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1.
Viktoria M. S. Kjær Loukas Ieremias Dr. Viktorija Daugvilaite Dr. Michael Lückmann Prof. Thomas M. Frimurer Prof. Trond Ulven Prof. Mette M. Rosenkilde Dr. Jon Våbenø 《ChemMedChem》2021,16(17):2623-2627
The G protein-coupled receptor GPR183/EBI2, which is activated by oxysterols, is a therapeutic target for inflammatory and metabolic diseases where both antagonists and agonists are of potential interest. Using the piperazine diamide core of the known GPR183 antagonist (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one (NIBR189) as starting point, we identified and sourced 79 structurally related compounds that were commercially available. In vitro screening of this compound collection using a Ca2+ mobilization assay resulted in the identification of 10 compounds with agonist properties. To enable establishment of initial structure-activity relationship trends, these were supplemented with five in-house compounds, two of which were also shown to be GPR183 agonists. Taken together, our findings suggest that the agonist activity of this compound series is dictated by the substitution pattern of one of the two distal phenyl rings, which functions as a molecular efficacy-switch. 相似文献
2.
Asbjørn Solheim Sverre Rolseth Egil Skybakmoen Lisbet Støen Åsmund Sterten Trond Støre 《Metallurgical and Materials Transactions B》1996,27(5):739-744
Temperatures for primary crystallization of Na3AlF6 in multicomponent electrolyte systems of interest for the aluminum electrolysis process were determined by thermal analysis. The results are presented as binary and quasibinary diagrams and discussed in view of the literature data. An empirical equation describing liquidus temperatures for primary crystallization of Na3AlF6 was derived: $$\begin{gathered} t/(^\circ C) = 1011 + 0.50[AlF_3 ] - 0.13[AIF_3 ] - \frac{{3.45[CaF_2 ]}}{{1 + 0.0173[CaF_2 ]}} \hfill \\ + 0.124[CaF_2 ] \cdot [AlF_3 ] - 0.00542([CaF_2 ] \cdot [AlF_3 ])^{1.5} \hfill \\ - \frac{{7.93[Al_2 O_3 ]}}{{1 + 0.0936[Al_2 O_3 ] - 0.0017[Al_2 O_3 ]^2 - 0.0023[AlF_3 ] \cdot [Al_2 O_3 ]}} \hfill \\ - \frac{{8.90[LiF]}}{{1 + 0.0047[LiF] + 0.0010[AlF3]^2 }} - 3.95[MgF_2 ] - 3.95 \hfill \\ \end{gathered} $$ wheret is the temperature in degree Celsius and the square brackets denote the weight percent of components in the system Na3AlF6-AlF3-CaF2-Al2O3-LiF-MgF2-KF. The composition limitations are [AlF3] ≈ [CaF2] ≈ [LiF] < 20 wt pct, [MgF2] ≈ [KF] < 5 wt pct, and [A12O3] up to saturation. 相似文献
3.
Trond Haga 《AI & Society》2009,23(1):17-31
Incremental change and innovation are often regarded as two separate concepts, with some interconnections. Based on two practical
cases that emphasize respectively incremental change and innovation, the article discusses whether a division between these
concepts can be maintained. Action research is seen as having a central role, offering an integral working method in industrial
networks.
相似文献
Trond HagaEmail: |
4.
Maria João Cardoso Anca Ioana Nicolau Daniela Borda Line Nielsen Rui Leandro Maia Trond Møretrø Vânia Ferreira Susanne Knøchel Solveig Langsrud Paula Teixeira 《Comprehensive Reviews in Food Science and Food Safety》2021,20(3):2716-2741
Nontyphoidal salmonellae are among the most prevalent foodborne pathogens causing gastrointestinal infections worldwide. A high number of cases and outbreaks of salmonellosis are associated with the consumption of eggs and egg products, and several of these occur at the household level. The aim of the current study is to critically evaluate the current status of knowledge on Salmonella in eggs from a consumer's perspective, analyzing the hazard occurrence and the good practices that should be applied to reduce salmonellosis risk. Following a HACCP (Hazard Analysis and Critical Control Point) based approach, some steps along the food journey were identified as Critical Consumer Handling (CCH)—steps in which consumers, through their behavior or choice, can significantly reduce the level of Salmonella in eggs and egg products. From shopping/collecting to consumption, each of these steps is discussed in this review to provide an evidence-based overview of risk factors of human salmonellosis related to egg consumption. The main message to consumers is to choose Salmonella-free eggs (those that some official entity or producer guarantees that does not contain Salmonella), when available, especially for dishes that are not fully heat treated. Second, as guaranteed Salmonella-free eggs are only available in a few countries, refrigerated storage from the point of collection and proper cooking will significantly reduce the risk of salmonellosis. This will require a revision of the actual recommendations/regulations, as not all ensure that eggs are maintained at temperatures that prevent growth of Salmonella from collection until the time of purchasing. 相似文献
5.
