Mediastinal space-occupying lesion with reduced perfusion of the left lung. Thoracic aortic aneurysm with compression of the left pulmonary artery

CONTEXT: An increase in the recreational use of personal watercraft (PWC) raises concern about an increase in associated injuries on a national level. OBJECTIVE: To estimate the relative frequency, types of injury, and demographic features of persons injured while using PWC in the United States. DESIGN: Case series. SETTING: Emergency department (ED) visits to hospitals participating a national probability sample. PARTICIPANTS: All persons treated for PWC-related injury from January 1,1990, through December 31, 1995. RESULTS: An estimated 32954 persons (95% confidence interval [CI], 22919-42989) with PWC-related injuries were treated in US hospital EDs, of which 3.5% were hospitalized. Personal watercraft-related injuries have increased significantly from an estimated 2860 in 1990 to more than 12000 in 1995. During this period, the number of PWC in operation increased 3-fold from approximately 241500 in 1990 to an estimated 760000 in 1995. The most prevalent diagnoses were lacerations, contusions, and fractures. MAIN OUTCOME MEASURES: The estimated number and percentage of patients treated in EDs for PWC-related injuries, by year, age, sex, and the number and rate per 1000 of PWC in operation by year. CONCLUSIONS: Since 1990, there has been at least a 4-fold increase in injuries associated with an increase in the recreational use of PWC. The rate of ED-treated injuries related to PWC was about 8.5 times higher (95% CI, 8.2-8.8; 1992 data) than the rate of those from motorboats. Specific training and adult supervision is recommended for minors using PWC. Furthermore, medical practitioners should encourage personal flotation device use and other protection for their patients who are known water enthusiasts.     

Query language-based inverses of schema mappings: semantics, computation, and closure properties

The inversion of schema mappings has been identified as one of the fundamental operators for the development of a general framework for metadata management. During the last few years, three alternative notions of inversion for schema mappings have been proposed (Fagin-inverse (Fagin, TODS 32(4), 25:1–25:53, 2007), quasi-inverse (Fagin et?al., TODS 33(2), 11:1–11:52, 2008), and maximum recovery (Arenas et?al., TODS 34(4), 22:1–22:48, 2009)). However, these notions lack some fundamental properties that limit their practical applicability: most of them are expressed in languages including features that are difficult to use in practice, some of these inverses are not guaranteed to exist for mappings specified with source-to-target tuple-generating dependencies (st-tgds), and it has been futile to search for a meaningful mapping language that is closed under any of these notions of inverse. In this paper, we develop a framework for the inversion of schema mappings that fulfills all of the above requirements. It is based on the notion of ${\mathcal{C}}$ -maximum recovery, for a query language ${\mathcal{C}}$ , a notion designed to generate inverse mappings that recover back only the information that can be retrieved with queries in ${\mathcal{C}}$ . By focusing on the language of conjunctive queries (CQ), we are able to find a mapping language that contains the class of st-tgds, is closed under CQ-maximum recovery, and for which the chase procedure can be used to exchange data efficiently. Furthermore, we show that our choices of inverse notion and mapping language are optimal, in the sense that choosing a more expressive inverse operator or mapping language causes the loss of these properties.     

Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past,Present and Future Applications

The integrin αIIbβ3 is the most abundant integrin on platelets. Upon platelet activation, the integrin changes its conformation (inside-out signalling) and outside-in signalling takes place leading to platelet spreading, platelet aggregation and thrombus formation. Bloodsucking parasites such as mosquitoes, leeches and ticks express anticoagulant and antiplatelet proteins, which represent major sources of lead compounds for the development of useful therapeutic agents for the treatment of haemostatic disorders or cardiovascular diseases. In addition to hematophagous parasites, snakes also possess anticoagulant and antiplatelet proteins in their salivary glands. Two snake venom proteins have been developed into two antiplatelet drugs that are currently used in the clinic. The group of proteins discussed in this review are disintegrins, low molecular weight integrin-binding cysteine-rich proteins, found in snakes, ticks, leeches, worms and horseflies. Finally, we highlight various oral antagonists, which have been tested in clinical trials but were discontinued due to an increase in mortality. No new αIIbβ3 inhibitors are developed since the approval of current platelet antagonists, and structure-function analysis of exogenous disintegrins could help find platelet antagonists with fewer adverse side effects.     

