Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required.     

Development of an octocalcium phosphate cement

From previous studies it is known that alpha-tertiary calcium phosphate and dicalcium phosphate form a cement upon mixing with water. In this study this cement was optimized in terms of the milling of the constituents, their molar ratio, the amount of hydroxyapatite added and the water/powder ratio. The optimum Ca/P molar ratio of the cement mixture was 1.36±0.03. X-ray diffraction showed the reaction product to be octocalcium phosphate. Addition of precipitated hydroxypatite of over 3% diminished the final strength of the cement significantly. However, admixtures of only 2% of precipitated hydroxyapatite (a) kept the final compressive strength at 30±5 MPa after soaking in Ringers solution at 37°C, (b) diminished the initial setting time from 27.5 to 10 min and the final setting time from 65 to 40 min, (c) diminished the time in which the final strength was reached from 36 to less than 14 h. The tensile strength of this cement is 19±1% of its compressive strength. The optimum water/powder ratio as found in this study was 0.30 g/g.     

Invariant three- and four-phase equilibria in the magnesium-rich corner of the Mg-Cu-Sn ternary system

Invariant three- and four-phase equilibria in the magnesium-rich corner of the Mg-Cu-Sn ternary system have been studied by differential thermal analysis, optical microscopy, electron probe microanalysis and X-ray diffraction. The L(Mg) + Mg₂ Cu + Mg₂Sn ternary eutectic reaction was found to be at 467 °C and at Mg–13.5 at % Cu–4.4 at% Sn. The LMg₂Cu + Mg₂Sn pseudo-binary eutectic reaction is tentatively located at 522°C and at Mg–26.0 at % Cu–7.7 at % Sn.     

Use of knee height to correct the body height of elderly Hispanics

Loss of stature in certain elderly subjects can be attributed to diseases such as osteoporosis, as well as to age and generational effects. In addition, many elders cannot stand straight for accurate measurement. For these cases, total height can be estimated with regression equations based on knee height. The aims of this study were, firstly, to evaluate the applicability of regression equations based on knee height for estimation of stature and, secondly, to document the differences between measured and estimated height in a group of elderly Hispanics with postural problems (n = 166) in comparison with a group of elderly Hispanic without postural problems (n = 270). Using both, estimated and measured height, we also calculated the body mass index (BMI) of both groups of elders. Statistical analyses were done with paired t-tests, within sex and study group. Within the group with postural problems, estimated height was higher than the measured height for both men (p < or = 0.001) and women (p < or = 0.001). There were no significant differences between measured and estimated height in the group without postural problems. Furthermore, in the group with postural problems, BMI values calculated with estimated height were lower than those estimated with the measured height, and these differences were also significant for both men (p < or = 0.001) and women (p < or = 0.001). With the aging of the Latin American population, there is a need for more nutrition and health research among elders. In order to do this we need to develop and use methods and criteria appropriate for each population.     

Finite element approximation of nonlinear transient magnetic problems involving periodic potential drop excitations

This paper deals with the computation of nonlinear 2D transient magnetic fields when the data concerning the electric current sources involve potential drop excitations. In the first part, a mathematical model is stated, which is solved by an implicit time discretization scheme combined with a finite element method for space approximation. The second part focuses on developing a numerical method to compute periodic solutions by determining a suitable initial current which avoids large simulations to reach the steady state. This numerical method leads to solve a nonlinear system of equations which requires to approximate several nonlinear and linear magnetostatic problems. The proposed methods are first validated with an axisymmetric example and sinusoidal source having an analytical solution. Then, we show the saving in computational effort that this methodology offers to approximate practical problems specially with pulse-width modulation (PWM) voltage supply.     

A Comprehensive Study of Particle Size Distributions with the Use of PostInjection Strategies in DI Diesel Engines

Control strategies such as variations in injection pressure and timing have been used by researchers to reduce in-cylinder exhaust emissions and meet legislation standards. Postinjection has been studied for several years and is now well known as an efficient strategy for reducing soot emission. Diesel gaseous and particle mass emissions have been progressively reduced over the last twenty years as a consequence of increasingly restrictive emission legislation and the application of aftertreatment devices. The main objective of this work is to better understand the effect of postinjection on particle size distribution in diesel exhaust. The approach uses a modern, well-instrumented research engine test cell equipped with a flexible high pressure fuel injection system. The results of this work provide guidelines for developing strategies to reduce particle size distribution in diesel engines. A major improvement in particle size distribution was found in the accumulation mode by using a close postinjection of a small quantity of fuel. For reduction in nucleation mode, a relationship was found with close postinjections of large quantities of fuel.     

Synthesis of Fatty Acid Amides of Catechol Metabolites that Exhibit Antiobesity Properties

A series of fatty acid amides of 3,4‐methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affinity for the CB₁ receptor and/or PPAR‐α; part of their biological activity may be caused by these double interactions.     

Towards a satisfactory conversion of messages among agent-based information systems

Over the last years, there has been a change of perspective concerning the management of information systems, since they are no longer isolated and need to communicate with others. However, from a semantic point of view, real communication is difficult to achieve due to the heterogeneity of the systems. We present a proposal which, considering information systems are represented by software agents, provides a framework that favors a semantic communication among them, overcoming the heterogeneity of their agent communication languages. The main components of the framework are a suite of ontologies – conceptualizing communication acts – that will be used for generating the communication conversion, and an Event Calculus interpretation of the communications, which will be used for formalizing the notion of a satisfactory conversion. Moreover, we present a motivating example in order to complete the explanation of the whole picture.