Partha Majumdar Andrey Chernykh Hanzhen Bao Elizabeth Crowley Mingqiang Zhang James Bahr Michael Weisz Chad Ulven Tingting Zhou Robert B. Moore Bret J. Chisholm 《Polymer Engineering and Science》2014,54(7):1648-1663
An array of perfectly alternating polycarbonate‐polydimethylsiloxane (PC‐PDMS) multiblock copolymers possessing systematic variations in block molecular weights were successfully produced by coupling preformed PC and PDMS telechelic oligomers using hydrosilylation. Based on gel permeation chromatography results, the multiblock copolymers were essentially void of the oligomeric precursors. Despite the relatively large difference in solubility parameter between PC and PDMS, the multiblock copolymers exhibited significant partial miscibility between the two phases. As expected, the degree of partial miscibility was dependent on the molecular weight of the blocks with the extent of partial miscibility increasing with decreasing block molecular weights. Morphological characterization using small angle X‐ray scattering showed that, at a given PC block molecular weight, the uniformity of the two phase morphology increased with increasing PDMS block molecular weight, which is consistent with a decrease in the extent of phase mixing with increasing PDMS block molecular weight. POLYM. ENG. SCI., 54:1648–1663, 2014. © 2013 Society of Plastics Engineers 相似文献
6.
Recycling carbon fiber composites using microwave irradiation: Reinforcement study of the recycled fiber in new composites
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Long Jiang Chad A. Ulven David Gutschmidt Michael Anderson Sloan Balo Mitchell Lee Jacob Vigness 《应用聚合物科学杂志》2015,132(41)
With increasing use of carbon fiber reinforced polymer (CFRP) composites in transportation, sports, and many other industries, recycling of the scrap and end‐of‐life composites has presented both great challenges and opportunities. In this work, we report our study on reclaiming carbon fibers from CFRP using energy efficient microwave irradiation. Different irradiation conditions were used and the optimal conditions were determined based on the surface morphology of the recycled fiber. Polypropylene (PP) and Nylon, representing nonpolar and polar polymers, respectively, were reinforced using the recycled fiber through extrusion and injection molding. For comparison, PP and Nylon reinforced by virgin carbon fiber were also prepared using the same processing conditions. Tensile, flexural, and impact test results showed that, while both carbon fibers could improve these properties, they exhibited different reinforcing effects on the two polymers. The recycled fiber outperformed the virgin fiber in reinforcing PP whereas the virgin fiber performed better in Nylon. This was due to the differences in surface roughness, surface bonding, and fiber aspect ratio between the two fibers. This study shows the great potential of recycled carbon fiber and microwave irradiation as an effective recycling technique. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42658. 相似文献
7.
Nataliya A. Mishchuk Trond Heldal Tormod Volden Janko Auerswald Helmut Knapp 《Microfluidics and nanofluidics》2011,11(6):675-684
A micropump based on strong polarization of ion-exchange beads and corresponding actuation by electroosmosis of the second
kind was designed and fabricated. Experimental results from operation with AC and DC voltage showed a close to second order
relationship between flow and voltage, in good agreement with theory. The difference between experimental and theoretical
flow rates and pressures is attributed to the hydrodynamic resistance of the channel network. A modified pump design which
should yield higher flow rates and pressures was suggested. 相似文献
8.
