADT) for several years while others progress more rapidly. Improving our ability to risk-stratify patients would allow for the optimization of systemic therapies and support the development of stratified prospective clinical trials focused on patients likely to have the greatest potential benefit. Here, we applied a liquid biopsy approach to identify clinically relevant, blood-based prognostic biomarkers in patients with mHSPC. Gene expression indicating the presence of CTCs was greater in CHAARTED high-volume (HV) patients (52% CTChigh) than in low-volume (LV) patients (23% CTChigh; * p = 0.03). HV disease (p = 0.005, q = 0.033) and CTC presence at baseline prior to treatment initiation (p = 0.008, q = 0.033) were found to be independently associated with the risk of nonresponse at 7 months. The pooled gene expression from CTCs of pre-ADT samples found AR, DSG2, KLK3, MDK, and PCA3 as genes predictive of nonresponse. These observations support the utility of liquid biomarker approaches to identify patients with poor initial response. This approach could facilitate more precise treatment intensification in the highest risk patients. 相似文献
10.
Giedrė Bubniene Tadas Malinauskas Vytautas Getautis Albina Stanisauskaite Vygintas Jankauskas Jonas Sidaravicius 《Synthetic Metals》2008
The synthesis and properties of amorphous hole-transporting 4,4′-bis[11-carbazol-9-yl)-6,8,10-tri(carbazol-9-methyl)-3-hydroxy-5,7,9-trioxa-1-thia]thiobisbenzene with two end and six pendant carbazolyl moieties, separated from the main chain by CH2 spacers, is reported. It was prepared by a multistep synthesis route from 1,6-di(carbazol-9-yl)-5-(carbazol-9-methyl)-4-oxa-2-hexanol glycidyl ether. Glass transition temperatures of intermediate and final products established by differential scanning calorimetry are reported. The hole drift mobility, measured by the time of flight technique, in this well defined molecular glass depends little on the strength of the electric field and exceeds 10−5 cm2 V−1 s−1. The ionization potentials measured by electron photoemission method, light absorption and fluorescence spectra are closed to those reported for the other organic photoconductors containing electronically isolated carbazole moieties. 相似文献