Effect of spark discharge parameters on the ignition of gas mixtures

The influence of the duration and spatial extent of a heat-releasing spark discharge on the critical conditions of spark ignition of a reactive gas is considered. A region insensitive to the effect of these parameters and, thus, suitable for work with the instantaneous source model is defined. Tomsk. Translated from Fizika Goreniya i Vzryva, Vol. 29, No. 5, pp. 3–7, September–October, 1993.     

Tuning On-Air Signatures for Balancing Performance and Confidentiality

In this paper, we investigate the trade off between performance and confidentiality in signature-based air indexing schemes for wireless data broadcast. Two metrics, namely, false drop probability and false guess probability, are defined to quantify the filtering efficiency and confidentiality loss of a signature scheme. Our analysis reveals that false drop probability and false guess probability share a similar trend as the tuning parameters of a signature scheme change and it is impossible to achieve a low false drop probability and a high false guess probability simultaneously. In order to balance the performance and confidentiality, we perform an analysis to provide a guidance for parameter settings of the signature schemes to meet different system requirements. In addition, we propose the jump pointer technique and the XOR signature scheme to further improve the performance and confidentiality. A comprehensive simulation has been conducted to validate our findings.     

The prospects and problems of utilizing biomass and combustible wastes to produce heat and electricity

Peculiarities of using biomass and combustible wastes as renewable sources of energy are considered. Positive outcomes resulting from involving these types of fuel in the fuel balance and the problems arising from this involvement are noted. Data on the use of biomass abroad are given.     

Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment

Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However, PSMA-TRT cannot be used for curative intent yet, thus additional research on how to improve the therapeutic efficacy is warranted. A potential way of achieving this, is combining TRT with poly ADP-ribosylation inhibitors (PARPi), which has shown promising results for TRT of neuroendocrine tumor cells. Currently, several clinical trials have been initiated for this combination for PCa, however so far, no evidence of synergism is available for PCa. Therefore, we evaluated the combination of PSMA-TRT with three classes of PARPi in preclinical PCa models. In vitro viability and survival assays were performed using PSMA-expressing PCa cell lines PC3-PIP and LNCaP to assess the effect of increasing concentrations of PARPi veliparib, olaparib or talazoparib in combination with PSMA-TRT compared to single PARPi treatment. Next, DNA damage analyses were performed by quantifying the number of DNA breaks by immunofluorescent stainings. Lastly, the potential of the combination treatments was studied in vivo in mice bearing PC3-PIP xenografts. Our results show that combining PSMA-TRT with PARPi did not synergistically affect the in vitro clonogenic survival or cell viability. DNA-damage analysis revealed only a significant increase in DNA breaks when combining PSMA-TRT with veliparib and not in the other combination treatments. Moreover, PSMA-TRT with PARPi treatment did not improve tumor control compared to PSMA-TRT monotherapy. Overall, the data presented do not support the assumption that combining PSMA-TRT with PARPi leads to a synergistic antitumor effect in PCa. These results underline that extensive preclinical research using various PCa models is imperative to validate the applicability of the combination strategy for PCa, as it is for other cancer types.     

Improving database performance with a mixed fragmentation design

The performance of database operations can be enhanced with an efficient storage structure design using attribute partitioning and/or tuple clustering. Previous research deals mostly with attribute partitioning. We address here the combined problem of attribute partitioning and tuple clustering. We propose a novel approach for this mixed fragmentation problem by applying a genetic algorithm iteratively to attribute partitioning and tuple clustering sub-problems. We compared our results to attribute-only partitioning and random search solution, resulting in a database access cost reduction of upto 70% and 67% respectively. We analyzed the effect of varying genetic parameters on the optimal solution through experimentation.     

Ignition of heterogeneous systems by radiant energy

Translated from Fizika Goreniya i Vzryva, Vol. 24, No. 4 pp. 3–10, July–August, 1988.     

Spark ignition of atomized liquid fuel

Tomsk. Translated from Fizika Goreniya i Vzryva, Vol. 26, No. 1, pp. 11–15, January–February, 1990.