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排序方式: 共有301条查询结果,搜索用时 0 毫秒
1.
Ian Stoppa Casimiro Luca Gigliotti Nausicaa Clemente Deepika Pantham Chiara Dianzani Chiara Monge Chiara Puricelli Roberta Rolla Salvatore Sutti Filippo Ren Renzo Boldorini Elena Boggio Umberto Dianzani 《International journal of molecular sciences》2022,23(13)
Background: ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune response and tissue repair. Aim: The aim of this study was to assess the in vivo effects of ICOSL triggering by ICOS-Fc, a recombinant soluble form of ICOS, on skin wound healing. Methods: The effect of human ICOS-Fc on wound healing was assessed, in vitro, and, in vivo, by skin wound healing assay using ICOS−/− and ICOSL−/− knockout (KO) mice and NOD-SCID-IL2R null (NSG) mice. Results: We show that, in wild type mice, treatment with ICOS-Fc improves wound healing, promotes angiogenesis, preceded by upregulation of IL-6 and VEGF expression; increases the number of fibroblasts and T cells, whereas it reduces that of neutrophils; and increases the number of M2 vs. M1 macrophages. Fittingly, ICOS-Fc enhanced M2 macrophage migration, while it hampered that of M1 macrophages. ICOS−/− and ICOSL−/− KO, and NSG mice showed delayed wound healing, and treatment with ICOS-Fc improved wound closure in ICOS−/− and NSG mice. Conclusion: These data show that the ICOS/ICOSL network cooperates in tissue repair, and that triggering of ICOSL by ICOS-Fc improves cutaneous wound healing by increasing angiogenesis and recruitment of reparative macrophages. 相似文献
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Antonio Qualtieri Dr. Elena Urso Maria Le Pera Sabrina Bossio Francesca Bernaudo Tiziana Ferraro Lucia Crescibene Umberto Aguglia Aldo Quattrone 《Proteomics. Clinical applications》2009,3(5):574-583
MALDI‐TOF protein profiling analysis permits the detection of peptides and small proteins in complex protein mixtures with great accuracy. We applied this analysis to cerebrospinal fluid (CSF) from 15 patients affected by Creutzfeldt‐Jakob disease (CJD). We compared the levels of the normalized ion signals of 11 sporadic and 4 genetic CJD forms with those from ten healthy control subjects and eight non‐CJD relapsing‐remitting multiple sclerosis patients. In so doing, we detected 61 differentially expressed ion signals in CJD samples compared to controls. Among the 61 signals, 3 signals had significantly increased levels with high statistical significance (p <0.0001) and were located at 3238.3 m/z, 4963.7 m/z, and 8565.3 m/z. We characterized the 5.0 and 8.6 kDa proteins as thymosin β4 N‐acetylated and free ubiquitin, respectively, while the 3.2‐kDa peptide remained uncharacterized. Although elevated ubiquitin levels have previously been described in CJD, we have demonstrated for the first time the involvement of thymosin β4 in a neurodegenerative disease. To support the validity of thymosin β4 levels obtained by MALDI‐TOF analysis, an independent enzyme immunoassay analysis was performed. Moreover, a validation cohort consisting of CSF from three CJD patients, five healthy subjects, and six non‐CJD relapsing‐remitting multiple sclerosis patients was analyzed in a similar way, yielding superimposable results. We propose that thymosin β4 is a potential new candidate marker for the ante mortem diagnosis of CJD disease. 相似文献
4.
Umberto?Ferraro-PetrilloEmail authorView authors OrcID profile 《Multimedia Systems》2017,23(4):469-484
Monitoring the performance of a web marketing campaign is usually a long-lasting, low-effort but distracting task, where a user repeatedly glances at some sort of visual analytics tools to check whether the campaign is going well. In this paper, we explore an alternative approach for this task, where the performance of a web marketing campaign is monitored through sonification, using the soundset of popular 8-bit arcade video games. On one hand, sonification would allow a user to be constantly informed about the current state of the campaign without being distracted. On the other hand, the sound metaphors coming from popular 8-bit arcade video games would be able to convey information about the status of the campaign in a simple and effective way (i.e., if the sonification of a campaign resembles the audio of a successful game session, then the campaign is going well). We investigated this idea by developing a prototype system for the sonification of the behavior of a web server activity through a configurable set of sound metaphors. We then analyzed the effectiveness of our approach by conducting a simple experimental study. This was done, first, by sonifying the progress of a given web marketing campaign using the soundset of two popular 8-bit video games: Super Mario Bros and Bubble Bobble. The outcoming soundtrack was then used in a controlled setting to assess the performance of a group of 20 participants listening to our soundtrack under different work conditions. 相似文献
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Renato Bacchetta Paolo Tremolada Cristiano Di Benedetto Nadia Santo Umberto Fascio Giuseppe Chirico Anita Colombo Marina Camatini Paride Mantecca 《Carbon》2012,50(12):4607-4618
Lethal and teratogenic potentials of carbon nanoparticles (CNPs) in their amorphous form were investigated by the standardized Frog Embryo Teratogenesis Assay-Xenopus (FETAX), a 96-h in vitro whole-embryo toxicity test based on the amphibian Xenopus laevis. Embryos were acutely exposed to 1, 10, 100 and 500 mg/L CNP suspensions and evaluated for lethality, malformations and growth inhibition. Larvae were processed for histological and ultrastructural analyses to detect the main affected organs, to look for specific lesions at the subcellular level and to image and track CNPs into tissues. Only the highest CNP suspension resulted in being embryolethal for X. laevis larvae, while malformed larva percentages significantly differed from controls starting from 100 mg/L. The stomach and gut were the preferential CNP accumulation sites, on the contrary, the digestive epithelium remained intact. The analyses showed the presence of isolated nanoparticles and/or aggregates in different secondary target organs. CNPs were found in circulating erythrocytes. The research confirms the good tolerance of X. laevis towards pure elemental carbon in its nanoparticulate amorphous form, but highlights the possibility of CNP transfer toward all body areas. 相似文献
7.