Uric Acid: The Sperm-Release Pheromone of the Marine Polychaete Platynereis dumerilii

In the marine polychaete, Platynereis dumerilii, reproductive behavior in the two sexes is synchronized by the consecutive discharge of male and female sex-specific pheromones. After the female releases the eggs into the free water column, immediate fertilization is achieved by several males circling around the eggs emitting sperm clouds. We report the isolation and identification of the sperm-release pheromone present in the coelomic fluid of sexually mature females. Each step in isolation was guided by bioassay. Isolation methods included extraction and solvent partitioning and separation methods included ultrafiltration and high-performance liquid chromatography. Uric acid was identified as the sperm-release pheromone that is discharged by the female with release of the eggs. The threshold concentration for sperm release by males was determined as 0.6 M.     

Ultraviolet photodetectors and readout based on a-IGZO semiconductor technology

In this work, real-time ultraviolet photodetectors are realized through metal–semiconductor–metal (MSM) structures. Amorphous indium gallium zinc oxide (a-IGZO) is used as semiconductor material and gold as metal electrodes. The readout of an individual sensor is implemented by a transimpedance amplifier (TIA) consisting of an all-enhancement a-IGZO thin-film transistor (TFT) operational amplifier and a switched capacitor (SC) as feedback resistance. The photosensor and the transimpedance amplifier are both manufactured on glass substrates. The measured photosensor possesses a high responsivity R , a low response time t _{R E S} , and a good noise equivalent power value NEP .     

Low retaining force optical viewport seal

We report on the experimental realization of an ultrahigh vacuum (UHV) indium sealing between a conflat knife edge and an optical window. The sealing requires a very low clamping force and thus allows for the use of very thin and fragile windows.     

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Semi‐Solid Processing of Metal Alloys

Semi‐solid metal casting is an innovative technology for the production of near‐net‐shape parts with demanding mechanical properties. The paper describes different processing routes and materials for semi‐solid‐metal casting (SSM), which have been investigated and also partially developed at the Foundry‐Institute of Aachen University. The standard thixocasting process for aluminium, highly reactive magnesium alloys and steel alloys with high melting points was investigated under variation of a wide range of process parameters. Specially adapted pre‐material production and reheating methods were developed for different materials and their application and future potential is pointed out. The thixocasting experiments were executed on a modified high pressure die‐casting machine with a specially designed “step‐die” providing wall thicknesses from 0.5 to 25 mm. The mechanical properties were tested in dependence of the wall thickness and the metal velocity. The results of these examination show high tensile strength values in combination with very good elongations. The rheocasting process is a new SSM‐forming method with liquid melt as feed‐stock and a high recycling potential. The research results of RCP‐technology (Rheo‐Container‐Process) invented at the Foundry‐Institute and of the Cooling‐Channel‐Process for aluminium and magnesium alloys are promising and are presented in this paper. Studies on semi‐solid processing of magnesium alloys and mixtures of them were conducted by Thixomolding^TM. To establish the most adequate process parameters, the temperature and the mixture relations were varied. Using a mould for tensile test specimens, the mechanical properties and the microstructure evolution could be evaluated. The chemical composition of the different phases was determined using SEM and EDX technologies. Evaluations of the flowing properties were conducted using a spiral mould with a total length of 2m and a cross section of 20mm x 1.5mm.     

Microstructural and microwave dielectric properties of LZT (Li2ZnTi3O8) ceramics sintered in presence of bismuth borate glass for LTCC applications

In the present research, the Li₂ZnTi₃O₈(LZT) ceramics were synthesized throughout solid-state ceramic processing, then mixed with bismuth borate (BiBO) glass prepared based on conventional melt quenching method. Wetting behavior of BiBO glass on the LZT ceramic substrate was monitored by hot stage microscopy. Afterward, dielectric LZT ceramics containing different amounts of BiBO glass (0.25–6 wt%) were sintered at various temperatures. X-ray diffraction and electron back scatter diffraction examinations revealed the presence of two crystalline phases of Li₂ZnTi₃O₈ and Bi₂Ti₂O₇. The maximum value of relative density (above 95%) was obtained in the case of specimens contained more than 5 wt% glass. The microwave dielectric properties of the finally sintered BiBO glass containing LZT ceramics were as follows: dielectric constant (ε_r) = 21.44–25.09, quality factor (Q × f) = 10839–54708 GHz and temperature coefficient of resonant frequency (τ_f) = (? 15.58) ? (? 12.86)ppm/°C.