Trond Nordfjærn Özlem Şimşekoğlu Hans Brende Lind Stig Halvard Jørgensen Torbjørn Rundmo 《Accident; analysis and prevention》2014
There is currently scant research on the role of transport priorities, risk perception and worry for travel mode use and preferences. The present study aims to examine these factors in relation to mode use and preferences among Norwegian commuters. A web-based survey was conducted in a randomly obtained representative sample of daily commuters in the extended greater Oslo area (n = 690). The results showed that those who prioritized efficiency and flexibility tended to commute by car, while those who prioritized safety and comfort used public (e.g. metro, tram, and train) or active (e.g. walking and cycling) transport. In a free choice scenario, the respondents who prioritized flexibility reported a preference for using a car, whereas those who prioritized safety and comfort preferred public and active transport for their commuter travels. Risk perception of high impact events, such as terrorism and major accidents, as well as risk perception related to personal impact risks (theft, violence etc.) were related to car use on commuter travels. Transport-related worry exerted weak influences on mode use and preferences. Increased speed on rail transport and more frequent departures may be effective in reducing car use on commuter travels. Risk communication should focus on highlighting the low risk of experiencing security and safety issues in the public transport sector, and this message should be complemented by efforts to reduce the probability of negative events affecting public transport. 相似文献
9.
Different patterns of biofilm formation in Staphylococcus aureus under food-related stress conditions 总被引:5,自引:0,他引:5
Rode TM Langsrud S Holck A Møretrø T 《International journal of food microbiology》2007,116(3):372-383
Staphylococcus aureus and its biofilm formation are recognized as a serious clinical problem. S. aureus is also a food borne pathogen, and little is known regarding biofilm formation of food-related strains. We have studied biofilm formation of both food-related and clinical S. aureus strains grown under different stress conditions (temperature, sodium chloride, glucose and ethanol) relevant for food processing. Strong biofilm formers were identified among food-related S. aureus strains, and biofilm formation was affected by environmental conditions relevant for the food industry. The results showed that temperatures suboptimal for growth increased the production of biofilm. The combined presence of sodium chloride and glucose enhanced the biofilm formation. Both temperature and osmolarity affected the expression of several biofilm associated genes (e.g. icaA and rbf). Variations in gene expression (e.g. icaA, agrA and sigB) between strains were also observed. Our results support the existence of both ica-dependent and ica-independent mechanisms of biofilm production in S. aureus. The phenotypic and genotypic results showed highly diverse and complex patterns of biofilm formation in S. aureus. This clearly demonstrates that caution must be exercised before drawing general conclusions about gene expression in S. aureus in relation to regulation of biofilm formation. The results are relevant for food safety as they indicate that food processing conditions could promote biofilm formation by S. aureus. 相似文献
10.
Development and application of new nucleic acid-based technologies for microbial community analyses in foods 总被引:8,自引:0,他引:8
Rudi K Nogva HK Moen B Nissen H Bredholt S Møretrø T Naterstad K Holck A 《International journal of food microbiology》2002,78(1-2):171-180
Several challenges still persist in the analysis of microorganisms in foods, particularly in studies of complex communities. Nucleic acid-based methods are promising tools in addressing new questions concerning microbial communities. We have developed several new methods in the field of nucleic acid-based microbial community analyses. These methods cover both sample preparation and detection approaches. The sample preparation method involves simplified DNA purification using paramagnetic beads. As an extension of this method, the same paramagnetic beads are used for both cell separation and DNA purification. This enables full automation. The separate detection of viable and dead bacteria is a major issue in nucleic acid-based diagnostics. We have applied a living/dead dye that binds covalently to DNA and inhibits the PCR from dead cells. In addition, a DNA array-based detection assay has been developed. The assay combines the specificity obtained by enzymatic labeling of DNA probes with the possibility of detecting several targets simultaneously by DNA array hybridization. In combination with 16S rDNA amplification, this is a promising tool for community analyses. Also, we have developed a novel approach for multiplex quantitative PCR. The multiplex PCR has been combined with our DNA array-based detection method. Finally, we are now in the process of adapting a system for monitoring microbial growth and death in real-time through the tagging of bacteria with green fluorescent protein (GFP) combined with fluorescence detection using a high-resolution confocal laser scanner. 相似文献