Synthesis and characterisation of N-toluyl methacrylatoethyl carbamates,homopolymers and copolymers with methyl methacrylate

The paper describes the synthesis of N-2/4-toluyl methacrylatoethyl carbamates using 2/4-toluyl isocyanate and 2-hydroxyethyl methacrylate. Homopolymerisation and copolymerisation of these novel monomers with methyl methacrylate was carried out using benzoyl peroxide as an initiator and tetrahydrofuran as solvent. Photopolymerisation of N-4-toluyl methacrylatoethyl carbamate could be carried out without the use of photosensitiser. Structural characterisation of copolymers was done using ¹H-NMR. Thermal stability of copolymers was evaluated in a nitrogen atmosphere by dynamic thermogravimetry.     

Deformation due to expanding ring load in modified couple stress thermoelastic diffusion in time and frequency domain

The two-dimensional problem of expanding ring load in a modified couple stress theory of thermoelastic diffusion with heat sources in time and frequency domains is investigated. The mathematical formulation prepared for thermoelastic diffusion solids with one and two relaxation times using Laplace and Hankel transforms. The displacements, stress components, temperature change, and chemical potential are obtained in a transformed domain. Numerical computation is performed for these quantities and the resulting quantities are shown graphically for the time and frequency domains. Comparisons are made with the results predicted by the two theories and different values of time and frequency. Particular cases of interest are also deduced.     

Factors determining informal tanker water markets in Chennai,India

Many developing world cities have seen the emergence of informal markets where private tanker truck operators transport water extracted from peri-urban wells to urban consumers. This study adopted a systems-modelling approach to analyzing the informal tanker market in India. The results indicate that the demand for tanker supply was caused by lack of groundwater availability in private wells as well as unreliable piped supply. The study shows that two groundwater factors are relevant: depth to water and aquifer productivity. Together, these could explain the difference in spatial, temporal and consumer-specific variations in tanker dependence.     

Sex Differences and Individual Differences in Cognitive Performance and Their Relationship to Endogenous Gonadal Hormones and Gonadotropins.

Sexually dimorphic cognitive performance in men (n=42) and women (n=42) was related to testosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and sex hormone binding globulin, measured in 10-ml blood samples collected between 0900 and 1030 and, among women, during the follicular phase of the menstrual cycle. Significant sex differences favored men on spatial tasks (Mental Rotation and Judgment of Line Orientation) and on an inhibition task and favored women on a verbal task (category fluency). However, there were no significant relationships between any of the hormones and cognitive performance, suggesting that there are few, if any, consistent, substantial relationships between endogenous, nonfluctuating levels of gonadal hormones or gonadotropins and these cognitive abilities in men or women. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Study of Brinkman–Bènard nanofluid convection with idealistic and realistic boundary conditions and by considering the effects of shape of nanoparticles

This study deals with linear and weakly non-linear stability analyses of Brinkman–Bènard convection in nanoliquid-saturated porous enclosures. Water with a dilute concentration of molybdenum disulfide nanoparticles with 0.06 volume fraction and 30% glass fiber-reinforced polycarbonate as a porous medium with porosity 0.88 are considered to be a working medium. The analytical solution is obtained in the present study for idealistic and realistic boundary conditions, and their results are compared. An analytically intractable Lorenz model with quadratic nonlinearities is reduced to a tractable Ginzburg–Landau amplitude equation with cubic nonlinearity using the multiscale method. Nanoparticles with different shapes are considered in the study, and their effects on the onset and heat transfer are discussed in great detail graphically in the presence of other parameters arising in the problem.     

Oxime-Modified Aluminum(III) Isopropoxide: A Promising Sol–Gel Precursor for Corrosion Resistive Nano-Alumina Coating on an Aluminum Alloy

Protection of Metals and Physical Chemistry of Surfaces - Dense alumina coatings were fabricated over aluminum alloy via dip coating method using oxime-modified aluminum(III) isopropoxide as a...     

Novel anhydrous composite membranes based on sulfonated poly (ether ketone) and aprotic ionic liquids for high temperature polymer electrolyte membranes for fuel cell applications

Novel composite membranes were prepared using imidazolium type aprotic ionic liquids and sulfonated poly (ether ketone) (SPEK) as polymer matrix by solution casting process. All the prepared membranes were characterized for their thermal stability, mechanical properties, ion exchange capacity, proton conductivity and leaching out of ionic liquids in presence of water. Ionic liquid based membranes were more flexible than neat SPEK membrane due to the plasticization effect of ionic liquids. The interactions and compatibility occurring among components were investigated by vibration spectroscopy (FTIR ATR) and scanning electron microscopy respectively. The thermal stability of composite membranes was higher than unmodified membranes. The ion conductivity of composite membranes under anhydrous conditions was found to be dependent on temperature, type and concentration of ionic liquid in SPEK matrix. Ion conductivities of composite membranes under anhydrous condition were found to be up to two orders (∼100 times) higher than neat SPEK membrane and it was found to be ∼5 mS/cm at 140 °C for SPEK/OTf-70. These composite membranes can be successfully operated at temperatures ranging from 40 °C to 140 °C under anhydrous conditions.     

Novel surface modified polymer–lipid hybrid nanoparticles as intranasal carriers for ropinirole hydrochloride: in vitro, ex vivo and in vivo pharmacodynamic evaluation

Here we report fabrication and evaluation of novel surface modified polymer–lipid hybrid nanoparticles (PLN) as robust carriers for intranasal delivery of ropinirole hydrochloride (ROPI HCl). Sustained release, avoidance of hepatic first pass metabolism, and improved therapeutic efficacy are the major objectives of this experiment. PLN were fabricated by emulsification-solvent diffusion technique and evaluated for physicochemical parameters, in vitro mucoadhesion, in vitro diffusion, ex vivo permeation, mucosal toxicity and stability studies. Box-Behnken experimental design approach has been employed to assess the influence of two independent variables, viz. surfactant (Pluronic F-68) and charge modifier (stearylamine) concentration on particle size, ζ-potential and entrapment efficiency of prepared PLN. Numerical optimization techniques were used for selecting optimized formulation sample, further confirmed by three dimensional response surface plots and regression equations. Results of ANOVA demonstrated the significance of suggested models. DSC and SEM analysis revealed the encapsulation of amorphous form of drug into PLN system, and spherical shape. PLN formulation had shown good retention with no severe signs of damage on integrity of nasal mucosa. Release pattern of drug-loaded sample was best fitted to zero order kinetic model with non-Fickian super case II diffusion mechanism. In vivo pharmacodynamic studies were executed to compare therapeutic efficacy of prepared nasal PLN formulation against marketed oral formulation of same drug. In summary, the PLN could be potentially used as safe and stable carrier for intranasal delivery of ROPI HCl, especially in treatment of Parkinson’s disease.