Umberto C. Gatti Susan M. Bogus Suzanne Schneider 《Construction Management & Economics》2014,32(6):548-564
The monitoring of construction workforce physical strain can be a valuable management strategy in improving workforce productivity, safety, health, and quality of work. Nevertheless, clear relationships between workforce performance and physical strain have yet to be established. An exploratory investigation of the relationship between task level productivity and physical strain was conducted. Nine participants individually performed a four-hour simulated construction task while a wearable physiological status monitor continuously assessed their physiological condition. Heart rate, relative heart rate, and breathing rate were utilized as predictors of physical strain, and task level–single factor productivity was used as an index of productivity. Numerous regression models were generated using the collected data. This investigation initially unsuccessfully attempted to establish a relationship between physiological condition and productivity at the individual worker level. However, an analysis of the regression models showed that there is a relationship between productivity and either heart rate or relative heart rate at the group level, and that this relationship is parabolic. Breathing rate was proved to not be a significant predictor of productivity. Research results significantly improve understanding of the relationship between work physiology and task productivity. Researchers and practitioners may use the tested monitoring devices, analysis methods, and results to design further applied studies and to improve workforce productivity. 相似文献
8.
Umberto De Rossi Johannes Moll Monika Spieles Günther Bach Siegfried Dhne Jrg Kriwanek Maria Lisk 《Advanced Synthesis \u0026amp; Catalysis》1995,337(1):203-208
Cyanine dyes ( 1a–d ) with the 5,5′,6,6′-tetrachloro-1,1′-dialkyl-3,3′-di-(3-carboxypropyl)-benzimidocarbocyanine chromophore differing only in the chain length of their alkyl groups in 1,1′-position have been synthesized, spectroscopically characterized, and compared with 5,5′6,6′-tetrachloro-1,1′-diethyl-3,3′-di-(4-sulfobutyl)-benzimidocarbocyanine( TDBC ). In aqueous solution the dyes form J-aggregates which, depending on the alkyl group chain length, exhibit J-bands differing in spectral positions, bandwidth, and in the number of peaks. 相似文献
9.
The substitution of the traditional analogic measurement and processing techniques with sampling methods is a trend in modern metrology. Many commercial instruments perform this determination by means of their internal firmware. An analysis is necessary when sampling instruments are employed within a laboratory, for the determination of one or more quantities. However, this analysis is possible only under some specific circumstances, where both the characteristics of the samples and the processing algorithms have to be known.The paper will consider the samples as input for the determination of given quantities and the methods to evaluate the uncertainty of the results from the uncertainty of the samples and their correlation. The example is derived by the uncertainty evaluation of the INRIM system for the precision measurement of the power, where the determination of the accuracy has been accomplished both by an almost analytical approach followed by a numerical evaluation. 相似文献
10.
The extremum seeking control (ESC) algorithm has been proposed to determine operating parameters that maximize power production below rated wind speeds (region II). This is usually done by measuring the turbine's power signal to determine optimal values for parameters of the control law or actuator settings. This paper shows that the standard ESC with power feedback is quite sensitive to variations in mean wind speed, with long convergence time at low wind speeds and aggressive transient response, possibly unstable, at high wind speeds. The paper also evaluates the performance, as measured by the dynamic and steady state response, of the ESC with feedback of the logarithm of the power signal (LP‐ESC). Large eddy simulations (LES) demonstrate that the LP‐ESC, calibrated at a given wind speed, exhibits consistent robust performance at all wind speeds in a typical region II. The LP‐ESC is able to achieve the optimal set‐point within a prescribed settling time, despite variations in the mean wind speed, turbulence, and shear. The LES have been conducted using realistic wind input profiles with shear and turbulence. The ESC and LP‐ESC are implemented in the LES without assuming the availability of analytical gradients. 相似文献